I-TNF Blocker Yokuqala Evunyelwe I-Arthritis Ye-Rheumatoid ngo-1998
I-Enbrel (etanercept) iyisimo se-biologicalic modifier (i-recombinant humor necrosis factor receptor fusion protein). I-enbrel isetshenziselwa izakhi zofuzo ukuze ibe njenge-receptors emzimbeni obopha isifo se-tumor necrosis (TNF-alpha). I-Enbrel isebenza ngokufaka i- TNF excess ngokweqile ngaphambi kokuba ifakekele kuma-receptor yemvelo.
I-TNF-alpha yi- cytokine ehilelekile enkambisweni yokuvuvukala.
I-TNF-alpha eyengeziwe ihlotshaniswa ne- arthritis ye-rheumatoid nezinye izinhlobo ze-arthritis evuthayo .
Izidakamizwa ezifanayo
I-Enbrel yayiyisilonda sokuqala sokulwa ne-TNF futhi yamukelwa ngo-1998 nge-arthritis ye-rheumatoid nezinhlobo ezithile zokuvuvukala kwamathambo. I-Remicade (i-infliximab) yayiyi-TNF yesibili inhibitor ezovunyelwa yi-US Food and Drug Administration ngo-1999. UHuma (adalimumab) yamukelwa ngo-2002. I- Simponi (golimumab) yamukelwa yi-FDA ngo-Ephreli 24, 2009. Cimzia (certolizumab pegol ) yayigunyaziwe yi-FDA ngoMeyi 14, 2009.
I-enbrel itholakala ngokusungula i-DNA yabantu kumaseli ase-Chinese hamster ovary nokudala amaprotheni okwenziwa izakhi zofuzo. I-Remicade isebenzisa amaprotheni omuntu kanye negundane ukudala i -anti- chimeric anti-monoclonal antibody . U-Humira usebenzisa amaprotheni omuntu ngokugcwele kanye nobuchwepheshe bokuphakamisa ubuchwepheshe ukuze akhiqize ama-antibodies omzimba.
Ukuphatha
I-enbrel ilawulwa njengemjovo engaphansi kwesikhashana kanye noma kabili ngesonto (izinsuku ezintathu noma ezine ngaphandle).
Isilinganiso esinqunyiwe sincike esimweni esiphathwayo. I-Enbrel kumele inqunywe udokotela wakho futhi idinga umshuwalense ngaphambi kokugunyazwa. I-enbrel ingasetshenziswa ngokuhlanganiswa ne-methotrexate ezigulini ezingaphenduli ku-methotrexate yedwa.
Imithi
I-Enbrel ivunyelwe ukwelapha isifo samathambo esiyinkimbinkimbi esiphezulu, esilinganiselwe ekubeni nesifo samathambo esiyinkimbinkimbi yesifo sofuba , i- psoriatic arthritis , i- spondylitis e-ankylosing , engenamaphesenti aphansi kuya kuma-plaque psoriasis amakhulu.
Isilinganiso esinconywe
Kubantu abadala abane-arthritis ye-rheumatoid, i-psoriatic arthritis, ne-anondlosing spondylitis, isilinganiso esivamile sase-Enbrel singama-50 mg ngesonto esilawulwa njengejoza elingaphansi kokusebenzisa i-syringe ye-50 mg / ml engasetshenziswa yodwa. Kunezimbozo ezingu-25 mg ze-Enbrel ezitholakalayo.
Isilinganiso se-Enbrel esenzelwe i-arthritis yezingane ezisencane isekelwe isisindo somntwana. Ukukhethwa kwe-once-weekly dosing kukhona kubantwana abanesisindo esingu-138 lbs noma ngaphezulu. I- psoriasis ye-plaque , umthamo ovamile u-50 mg kabili ngesonto izinyanga ezintathu, wehla kanye kanye ngesonto.
Ukukhathazeka Okukhethekile
I-Enbrel ayikhuthazwa ngabesifazane abakhulelwe noma abahlengikazi. Iziguli ezinezifo ezinzima akufanele ziphathwe nge-Enbrel. Abantu abajwayele ukutheleleka noma labo abanesifo sikashukela abangalawuleki akufanele basebenzise i-Enbrel. Iziguli ezinezimo ezithile zesimiso sezinzwa eziphakathi kufanele futhi zigweme i-Enbrel.
Imiphumela Ejwayelekile Ejwayelekile
Imiphumela emibi evamile ehlobene ne-Enbrel ihlanganisa:
- ukuphendula kwe-injection site
- ukutheleleka okuphezulu kokuphefumula, kufaka phakathi izifo zesifo
- ikhanda
- isiyezi
- ikhala eligijima
- ukucasuka komphimbo
Ukusabela Okubi Okubi
I-enbrel ingandisa ingozi yezifo ezinzima. Kubantu abaphathwa nge-Enbrel, kube khona imibiko ye- multiple sclerosis , i-myelitis (ukuvuvukala komgogodla), i-optic neuritis (ukuvuvukala kwe-optic nererve), ne-pancytopenia (izinombolo eziphansi zamaseli abomvu, amaseli amhlophe, amaplatelets).
Isitoreji
I-enbrel kufanele igcinwe ekushiseni kwama-36 kuya ku-46 degrees Fahrenheit. Nokho, i-Enbrel ingagcinwa ekamelweni lokushisa izinsuku ezingaba ngu-14. I-enbrel akumele ilondolozwe efrijini.
Ngokusho kwe-enbrel.com, uma uhamba amahora angaphezu kwambalwa, kufanele ugobe i-Enbrel ekugubungeni kwe-bubble bese uyibeka endaweni epholile yokuhamba egcwele iqhwa. Engeza i-thermometer ku-cooler bese uyihlola njalo amahora ambalwa. Ungathola ukupholisa okuhamba mahhala ne-ice pack ye-Enbrel ngokubiza ukuxhaswa kwe-Enbrel ku-1-888-4ENBREL. Uma uhamba emoyeni, hlola ne-airline ngezidingo zazo.
Imithombo:
I-arthritis ngaphandle kobuhlungu, uScott J. Zashin, MD, Ishicilelwe nguSarah Allison Publishing Company.
Enbrel - I-Pill Book, Edition 10
Umhlahlandlela Wezokwelapha. Enbrel.com. Kubuyekezwe 11/2013. http://pi.amgen.com/united_states/enbrel/derm/enbrel_mg.pdf
Ukubeka imininingwane. Enbrel.com. Kubuyekezwe 03/2015. http://pi.amgen.com/united_states/enbrel/derm/enbrel_pi.pdf