I-Epigallocatechin-3-Gallate (EGCG) ne-Breast Cancer
Ingabe itiye elihlaza lingabamba iqhaza ekuvimbeleni-noma ngisho nangomdlavuza webele webele? Kube nokukhuluma okuningi ngezinzuzo zokuphuza itiye eluhlaza eminyakeni yamuva. Phakathi kwalezi zihloko kukhona izinsolo eziningi zokuthi ikhemikhali elitholakala kusiphuzo lingase libe yisikhali esinamandla ngokumelene nomdlavuza webele. Kodwa ngaphambi kokuthi ulayishe izikhwama zetiyi eziluhlaza bese uqala ukugxila, kufanele ufunde okunye mayelana nalesi sifo sesimangaliso esasimangalisa nesayensi ngemuva kwayo.
Itiye elihlaza lenziwe ngamaqabunga eCamellia sinesis , isitshalo esizalwe ezindaweni ezithile zase-Asia. Kuye kwaba isiphuzo esidumile kulowo mkhakha wezwe iminyaka eminingi futhi uthola ukuthandwa lapha eNtshonalanga. Empeleni kwakuyizinga eliphansi lomdlavuza webele (nezinye ezinye umdlavuza) ezindaweni lapho abantu bephuza khona itiye eliluhlaza okwenza abacwaningi bacabangisise indima yetiye ekuvimbeleni umdlavuza.
Ama-antioxidants nama-Radicals wamahhala
Umdlavuza we-tea we-Green Green uvela kuma-polyphenols, amakhemikhali anomzimba we-antioxidant (phakathi kwabanye). Ama-antioxidants avikela amangqamuzana emzimbeni wakho kusuka kuma-radicals mahhala , ama-molecule asebenzayo aphuthumayo aphuthumayo umonakalo obangelwa amakhemikhali endaweni noma ukuguga, futhi okungaholela ekuthuthukiseni umdlavuza.
Ama-radicals amahhala angalimaza izicubu ngezindlela eziningi, kufaka phakathi i-DNA eyingozi ngqo. Njengoba kubhidliza ukuguquka kwe-DNA-gene-okuholela ekwakhiweni komdlavuza, kuye kwaba nesithakazelo esikhulu ezakhiweni ezingasondeza lezi radicals mahhala ngaphambi kokuba zenze umonakalo.
Enye ye-antioxidants etholakala cishe etizeni oluhlaza kuphela i- epigallocatechin-3-gallate (EGCG) , eye yasenhliziyweni yezinhlayiya zamuva zetiyi. Ezinye izibonelo zama-antioxidants zihlanganisa i- lycopene , etholakala kuthelisi ephekwe, ne-vitamin A, etholakala ezinqoleni.
Njengoba sikhuluma ngezimo ezihlukene ezimbili-labo abazimisele ukwenza konke okusemandleni ukuvimbela ngokwabo ekuthuthukiseni umdlavuza webele, nalabo abafuna ukwenza konke okusemandleni ukuphatha umdlavuza wabo webele - sizokwehlisa lezi zindawo ezihlukene.
I-Green Green ne-Breast Prevention Prevention
Ucwaningo oluningi lubuke indima yetiyi eluhlaza kanye nokuvimbela umdlavuza webele. Lezi zihlanganisa izifundo ezibuke itiye elihlaza ngokombono wokwazi ukuthi i-antioxidant, kanye nezifundo ezisezingeni eliphansi lomdlavuza webele esifundeni lapho kusetshenziswa khona itiye eluhlaza. Akuwona wonke ucwaningo oluthole inhlangano ephakathi kwetiyi eluhlaza nokuphuza umdlavuza webele webele, kodwa ezinye zezifundo ezinkulu kakhulu, ezithembekile kakhulu zithola inhlangano.
Ku-Prostate, Lung, Colorectal, ne-Ovarian Screening Trial, isifundo esibheke abantu abangaphezu kuka-100 000, kwafunyanwa ukuthi labo abadla itiye elihlaza babenengozi ephansi yomdlavuza-ngamanye amazwi, kubonakala kunciphisa ingozi noma yimuphi umdlavuza ocwaningweni. Izindaba ezinhle azizange zime lapho, nokho, futhi kukhona okuningi. Nakuba ezinye izifundo zibuke kakhulu kakhulu itiye elihlaza-kuthiwa, ukuphuza izindebe ezingu-30 nsuku zonke-lolu cwaningo lubheka abantu abaphuza indebe eyodwa yetiyi eluhlaza nsuku zonke. Lokho kuhle kakhulu kuningi lethu.
