Isizathu esiyinhloko udokotela wakho ufuna ukunciphisa i-cholesterol yakho ukunciphisa ingozi yokuhlaselwa kwenhliziyo nokufa ngaphambi kwesikhathi kusuka e- coronary artery disease (CAD).
Futhi naphezu kokuthi amakilasi amaningana wemithi avunyelwe ukunciphisa i- cholesterol ye-LDL (i-LDL yiyona "uhlobo olubi" lwe-cholesterol), izidakamizwa kuphela ezikhonjisiwe ngokuphindaphindiwe ukunciphisa ingozi yokuhlaselwa kwenhliziyo nokufa ngaphambi kwesikhathi kubantu abanesifo senhliziyo ingozi iphakanyisiwe yiziqu zesimanje .
Eqinisweni, izifundo ezinkulu ziye zaphakamisa nokuthi ezinye zemithi engeyona i-statin ye-cholesterol ingaba nemiphumela emibi kakhulu.
Njengamanje, kucatshangwa ukuthi ama-statins angcono kunezinye izidakamizwa ekuthuthukiseni imiphumela ngoba banemivuzo eminingana ezuzayo ngaphezu kwamakhono abo okunciphisa i-cholesterol. Lemiphumela "eyengeziwe" ingasiza ekuvimbeleni ukuhlukana kwama- atherosclerotic plaques emithanjeni ye-coronary futhi kungasiza ekuvimbeleni i-coronary syndrome enamandla .
Imiphumela Engezona-Cholesterol-Ukunciphisa Kwezitatimende
Imiphumela "engaphezulu" engeyona ye-cholesterol-yehla yezimiso zihlanganisa:
- Umphumela olwa nokuvuvukala.
- Umthelela wokuvimbela ama-anti-clotting.
- Umthelela oqondile we-plaque-stabilizing.
- Ukunciphisa amazinga amaprotheni asebenzayo e- C (CRP)
- Ukuthuthukiswa komsebenzi we-vascular.
- Ukunciphisa ama-arrhythmias enesifo senhliziyo.
- Okunye ukuguqulwa (ukwehla) kwamapuleti a-atherosclerotic ngokwabo.
Lezi "ezengeziwe" imiphumela yezimiso zingase zibaluleke kakhulu (noma ebaluleke nakakhulu) kunokunciphisa i-cholesterol emiphumeleni yokuthuthukisa.
Isibonelo, lezi zimphumela ezingezona i-cholesterol zingase zibe isizathu sokunikeza izitho zomzimba ngesikhathi sokuhlaselwa kwenhliziyo ephuthumayo kunikeza inzuzo yomtholampilo ngokushesha - lokhu akulona umphumela ongayilindela uma into kuphela eyenziwa yi-statins kwaba ukunciphisa i-cholesterol. Lezi zinto ezingezona ukwehla kwe-cholesterol zingase zichaze nokuthi kungani izitembu zingathuthukisa imiphumela kwezinye iziguli ezinobungozi obukhulu amazinga e-cholesterol awaqakathekile kakhulu ukuqala ngawo.
Ngempela, izinzuzo eziyingqayizivele zezinhlavu ziye zabangela ezinye izazi ukuba zibuze yonke "i- cholesterol hypothesis " (i-hypothesis ukuthi ukunciphisa i-cholesterol izokwehlisa ingozi). Laba "baphikisho" bakholelwa ukuthi akuyona ukwehlisa kwe-cholesterol ye-LDL eyenza ama-statins aphumelele ekuthuthukiseni imiphumela, kodwa neminye imiphumela yezidakamizwa ze-statin. Ngakho (bayaqhubeka ukusikisela) mhlawumbe ukwehlisa i-cholesterol ngokwayo akubalulekile njengoba sonke sicabanga.
Okubalulekile
Noma yikuphi, uma udokotela wakho uncoma ukwelashwa kwe-statin njengendlela yokwelashwa okungcono kakhulu kwezidakamizwa ze-cholestolol yakho ephezulu ye-LDL, ubonisa nje ulwazi lwakhe ngobuningi bobufakazi obonisa ukuthi izitembu zizuzisa ngokukhethekile.
Ungafunda ngamanye ukwelashwa okunciphisa i-cholesterol . Futhi nansi isihloko mayelana nokuthi unganquma kanjani ukuthi udinga ukwelashwa nge-cholesterol.
> Imithombo:
> Liu PY, Liu YW, Lin LJ, et al. Ubufakazi Be-Statin Pleiotropy Kubantu: Imiphumela Ehlukile Yezimpawu Ne-Ezetimibe Kwi-Rho-Associated Coil-Coil Ephethe iProtheni Kinase Umsebenzi, Endothelial Function, And Inflammation. Ukujikeleza ngo-2009; 119: 131.
> Nissen, SE. Izitatimende eziphezulu kakhulu ezinama-coronary acute syndrome. Akuwona nje amazinga we-Lipid. I-JAMA 2004; 292: 1365.
> Stone NJ, uRobinson JG, uLichtenstein AH, et al. Umhlahlandlela we-ACC / AHA ka-2013 On Treatment Of Blood Cholesterol Ukunciphisa Ingozi Ye-Atherosclerotic Inhliziyo Kubantu Abadala: Umbiko We-American College of Cardiology / American Heart Association Task Force on Guidelines Practice. Ukujikeleza 2014; 129: S1.