Uhlaka lwe-TSH: Isiqondiso seziguli ze-Thyroid

Konke Okudingeka Ukwazi Nge-Thyroid Yokuvuselela I-Hormone Test

I-test ye-hormone test stimulating-eyaziwa nangokuthi ukuhlolwa kwe-TSH-iyisivivinyo esiyinhloko esetshenziswa ngabadokotela abavamile abaxilongwa nokuphathwa kwesifo se-thyroid. Kubalulekile ukuthi njengesiguli se-thyroid, uqonda lokhu kuhlolwa, incazelo yemiphumela yakho, kanye nezingxabano ezizungeze uhla lwezintandokazi ze-TSH.

Uyini umbuzo we-TSH?

Isivivinyo se-TSH silinganisa i-hormone noma i-TSH ye-thyroid.

I-TSH i-hormone ikhishwa yi-pituitary gland yakho ekuphenduleni amazinga we-hormone yegciwane egazini lakho legazi. Uma ama-hormone we-thyroid aphansi afunyanwa, i-pituitary ikhishwa ngaphezulu kwe-TSH ukukhuthaza igciwane lakho le-thyroid ukuze likhiqize ama-hormone amaningi. Uma i-hormone ye-thyroid ekhulu kakhulu itholakele, i-pituitary inciphisa ukukhiqizwa kwe-TSH.

Isivivinyo se-TSH yisilingo segazi lokuqala sokusetshenziswa kwegazi esetshenziselwa ukuxilonga isifo segciwane bese uphatha ukwelashwa kwegciwane. Ezingeni eliyisisekelo, amazinga aphakanyisiwe we-TSH abhekwa njengobungqina be-hypothyroidism, i-thyroid engasebenzi. Amazinga aphansi ka-TSH abhekwa njengobungqina bokuthi i-hyperthyroidism, i-thyroid engasebenzi kakhulu.

Ama-Rang Reference Ranges

Ibanga lokubhekisela litholakala ngokuthatha iqembu elikhulu labantu emphakathini, eqhuba uvivinyo oluthile, ukubala amanani, nokudala ububanzi obufanele ukumela amazinga "avamile" abantu abangenaso isifo esithile noma okungavamile .

Uhlu lwetheksthi le-TSH lumelela ububanzi bamazinga e- TSH abantu ababizwa ngokuthi banenkinga yesifo se-thyroid futhi abanomsebenzi ovamile we -roid.

Njengamanje, kuma-laboratories amaningi e-US, ibanga lokubhekisela lezinkinga ze-TSH cishe li-0.5 ukuya ku-5.0 mU / l. Kuye ngelebhu, ungase ubonakale umehluko othile, okungukuthi u-0.4 kuya ku-5,5 mU / l, noma u-0.6 kuya ku-4.5 mU / l, njll, kodwa ngokuvamile, u-0.5 kuya ku-5.0 mU / l kubhekwa njengama-lab.

Ngokuvamile, udokotela wakho uzohumusha izinga elingezansi kwe-0.5 mU / l njengendlela ekhombisa ukuthi i-hyperthyroidism (i-thyroid engasebenzi kakhulu), nezinga elingenhla ku-5.0 mU / l njengendlela ebonisa ukuthi i-hypothyroidism (i- thyroid engasebenzi ).

Ishadi elilandelayo libonisa ububanzi bokubhekisela kwe-laboratory ye-TSH:

I-TSH Reference Range Ukuhumusha
0.5 kuya ku-5.0 mU / l - Izansi ngezansi kwe-0.5 mU / l okubonisa
hyperthyroidism
- Izinga elingaphezulu kuka-5.0 mU / l lokubonisa
hypothyroidism

I-Reference Range Controversy

Uhla lwamarekhodi we-TSH langempela luphikisana iminyaka engaphezu kweyishumi. Emuva ngo-2003, ngemuva kokufakazela ukuthi iziguli ezaba namazinga e-TSH ekugcineni okuphezulu kobubanzi bezinkomba ze-TSH zazivame ukuqhubeka nokuthuthukisa i-hypothyroidism kaningi kunezo ezisekupheleni kwebanga, i-American Association of Clinical Endocrinologists (AACE) Kunconywa ukuthi odokotela "bacabangele ukwelashwa kweziguli ezivivinya ngaphandle kwemingcele ye-margin encane esekelwe izinga elibhekiswe ku-TSH lika-0.3 kuya ku-3.0 mU / l. Ngaleso sikhathi, i-AACE ikholelwa ukuthi uhla olusha " luyoba nokuxilongwa kahle kwezigidi zabantu AmaMelika aphethwe yisifo esibucayi se-thyroid, kodwa angaphathwa kabi. "

Ngokusho kukaMengameli we-AACE uHossein Gharib, MD,

Ukusabalalisa kwesifo se-thyroid esingatholakali e-United States kusaphazamisa phezulu ... Uhla olusha lwe-TSH oluvela emihlahlandleleni ye-AACE lunikeza odokotela ulwazi oludingayo ukuze bahlolisise isifo esibuhlungu ngaphambi kokuba kuholele emiphumeleni eyingozi kakhulu empilweni yesiguli, i-cholesterol ephakeme, isifo senhliziyo, ukuphefumula kwamandla, ukuphelelwa amandla, nokucindezeleka. "

Ngaleso sikhathi, isimemezelo esivela ku-AACE sabonakala ngabaningi njengokuthuthukiswa kwesikhathi eside nokudinga kakhulu iziguli.

