Isidakamizwa se-biologic esingenayo i-rheumatoid arthritis
U-Adalimumab, owaziwa ngokuthi u-Humira, ungumuthi we-biologic osebenza ngokuvimbela iphrotheni eyaziwa ngokuthi i- TNF-alpha . Ngokuvamile, i-TNF-alpha iyasiza ukulwa nokutheleleka, kepha ngokweqile, kungabangela ukuvuvukala okubuhlungu nokulimala okuhlangene (okusho izimpawu ezivamile zesifo samathambo kanye nezinye izinhlobo ze- arthritis evuthayo ). Izidakamizwa ezifana noHumira zisize iziguli eziningi ze-rheumatoid arthritis ngokunciphisa ubuhlungu, ukuthuthukisa umsebenzi wokujoyina, nokunciphisa ukuqhuma kwezifo.
Sibutsetelo
U-Humira uyilwane lomzimba elilodwa eligcwele ngokuzijabulisa. Lokhu kusho ukuthi, noma ngabe kwenziwa ezinkambisweni ezingezona zomuntu eziphilayo, okwenziwe amaprotheni wangempela wesidakamizwa kufana nalokho okulwa namagciwane omuntu. Futhi lo Hume ovelele ovela kwi-blocker ye-monoclonal antibody-TNF eyayivunyiwe ngaphambi kwayo-ukubunjwa kwamaprotheni kwakutholakala ngokuyingxenye kusuka kumuntu ongeyena umuntu (i-mouse).
Ngo-2002, u-Humira wamukelwa okokuqala yi-US Food and Drug Administration (FDA) njengokwelashwa kwesifo samathambo e-rheumatoid. Ngenye yezidakamizwa eziningana ze-biologic ezivimba i-TNF-alpha, kuhlanganise:
- I-Enbrel (Etanercept) : Isidakamizwa sokuqala se-TNF esamukelwe yi-FDA ngesifo samathambo kanye nezinhlobo ezithile zokuvuvukala kwe-arthritis ngo-1998.
- I-Remicade (Infliximab) : I-TNF yesibili inhibitor ezovunyelwa yi-FDA ngo-1999.
- Simponi (Golimumab) : Kuvunywe yi-FDA ngo-Ephreli 24, 2009.
- I-Cimzia (Certolizumab Pegol) : Yamukelwa yi-FDA ngoMeyi 14, 2009.
Ukuzikhohlisa
U-Humira unikezwa ngaphansi (ngaphansi kwesikhumba) ukuzijocavoca kanye njalo ngemva kwamasonto amabili. Iziguli zingase zitshelwe udokotela wazo ukuba azijobe njalo ngesonto uma zonke izinsuku ezingu-14 zinganele.
Kwakuqala ukutholakala ngokusetshenziswa okukodwa, isirinji esandulele. Ukusetshenziswa okukodwa, uhlelo lokudiliva olulahlwayo luye lwasungulwa, olubizwa ngokuthi i-Humira Pen.
I-dose ephakanyisiwe, noma kunjalo, i-40mg njenge-auto-injection yangaphansi kokusebenzisa i-syringe ngaphambi kokugcwaliswa noma i-Humira ipeni njalo njalo ngesonto. I-Methotrexate , amanye ama- DMARD angewona ama-biologic, i- glucocorticoids , izidakamizwa ezingezona ukuvuvukala (ama-NSAID) , noma ama- analgesics (imithi yobuhlungu) ingaqhubeka nokuphathwa nge-Humira. Kodwa-ke, ezinye i-DMARD ye-biologic akufanele isetshenziswe.
Izinkomba
Ezinye izinkomba zengezwe nge-Huma kusukela ekuqaleni zavunywa yi-FDA. Kungabe kunqunyelwe ukuthi uphinde uphathe:
- I-rheumatoid Arthritis
- I-Ankylosing Spondylitis
- I-Arthritis Psoriatic
- I-Juvenile Idiopathic Arthritis
- I-Plaque Psoriasis
- Ulcerative Colitis
- Isifo Sabantu Abadala kanye Nezingane Zase-Crohn
- I-Hidradenitis Suppurativa
Okuqhamuka uma udla imishanguzo
Imiphumela emibi ejwayelekile ehambisana neHuma ihlanganisa:
- Impendulo yesakhiwo somzimba omncane
- Rash
- Izinwele
- Ukucasuka kwesisu noma isicashu
- I-pneumonia
Ukusabela okubi
Ngenxa yokuthi igxilisa impendulo yomzimba emzimbeni ovame ukulwa nokutheleleka, uHuma uye wahlobana nezifo ezinzima, ezifana nesifo sofuba, isifo sofuba nesifo sofuba. Kungase kube nzima nakakhulu izimpawu zezifo zesimiso sezinzwa (isb., Ukuphazamiseka kwezidakamizwa). Ezilingo zomtholampilo, ezinye iziguli zinezinga eliphezulu lomdlavuza ne-lymphoma esikhathini esingangezinyanga ezingu-24.
Ngubani ongafanelanga ukuthatha u-Huma
U-Humira akufanele asetshenziswe iziguli ezinezifo ezithinta izidakamizwa ezidakamizwa noma izingxenye zayo. Akufanele futhi isetshenziswe iziguli ezikhulelwe noma zokunakekela.
Isidakamizwa akufanele sikhishwe isiguli esinesifo esithathelwanayo noma iziguli ezithintekayo ekutheleleni, kufaka phakathi iziguli ezine- diabetes ezingalawuleki noma iziguli ezinomlando wezifo eziqhubekayo.
Tshela udokotela wakho
- Uma une-infection ekhuthele
- Uma usulelekile nge-Hepatitis B noma uyithwala (i-Humira ihlotshaniswa nokuvuselelwa kwesifo se-Hepatitis B)
- Uma unama-numbness, u-tingling, noma multiple sclerosis noma i-central central nerveous disorder disorder
- Uma uphathwe ukuhluleka kwenhliziyo
- Ngaphambi kokuthola noma yimiphi imithi noma ukuhlinzwa
Ukuze ubike ukusabela okubi okusolakala ukuthi kuyingozi, ungaxhumana no-AbbVie Inc.at 1-800-633-9110 noma i-FDA ku-1-800-FDA-1088 noma ku-www.fda.gov/medwatch.
Imithombo:
Zashin, MD, Scott J .. I-arthritis ngaphandle kobuhlungu. Inkampani yakwaSara Allison Publishing.
Humira . Abbott laboratories. Ukubeka imininingwane. 2016.