Ngokuvamile uMelatonin waziwa ngokuthi ukwelashwa kwe- jet lag nokulala . Izwe lezokwelapha elididiyayo liyakhuthaza kakhulu abesifazane besifo somdlavuza webele , kanye ne- fibromyalgia kanye nesifo esingapheli sokukhathala . Kodwa i-melatonin ithola isithakazelo esikhulu ukuthi ikhono layo liyakuthinta i-thyroid namahomoni akho.
I-Melatonin iyi-hormone ngokwayo, eyenziwa yi-gine plandal, okuyi-gland encane ekhona ebuchosheni.
I-pineal gland ibhekwa njengomphathi we-clock yomzimba wethu, kufaka phakathi iwashi yethu yosuku nosuku olusitshela ukuthi sizolala nini nokuthi sizovuswa nini, kanye newashi lezinto eziphilayo isikhathi eside esichaza izigameko ezinkulu ze-hormone, njengokuthi faka ubusuku nokuya esikhathini .
I-pineal gland ilawula isigqi se-circadian ngokukhulula i-melatonin, i-hormone ekhiqizwa ngokuyinhloko ebusuku. Ukuhlanganiswa kwe-Melatonin nokukhululwa ngokuyinhloko kugqugquzelwa ubumnyama.
Ngokusekelwe indima yawo emgqeni we-circadian nokulala, i-melatonin iye yaziwa kahle njengesizo esiwusizo sokulala, njengokwelashwa ukusiza ukuvimbela i-jet lag nokusetha kabusha iwashi lomzimba endaweni yesikhathi esisha, kanye nabasebenzi bebusuku ababhekene nobunzima bokulala.
Kwakunjengokusiza kokulala engangiqala ukusebenzisa ubusuku be- melatonin lapho ngisesikhathini sokuqala. Ngangivame ukuvuka kaningi, futhi ngokuvamile angakwazi ukubuyela emuva. Khona-ke, lapho ngiphakamiswa ekuseni, ngazizwa ngingenangqondo futhi ngikhathele.
Ngaqala ukuthatha umthamo ophansi we-melatonin (3 mg), engathatha cishe ngo-11 ntambama, cishe ihora ngaphambi kokuba ngivame ukulala. Ngemva kwesonto, ngabona ukuthi ngiphakamise kangako, futhi lapho ngenza, ngakwazi ukujika futhi ngibuye ngilale kalula. Ngcono nakakhulu, ngangivuka ekuseni ngizizwa ngiqabulekile futhi nginamandla, ngenjabulo enkulu.
Okumangalisa nakakhulu, empeleni ngangiphakamisa imizuzu embalwa ngaphambi kwe-alamu yami. (Lokhu akuyona into ephawulekayo, njengoba ngangingomunye walabo bantu abashaya ibhulogi ngokuphindaphindiwe izikhathi eziningi, futhi kuphela lapho ngikhathazeka ngidonsa ngisuka embhedeni. Ngakho ukuvuka phambi kwe-alamu, ukuzwa kahle, kwakungavamile!)
Ngesikhathi ngiqala i-melatonin, ngangibuye ngisemkhatsini wami. Nginezinkathi eziphuthumayo iminyaka emibili, futhi bekuyizinyanga ezinhlanu kusukela esikhathini sami sokugcina sokuya esikhathini . Nganginamathele ngesikhathi sokushisa okushisayo ngisebenzisa isithasiselo esibizwa ngokuthi iRoyal Maca , futhi ukushisa okushisayo sekuphelile. Ngangibona udokotela wami, owathola ukuthi nginamazinga aphakeme kakhulu e- FSH nama-LH-ama- markers angakwazi ukuqinisekisa ukuthi umama uyaphila esikhathini esithile-futhi amazinga ami e- estrogen nama-progesterone ayephansi. Ngakho mina nomdokotela wami bobabili bacabanga ukuthi ngise- menopaus e-konke engangikudingayo ukuba ngihambe izinyanga ezingu-12 ezigcwele ngaphandle kwesikhathi, futhi bekuyoba ngokomthetho. Ngakho-ke okwenzeka ngemva kwalokho kwangimangaza.
