Ukwelashwa Kwe-Antiretroviral Inhlanganisela
I-CART yesikhala isho ukuhlanganiswa kokwelashwa kwama-antiretroviral. Lokhu kusho ukuhlanganiswa kwezidakamizwa ezisetshenziselwa ukugcina ukutheleleka nge- HIV ngaphansi kokulawula. Lezi zivame ukubizwa ngokuthi yi- HAART nemigomo yegama eliye laqhubeka nokuguqula imishanguzo ye-ART ukuze imishanguzo ye-antiretroviral.
Izinhlanganisela ezidakamizwa ezisetshenziswe emgodini zihlanganisa ubuncane bezidakamizwa ezimbili ezisebenzayo ezivela emakilasini amabili.
Ngokuvamile ziqukethe izidakamizwa ezintathu noma ngaphezulu. Ukusebenzisa inhlanganisela yezidakamizwa ezahlukene kwenza ukwelashwa kuphumelele kakhulu. Futhi kunciphisa ingozi ukuthi isiguli singase sikwazi ukumelana nezidakamizwa.
Amakilasi amakhulu emithi ngokuvamile ehlanganisiwe emigodini yegciwane ahlanganisa:
- I-Nucleotide reverse transcriptase inhibitors (i-NRTIs)
- Ama-non-nucleotide reverse transcriptase inhibitors (NNRTIs)
- Ama-protease inhibitors (ama-PIs)
- Integrase inhibitors
Uhlobo ngalunye lwesidakamizwa luphazamisa izigaba ezahlukene zokutheleleka ngegciwane lesandulela ngculazi kanye nenqubo yokuphindaphinda.
Kungani i-ART nekhadi lifaka esikhundleni se-HAART?
Igama elithi HAART (ukwelashwa kwama-antiretroviral kakhulu) lisetshenziswe iminyaka eminingi. Kungaba ukudideka ukubona i-term term noma i-ART isetshenziselwa esikhundleni. Kungani ososayensi abathile baqala ukuhamba ukusuka eHART ? Njengoba kuvela, empeleni kukhona isizathu esihle sokushintsha. Leli gama yindlela eya odokotela ukuba bachaze ukusetshenziswa kweminye imishanguzo ye-antiretroviral esikhathini lapho kunentshisekelo ekhulayo kwi-monotherapies.
I-Monotherapies yizifo zokwelashwa ezingashadile ze-HIV / AIDS.
Nakuba ukwelashwa kwe-HAART ngokuvamile kuhlanganiswa njengenhlanganisela, leli gama lingase lisetshenziselwe ukubhekisela ku-monotherapy esebenzayo. Ukubhekisela ikakhulukazi emgodini kuvumela odokotela ukuba bahlukanise ngokucacile phakathi kwama-cocktails wezidakamizwa nemithi eyodwa.
Ngokuphambene nalokho, ukusebenzisa igama elithi HAART likhuluma kuphela ngamazinga okusebenza kwemithi. Kungenzeka ukuthi ubheke ikalini elisetshenziswa ezincwadini emva kuka-2009.
Isinyathelo esilandelayo kwakuwukushintshela kuma-ART njengesigameko esivamile, nakuba sisacabanga ukusebenzisa izidakamizwa ezintathu noma ngaphezulu, ezingase zithathwe ngokwazo noma ngokuhlanganiswa kokuhlanganiswa.
I-Monotherapies vs. Imithi yokwelashwa
Intshisekelo ku-monotherapies ivela esifiso sokunciphisa izithiyo zokuthola ukwelashwa kwe-HIV / AIDS. Lezi zithiyo zibandakanya izindleko zemithi kanye nezinkinga zokuthatha imithi njengoba kunqunyiwe. Izindlela zokwelashwa ezilodwa ezingasetshenziswa zingase zisetshenziselwe ukunciphisa izingozi zokwelashwa kwesikhathi eside nemithi ehlukahlukene ye-HIV . Isibonelo, zingase zisetshenziselwe ukubhekana nemiphumela emibi njengokuguga okungakapheli kanye nokungasebenzi komzimba.
Izimpikiswano ngokumelene nokusetshenziswa kwe-monotherapies zibandakanya ukukhathazeka ngokuthi ukusebenzisa ukwelashwa okulodwa kwandisa ingozi yokugqugquzela ukwakhiwa kwezinkinga zemithi ezingamelana nezidakamizwa. Kukhona futhi izinkathazo zokuthi izidakamizwa ezilodwa zedakamizwa zingase zingabi ngempumelelo njengezinhlanganisela ezihlanganisiwe.
Kodwa-ke, ngisho nalabo abavuma ukuthi i-monotherapy ingase ingabi usizo kuzo zonke iziguli ze-HIV zivame ukuvuma ukuthi kungenzeka ukuthi kufanelekile kwezinye izigaba ezithile.
Isibonelo, i-monotherapy ingase ibe usizo kubantu abaye baba nokuhle, isikhathi eside sokunciphisa i-HIV yabo besebenzisa izindlela eziningi zokwelapha zendabuko.Babonise ukuthi bangathatha imithi yabo njalo. Kungase futhi badinga imithi encane ukuze kugcinwe ukulawulwa kwegciwane.
Izwi elivela
Ungaqhubeka nokubona wonke amagama amathathu ezincwadini naku-intanethi. Nakuba kungase kudideke iminyaka embalwa, igama elithi ART libandakanya izinhlobo eziningi zokwelashwa okuphumelelayo kwe-HIV. Uzobona i-ART isetshenziswa kuhulumeni wase-US kanye nezindawo ze-World Health Organization nezincwadi.
> Umthombo:
> Ukwelashwa kwama-antiretroviral (ART). UMnyango WezeMpilo waseMelika kanye Nezinsizakalo Zabantu. https://aidsinfo.nih.gov/understanding-hiv-aids/glossary/883/antiretroviral-therapy/.