Izifundo Thola Ukuxhumeka Okungenzeka Kuphakathi Kwezitembu Nezivalo
Ucwaningo luye lwaveza imiphumela ezuzisayo yezakhiwo, kufaka phakathi ubudlelwane phakathi kwama-statins nokuvuvukala .
Kuyini ukuvuvukala?
Ukuvuvukala yingxenye yempendulo evamile yomzimba kokulimala noma ukutheleleka. Uma uthola ukulimala okuncane (ukuchithwa noma ukusika), indawo ewuzungezile ngokuvamile ibomvu futhi ivule kancane. Lezi zibonakaliso zangaphandle zokuvuvukala, izibonakaliso zomzimba ezibuthakathaka ebusweni bomonakalo.
Kuyinto engokwemvelo yenqubo yokuphulukisa. Kodwa akusiyo njalo ewusizo.
Ukuvuvukala kwenzeka lapho isimiso somzimba sokuzivikela sisithumela kumangqamuzana egazi amhlophe ayingqayizivele endaweni ewonakele. Lawa maseli asiza ukulwa nanoma yikuphi ukutheleleka futhi ahlanze amaseli afile asele ngemuva. Inqubo efanayo eyenzeka ngokusika, ukulimaza noma ukulimala kwenzeka nangokulimala kumisipha yenhliziyo noma kwemisipha.
Indima ye-LDL Cholesterol ekuvuvukala
Ngendlela efanayo, umzimba uthumela amasosha omzimba wokudonsela amandla emzimbeni ezindaweni ezishisayo ezijikelezayo - okungukuthi, ama-plaques akhiwa yi-cholesterol embi (i- LDL ) emadongeni ase-artery. Ngeshwa, uma ama-macrophage ethatha lezi zinhlayiya, angaba ne-cholesterol bese egcina enezela emzimbeni jikelele (nokuthungatha) we-plaque. Nakuba kuhloswe ukulwa ne-plaque, impendulo yokuvuvukala empeleni yenza i-plaque ibe yintengantengwane futhi isheshe ihlukane, futhi lokho kungaholela ekuhlaselweni kwenhliziyo noma ngesifo sohlangothi.
Ngaphezu kwalokho, ukuvuvukala enhliziyweni nasemithanjeni yegazi kubangela izindonga zamanzi wegazi ukuba zibe "okunamathelayo" futhi zijwayele ukuheha amangqamuzana egazi engeziwe ne-cholesterol, eyenza i-plaque, noma izinqwaba ezibekwe kwi-deposit deposit esevele ikhona. Ekugcineni, le nqubo ingavimbela ukugeleza kwegazi ne-oxygen.
Uma i-artery ethintekile inika inhliziyo noma ubuchopho, futhi, umphumela ungase ube ukuhlaselwa yinhliziyo noma isifo sohlangothi .
Iprotheyini esebenzayo ye-C ekuvuvukala
Uma ukuvuvukala kukhona noma kuphi emzimbeni, amaprotheni akhethekile akhululwa egazini elingasetshenziswa ngokuhlolwa kwegazi. Ukuhlolwa okunye, okufana nesilinganiso se-erythrocyte sedimentation (ESR, noma i- "sed rate sed") yizilinganiso ezijwayelekile zokuvuvukala. Iprotheyini esebenzayo ye-C (CRP) yinye isilinganiso sokuvuvukala noma ukutheleleka emzimbeni. Amazinga e-CRP angaphezulu kuka-10 mg / L ayimpawu yokuthi ukuvuvukala kukhona endaweni ethile emzimbeni. Kodwa-ke, uma i-CRP iphakanyiswa kahle, phakathi kuka-1 mg / L kuya ku-3 mg / L, ihlanganiswe nezinkinga zesimiso senhliziyo, okungukuthi, inhliziyo nemithwalo yegazi.
Ngenkathi amazinga e-CRP ayingxenye yempendulo yemvelo yomzimba enkingeni, nazo ziyizindaba ezimbi. Bangakwazi ukubikezela ukuhlaselwa kwenhliziyo kubantu abangakaze babe nakho ngaphambili. Endabeni yeziguli ezithatha izinqubo ezithile zenhliziyo - kuhlanganise i- angioplasty , ukubekwa kwe-stent, ne- coronary artery -pass - nalabo abanezinhlungu zesifuba esihlobene nesifo senhliziyo - angina enhle noma angina engaqiniseki - la mazinga aphezulu e-CRP axhumene ingozi eyengeziwe yokwehla kwesifo senhliziyo noma isifo sokushaya isisu kanye nempilo enkulu yokufa.