Cishe ngemva kwezinyanga ezimbili ngiqala i-melatonin, isikhathi sami sabuya. Futhi lapho bebuya, babejwayelekile kakhulu. Babengenamandla ngokweqile, njengoba bebekade bekhona. Umbala wawungokwemvelo futhi mhlawumbe umangalisa kakhulu, baqala ukuza njalo ezinsukwini ezingu-28, okwakungakaze kwenzeke iminyaka eminingana.
Angizange ngixhumane ngokushesha ne-melatonin ngokubuya komjikelezo ojwayelekile wokuya esikhathini. Kodwa ngaphandle kokunye okushintshile emgomeni wami, kwakudingeka ngizibuze ukuthi imijikelezo evamile yokuya esikhathini emadodeni ka-perimenopausal / menopausal yayiyimiphumela emibi eyaziwayo ye-melatonin. Ngacwaninga kulolu cwaningo. Futhi yilapho ngathola uDkt. Walter Pierpaoli, kanye nokucwaninga kwakhe okuthakazelisayo nokwenza umonakalo nge-melatonin.
I-Melatonin nama-hormone ethu
Udokotela wase-Italy uWalter Pierpaoli, MD, wabuyela emuva ngo-1996 ngokukhululwa komhlaba wonke wencwadi yakhe, iMelatonin Miracle: Ukuphila Kwemvelo-Ukuguquka, Ukulwa Nezifo, Ukulwa Nezicansi-Ukuthuthukisa I-Hormone .
Le ncwadi yayiyi-bestseller, futhi iMalatonin Miracle kaDkt. Pierpaoli yasungula amaMelika ukuba i-melatonin, eyayisanda kutholakala phezu kwe-counter e-US eminyakeni embalwa ngaphambili, nezindima zayo njengesiza sokulala, i-jet lag remedy, i-immune enhancer, namandla antioxidant umdlavuza womdlavuza.
Kodwa le ncwadi yayingeyona yesikhathi esisodwa esenziwa nguDkt. Pierpaoli. Sekuyiminyaka eminyaka, ucwaninga futhi ufunda i-melatonin nemiphumela yayo.
Ngemva kokufunda incwadi kaDkt. Pierpaoli, ngifunde nomagazini wezocwaningo owawunikele kulo, i-Annals ka-2005 ka-New York Academy of Sciences, ebizwa ngokuthi Ukuguqula Ukuguga: Ukusetha kabusha i-Clock Pineal . Lolu hlobo lwe-Annals lunezihloko eziningi zesayensi kanye nokuthola ucwaningo oluhlobene ne-melatonin, kufaka phakathi imibiko eminingana evela kuDkt. Pierpaoli. Ngathola injabulo yokukhuluma noDkt. Pierpaoli ngokwabo, ukufunda kabanzi ngemibono yakhe mayelana ne-melatonin kanye namahomoni we-thyroid.
Ngafunda ukuthi abacwaningi abaningi bacabanga ukuthi i- melatonin ingaphezu kokusizwa kwe-hormonal sleep. Kunalokho, bacabanga ngokuthi i-melatonin ibe yinkinga enkulu yamakhemikhali esebenza ngezindlela esingayiqondi ngokuphelele, kodwa ukuthi uDkt Pierpaoli nabanye bafunda kabanzi.
Okushiwo yiDkt. Pierpaoli encwadini yakhe kanye nokuthola ucwaningo ukuthi i-pineal gland ikhiqiza i-melatonin encane njengoba sisebudala, kodwa uma izithako ze-melatonin zithathwa uma amazinga e-melatonin ehluleka ngokwemvelo, eminye yemiphumela yokuguga ingancipha, imiswe, noma ngisho, kusho uDkt. Pierpaoli. UDkt. Pierpaoli naye ukholelwa ukuthi i-melatonin ingakwazi ukuvumelanisa nje kuphela izilinganiso eziphakathi komjikelezo we-wake-sleep kodwa uhlelo lwe-endocrine jikelele.