Ngeshwa, lokho okwakucatshangwa ukuthi ukuthuthukiswa okwenziwe ngeziguli ze -roid akuzange kube nomthelela omkhulu, ngezizathu eziningana:

Odokotela Martin Surks, uGayotri Goswami kanye noGilbert Daniels bathi i-reference reference kufanele ihlale ifana nalokho okushiwo "Ukuphikisana Endocrinology Clinic: I-Thyrotropin Reference Range Kufanele Ihlale Ingaguquki." Besebenzisa izimpikiswano zabo ngokufakazela kwabo ukuthi "ngoba ukwelashwa kwesifo se-levothyroxine akukhuthazwa nge-subclinical hypothyroidism, ngokuqinisekile akuqinisekisiwe kubantu abanezintambo eziphezulu ze-TSH" amazinga ka-2.5 kuya ku-4.5 mU / l.

Odokotela uLeonard Wartofsky noRichard Dickey bathi ku-athikili yabo, "Ubufakazi be-Narrower Thyrotropin Reference Range buphoqeleka," ukuthi izintambo ezisekelwe ngaphambili zangasesezivumelekile ngoba izithenjwa ezibhekwa ngaphambili zibhekwa zijwayelekile "zazingcoliswa" nabantu abanamazinga ahlukene ngesifo se-thyroid. Batshela ukuthi izinzuzo zokwelashwa zidlula zonke izingozi ezingezansi.

Odokotela Wartofsky noDickey bavikela ukushintshela ebangeni elisha, bethi:

Ngeke mhlawumbe singalokothi sibe ne-cutoff ye-value ngokuphelele ye-TSH ehlukanisa ukujwayelekile nokungajwayelekile, kodwa ukuqaphela ukuthi isilinganiso samanani ajwayelekile we-TSH kuphela phakathi kuka-1.18 no-1.4 mU / l nokuthi ngaphezulu kuka-95% wabantu abajwayelekile bayoba nezinga le-TSH ngaphansi ngaphezu kwe-2.5 mU / l ngokucacile kusho ukuthi noma ubani onenani eliphakeme kufanele ahlolwe ngokucophelela ngokuhluleka kwe-thyroid ekuqaleni.

Ngonyaka ka-2006, amaqembu e-endocrinology ashiye incomo yokwandisa uhla lwezintandokazi ze-TSH, Noma kunjalo, ingxabano elandelana emuva ibuye yaqhubeka iminyaka engaphezu kweyishumi, futhi kusukela ngo-2017, ukuphikisana kuyaqhubeka. Noma kunjalo, iningi labasebenzi bezempilo abavamile bayalwa ukuba basebenzise uhla lwe-TSH olubanzi lokubhekisela ekuhloleni nasekuphatheni iziguli ze-thyroid.

I-TSH evamile ne-Hypothyroidism

Kubalulekile iziguli ze-thyroid ukwazi ukuthi ucwaningo lubonise ukuthi:

Uma umphumela wakho wokuhlolwa we-TSH ungena ebangeni lokubhekisela futhi utshele ukuthi "i-TSH yakho iyinto evamile," ungabe usaba i-hypothyroid? Odokotela abaningi abavamile basho ukuthi cha, futhi ochwepheshe abaningi abahlangene nabaphelele bathi yebo. Kungakhathaliseki ukuthi ungaba i-hypothyroid ngezinga elijwayelekile le-TSH ekugcineni lihlala liyingxabano.

Izwi elivela

Njengoba ufunde, incazelo yezinga elithi "evamile" le-TSH lincike kudokotela obonisana nabo nemibono yakhe mayelana nesifo se-thyroid. Ngesikhathi esifanayo, ukuhlolwa kwe-TSH kanye ne-TSH yokubhekisela kubaluleke kakhulu empilweni yakho yezokwelapha kanye nokwelapha. Ngenxa yalokho, kukhona izinto ezibalulekile okufanele uzikhumbule.