Ngakolunye uhlangothi, ukuvimbela ukuvuvukala kusiza abantu abasengozini yesifo senhliziyo. Izinkinga ezibalulekile zezinhliziyo zenhliziyo zibandakanya ukuphakama okukhulu kwegazi , isifo sikashukela , i-cholesterol ephakeme, ukubhema noma umlando womndeni wesifo senhliziyo.
Yini izitatimende ezenzayo ekuvimbeni nasekunciphiseni amazinga e-CRP?
Izitatimende ziyisigaba esibalulekile semithi ephansi yamazinga we-cholesterol. Izitatimende zisiza ukuvimbela isifo senhliziyo, ukushaywa kanye nokulimala okuhlobene ne-cholesterol embi kakhulu (i-LDL) egazini. Ngokuzithoba ziphakamisa amazinga wegazi we-cholesterol enhle (i- HDL ). Izitatimende zisebenza ngokuvimbela i-enzyme ebizwa ngokuthi i-HMG-CoA yokunciphisa okubalulekile ekwenzeni i-cholesterol embi kumafutha agcwele ukudla.
Ngaphezu kokunciphisa amazinga we-cholesterol amabi, izitembu zisiza futhi ukwehlisa izinga legazi le-CRP. Nakuba umphumela wokuvimbela i-cholesterol uqondwa kahle, izindlela zokunciphisa i-CRP nokuvuvukala aziwa ngokugcwele. Ososayensi bakholelwa ukuthi izitembu zivimbela amaprotheni namaseli omzimba okukhululwa njengengxenye yenqubo evamile yokuvuvukala komzimba. Ukunciphisa lamazinga amaprotheni kungavumeli ukuvuvukala kungenzeki.
Kubuye kubonakale ukuthi ukusetshenziswa kwesikhathi eside kwezimiso zomzimba kubangela ukuvuvukala okuncane enhliziyweni kanye nezinkinga ezimbalwa. Izifundo zeziguli ezithinta i- angioplasty ngesibonakaliso esivusa amadlingozi ukuthi labo ababethatha ama-statins ngaphambi kwenqubo babe namazinga aphansi e-CRP kamuva futhi babengenaso amathuba okuhlaselwa yinhliziyo noma bafa ngonyaka ngemuva kwenqubo.
Izifundo zeziguli ezineziphazamiso zesischemic zithole ukuthi esikhathini esifushane kuze kufike ku-1 unyaka ngemva kokushaywa, iziguli ezithatha izitho zomzimba zinezinga eliphansi le-CRP nemiphumela ethuthukisiwe. Lezi zinzuzo zazihlanganisa ukukhubazeka okuncane kwezinzwa, njengokukhuluma nezinkinga zokunyakaza. Kwakukhona nesifo esingaphansi konyaka ngemuva kokushaywa yisifo. Ngaphezu kwalokho, izitembu zinciphisa ingozi yokuphazamiseka kwabantu abaye babhekene nesenzakalo esibucayi se-coronary, njengokuhlasela kwenhliziyo.
Njengoba nje ukuba khona kwe- CRP egazini kungakwazi ukubikezela izinkinga zenhliziyo, ukunciphisa amazinga e-CRP kunciphisa izingozi zenhliziyo zokuhlasela kwenhliziyo noma ezinye izenzakalo zenhliziyo, kuhlanganise nesifo sohlangothi. Nakuba inqubo ecacile isacacile, ososayensi baye bakhetha ukuxhumana okucacile phakathi kwama-statins kanye nokwehlisa amazinga e-CRP. Ngaphezu kwalokho, ucwaningo lubonisa ukuthi inzuzo enkulu kakhulu ekuthatheni ama-statins kulabo bantu abaqala ngamazinga aphezulu e-CRP; lezi zinzuzo zingaphezu kokuthi zingabalwa ngenxa yethonya lamazinga e-cholesterol yedwa.
Kubalulekile ukukhumbula ukuthi ukwehlisa amazinga e-CRP nama-statins akwanele ngokwayo ukuvimbela isifo senhliziyo. Nakuba amazinga aphansi e-CRP azuzisa, zonke izinkinga ze-cardiovascular risk - ezifana nesifo sikashukela, umfutho wegazi ophakeme , ukubhema, ukukhuluphala kanye / noma i- cholesterol ephakeme- inesifo senhliziyo futhi iphakamisa ingozi yokuba nesifo senhliziyo noma isifo sohlangothi. Indlela engcono kakhulu yokugwema lezi zenzakalo ukuzivocavoca, landela ukudla okunomsoco, okunomsoco ophansi futhi uthathe imithi enqunyiwe njengoba kunconywa umhlinzeki wakho wezempilo ukuze usize izingozi zakho ezingezansi ngangokunokwenzeka.
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