UDkt. Pierpaoli uthi ukuhlinzeka nge-melatonin eyengeziwe , ngo-3 mg ubusuku bonke, kuvumela ukugcoba kwe-pineal ukuba "uphumule" ukukhuluma, futhi kuvikela i-pineal gland ekugugeni, okuyinto eyanciphisa inqubo yokuguga kwezinye izigulane nezitho. Ingumqondo ophikisanayo, kodwa uDkt. Pierpaoli nabanye baye baqhuba izifundo ezithakazelisayo ezibonisa ukuthi ukhona okuthile.
Emibhalweni yakhe, uDkt. Pierpaoli uchaza iziqu zezilwane ezathola ukuthi izilwane ezindala eziphathwa nge-melatonin zibuyela ebhayisikili evamile yamahomoni wegciwane. Amantombazane ayenezinyanga ezingu-24 ubudala futhi aphathwa nge-melatonin, izinyanga ezingu-24 lilingana negundane elineminyaka engama-75 ubudala kubantu, lalinamaqanda aphindwe kabili ubukhulu bezinkoma ezingaphenduliwe, okuphakamisa umsebenzi osemusha ocansini. UDkt. Pierpaoli wabuye wafaka izigulane ze-pineal zegundane lokuguga emagundaneni amancane, futhi ngokufanayo. Iigundane ezincane ezinamahlombe ezindala zepayini zakhula zonke izifo ezihlobene nokuguga, zaba namandla amakhulu futhi zivundile, futhi zafa ezincane kunazo zonke. Amagundane amadala anezinhlayiya ezincane ze-pineal avuselela izinwele, athola amandla, ahlakulele i-sex drive entsha, futhi aphile, ngokwesilinganiso eside kakhulu ukuthi uma bengabantu, bebengaba namandla, abakhuthele, abanempilo futhi benempilo eminyakeni engaphezu kwengu-100 yobudala.
Kodwa yini eyachaza ukubuya kwami okumangalisayo kwemijikelezo evamile yokuya esikhathini kwakuyi-study yase-Italy eqhutshwa uDkt. Pierpaoli eyayibuka abesifazane besifazane abaneminyaka engu-42 kuya ku-62 ubudala, abahlola imiphumela yomuthi wansuku zonke we-3 mg we-synthetic melatonin ezinyangeni eziyisithupha. Lelo cwaningo lathola ukuthi i-melatonin yanda amazinga e-estrogen nokusebenza kwe -roid ngcono. Abesifazane abangaphansi kweminyaka engu-50 basebenzisa i-melatonin futhi banciphisa i-hormone ye-luteinizing (LH) ne- follicle-stimulating ama-hormone (FSH) amazinga ngenxa ye-melatonin. Kwabanye besifazane abasebasha, imijikelezo evamile yokuya esikhathini yavuselelwa. Futhi-ke, kuyamangaza ukuthi abesifazane abaningana base bevele bangena emaphoyisopha baze babuyele emijikelezweni evamile yokuya esikhathini. Ngokuyinhloko, ngokusho kukaDkt. Pierpaoli nabanye abacwaningi, umthamo ophansi we-melatonin wawulibaleka-noma kwezinye izimo, ngokusobala ushintsho lwe-endocrine oluphawulekayo olwenzeka ngesikhathi sokuya esikhathini.
Mayelana ne-thyroid, i-melatonin ayibonakali ukuguqula amazinga we- TSH kepha yasiza ukwenza lula ukuguqulwa kwe-T4 kuya ku-T3 , okuholela ekukhuleni amazinga we- T3 eqenjini lokucwaninga.
