Abacwaningi Benza Ukuthi "Kick" I-HIV Engaphandle Kwendawo Yayo Yokufihla
Amagumbi okugcina angamaseli omzimba lapho i-HIV ikwazi ukufihla (noma "ukuphikelela") ngisho nalapho ubhekene ne- antiretroviral therapy efanele. Lezi zinqolobane zamaselula zitholakala kuzo zonke izinhlaka zomzimba, kuhlanganise nobuchopho, izicubu ze-lymphoid, umnkantsha wamathambo kanye nomzila wesisu.
Esimweni sayo esivamile (noma "proviral" ), i-HIV ingakwazi ukuhlanganisa izinto zayo zofuzo zibe yi-DNA yeselula, kepha kunokuba ibulale, imane iphindaphinda kanye nomphathi.
Ngokungafani negciwane lesandulela-ngculaza, la ma-provirus afihlekile ayitholakali ngesistimu yomzimba womzimba. Esikhundleni salokho i-genome yegciwane ithathwa kusukela esizukulwaneni kuya esizukulwaneni, ikwazi ukuvuselela lapho iholwa ukuwa emsebenzini wokuzivikela omzimba.
Empeleni, impendulo yomzimba yomzimba ehlinzeka nge-HIV ngamaselula ayo. Uma izimpendulo zamasosha omzimba zivuliwe phambi kwe-HIV, umzimba uzokhipha ama- CD4 T-cell , okuyisimanga ukuthi yilokho okuyinhloko yokutheleleka. Amaseli asele anesandulela ngculazi azokhula, akhiqize amangqamuzana amaningi anegciwane lesandulela ngculazi futhi akhulise ibhakede legciwane.
Kuyinto ukuphikelela kwalezi amagciwane ezifihliwe eziqhubeka ukuvimbela imizamo yokuthuthukisa ukwelashwa kwalesi sifo.
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Inselele enkulu ebhekene nabacwaningi namuhla ukuthola izindlela zokuvuselela futhi ukuhlanza igciwane lesandulela ngculazi emanzini ayo, bese ibeka eminye imikhakha yokuqeda izinkomba .
Ngesikhathi i-ART ikwazi ukuchitha lezi ziqhingi ngokuhamba kwesikhathi, yenza kancane kakhulu. Amamodeli wezibalo abonise ukuthi kuzothatha iminyaka engama-60 kuya kwengu-80 ukuqeda ukuqeda.
Ngokuqhubekayo, abacwaningi babheka ukusetshenziswa kwezidakamizwa ezithile ezibonakala zikhuthaza ukusetshenziselwa i-HIV esondelene.
Phakathi kwazo kukhona ama-agent okuthiwa ama-HDAC inhibitors, asetshenziswe isikhathi eside njengama-stabilizers and anti-epileptics.
Futhi ngenkathi sekube khona impumelelo ekusebenziseni i-HIV engavamile, ososayensi abaqapheli nakakhulu ukuthi lezi zinqolobane zingakanani noma yiziphi ezinye amaseli ezingase zinikeze i-HIV indawo yokucasha. Ngakho-ke, akunakwenzeka ukwazi ukuthi lezi zinqolobane ziye zahlulwa ngempela yizi zinkampani zamakhemikhali.
Ucwaningo lwamuva, eqinisweni, luye lwabonisa ukuthi nakuba ezinye izidakamizwa ze-HDAC inhibitor zinekhono lokuqalisa i-HIV engavamile, abukho ubufakazi boqobo bokuthi ukuvuselela okunjalo kuye kwayanciphisa usayizi wamagumbi.
Abanye ososayensi, okwamanje, bebuza ukuthi "ukukhahlela" i-HIV emagodini ayo kuzokwanela ukufezekisa. Ngenxa yalokho, amaqembu amaningi okucwaninga ahlola ama-agent avela akwazi ukubulala igciwane elisanda kukhululwa nge-toxicity encane. Phakathi kwalabo abazethembisayo kakhulu yi-acitretin, ifomu le-vitamin A okwamanje elisetshenziselwa ukwelapha i-psoriasis enzima kubantu abadala.
Imiphumela ye-Persistency Latent
Esinye sezici ezikhungathekisa kakhulu ze-viral latency yukuthi, ngisho nasesimeni sayo, ukutholakala kwe-HIV ngaphakathi kwamaseli kubangela impendulo ephikisayo yokuvuvukala. Ngisho noma umuntu enesandulela ngculaza esebenzayo futhi ekwazi ukulondoloza umthamo wegciwane elingenakutholakali, ukuvuvukala okungapheli kwezinga elingaphansi kungaqhubeka ngendlela yokuthi amangqamuzana nezicubu baphindaphinda, ngokusheshisa ukuqhuma kwenqubo yokuguga.
Le nqubo, ebizwa ngokuthi i- senescence engakapheli isikhathi eside , yisona sizathu sokuthi abantu abanesandulela ngculazi isikhathi eside bayingozi engozini ye-cancer, isifo senhliziyo, ukukhubazeka kwamathambo, kanye nezinkinga ezibangelwa yi-neurocognitive-futhi ngokuvamile iminyaka engu-10 kuya ku-15 ngaphambi kwalokho okungalindeleke ku-jikelele inani labantu.
Imithombo:
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Søgaard, O .; Graverson, M .; ULeth, uS .; et al. "I- HDAC inhibitor romidepsin iphephile futhi iphumelela ekubuyiseni i-HIV-1 latency in vivo njengoba ilinganiswa nezilinganiso ezijwayelekile zemitholampilo." Ingqungquthela ye-20 Ye-AIDS Yonke NgoJulayi 22, 2014; EMelbourne, e-Australia; abstract TUAA0106LB.
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I-Peilin, L .; Kaiser, P .; Lampris, H .; et al. "Yehlisa i-RIG-1 indlela yokubulala amaseli ezinqolobaneni ezilindelekile ngemuva kokusebenza kwe-viral." Umuthi Wemvelo. Ngo-Juni 13, 2016; 22: 807-8-11.