Ukuphikisana Okuvamile Nezifo Zamafo KaPasinson
Ukuguqulwa kwe-dopamine ngendlela ye-carbidopa / levodopa yezidakamizwa kungenye yezokwelapha ezisezingeni elihle kakhulu ku-neurology futhi ivumela iziguli ngesifo sikaParkinson ukuthi zithole ukukhululeka okukhulu nokucindezeleka kwazo. Nokho, ngezinye izikhathi, ukushintshwa kwe-dopamine kuza nemiphumela emibi. Okuziwa kakhulu kulawa kufaka ukuxhuma (ukunyakaza okuningi) noma ngisho nokuhlelwa.
I-Dopamine dysregulation syndrome (i-DDS) ingenye ingcindezi engenzeka, eyenzeka cishe ngamaphesenti angu-4 eziguli ezitholwa yi-dopaminergic therapy.
Izimpawu ze-Dopamine Dysregulation Syndrome
Uphawu oluvame kakhulu lwe-dopamine dysregulation luyisifiso sokuphoqelela imishanguzo kaParkinson efana ne- carbidopa / levodopa . Ngisho noma kungekho izimpawu (njengokuthuthumela noma ukuqina), isiguli singase sibe nomuzwa wokuthi sidinga imithi. Abanye bangase bazame ukulinganisa izimpawu zabo zeParkinsonia noma ukufumbathisa abangane noma amalungu omndeni ukuze bathole imithi efunwa - lokhu kuyisimo esinamandla kakhulu.
Ngaphezu kwalokho, abantu abanesifo se-dopamine dysregulation syndrome bangase bazizwe benesisindo somzimba noma bangenaso imithi, bangase bazizwe becindezelekile noma bekhathele. Futhi, izinkinga zokulawula umfutho, njengokuncintisana nokugembula noma ezothenga, ukuphazamiseka kokudla noma ezinye izimo zokulutha, kungenzeka, ngenxa ye-dopamine dysregulation.
Ukuziphatha okulula okulula, njengokuqoqa izinto noma ukubeka izinto ngokucindezela emgqeni, kungase kuvele futhi. Izimpawu ezinjenge-psychosis nazo zingenzeka kule syndrome
Yini eyenza i-Dopamine Dysregulation Syndrome?
I-Dopamine ixhunywe nesistimu yethu yokuvuza ngaphansi kwe-lobes yangaphambili, kufaka phakathi indawo ye-ventral tegmental .
Eqinisweni, izidakamizwa eziluthayo, ezifana ne-cocaine, zikhuthaza ukukhululwa kwe-dopamine kule ndawo. Umsebenzi we-Dopamine kule ndawo yobuchopho kuye kwacatshangelwa ukuthi kubangela i-dopamine syndromeulation syndrome. Uma kuthiwa, izindlela eziqondile aziqondi kahle. Ngaphezu kwalokho, uma i-dopamine ibaluleke kakhulu kokubili ukunyakaza kanye nesistimu yokuvuza, mhlawumbe kuyamangaza ukuthi i-DDS ayinqamile.
Uma kunesidakamizwa esiluthayo, isimiso somvuzo singakwazi ukujwayela inani lomvuzo, okudingeka ukuthi kuningi kakhulu ukunikeza umphumela ofanayo. Siyazi ukuthi lokhu kuyiqiniso nangokwelashwa kwe-dopamine kuma-Parkinson - amanani amaningi kakhulu azogcina adingekayo ukuze adinge umphumela ofanayo. Nakuba ezinye zalezi zizathu kungenzeka ngenxa yokuqhubeka kwesifo, abanye ososayensi bayabuza ukuthi lesi sidingo esengeziwe singase sibonise uhlobo lokuhlala, okuyinto ohlelweni lokuvuza, kungabangela uhlobo lokufuna.
Ngubani othola i-Dopamine Dysregulation Syndrome?
Ukuhluleka kwe-DDS kusikisela ukuthi abantu abaningi bavikelekile ngokumelene nale disorder, kanti abanye bangase babe nezinto eziyingozi zokuthuthukisa lesi sifo. Amadoda anezifo zakuqala angase afike engozini enkulu. Ukuziphatha okuphoqelekile kwangaphambili, njengokusebenzisa kabi izidakamizwa, kungenye yezinto eziyingozi kakhulu.
I-Dopamine Dysregulation Syndrome iphathwa kanjani?
Ngenxa yokuthi iziguli ezine-DDS zinezidakamizwa ezidakamizwa ezidingekayo ukuze zisebenze, ukwelashwa okungcono kuhilela ama-dopamine noma i-dopamine agonists (imithi evuselela i-dopamine receptors). Izimpawu zokuhlukunyezwa zizokwehla njengoba umthamo wezokwelapha uyancipha. Njengazo ezinye izidakamizwa, ukusekelwa kwezenhlalakahle kuyodingeka ukusiza ukuqinisekisa ukuthi imithi ithathwa njengoba ishiwo futhi ilawula ezinye izimo zokucindezela. Ezimweni ezimbi kakhulu, i-antipsychotics ingase ibe usizo ukuphatha ukuhlukunyezwa noma ukucindezeleka kwengqondo, nakuba lokhu kwandisa ingozi yokwehliswa kwesifo se-Parkinson.
Ngaphansi
I-Dopamine iyinhlangano ye-neurotransmitter eyinkimbinkimbi eyithinta ukunyakaza kwethu, isisusa sethu, kanye nesistimu yethu yomvuzo ngezindlela esingaziqondi ngokugcwele, naphezu kokucwaninga amashumi eminyaka. Nakuba i-dopamine dysregulation syndrome engavamile kulesi sifo sikaParkinson, kungenzeka, futhi ukungenelela okungcono kakhulu okuqala futhi kusekelwa udokotela womuntu othintekayo, umnakekeli, kanye / noma abathandekayo.
Imithombo:
Cilia, R., et al. (2014). I-Dopamine dysregulation syndrome kulesifo sikaParkinson: kusuka ekuziphatheni kwe-neuropsychological emtholampilo ekuphatheni kanye nomphumela wesikhathi eside. Journal of Neurology, Neurosurgery, & Psychiatry , 85 (3): 311-8.
Evans, AH, Lees, AJ (Agasti 2004). I-Dopamine dysregulation syndrome esifo sikaParkinson. I-Opinion yamanje ku-Neurology , 17 (4): 393-8.
Lawrence, AD, Evans, AH, Lees, AJ (Okthoba 2003). Ukusetshenziselwa ukuphoqeleka kwe-dopamine ukuguqula ukwelashwa kwesifo sikaParkinson: izinhlelo zokuvuza ziphelile? I-Lancet Neurology , 2 (10): 595-604.
I-Pezzella, FR, et al. (Januwari 2005). Ukuvama kanye nezici zomtholampilo we-hedonistic homestatic dysregulation esifweni sikaParkinson. "Umv. Disord. 20 (1): 77-81.