Abesifazane abangamaphesenti angama-96 ocwaningweni abathathe i-melatonin nabo babike ukunyamalala okuphelele kwesimiso sokucindezeleka ekuseni, uphawu oluvamile kubesifazane besifazane nabesifazane besilisa . Laba besifazane babe nezikhalazo ezimbalwa mayelana nokushisa okushisayo, izintambo ezincane zentliziyo, kanye nekhwalithi engcono nokulala kwesikhathi.
Nakuba lokhu kwakungesona isifundo esikhulu, senziwa ngokuqinile, futhi siphakamisa ukuthi i-melatonin ingadlala indima ebalulekile emithethweni ye-hormonal kwabesifazane be-perimenopausal ne-menopausal, futhi mhlawumbe nakakhulu kulabo abane-ukungalingani kwe-thyroid.
UDkt. Pierpaoli unomuzwa wokuthi ukwehla kwe-melatonin okwenzeka emasimini wesifazane kungase kube isignali ye-hormone esitshela umzimba ukuthi uqale ushintsho lwe-perimenopausal. Siyazi ukuthi kwabesifazane besuka ku-40 kuya ku-44, i-melatonin ngokuvamile iyancipha kakhulu. Ngokuthakazelisayo, leli yilo phuzu elivame ukuqala kwesikhashana. Iphuzu elikhulu elilandelayo eliphawulekayo lokuncipha kwe-melatonin livela eminyakeni engama-50 kuya kwezingu-54, eduze nendawo lapho isikhathi sokuya esikhathini sokugcina siyeka ukusebenza kahle kwabesifazane abaningi.
Umbono kaDkt. Pierpaoli othakazelisayo wathola ukusekelwa yiziphumo zocwaningo olwenziwa ngo-2008 olwakhulunywa encwadini ethi Menopause. Lelo cwaningo lathola ukuthi i-pineal gland, nge-melatonin, ihileleke ezindleleni ezilawula ukuqala kokuya esikhathini, futhi ngokugcina amazinga aphezulu we-melatonin, ukuqala kokumisa esikhathini kungase kubambezeleke.
UDkt Pierpaoli, ngaphandle kombuzo, ummeli oshisekayo we-melatonin. Udokotela uqobo lwakhe uyisimemezelo esimnandi sokuphikisana nokuguga kwakhe, ngaphezulu kuka-80, amandla, nokugcina isimiso esinzima semisebenzi, ucwaningo, ukukhuluma, ukubhala nokuhamba emhlabeni wonke. UDkt. Pierpaoli uthe uma ebuyela emuva ngesikhathi esazi ukuthi uyayazi, ngabe uqale ukuthatha i-melatonin cishe eminyakeni engama-30.
UDkt. Pierpaoli uqinisekisa ukuthi i-melatonin yenza njenge-adaptogen ye-hormonal, esiza ukulinganisela ama-hormone e-adrenal, i-thyroid kanye nokuzala, nokugcina ubusuku busuku, nyanga zonke, ukuhamba ngezikhathi ezithile kanye nokuphila kwama-hormone. UDkt. Pierpaoli naye ukholelwa ukuthi i-melatonin yandisa ubukhulu bama-receptors e-estrogen ezihlotsheni ezibhekiswe njengezibele, isisu, nama-ovari, futhi kuthuthukisa ubuzwe babo.
Eminye yeminye imiphumela ye-melatonin ebikwe uDkt. Pierpaoli ihlanganisa:
- kusiza ukulinganisela amazinga e-cortisol
- kuvimbela i-atrophy yama-ovari, isisu, nesisu
- kwandisa ukuzala
- iphakamisa i-HDL ("okuhle") i-cholesterol
- unciphisa ukucindezelwa kwegazi
UDkt. Pierpaoli uthi:
I-Melatonin ayiyona i-hormone ngokwayo, kodwa ngempela "indlovukazi yazo zonke amahomoni," ehlola futhi eqondisa lonke "i-orchestra yama-hormona."
