Ingabe Ingozi Yokwelashwa Ikhuphuka Ngokusetshenziswa kwe-Blocker ye-TNF?
Umbuzo: Ingabe kukhona ingozi eyengeziwe yokutheleleka ngokusetshenziswa kwe-block block TNF?
Uyini ubuhlobo phakathi kwe- TNF (i-tumor necrosis factor) nokutheleleka? Ingabe ikhona icala lapho umlando wezokwelapha isiguli noma izimpawu zomtholampilo kungavimbela ukucacisa abanikazi be-TNF ? Futhi, ingabe kukhona isikhathi lapho lezi zidakamizwa kufanele zikhishwe noma ziyeke okwesikhashana, njengokuthi isiguli sinomkhuhlane, umkhuhlane, ukutheleleka, noma ukuhlinzwa okuzayo?
Impendulo: Izivimbela ze-TNF ziyindlela ephumelela kakhulu yokwelashwa kwesifo se- rheumatoid arthritis . Njengemithi yonke, kunezimo ezimbi ezingase zibe khona. Ama-block 5 a-TNF: i- Enbrel (etanercept), i- Humira (i-adalimumab), i- Remicade (infliximab), i- Simponi (golimumab) ne- Cimzia (certolizumab pegol) yandisa ingozi yokuthuthukiswa kwesifo sofuba (TB). Isizathu salokhu kwenzeka ukuthi i-tumor necrosis factor (TNF) idlala indima ebalulekile ekuzivikelweni komzimba ngokuvikela amabhaktheriya abangela i-TB. Ngenxa yalokho, kunconywa ukuthi odokotela bahlola iziguli ezihlolwa ngesikhumba se-TB ngaphambi kokuqala ukwelashwa nge-blocker ye-TNF. Uma kukhona ubufakazi bokuthi ukutholakala kwangaphambili (indawo ebomvu ephakanyisiwe izokhula phakathi kwezinsuku ezingu-2-3 endaweni yesicingo sesikhumba), imithi inganikezwa ngokuhambisana ne-TNF blocker ukuvumela ukwelashwa.
Ngaphezu kwalokho, kukhona ubufakazi obuvela ezifundweni zemitholampilo kanye nemibiko yokuthunyelwa kwe-post-marketing (imibiko evela ezigulini nodokotela abasebenzisa izidakamizwa ngemuva kokuvunyelwa yi-FDA) ukuthi i-TNF ivimbela ingozi yezifo ezinzima (ngaphezu kwesifo sofuba) uma kuqhathaniswa kubantu abaningi.
Naphezu kwemiphumela emihle emitholampilo eqenjini le-rhumatoid, kusekhona ukukhathazeka ukuthi lezi zidakamizwa empeleni zikhulisa ingozi yokutheleleka okukhulu ngenxa yokuthi, ngokuvamile, iziguli ezinempilo ziyangena ezifundweni zemitholampilo futhi amacala amaningi okutheleleka awabikwa uma isidakamizwa sisekuqaleni emakethe.
Nakhu okusemqoka:
- Kunconywa ukuthi ama-block block we-TNF angaqaliswa ngumuntu onokutheleleka okusebenzayo.
- Iziguli ezinezifo ezinzima eziphindaphindiwe noma izifo ezingapheli kufanele zigweme ukusebenzisa i-TNF blockers.
- Ngaphezu kwalokho, izivimbela ze-TNF kufanele zikhishwe okwesikhashana kulabo abagulayo abahlakulela isifo esibi kakhulu ngenkathi besebenzisa i-blocker ye-TNF noma labo abadinga ama-antibiotics ukuze baphathe ukutheleleka kwabo.
UScott J. Zashin, MD uthe, "Ukuthi noma ukuyeka ukwelashwa kweziguli ezinezifo ezincane akucaci, kodwa ngivame ukugwema ukwelashwa ngoba angizizwa izinzuzo zokwelashwa okuqhubekayo ngesikhathi sokutheleleka kunaphezu kwezingozi. azikho izincomo ezivela ezinkampanini zokuthi noma ukuyeka okwesikhashana ukwelashwa. Kukhona idatha elinganiselwe futhi ephikisanayo nomphumela we-block blockers we-TNF emiphakathini yokuhlinzeka. Ezimweni eziningi, ngincoma ukuyeka i-Enbrel 1-2 amasonto ngaphambi kokuhlinzwa, bese uphinde uqale 1 ngesonto elizayo, uma kungekho zibonakaliso noma izimpawu zokutheleleka. Huma kufanele amiswe amasonto amabili ngaphambi futhi aphinde abuyele ngemva kweviki elilodwa. Ukukhumbuza kumele kumiswe amasonto amane ngaphambi futhi kuvuselelwe izinsuku ezingu-10 kuya kumaviki amane emva kokuhlinzwa. "
Inothi: Sicela uxhumane nodokotela wakho ukuze uthole iseluleko ukuthi kufanele ubeke okwesikhashana i-Enbrel, i-Humira, i-Remicade, i-Simponi noma i-Cimzia ngaphambi kokuhlinzwa.
Odokotela bangase babe nezidingo ezahlukene.
Umthombo:
UScott J. Zashin, MD ungumprofesa wocwaningo lwezempilo ekliniki yase-University of Texas Southwestern Medical kanye nodokotela ozofika esibhedlela sasePresbyterian eDallas nasePlano. UDkt. Zashin ungumbhali we- Arthritis Ngaphandle kobuhlungu - Isimangaliso se-TNF Blockers nombhali-mbhali we- Natural Arthritis Treatment .