  1. Udinga ukubuza ukuthi isiphi i- TSH esilinganisa udokotela wakho ekubhekisele kuwe, futhi kungani. Ungase ube nodokotela okholelwa ukuthi ukugcina phezulu kwebanga kuwumgomo oyedwa noma ogxila kwi-TSH ephansi nokusizwa kwezibonakaliso zakho. (Futhi, odokotela bahlose amazinga e-TSH aphansi kakhulu noma acindezelayo abanye abasindiswa ngumdlavuza we-thyroid, njengendlela yokuvimbela ukuphindaphindiwe komdlavuza.) Iningi labodokotela, namanje, basasebenzisa uhla lwe-TSH lokubhekisela kulo lonke u-0.5 kuya ku-5.0 ukuxilongwa nokuphathwa isifo sakho se-thyroid.
  2. Akufanele wamukele izimpendulo "ezivamile," "eziphezulu," noma "ezansi" njengombiko wokuhlolwa kwegazi lakho. Esikhundleni salokho, cela izinombolo zangempela bese ucela ibanga lokubhekisela lebhulabhu. Ngisho nakakhulu okwamanje, cela ikhophi yemiphumela yangempela yokuhlolwa kwegazi.
  3. Uma amazinga wakho wokuhlola we-TSH angaphakathi kwebala lokubhekisela, futhi unezimpawu ezihambisana ne-hypothyroidism, ungase ufune ukucela ukuhlolwa okungeziwe ukuze usize ngokuxilongwa ngokugcwele. Ngenkathi odokotela abavamile bexhomeke ekuvivinyweni kwe-TSH kuphela, abanye odokotela balinganisa ama-hormone e-thyroid (i-thyroxine (T4) ne- triiodothyronine (T3) - kanye namazinga we-antibody we-thyroid futhi abuyele emuva ku-T3. Laba odokotela bafuna izinyathelo ezengeziwe zokuthola ukuxilongwa. Isibonelo, uma amazinga akho ama-hormone e-T4 ne-T3 ephansi, kusolakala ukuthi i-hypothyroidism, futhi uma iphakeme, i-hyperthyroidism iyasolakala. Ama-antibodies-ikakhulukazi amasosha omzimba we-peroxidase (TPO) angakwazi ukuhlola isifo sikaHashimoto-ngezinye izikhathi akholelwa. I-subset of practitioners ikholelwa ukuthi isifo se-thyroid esesimweni sokuhluleka okuzenzakalelayo-njengoba kuboniswa ngamazinga aphezulu we-anti-TPO-angabangela izimpawu ze-hypothyroidism ngaphambi kokuba i-hypothyroidism iboniswe ku-TSH, noma ngisho ne-Free T4 ne-Free T3, ukuhlolwa. Baphinde bakholelwa ukuthi ukwelashwa ngezidakamizwa ezithathelanayo ze-hormone kungasiza ekunciphiseni izimpawu zakho, ukunciphisa amazinga akho e-antibody, futhi kukuvimbele ukuba ungaphezu kwe-hypothyroid.
  4. Uma amazinga wakho wokuhlola we-TSH awela ekugcineni okuphezulu kwereferensi yokubhekisela, futhi unezimpawu ezihambisana ne-hypothyroidism, cabanga ngokuxoxa ngesilingo sokwelashwa kwesimo se-hormone ye-thyroid nodokotela wakho.
  5. Uma udokotela wakho enqaba ukusebenzisa izivivinyo ezengeziwe noma enqaba ukukuphatha, cabanga ngokuthola udokotela omusha ukunakekela kwakho kwe-thyroid. Odokotela abahlanganisayo nabaningi bavame ukufaka izivivinyo eziningi ngaphezu kwesilingo se-TSH, bese uthatha umlando wakho wezokwelapha kanye nezimpawu, ngokufaka umgomo wokuthola i- TSH ephephile futhi enempilo ezosiza ngokukhululekile izimpawu zakho.

> Imithombo:

> Anderson et. I-"." Ukuhlukahluka Kwamanye Omunye Ku-Serum T4 no-T3 kwizihloko ezijwayelekile: I-Clue ekuqondeni izifo ze-Thyroid, "Journal of Clinical Endocrinology kanye neMetabolism, 87 (3): 1068-1072.

> Garber J, uCobin R, Gharib H, et al. Imikhombandlela yokusebenza emitholampilo ye-hypothyroidism kubantu abadala: I-Cosponsored yinhlangano yamaMelika ye-endocrinologists yemitholampilo kanye nomhlangano we-American thyroid. I-Endocrine Practice. 2012; 18 (6): 988-1028. doi: 10.4158 / ep12280.gl.

> I-Guber HA, i-Farag AF. Ukuhlolwa komsebenzi we-endocrine. Ku: McPherson RA, Pincus MR, eds. Ukuhlolwa Nokuphathwa Kwemitholampilo kaHenry's by Methods Methods. 22nd. Philadelphia, PA: Elsevier Saunders; 2011: isahluko 24.

> Surks, et.al. "Ukungqubuzana Endocrinology Clinic: I-Thyrotropin Reference Range Kufanele Uhlale Ungaguquki," I-Journal of Clinical Endocrinology ne-Metabolism 90 (9) / 5489-5496.

> Wartofsky & Dickey, "Ukuphikisana Endocrinology Yemithi: Ubufakazi Bokweqakathekile I-Thyrotropin Reference Range Kuphoqelela," I-Journal of Clinical Endocrinology ne-Metabolism.