I-CRE yi-Carbapenem-Resistant Enterobacteriaceae . Lawa amabhaktheriya alwa futhi aphumelele emelene namagciwane. Ama-bacteria amelana futhi anqobe ama-antibiotics asho ukusivikela. Lawa mabhaktheriya asisondeza esikhathini esingaphambi kwama-antibiotic.- noma njengoba sisho, inkathi ye-post-antibiotic esithemba ukuthi ngeke yenzeke.
Ake siwaphule phansi
I-Carbapenems yilasilasi lama-antibiotics.
Leli klasi lemithi elwa namagciwane kaningi liwumzila wokugcina wokuzivikela okuhle ngamabhaktheriya anomelana nawo. Odokotela bavame ukufinyeleleka kula ma-antibiotics uma amanye ama-antibiotic engasebenzi, ngokuvamile ngenxa yokuphikiswa kwama-antibiotic. Lezi antibiotics kaningi lokho esikubiza ngokuthi ama-antibiotics wesibili. Leli klasi lihlanganisa i-meropenem, i-ertapenem, i-imipenem, ne-doripenem .Lezi zinhlobo zokulwa namagciwane ziphatha izinhlobo eziningi ezahlukene zamabhaktheriya ( igramu elihle futhi elibi , i-aerobic ne-anaerobic) ezingxenyeni eziningi ezihlukene zomzimba kusukela esikhumbeni kuya egazini kuya enhliziyweni kuya ku-genitourinary ipheshana. Ngenxa yalokho, la ma-antibiotic avame ukugcinwa izifo ezinzima kakhulu lapho amanye ama-antibiotic engasebenzi.
Amabhaktheriya anqabile yilabo abangaphenduli kuma-antibiotics. Sikhetha ama-antibiotic ngokuqondile uhlobo lokutheleleka noma imbangela ecacisiwe yokutheleleka. Ngezinye izikhathi ama-antibiotic ayeka ukusebenza, izikhathi eziningi ngoba athole izakhi zofuzo ezivumela ukuba ziqede indlela amabhaktheriya abhekana ngayo nemithi elwa namagciwane.
Lokhu kusho ukuthi i-antibiotic ayikwazi ukulimaza amabhaktheriya - noma ayikwazi ukwenza lokho ngokwanele ukuze iphumelele.
I-Enterobacteroacae iyinhlangano yegciwane lesigamu esingalungile esimweni sezinduku. Amabhaktheriya avela kulo mndeni atholakala emapheshana ethu emathumbu. Ziyingxenye ye-flora yethu evamile yamanzi - i-microbiome.
Ngezinye izikhathi nakuba kungasenza sigule. Kungabangela noma yini emithanjeni ye-urinary ukuya emangeni yokubeletha ukuze i-pneumonia ihudo ukuya ekutheleleni kwegazi emathanjeni.
Amabhaktheriya avamile avela kulo mndeni yi-Enterobacter, i-Escherichia, i-Klebsiella, i-Proteus, i-Providencia, i-Salmonella, iShigella neSerratia.
Ubani Obathola Lezi Zifo?
I-CRE ivame ukuphazamisa umuntu osevele esesibhedlela, ekhaya elingumhlengikazi, noma enenqubo emtholampilo ophulukisiwe. Labo abanoma yiluphi uhlobo lwamadivaysi angaphandle noma imishini yezokwelapha efakiwe bayingozi kakhulu. Lokhu kusho ukuthi labo abanamakhemikhali okuvota, i-IV line, noma i-ventilator yokubasiza ukuphefumula basengozini enkulu. Labo abathatha ama-antibiotic amaningi nabo bangengozini enkulu.
Ukudluliselwa kuvame ukuvela ezandleni zabasebenzi bezempilo noma emishini yezokwelapha engazange ikhutshazwe ngokuphelele phakathi kokusetshenziswa. Kwakukhona ukuqhuma phakathi kwalabo ababenesisindo somzimba esabangela amabhaktheriya, naphezu kokuthi idivayisi ihlanjululwe futhi ixiliswe nge-disinfected.
Ngokuvamile, abantu abanempilo abatholi CRE.
Lokhu kusho ukuthi labo abathola i-CRE bavame ukugula. Lokhu kungasiza ekwenzeni ukufa okuphezulu kubonwe, cishe okuphezulu njengama-50% kulabo abathintekile.
Lezi zifo zingamelana cishe nawo wonke ama-antibiotic.
Ingabe Abantu Abaningi Bakuthola Lokhu?
Akusekho e-US. Ukukhathazeka ukuthi uma kwaqala ukusakazeka ukuthi ngeke sibe nemithi elwa namagciwane ukuze siyibeke kalula ekusakazeni ezibhedlela.
Kuphi?
Lezi zibubuhle zitholakala emhlabeni wonke kusukela eNdiya kuya eGrisi kuya ePuerto Rico naseNew York City. Akuvamile uma lezi zidakamizwa zingavamile kakhulu, njengamazwe aphansi ezinsiza. Kukhona ama-hotspots athile emhlabeni jikelele lapho izinga lokutheleleka liye lakhuphuka.
Ingabe Wonke Umuntu Othole Bug Ugule?
Cha, abanye abantu bakoloniwe. Lokhu kusho ukuthi amabhaktheriya ahlala endaweni ethile emzimbeni ngaphandle kokubangela ukutheleleka.
Lawa ma-bacterium angahlala emanzini ngaphandle kokubangela izinkinga zempilo. Kodwa-ke, babengadlulisela ukumelana kwamanye amabhaktheriya emathunjini futhi, esikhathini esizayo, bangabangela ukutheleleka, njengokutheleleka kwamagciwane.
Ama-bacteria ayaba kanjani nokuphikisa?
Ngezinye izikhathi ukuguquka kwemvelo kuthuthukisa. Ngokuvamile, ama-plasmids, aqukethe iziqu zezinto eziphilayo, udlulise ukumelana kusuka kubhaktheriya owodwa kuya kwenye.
Ingabe Kunezinhlobo Ezihlukahlukene?
Kunezinhlobo eziningi . Odokotela bayazi nge-Klebsiella pneumoniae carbapenemase (KPC), i-New Delhi metallo-β-lactamase (NDM), i-verona integron encoded metallo-β-lactamase (VIM), i-imipenemase metallo-β-lactamase (IMP), ne-oxacillinase-48 (i-OXA- 48).
E-US, i-KPC ivame kakhulu. Ukwenza udonga lwamaseli lungadluli kalula.
Ukukhathazeka okungaphezulu kube yizinkinga zokukhiqiza i-carbapenemase (KPC, NDM, VIM, IMP, ne -OXA- 48). Lezi ziqale ukusakazeka kabanzi emhlabeni jikelele.
Lokhu Kuhluke Kanjani Kweminye I-Superbugs?
Lawa ma-bacterium uhlobo oluthile lwamabhaktheriya abizwa ngokuthi amagciwane angalungile. Lokhu kwenza i-CRE ihluke kwamanye ama-Superbugs amaningi anjenge-MRSA ne-VRE, okuyinto amagremu ama-gram ayenayo. Ama-bacteria ama-Gram aphendule kuma-antibiotic ahlukene angase angaphatheli izifo ezingalungile. Kukhona amanye ama-antibiotic angaphatha kokubili.