Indlela iProstaglandin Ephatha Ngayo Ukuvuvukala Nezinhlungu

Ama-Influencers wezinhlungu zomzimba

I-Prostaglandin yi-hormone enethonya elikhulu phezu kwezinqubo eziyinhloko zomzimba emzimbeni wakho. Zombili imiphumela emihle futhi emibi empilweni yakho. Ngamanye amazwi, i-prostaglandin ihlinzekela i-homeostasis, kodwa iphinde ikhuthaze izinqubo zezifo.

Izinhloso

Lezi zinto ezinomphela ziyenziwa ngamafutha amaningi, futhi zidlala indima emisebenzini eminingi eyisisekelo.

Enye yale misebenzi ihlanganisa, isibonelo, i-vasodilation ne-vasoconstriction. I-Vasodilation ne-vasoconstriction, ngokulandelana, inqubo yokuzenzakalela yokuvula imithi yegazi nokuvula. Ezinye zihlanganisa i-bronchoconstriction, okungukuthi i-constriction yendlela yokuhamba emoyeni, ukumboza igazi, ukuvinjelwa kwegazi, ukukhulelwa, nokugcinwa kwezicubu ezifana nesilonda sakho esiswini.

Kanye nezinto ezibalulwe ngenhla, i-prostaglandin ithonya amazinga obuhlungu futhi ilawula ukuvuvukala, izinqubo ezimbili zomzimba ezithinta cishe wonke umuntu osebenzelana nentambo noma inkinga yangemva.

Ngokomhleli we-2003 ku- Nature Structural Biology , kunezinhlobo ezingaba ngu-24 ze-prostaglandins.

Imithi Elandelwayo I-Prostaglandins

Ngenxa yokuthi i-prostaglandin idlala indima ebalulekile ekuqaliseni nasekuqhubekiseni ukuvuvukala, izidakamizwa eziningi ziye zathuthukiswa eminyakeni edlule ukulwa nesenzo sabo. Lezi zidakamizwa zithathwa njengeziphumelelayo futhi ezingabizi kakhulu, futhi abantu emhlabeni jikelele futhi phansi eminyakeni eminingi baye bavakashela njalo ukuze bathole usizo.

Ezikhathini zasendulo, i- willow gark yayisetshenziselwa ukukhulula ubuhlungu nokunciphisa umkhuhlane, futhi lezi zinsuku eziningi ze-herbalist ephelele zincoma lesi sitshalo kumakhasimende abo omkhuhlane. Ngomnyaka we-1820, isithako esisebenzayo se-willow amagxolo laqanjwa ukuba yi-salicylic acid. Kodwa lapho iziguli zinezinkinga ezinkulu zesisu, kuhlanganise nokuhuda nokuhlanza, ngenxa yokuthatha i-salicylic acid, i-acetylsalicylic acid yaqala ukusetshenziswa endaweni yayo.

Ngama-1890, i-acetylsalicylic acid yaqala emakethe njenge-aspirin yinkampani eyaziwa njengamanje njengeBayer.

I-COX Inhibitor Izidakamizwa

Ema-1960s isigaba sezidakamizwa okuthiwa i-phenylolkanoic acid satholakala ukunciphisa ukuvuvukala nobuhlungu. Lawa ma-acids enza kanjalo ngokuvimbela i-cyclooxygenase enzyme, noma i-COX. (I-COX enzymes ijwayele ukwenza isinyathelo ekuqaleni kwesizukulwane se-prostaglandin.) "I-Painkillers ne-prostaglandins" ithi isihloko se-COX enzymes sitholiwe: COX 1 evikela ipheshana lakho le-GI, i-COX 2, edlala indima ekuvuvukala, umkhuhlane , nobuhlungu, ne-COX 3 etholakala ikakhulu ebuchosheni. I-COX inhibitors eyaziwayo (okwamanje emakethe) ngobuhlungu nokuvuvukala-uhlobo oluthathwa ngabantu abanezintamo noma ubuhlungu be-back-zifaka i-aspirin ne-ibuprofen ( Advil ). I-Aspirin ne-Advil ivimbela kokubili i-COX 1 ne-COX 2 enzymes. Imiphumela emibi yalezi zimithi izilonda futhi ziphuma emgodini wesisu.

U-Advil uphinde abe neengozi yokuhlaselwa inhliziyo kanye nokushaya, ngeshwa.

Eqinisweni, ngaphandle kwe-aspirin, zonke izidakamizwa ezingezona izifo ezivukela ukuvuvukala (ama-NSAID) ziza nesilumkiso se-FDA esithi "ibhokisi elimnyama" ukuthi ukuthatha imithi kuphakamisa ingozi yesifo senhliziyo.

Ungase ukhumbule i- Vioxx no-Bextra , ukuvuselelwa kabuhlungu okwakungenwe ngaphambili okukhishwe emakethe ngo-2004. Isenzo salezi zidakamizwa kwakuwukuvimbela kuphela i-COX 2 enzyme; kanjalo, beyaziwa nangokuthi COX 2 inhibitors. Inzuzo yabo yayiwukuthi imiphumela yecala ehlobene nesisu yayingekho; inkinga ukuthi ngesikhathi esifanayo lezi zidakamizwa zazijabulela isimo se-blockbuster emakethe, kwakunqunywa ukuthi ama-inhibitors e-COX-2 akhulisa ingozi yokuhlaselwa kwenhliziyo engathí sina noma ebulalayo.

Ngo-September ka-2004, uMerck ngokuzithandela wathatha u-Vioxx emakethe. Ngo-Ephreli 2005, i-FDA yayala umenzi wezidakamizwa uPfizer ukuthi adonse uBextra emakethe kodwa wavumela iCelebrex (Celecoxib) ukuba ihlale, lapho yenza khona kuze kube yilolu suku.

Izwi kusuka

Kuyaziwa ukuthi ukuvuvukala kungumsuka wezifo eziningana zanamuhla, kuhlanganise nobuhlungu obungapheli. Kuyaziwa nangokuthi ukuphuza imithi ukuxazulula izifo ezihambisana nokuvuvukala kungase kube nemiphumela emibi, okunye okungase kube yinkimbinkimbi ngempela, ngempela.

Ukuze kwenzeke lokho, abahlinzeki abaningi bezempilo, iziguli, kanye nezishoshovu zemithi yemvelo zikhuthaza noma zilandele ukudla okuphikisayo. I-athikili eshicilelwe eHarvard Women's Health Watch ibike ukuthi izifundo eziningi zibonise ukudla kungaba nomthelela wokuvimbela.

Ukwazi ukuthi yiziphi ezingasiza ukudala isisekelo sokudla okungasiza ekulwa nemiphumela yokuvuvukala.

Abanye abantu baphinde bathathe ama-anti-inflammatory herbs noma ama-supplements , afana ne-willow bark, okukhulunywe ngakho ngenhla.

> Imithombo:

> Umhleli. Ama-Painkillers nama-prostaglandin. I-Nature Structural Biology. 2003

> I-Harvard Women's Health Watch. Ukudla okulwa nokuvuvukala ngo-Agasti 2017.

> Ricciotti, E., PhD, FitzGerald, Garret A., MD. I-Prostaglandins ne-Inflammation. I-Arterioscler Thromb Vasc Biol. Meyi 2011.