Ucwaningo lwango-2017 lubuke ubuningi bama-mammographic kubantu besifazane abanikezwa isithasiselo se-EGCG unyaka owodwa. Nakuba isibalo sebele sasingashintshi kwabesifazane asebekhulile, kwehliswa kakhulu kwabesifazane abancane, okufana nomphumela we-tamoxifen (ngezinye izikhathi esetshenziselwa ukunciphisa ingozi yomdlavuza wesifuba kubantu abengozi kakhulu) Abacwaningi baphetha ngokuthi izifundo ezengeziwe kufanele zenziwe ekwenzeni itiye eluhlaza ekunciphiseni ingozi yomdlavuza wesifu kubesifazane abasha.
I-Green Green kanye ne-Treatment Cancer Treatment
Kungenzeka yini ukuphuza itiye eluhlaza okweluhlaza kulabo abasenomdlavuza webele? Ngamanye amazwi, ingabe inganciphisa inqubo yesifo ekhona? Kuze kube manje izifundo eziningi zenziwe kumaseli omdlavuza webele embukheni, noma kumagundane, kodwa imiphumela kuze kube manje iduduza. Emva kwakho konke, uma uhlala nomdlavuza webele uyabona ukuthi iningi lezokwelapha liza nemiphumela emibi kakhulu. Ngeke yini kube mnandi ukuthi ube nokuthile okungekho kuphela eminye imiphumela emibi, kodwa kuyajabulisa ukuhlehlisa? (Kulezi zifundo itiye eliluhlaza alisetshenziswanga njengokwelashwa okwejwayelekile, kepha kunalokho kuhambisana nezindlela zokwelashwa ezingcono kakhulu zamanje.)
Izindaba ezithinta ukwelashwa zihle futhi, abanye abacwaningi basikisela ukuthi itiye elihlaza lingase libe yingxenye yelungiselelo lokulashwa kwemdlavuza webele. Ukuze uqonde ukukhula komdlavuza, nokuthi itiye elihlaza lingasebenza kanjani, kuyasiza ukucabanga ngezinqubo ezehlukene okumelwe zenzeke ngomdlavuza ukuze zikhule futhi zisakaze. Uma sibheka lezi zinyathelo ezihlukene ekucwaningeni abacwaningi abatholile:
- Leli tayi eliluhlaza libonakala livimbela ukukhula komdlavuza. Ucwaningo oluthile luye lwathola ukuhlukaniswa kwamangqamuzana omdlavuza wesifuba nokwanda ngobukhulu besisu (noma esiteshini selebhu noma kumagundane) behlelwe yizingxenye zetiyi eziluhlaza.
- Itiye elihlaza litholakala ezifundweni ezimbalwa ukuvimbela ukusakazeka -metastasis-yamaseli omdlavuza webele. Njengoba abantu abaningi befa ngenxa yesifo somdlavuza kunomdlavuza oyinhloko umdlavuza ngokwayo, yizindaba ezinhle kakhulu. Ithiya elihlaza elinikezwe amagundane nomdlavuza wesifuba litholakale ukukhawulela imitha emaphashini nasibindi, izindawo ezivamile zomdlavuza webele.
- Leli tayi eliluhlaza lingasiza ngokushona kwamaseli okuhlelwe-okupophisisi-kwamaseli omdlavuza webele. Ukuqonda lokhu kusiza ukuqonda ukuthi amangqamuzana avamile "azinikeze" i-apoptosis uma belimala noma bebadala. Amaseli e-Cancer abonakala athole indlela yokugwema le nqubo, okwenza "bangafi" ngendlela.
