Abanye abantu basuke benengozi enkulu yokutheleleka nge- HIV kunezinye.
Ukuguquka kokuqala kwezakhi zofuzo okuhlobene nokutholakala kwe-HIV kwabonakala phakathi nawo-1990. Eyaziwa ngokuthi yi- CCR5-Delta32 ishintsho, kubonakala sengathi imelana nokutheleleka okuqinile ekuthelelekeni nge-HIV. Lokhu kuguqulwa kwezakhi zofuzo kutholakala kakhulu ezindaweni ezithile zaseYurophu. Lokhu kungenzeka ngoba kwakuhlobene nokuphikiswa kwezinye izifo ezifana nesibhoksi noma isifo se-Bubonic.
Iprotheni ye-Pk ne-HIV Resistance
Ekuqaleni kuka-2009, kwanyatheliswa iphepha elimemezela ukuthi ezinye izakhi zofuzo zingase zinikeze izinga lokumelana ne-HIV. Lokhu kuguquguquka kuthinta izinga lokubonakaliswa kweprotheni ebizwa ngokuthi i-Pk. I-Pk itholakala ebusweni bezinhlobo eziningana zamaseli egazi. Ngokuyinhloko, itholakala ezinhlobonhlobo zamangqamuzana anesifo sengculaza. Lesi sifundo esincane sathola ukuthi amangqamuzana anamazinga aphezulu e-Pk ayeba nzima kakhulu ukutheleleka nge-HIV kunamaseli angenawo uPk. Ososayensi abafanayo baye bashicilela ucwaningo olubonisa ukuthi abantu abanesimo (isifo sika-Fabry) okwandisa amazinga abo e-Pk kubonakala sengathi abelana nomhlobo owodwa we-HIV.
Kuyathakazelisa ukuthi lokhu ukuphikisana kwezakhi zofuzo kuye kwadlala indima ebalulekile ekucwaningeni okusebenzayo kokwelashwa . Icala lesiguli saseBerlin sasihilela indoda eyanikezwa ngamathambo omnkantsha avela kumuntu onokushintshashintsha kwe-CCR5.
Ehlanganiswe nokwelashwa kwe-antiretroviral , lokhu kugula kubonakala sengathi kuqede igciwane ohlelweni lwakhe. I-Virus ibonakala sengathi isusiwe kusuka kumgodla wayo wegciwane.
Qaphela: Ucwaningo luka-2009 luye lwashiwo kakhulu ngokuthi uhlobo lwakho lwegazi lungakuvikela e-HIV. I-Pk iyindlela yokuthayipha igazi. Kodwa-ke, akusetshenziswanga kakhulu futhi akuyona ingxenye ye-A / B / O noma izinhlelo ze-Rh zokuthayipha. Ngaphezu kwalokho, lolu cwaningo olubucayi lubukeka kuphela ekuthandweni kwe- vitro futhi ukufundwa kwabo kwangaphambili kubantu bathole ukuphikisana nohlobo olulodwa lwe-HIV. Ngakho-ke kubalulekile ukuthi ungadluleli imiphumela yocwaningo. Kubonakala sengathi abantu abanezinguquko ezandisa inani le-Pk bazobe benomelana kakhulu ne-HIV kunabantu abanamazinga aphansi e-Pk. Lolu lwazi lungase lubangele izinhlobo ezintsha ze-HIV zokwelapha. Kodwa-ke, ukusho ukuthi uhlobo lwegazi lungavimbela ukutheleleka ngegciwane lesandulela ngculaza lungakafiki ngaphambi kwesikhathi.
Imithombo:
UDean M et al. "Ukuvinjelwa kwezakhi zofuzo zokutheleleka nge-HIV-1 nokuqhubekela phambili kwe-AIDS ngokususwa kokuphela kwesakhi sofuzo se-CKR5. Isifundo seHemophilia Growth and Development, Isifundo Esiphezulu Se-AIDS Cohort, Isifundo Esiphakeme Se-Hemophilia Cohort, iSo Francisco City Cohort, ISIFUNDO SOKUPHILA." Isayensi. 1996 Sep 27; 273 (5283): 1856-62.
I-Galvani AP & Slatkin M. "Ukuhlola isifo ne-ingulube njengezingcindezi zomlando zokukhetha i-CCR5-Delta 32-ukumelana ne-HIV." Proc Natl Acad Sci US A. 2003 Dec 9; 100 (25): 15276-9 .
Lund N et al. "I-Pk histo-blood group antigen ihlinzeka ngokuvikelwa ngokutheleleka kwe-HIV-1." Igazi. 2009 Jan 12. U-Epub ngaphambi kokuphrinta
Lund N et al. "Ukungabi khona kwamandla amangqamuzana avela ezigulini ezine-Fabry isifo ukutheleleka okukhiqizayo ne-R5 yabantu immunodeficiency virus." AIDS 2005; 19: 1543-6.
I-Symons J, i-Vandekerckhove L, i-Hütter G, i-Wensing AM, i-Van Ham PM, i-Deeks SG, i-Nijhuis M. Ukuxhomeka kwi-CCR5 i-coreceptor yokuphindaphinda kwe-viral ichaza ukungabi khona kwesimo se-CXCR4-esabikezelwa isandulela-ngculazi esigulini saseBerlin. I-Dis Infect Dis. 2014 Aug 15; 59 (4): 596-600. doi: 10.1093 / cid / ciu284.