Okudingayo Ukukwazi Nokulinda Uma Ukhona Theophylline
I-Theophylline iyi-methylxanthine eyombili i- bronchodilator futhi ingase ibe nemiphumela emibi yokulwa nokuvuvukala. Nakuba ingasetshenziswa njengendlela yokwelapha, ukwelashwa okunye nge- steroid engaphazamisekile , lokhu akuyona isidakamizwa esikhethwayo uma i-asthma ephikisanayo idinga imithi eyengeziwe yokulawula i-asthma. I-Theophylline ngezikhathi ezithile iba yinto ethandwa kakhulu bese ingavunyelwa nodokotela ukuphatha i-asthma.
Kodwa-ke, enye yezinzuzo zayo eziyinhloko uma kuqhathaniswa nayo yonke imithi yokwelashwa yomoya we-asthma ukuthi ayibizi. Lokhu kwenza kube okukhangayo kakhulu njengokwelashwa okungeziwe ngemuva kwe-steroid engatholakali engakwazi ukulawula ngokwanele izimpawu ze-asthma ezingqondweni zeziguli eziningi.
Ngenxa yokuthi i-theophylline ingahlala amahora angaba ngu-24, abanye odokotela bazosebenzisa i-theophylline ukuze balawulwe izibonakaliso zesimiso se-asthma ebusuku, ikakhulukazi ngokuphefumula okuqhubekayo okuqhubekayo noma okulinganiselayo .
Indlela iTheophylline esebenza ngayo
I-Theophylline imithi yokulawula esebenza njenge-bronchodilator futhi ivuselela imisipha eqinisa njengengxenye ye-asthma yakho. I-Theophylline nayo inezinto eziphikisana nokuvuvukala kanye nezingozi zomzimba okungenzeka ukuthi zingcono ukuchaza ikhono layo lokusiza ukulawula izimpawu zesifo se-asthma kunokuba izakhiwo zayo zine-bronchodilatory zodwa.
Ngenxa yezinye izindlela eziphephile ezifana ne-steroids engatholakali (kanti odokotela ekuqeqeshweni namuhla banokuhlangenwe nakho okuncane kakhulu nalesi sidakamizwa njengoba sisekhona esikhathini lapho singekho emphakathini wezokwelapha), ama-agonists asebenta isikhathi eside (i-LABAs) ne-leukotriene i-modifiers, i-theophylline ngokuvamile ayinqunywe njengomugqa wokuqala noma ukwelashwa kwemigqa yesibini yesikhwama se-asthma ngudokotela wakho.
Isizathu sokuthi i-theophylline ayitholanga umusa ukuthi ayibonakali ukusebenza nezinye izidakamizwa ze-asthma. Izifundo azibonanga ukuthi i-theophylline ilingana ne-steroids e-inhaled ekwelapheni kwe-asthma. Ngokufanayo, ucwaningo luye lwabonisa ukuthi ama-LABA ayasebenza kakhulu lapho enezela umuthi wesibili ngaphezu kokufaka i-theophylline.
I-Theophylline idinga ukuthi amazinga egazi elithile atholakale ukuze abe nomthelela wokwelapha kodwa futhi angabangela imiphumela emibi lapho leli zinga lidlulile. Odokotela bavame ukuchaza lokhu njengohlu oluncane lwezokwelapha.
I-Theophylline idayiswa ngaphansi kwamagama omkhiqizo alandelayo:
- Elixophyllin
- Theo-24
- I-Theo-Bid Duracap
- I-TheoCap
- Theochron
- Theo-Dur
- I-Theo-Dur Phuza
- I-Theolair
- Theovent LA
- Slo Bid
- Slo-Phyllin
- Uniphyl
Ukuqapha amazinga weTheophylline
Ngaphezu kwemiphumela emibi, into eyodwa okungafani neziguli ezithandwayo mayelana nokusebenzisa i-theophylline yukuthi kuzodingeka ukuthi uchithe igazi ukuze uqaphe amazinga we-theophylline egazini lakho. Kuye ngokuthi wenza kanjani, kungadingeka wenze lokhu njalo kanye ngenyanga uze ufeze izinga eliqinile, eliphumelelayo le-theophylline egazini lakho. Ngokuvamile, udokotela wakho uzama ukuthola i-theophylline egazini lika-5-15 μg / ml. Uma izinga lakho le-theophylline lingaphansi kwalesi sizinga, unethuba elikhulu lokubhekana nemiphumela emibi.
