Imiphumela emihle kanye emibi ye-testosterone therapy
Ingabe i-testosterone therapy ingumqondo omuhle? Izinga eliphansi le-testosterone liye lahlotshaniswa nemiphumela emibi yezempilo njengoba ukukhuluphala, ukumelana kwe-insulin kanye nohlobo lwe-2 lwesifo sikashukela, ukuvuvukala, ne-cholesterol ephakeme kanye ne-triglycerides okuholela engozini eyanda kakhulu yesifo senhliziyo. Kodwa-ke, ukufaka esikhundleni se-testosterone kuhambisana neqoqo lezinto ezikukhathazayo, ikakhulukazi, imiphumela engaba khona emibi ohlelweni lwezinhliziyo.
Kusukela ngo-2015 i-FDA idinga ukuthi imikhiqizo ye-testosterone ibhalwe phansi ukuze ixwayise abathengi mayelana nokwanda okungase kube khona engozini yokuhlasela kwenhliziyo nokushaywa yisifo. Ngaphambi kwalesi sixwayiso, imiyalelo yaphakama kathathu phakathi kuka-2001 no-2011, kubonakala sengathi ikhombisa ukuthi i-testosterone yayimiswe ngaphandle kobufakazi beqiniso bamazinga aphansi.
Kungani amazinga we-Testosterone ahlaselwa
Kuyaqondakala ukuthi ukulahlekelwa kwe-testosterone, i-hormone ehambisana nobukhulu nobunzima, kungase kuphazamise kwamanye amadoda, kodwa inqubo yemvelo. I-hormone ihlangana namadoda uma iseneminyaka engamashumi amabili, bese ukwehla kwemvelo kuqala. Lokhu kuncipha kuyashesha futhi kuyashesha, ngokungafani nokungazelelwe kokuya esikhathini abafazi ababhekana nakho.
Nakuba i-testosterone inqamuka ngokuguga, ukuguga akuyona nje isizathu sokuthi amazinga ahlehlise. Amafutha amaningi omzimba ahlotshaniswa ne-testosterone ephansi , kanye nezimo zemvelo ezifana nokuchayeka kwamakhemikhali aphethwe yi-endocrine atholakala kuma-plastiki, ezinye izinsalela ze-pesticide kanye nokungcola okutholakala ezinhlanzi kanye nokunye ukudla kwezilwane nakho kungase kube nomthelela.
Kunomjikelezo cishe lapho amafutha omzimba aphezulu ekhuthaza u-testosterone ophansi, okhuthaza amafutha amaningi omzimba, okuholela esifo sikashukela nesifo senhliziyo. Ngaphezu kwalokho, izidakamizwa ze-cholesterol ezinciphisa izidakamizwa zingase zenze lokhu kube nzima. Kodwa-ke, imikhuba yokuphila enempilo , njengokungabhemi, ukwenza njalo ngokomzimba, inyama ephansi kanye nosawoti, nokugcina isisindo esinempilo, ihlotshaniswa namazinga aphezulu e-testosterone kumadoda amadala.
I-hormone iyaziwa ngemiphumela yayo ekusebenzeni kocansi, kodwa ibuye iqhaza ekutheni amandla, imetabolism, ukubunjwa komzimba (ubunzima besisindo ngokukhululeka kwamanoni), kanye ne-bone mineral mass. Ngaphezu kwalokho, i-hormone ithinta imithwalo yegazi, ivumela ukuphumula kombhede osibusayo we-muscle ukuze kukhuthazwe umfutho wegazi ophansi nokugeleza kwegazi okungcono.
I-Cardiovascular Concern With Therapy Hormone
Emadodeni ane-testosterone ephansi, ukwelashwa kwe-testosterone kuye kwakhuphula i-cholesterol ye-LDL, ukucindezelwa kwegazi, inkomba yomzimba, insulin ukuzwela nokuzivocavoca ukusebenza. Kodwa-ke, isilingo somtholampilo we-testosterone therapy eyenziwa amadoda amadala anesifo esiphakeme sezinzwa zenhliziyo samiswa ngo-2009 ngenxa yezinga eliphezulu lokuhlaselwa kwenhliziyo kanye nemivimbo.