Ezinye odokotela eMelatonin
UDkt. Pierpaoli akuyena kuphela ummeli we-melatonin. Isazi se-thyroid nesifo se-hormone uDavid Brownstein, MD , sincoma ukuthi i-melatonin "iphephile kakhulu," iziguli eziningi. UDkt. Brownstein uthi:
Umthamo ophansi we-melatonin ungaba yingxenye ewusizo kakhulu yokulinganisela kwe-hormone. Akuyona nje kuphela ewusizo ukulala, kodwa futhi kuyasiza ekusizeni amanye ama-hormone, futhi ikakhulukazi, ukuguqulwa kwe-T4 kuya ku-T3.
UDkt. Jacob Teitelbaum , osebenza ngokugula okungapheli syndrome , i-fibromyalgia neziguli ze-thyroid , unomuzwa wokuthi ukuphumelela kwe-melatonin kungase kuvele amandla okukhuthaza ukulala kwekhwalithi. UDkt Teitelbaum uthi:
Okwenzekayo uma ungenalo ubuthongo, upheqa uhlelo lonke. Ukulala kahle kufanele ubuyekeze umsebenzi we-hypothalamic. Futhi i-melatonin, okungenani, kusiza ukuqinisekisa ikhwalithi engcono yokulala. Futhi ngaphezu kwalokho, kuwo wonke uhlelo lwe-hormone, i-pineal ingabhekwa njengomholi we-orchestra yonke. Uma kungenangqondo, lonke uhlelo lwe-hormonal lungase lube lukhuni.
Ukwengeza nge-Melatonin
Ungeze kanjani nge-melatonin?
Kunconywa kukaDkt. Pierpaoli ukuthatha i-3 mg ye-melatonin ekhishwe isikhathi, ngo-11 ntambama noma ihora ngaphambi kokulala, noma yikuphi ngaphambili. Lokhu kukuvumela ukuba ube "nokunyuka kwe-melatonin" ngesikhathi umzimba ungakukhiqiza ngokwemvelo.
Imiphumela emibi kakhulu ezincwadini ezisuka kumthamo ophansi we-melatonin kubonakala sengathi i-grogginess ethile ekuseni, iphupho elicacile, nezinkinga ezibuhlungu, noma ikhanda eliphansi ngemva kokusetshenziswa kumaphesenti amancane abasebenzisi. Lesi isibonakaliso sokuthi ungase ufune ukubuyela emuva kumthamo ophansi .
Ngokusho kwe-hormone nesazi se-thyroid uRichard Shames, MD:
Ungase ufune ukuqala nge-3 mg, bese ubona ukuthi ungathola yini inzuzo enhle ukusuka ku-2 mg, bese mhlawumbe u-1 mg. Umbono wami jikelele ukuthi umthamo we-1 mg awukona ubangele ukuphathwa ikhanda nokucindezeleka njengomphumela ohlangothini.
Ayikho ngempela imfundo ekhishwa isikhathi eside ehlola idatha ye-melatonin ephansi. Kodwa bonke odokotela engiwakhulume nabo, abaningi abasebenzisa i-melatonin ye-dose ephansi ngokwabo futhi bayincoma kumaguli, bazizwa ukuthi ngokusekelwe emiphumeleni yezifundo zesikhashana esifushane, asikwazi ukuthola noma yiziphi izinkinga ngokusetshenziswa kwesikhathi eside i-melatonin yesilinganiso esincane. Nokho, i-Melatonin akufanele isetshenziswe ngabesifazane abakhulelwe noma abalahlayo.
Uma unesithakazelo ekuxhaseni ne-melatonin, ngemva kokukhuluma nodokotela wakho, khetha umkhiqizo wakho ngokucophelela. Ufuna ukuqinisekisa ukuthi uthola i-melatonin ye-grade ehlanzekile, yezokwelapha, futhi ochwepheshe bakhombisa ukuthi usebenzisa kuphela i-synthetic melatonin hhayi i-melatonin etholakala ezilwaneni.
