I-Stelara I-Anti-Monoglonal Antibody Eyasetshenziselwa Ukwenyuka Okulinganiselwe Kuka-Crohn's
Sibutsetelo
I-Stelara (ustekinumab) iyindlela yokwelapha ye-biologic ehlose i-interleukin (IL) -12 kanye ne-cytokines ye-IL-23. Ngokuyinhloko yi-anti-monoclonal anti-immunoglobulin antibody ephelele eyenza i-IL-12 ne-IL-23 ehlanganyelwe i-P40 subunit. UStelara waqale wamukelwa ngo-2008 ukuphatha i-psoriasis yama-plaque futhi manje uvunyelwe ukuphatha isifo esibucayi esifundazweni sikaCrohn.
Okubalulekile Okufanele Ukwazi
- I-Stelara ayisona isifo se-Crohn's
- I-Stelara inikezwa kuqala nge ukumnika futhi nge-injection engenziwa ekhaya
- Abantu abanesifo samanje akumele bathole i-Stelara
- Kukhona ingozi eyengeziwe yokutheleleka kanti noma yiziphi izimpawu zokutheleleka kufanele zixoxwe nodokotela ngokushesha
- I-Stelara ayizange ifunde kabanzi ngesikhathi sokukhulelwa nokuncelisa futhi udokotela kufanele axoxwe ngaso leso sikhathi esimweni sokukhulelwa
- Iziguli kufanele zihlolwe isifo sofuba (TB) ngaphambi kokuqala i-Stelara
Ukuphatha
I-Stelara inikezwa ngenqubo yesigaba ezimbili. Ukwelashwa kokuqala nge-Stelara kwenziwa nge-infusion. Isidakamizwa sinikezwa ngaphakathi ngaphakathi esikhungweni sokungenisa ngaphakathi noma ehhovisi likadokotela. Inani leStelara elisetshenzisiwe liyingqayizivele futhi ibalwa ngokususelwa ngesisindo sesiguli. Emva kwalokho, uStelara unikezwa izijovo ezincane (umjovo onikezwe ngaphansi kwesikhumba) njalo ngemva kwamasonto angu-8, okungenziwa ekhaya.
Iziguli ziqeqeshwe ngumhlengikazi noma omunye ochwepheshe bezempilo mayelana nendlela yokunikeza izijovo. Isidakamizwa sifika ku-injection ekhethekile isiguli esinikela yona noma enomngane noma ilungu lomndeni abanike lona. Iziguli zingafaka iSlalara emthangeni, esiswini, ematheni, noma engxenyeni engaphezulu.
Izinkomba
I-Stelara ingase ihlelwe ukuthi ilawule isifo esibi kakhulu se-Crohn kubantu abangaphezu kweminyaka engu-18. UJanssen Biotech, Inc, umkhiqizi ka-Stelara, uthi le mithi ivunyiwe iziguli ezine-Crohn's disease "ezazingavumi ukwelashwa ngama-immunomodulators noma ama-corticosteroids kodwa akakaze ahluleke ukwelashwa ngesibindi se-necrosis factor (TNF) , noma ohlulekile noma engavumelani nokwelashwa nge-block eyodwa noma ngaphezulu kwe-TNF. " Lokhu kusho ukuthi kusetshenziselwa iziguli ezaphathwa ngezinye izinhlobo zemithi futhi azizange zithuthuke. Lokhu kungabandakanya izidakamizwa ze-immunomodulator (ezivimbela isistimu yomzimba), i-steroids njenge- prednisone , noma i-blocker ye-TNF (ngezinye izikhathi ibizwa ngokuthi yi-biologics).
Ezinye izifo ezithathelwana ngokuzivikela ezithathwa yiStelara e-United States zihlanganisa i-psoriasis ne-psoriatic arthritis. I-Stelara ayitholakali okwamanje yi-FDA yokwelapha i-ulcerative colitis. I-Stelara ayivunyelwe ukusetshenziswa ezinganeni noma kwentsha engaphansi kweminyaka engu-18.
Indlela Esebenza ngayo
I-Stelara isetshenziselwe ukuphatha izimo ezixubile kumzimba, kanti isifo sikaCrohn siyisifo sakamuva esitholakale siphumelele. I-Stelara ivimbela i-interleuken (i-IL) -12 ne-IL-23, etholakala emzimbeni ngokwemvelo kodwa kucatshangwa ukuthi ifaka ukuvuvukala kwesifo sikaCrohn.
I-Stelara ayisona isifo se-Crohn's.