Ukwengeza, kubalulekile ukuvumela noma yimuphi udokotela owaziyo ukuthi uyawe-theophylline. Ngenxa yokuthi i-theophylline ihlangene nezinhlobo eziningi zemithi, noma yikuphi udokotela obona okudingeka ukuthi wazi ukuthi u-theophylline. Ucwaningo luye lwabonisa ukuthi amaphesenti angu-35% we-theophylline anqunywe imithi ethile ephikisana kakhulu ne-theophylline.
Eminye imithi esebenzisana ne theophylline ihlanganisa:
- I-Allopurinol: Kungase kwandise ama-blood theophylline
- Benzodiazepines: Theophylline inganciphisa ukusebenza
- I-Beta-Blockers : Kunganciphisa umphumela we-bronchodilatation we-theophylline
- I-Carbamazepine: Theophylline inganciphisa amazinga egazi nokwandisa ingozi yokuthola ingozi
- I-Ciprofloxacin: Amazinga weTheophylline akhula nale mithi elwa namagciwane nawo wonke amanye ama-antibiotic kuleli klasi. Uma uthola i-theophylline ne-IV ciprofloxacin nge-IV line efanayo, i-crystallization ingenzeka
- Formoterol: Theophylline yandisa ingozi ye-potassium ephansi
- I-Zafirlukast: Theophylline inganciphisa amazinga egazi we-zafirlukast
- I-Zileuton: Kungase kwandiswe ukuhlushwa kwe-serum ye-theophylline
Futhi, uma unenkinga ethile yezokwelapha noma izimo okudingeka uqaphele uma uthatha i-theophylline:
- Isifo sesibindi: Uma unenkinga yesibindi umzimba wakho awubonakali i-theophylline ngokushesha njengomuntu ovamile, kanti umthamo wakho udinga ukwehla.
- Ukuhluleka kwenhliziyo ukukhumula: I-Dose idinga ukwehla njengesifo sesibindi
- Ukubhema: Uma ubhema, ungadinga i-theophylline ephakeme. Futhi, uma unquma ukuyeka ukubhema ungadinga ukwehlisa umthamo wakho we-theophylline.
Izinkomba zamanje zeTheophylline
Kunezindawo eziningana ezijwayelekile lapho i-theophylline isetshenziswa khona namuhla ekwelapheni kwesifo se-asthma:
- Njengendlela yokwelashwa ngokuqondisa lapho i-steroids engatholakali ingalawuli izimpawu ze-asthma noma lapho amanye ama-agent ehlanganisiwe ( LABAs) noma (i- leukotriene modifiers) futhi engasebenzi kahle ekulawuleni izimpawu.
- Njengokwelashwa okuyinhloko lapho isiguli singalandeli (noma kunzima kakhulu noma sinzima) ku-steroid engaxhunyiwe futhi i-leukotriene modifier ayiphumelelanga.
- Uma isiguli siseseyunithi yokunakekelwa okujulile enezifo eziphuthumayo ze-asthma futhi ungaphenduli kwezinye izifo.
Theophylline Side Effects
Esinye sezizathu eziyinhloko ukuthi i-theophylline ayisetshenziselwa ukusetshenziswa kakhulu ngenxa yemiphumela emibi. Nokho, iziguli eziningi azitholi nemiphumela emibi ku-theophylline. Ezinye iziguli nazo zithola imiphumela emibi phakathi nesonto lokuqala lokwelapha nge-theophylline. Uma ungakwazi ukubekezelela ekuqaleni, umzimba wakho uzoba ngaphezu kokubekezela. Izimpawu umzimba wakho ozolithola ngazo, kodwa udinga ukukhuluma nodokotela wakho uma ungahambi, faka:
- Ukukhathazeka kwesisu noma ubuhlungu
- Uhudo
- Izinwele
- Ukungalali
- Ukuthukuthela
- Ukuphumula
Imiphumela emibi kakhulu oyidingayo ukuze wazise udokotela wakho ngokushesha kufaka:
- Inhliziyo engavamile yokushaya noma ukukala
- Ukuzizwa
- Ukukhwabanisa isikhumba
- Ukuvota
Imithombo:
UPasko S, Simons WR, Sena MM, iStoddard ML. Isilinganiso sokuchayeka ekusebenzisaneni kwe-theophylline-izidakamizwa. I-Clin Ther. 1994-Nov-Dec; 16 (6): 1068-77.
> UpToDate. Theophylline: Ulwazi lwezidakamizwa ezigulayo
I-National Heart, Lung, ne-Blood Institute. Umbiko wePhaneli Wabachwepheshe 3 (EPR3): Izinkombandlela Zokuthola Ukuhlolwa Nokuphathwa Kwe-Asthma