Umphumela weTiye elihlaza okwelashwa kwebelevuza
Kubalulekile ukukhuluma nodokotela wakho mayelana nokudla kwakho ikakhulukazi noma yiziphi izithako zokudla okunomsoco noma amavithamini othanda ukuyisebenzisa ngenkathi ukwelashwa umdlavuza. Amanye ama- vitamin noma ama-mineral supplement angase aphazamise ukwelashwa , futhi lokhu kuyiqiniso nakwezinye izithako zokudla. Lokhu kulula ukuyiqonda uma ucabanga ngenhloso yokwelashwa njenge-chemotherapy kanye nokwelashwa kwemisebe. Lezi zokwelapha zenzelwe ukubulala amangqamuzana omdlavuza. Kungaba yinto engalungile ukusebenzisa isithasiselo "esivikelwe" amangqamuzana omdlavuza. Lokho kusho ukuthi amanye amakhemikhali amakhemikhali avela enomphumela wokuzivikela emangqamuzaneni ajwayelekile kodwa hhayi amangqamuzana omdlavuza.
Okubaluleke kakhulu kubantu abaningi abaphathwa nge-cancer yomabele kungumphumela ongenakwenzeka ekwelapheni isikhathi eside-ukwelashwa kwe-hormonal-umdlavuza webele. Izindaba kule akhawunti zibukeka kahle. Kutholakala ezincwadini ezimbalwa ukuthi itiye eluhlaza lisebenza kanye noTamoxifen noRaloxifene ngendlela enhle. Ngamanye amazwi, inhlanganisela yetiyi eluhlaza kanye nalunye lwala mithi lasebenza kangcono ekuvimbeleni amangqamuzana omdlavuza wesifuba we-estrogen kunomuthi, noma itiye eluhlaza, yedwa. Elinye imithi abantu abanomdlavuza wesifuba ngokuvamile basebenzisa isikhathi eside isikhathi esisodwa se- aromatase inhibitors njenge-Aromasin. Ucwaningo lubonisa ukuthi itiye elihlaza aliphazamisi umsebenzi walo muthi.
Ngokuthakazelisayo, ukuhlola okubheka kokubili isrogen receptor positive futhi isrogen receptor ezingekho amagciwane umdlavuza webele wathola ezinye izinzuzo kungenzeka kusuka tea oluhlaza.
Amathiphu Wokujabulela I-Green Green
Njengoba ithandwa layo likhula ezweni laseNtshonalanga, itiye elihlaza lilula ukuthola; uma engekho eshalofini esitolo sakho sendawo, hlola esitolo esiseduze sezokudla noma imakethe yase-Asia. Itiye elihlaza liqukethe i- caffeine , nakuba kunezinhlobo zama-caffeine ezingenayo. Hlola imiphumela emibi engaba khona, njengezinhlanzi zenhliziyo kanye nokwesaba, futhi ulungise ukusetshenziswa njengoba kudingeka. Funda indlela yokuphuza itiye eluhlaza ngezinzuzo zezempilo njengoba indlela yokuphuza itiye ingenza umehluko emlilweni we-EGCG.
Uma uvame ukufaka i-creamer tea yakho eluhlaza, ungase ufune ukuyeka. Imikhiqizo yobisi iqukethe izinhlanganisela ezibopha i-EGCG futhi zivimbela ukumuncwa. Ngokuphambene nalokho, ukwengeza ukuthinta ilamula kubonakala kuholela ekwenzeni okungcono (ngakho-ke ukusebenza) kwe-EGCG itiye elihlaza.
Okokugcina, uzodinga into oyidla ngayo itiye lakho. I- walnuts encane ingasiza ekulwa nomdlavuza wesifuba, kanti ama-omega-3 ezinhlanzi angasiza ekuvimbeleni umdlavuza webele. Futhi ungakhohlwa ukubeka imfucumfucu emifino e- cruciferous , ehlanganiswe namandla okulwa nomdlavuza .
> Imithombo:
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> Samavat, H., Ursin, G., Emory, T. et al. Isivivinyo Esilawulwe Ngokungahleliwe Seqhwa Ehlaza Khipha Ukwesekwa Nokulingana Kwemammografia Kwabesifazane Abakwa-Postmenopausal Emngciphekweni Okhulayo We-Cancer Breast. Ucwaningo Lokuvimbela I-Cancer . 2017. 10 (12): 710-718.
> Sartippour, M. et al. Inhlanganisela itiye eluhlaza kanye ne-tamoxifen iphumelela ngokumelene nomdlavuza webele. I-carcinogenesis . 2006. 27 (12): 2424-33.
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