Ubani Akufanele Awuthathe
Tshela udokotela wakho uma unezimo ezilandelayo:
- Isenzo sangaphambilini sokugula esivela ku-Stelara
- I-latex yokungezwani komzimba, ngoba isirashi esandulele isingenayo i-latex
- I-vaccination yakamuva ne-vaccine ephilayo, noma ilungu lomndeni wakho linomuthi ophilayo
- Uthole umuthi wokugoma we-bacille Calmette-Guerin (BCG) ngoba akufanele unikezwe kungakapheli unyaka wokuthatha uStelara (mhlawumbe ngaphambi noma ngemuva)
- Noma yisiphi isikhumba sihamba
- Okwamanje ukuthola izibhamu ze-allergies, ikakhulukazi ekuphenduleni okukhulu kwe-allergenic
- Wake waphathwa nge- phototherapy (ukwelashwa okulula)
- Ukukhulelwa noma ukuncelisa, noma angakhulelwa noma ahlele ukuncelisa ngenkathi ethatha u-Stelara
- Unomlando wezifo noma ukutheleleka kwamanje
Isixwayiso sokungezwani komzimba
Isizathu sokuthi udokotela uzodinga ukwazi ngani izifo zokungabi namagciwane kanye nezifo ezinzima ngoba uStelara angashintsha indlela umzimba ophendula ngayo kulawo mshini. I-Stelara ingase ibangele ukubhebhetheka kobuchopho idutshulwa kancane noma ikhulise ingozi yokuba ne-reactionergic emva kokuthola isibhamu. Kubalulekile ukusebenza eduze ne-allergen ne- gastroenterologist ukunciphisa ingozi yokuthola ukugula. Ukuphendula okukhulu kwe-allergen ku-Stelara akuvamile.
Izifo Ezihlobene
I-Stelara ingandisa ingozi yokuhlaselwa isifo ngoba ingathinta isisindo somzimba . Iziguli kufanele ziqaphe ngokuqapha noma yiziphi izimpawu noma izimpawu zokutheleleka futhi zibike kudokotela ngokushesha. Lokhu kuhlanganisa:
- Ubuhlungu besisu
- Isikhukhula
- Ukushaya igazi
- Uhudo
- Ukukhathala
- Fever
- Ubuhlungu besisu
- Ubuhlungu noma ukuvutha ngenkathi uchama
- Ukuphelelwa umoya
- Ukuphuza isikhumba
- Ama-Sweats
- Ukulahlekelwa kwesisindo esingachaziwe
Ukuphepha
Ngesikhathi sokukhulelwa
Ukuzikhukhumeza ngenkathi umama ayamukela iStela akuzange kufundwe kabanzi. Kube nokukhulelwa okumbalwa kwabesifazane abane psoriasis ababethatha uStelara. Lezi zonke ziye zaba nemibiko yecala, okusho ukuthi ngumcimbi owodwa ofundiswayo. Akuzange kube nezifundo ezinkulu ezibuka ukuthi uStelara uthinta kanjani abantwana abangakazalwa. Okungenani kube nomphumela wokukhulelwa kwesisu, kodwa akuzange kube nokucwaninga okwanele kokwazi ukuthi uStelara ungalimaza yini ingane yakho noma ayiyikulimaza.
Umkhakha we-FDA wokukhulelwa we-Stelara wuhlobo B. Lokhu kusho ukuthi umphumela uStelara onomntwana ongakazalwa awufundiwe kakhulu. Okwamanje kunconywa ukuthi uStelara kufanele asetshenziswe kuphela ngesikhathi sokukhulelwa uma kudingeka ngokucacile. Udokotela ochaza ukuthi uStera kufanele afintane ngokushesha uma kwenzeka ukukhulelwa.
Ngenxa yokuthi kunolwazi oluncane kakhulu mayelana nokukhulelwa kanye no-Stelara, noma ubani okhulelwe uyacelwa ukuba abambe iqhaza ekubhaleni kokukhulelwa ngokubiza u-1-877-311-8972. Lokhu kungasiza ososayensi bafunde kabanzi ngokuthi uStelara uthinta kanjani omama nabantwana ukuthuthukisa ukunakekela ezinye iziguli esikhathini esizayo.
Ngesikhathi sokubeletha
Kucatshangwa ukuthi uStela angadlulela esifubeni ngakho-ke kufanele athathwe ngumntwana. Ukuhlengikaza ingane ngenkathi ithola uStera kufanele kukhulunywe namalungu enkampani yezokunakekela impilo futhi kufanele yenziwe ngokwezifiso zabanye.
Izwi elivela
I-Stelara isetshenzisiwe kusukela ngo-2008 ukuphatha izimo eziphambene nomzimba. Isimo sakamuva uStelara avunyelwe yisifo sikaCrohn. Nakuba uStelara engelapheki, kuye kwaboniswa ukuthi kuphumelela ekuphatheni isifo sikaCrohn kwezinye iziguli.
> Imithombo:
> Engel T, Kopylov U. "Ustekinumab esifo sikaCrohn: ubufakazi kuze kube manje nendawo yokwelapha." I-Ther Adv Chronic Dis . 2016 Jul; 7: 208-214.
> Janssen Biotech, Inc. "Imininingwane Yokuphepha Ye-Stelara." 24 Septemba 2016.
> Levy RA, de Jesús GR, de Jesús NR, Klumb EM. "Ukubuyekezwa okubalulekile kwezincomo zamanje zokwelapha izifo zesifo sokuvuvukala kwesimiso ngesikhathi sokukhulelwa nokukhwabanisa." I-Autoimmun uMsindisi . 2016 Oct; 15: 955-963.
> Niederreiter L, Adolph TE, Kaser A. "Anti-IL-12/23 ngesifo sikaCrohn: ibhentshi kanye nombhede." Izinhloso ZeDrrr . 2013 Nov; 14: 1379-1384.
> Rocha K, Piccinin MC, Kalache LF, Reichert-Faria A, uSilva de Castro CC. "Ukukhulelwa ngesikhathi se-Ustekinumab Ukwelashwa kwe-Psoriasis enamandla." Dermatology . 2015; 231: 103-104.