Ngezinye izikhathi uzozwa ukuthi i-melatonin ayinconywa kubantu abanezifo ezizimele , futhi kulabo besifazane abanezinkinga ze- thyroid ngenxa yokugula kwesifo sikaHashimoto noma se-Graves, lokhu kungase kubonakale kuyinkinga. Kusengenkinga ephikisanayo. Kodwa ngabuza uDkt. Pierpaoli ngalokhu, futhi wathi kukhona icala elilodwa elilodwa lapho i-melatonin ixhunywe khona nesifo sofuba esibangela ukufa. Uthe ukukhathazeka akusekelwe, ukuthi i-melatonin ibonakala isisiza isimiso somzimba samasosha omzimba sisebenze kahle, hhayi ngaphezu komsebenzi, njengabaphikisi abasikiselayo. UDkt. Pierpaoli - kanye nabanye odokotela engiwakhulume nabo-bazizwa ukuthi i-melatonin iyasiza ngezifo ezizimele. wachaza ukuthi kungani engxoxweni eyinikeza i-International Anti-aging Systems, i-pharmacy yase-UK:
Ngokuqondene nokuzimela komzimba, i-melatonin kufanele isetshenziswe ngezifo ezizimele ngoba nje izobuyisela ukusabela okuzivikela ngokuzivikela komzimba kanye namandla omzimba wokuvikela omzimba ukuze zibone "ama-self" antigens. Sibheke ukutakula okuphelele! I-etiology yazo zonke izifo ezizimele ezithinta isikhumba, izigulane, igazi kanye nanoma yiziphi ezinye izicubu zisekelwe ekungeneni kokubeletha noma ezitholakalayo ukuthi zikwazi ukubona izicubu zomzimba zethu ngakho-ke ukufaka ukuphendula okuzenzakalelayo. Ukuguga ngokwayo ngokuyinhloko kuyindlela efihlakeleyo efihliwe, engavamile futhi ekhohlisayo eholela ekutheni i-vasculitis (i-sclerosis yemikhumbi), i-autoantibodies nomdlavuza. Umsebenzi wethu weminyaka engama-40 uye wabonisa ukuthi ukuzivikela komzimba kungaphansi kokulawulwa kwama-hormone. I-Melatonin ngeke ikhulise ukuhlanganiswa kwama-autoantibodies anonya, ngokuphambene nalokho izoholela ngokuqhubekayo ekuphulukisweni kwezingqalasizinda eziyisisekelo ze-hormonal futhi iqala inqubo yokuzimela.
Imithombo:
UDiaz, uBerriz López; Llaneza, i-Plácido Coto. "Umthethonqubo we-Endocrine we-course of the menopause ngomlomo we-melatonin: umbiko wokuqala wecala." Ukunqamuka kwesikhathi . 15 (2): 388-392, Mashi / Ephreli 2008.
U-Parry, uBarbara, no-et. al. "I-Melatonin eyanda futhi ihlehlisiwe ekucindezelweni kwe-Menopausal: Indima Yeminyaka edlule Ukunqamuka Kwesilisa, I-Follicle-Ukukhuthaza I-Hormone, Isikhathi Sokulala, ne-Body Mass Index" Journal of Clinical Endocrinology & Metabolism . Kushicilelwe ku-Online: Julayi 02, 2013 Online.
Pierpaoli, Walter "Ukuguqulwa kokuguga: Ukusetha kabusha i-Clock Pineal." December 2005, uWiley-Blackwell. Online.
Toffol, Elena et. al. "I-Melatonin kuma-perimenopausal nabesifazane be-postmenopausal: ukuhlanganiswa kwemizwelo, ukulala, izimpawu zomzimba, kanye nekhwalithi yokuphila," Ukunqamuka kwesikhashana . May 2014 - Umqulu 21 - Issue 5 - p 493-500