Olunye ucwaningo olushicilelwe ngo-2013 lwaphindaphindiwe lucwaningo lwama-veterans abesilisa abane-testosterone ephansi abaye bathola noma abatholanga ukwelashwa kwe-testosterone. Lelo cwaningo lathola ukuthi ukusetshenziswa kwe-hormone kwakuhlotshaniswa nengozi enkulu yokufa kwezinto zonke, ukuhlasela kwenhliziyo, nokushaya isisu.
Ngaphezu kwalokho, ukuhlaziywa kwemeta ye-placebo-elawulwa yi-placebo, elawulwa ngezikhathi ezithile ezivivinyelwe ukwelashwa kwe-testosterone ithola amaphesenti angu-54 okwandisa ingozi yemicimbi ye-cardiovascular. Futhi, ekufundeni kwamadoda abasebenzisa i-anabolic steroids, abacwaningi bathola ukwanda kwesifo senhliziyo, okubenza babuze ukuthi ngabe i-testosterone yokwelapha nayo iphakamisa ingozi.
Indlela Yokwemvelo Ingase Ibe Ngcono Kakhulu
Ubufakazi busekela ukugcina amazinga e-testosterone ngaphakathi kwezinga elilinganiselwe. Nakuba i-testosterone ephansi kakhulu ingaba yingxaki, ukubuyisela amazinga omusha kuyingozi. Ngaphezulu kokufunda okulandela iminyaka eyisikhombisa, amadoda amadala ane-midrange ama-testosterone anezinga eliphansi lokufa uma kuqhathaniswa ne-quartiles ephakeme noma ephansi kakhulu.
Into enempilo kakhulu ukuyenza ukuvimbela i-testosterone ukuba ingabi phansi kakhulu ngokuphila kahle, ngakho-ke ngeke kudingeke uthathe ama-hormone asebenzayo. Ucwaningo lwamanje lubonisa ukuthi amadoda angandisa i-testosterone hormone ngokwemvelo. Izifundo ezimbili zabantu abakhuluphele ngokweqile kanye nabanamafutha abambe iqhaza ekudleni kwamaviki angu-12 nokuzivocavoca umzimba bathola ukuthi balahlekelwa isisindo, baphuthukisa ukucindezelwa kwegazi, kanye namazinga e-testosterone ejikelezayo.
Ukudla okufanele, kuhlanganiswe nokuzivocavoca umzimba, kunciphisa amafutha omzimba futhi kwandisa ubukhulu bemisipha namandla.
Uma ukhathazekile ngokugcina ama-testosterone amazinga afanele kufanele ulwele amazinga aphansi omzimba womzimba ngokudla ukudla okunomsoco ophezulu (wokudla komzimba), ukudla okulinganiselwe okusetshenzisiwe kanye nemikhiqizo yezilwane, uthole umzimba ovamile, ovuthiwe futhi uqiniseke ukuthi i-vitamin D ne-zinc isimo esifanele. Zonke ziphephile, izindlela zemvelo zokugcina ubungqabavu, impilo kanye namandla njengoba ukhula.
> Imithombo:
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> Yeap BB, Almeida OP, Hyde Z, et al. Indlela yokuphila enempilo ibikezela ukuthi i-testosterone ephakeme ehamba phambili emadodeni amadala: Isifundo se-Health In Men. I-Clin Endocrinol (Oxf) ka-2009, 70: 455-463.
> Kumagai H, Zempo-Miyaki A, Yoshikawa T, et al. Ukuguqula indlela yokuphila kukhulisa izinga le-serum testosterone futhi kunciphisa ukucindezela kwegazi okuphakathi kwamadoda angaphezu kwamandla omzimba. Endocr J 2015, 62: 423-430.
> Schulte DM, Hahn M, Oberhauser F, et al. Umkhawulo we-caloric ukwandisa ama-serum testosterone ekugxilweni kwezifundo eziphakeme kakhulu zesilisa ngezindlela ezimbili ezihlukene. I-Horm Metab Res 2014, 46: 283-286.