Izimo ezithile ze-autoimmune ngezinye izikhathi zibizwa ngokuthi "izifo ezingabonakali". Umuntu obhekene ne-autommune flare kungenzeka angabonakali agule ngaphandle kwabanye; nokho, yena ubhekene nokuguquka komzimba okujulile futhi unzima ukuqhubeka ehamba. Ngokusho kukaDkt. Bonnie Feldman, umsunguli weDrBonnie360-Ukuxhumeka Kwakho Okuzimele, kuthatha iminyaka eyi-3.6 no-5 odokotela ukuba bafinyelele ekuhloleni ngokuzenzakalelayo.
Ngokuvamile, abantu banikwa igama elibanzi, elingacacisiwe lesimo esinezici ezizenzakalelayo.
Lokhu kusho ukuthi abantu abaningi baphila ekuqhudeni iminyaka eminingi ngaphambi kokutholwa ukuthi bafanelekile. Kodwa-ke, iziguli eziningi-futhi zikhona amacala amasha angama-250,000 unyaka ngamunye-ukuthola ukuxilongwa okulungile kungukuqala kohambo olude. Imithi yokwelashwa ejwayelekile ngokuvamile ivame ukubonisa ukuthi iyasebenza futhi incike kwizidakamizwa ezingasebenzi ngaso sonke isikhathi ngendlela ehlala njalo futhi / noma zibe nemiphumela emibi engathandeki. Ngakho-ke, abantu abaningi baphendukela ezindleleni ezihambisanayo. Isibonelo, ukudla kuvela njengesimiso esingahle sokwelapha lezi zimiso nokwandisa izinga lomuntu jikelele lokuphila.
Abanye ochwepheshe bakholelwa ukuthi amathuluzi adijithali nobuchwepheshe bezokwelapha bangabangela ukhetho olungcono lwezokwelapha iziguli ezinezifo ezizimele. Ubuchwepheshe bungenza ndawonye izinhlobo ezahlukene zeziguli ezizimele (kunezimo ezingaphezu kwezingu-100 ezihambisana nesambulela esizimele) futhi uvumele ukwabiwa kwedatha.
Ubuchwepheshe bungase futhi bukwazi ukusiza ukwakha ibhuloho emkhatsini we-theory nokusebenza. Izinhlangano ezinjengeDrBonnie360 zihlose ukuxhuma ubuchwepheshe bedijithali ngokutholakala kwamuva kwezesayensi nokuguqulwa kwendlela yokuphila ukuze abantu abaphila nezimo ezizimele bakwazi ukwandisa inhlalakahle yabo.
Gut njengoba njenge-Autoimmune Organ
Ucwaningo lwakamuva lwalubona umgudu njengengxenye esemqoka yomzimba wokuxilonga umzimba, ubuchopho nama microbes ahlala kithi nakithi. UProfesa Michele Kosiewicz weYunivesithi yaseLouisville, onesithakazelo esikhethekile sokucwaninga nge-autoimmunity and microbiota, washicilela izinombolo eziningi ezihlosiwe ngale ndaba, kufaka phakathi eyodwa echaza ubudlelwane obuyinkimbinkimbi phakathi kwama-bacterial gut kanye nokuthuthukiswa kwezifo kwezinye izitho. Uchaza ukuthi ukuxhumana phakathi kwama-gut microbiota namaseli omzimba omzimba kudlala indima ebalulekile ekuthuthukiseni izimo ezivuthayo, njengezifo ezizimele nezifo.
Lo mbono usemncane; Kodwa-ke, ukungenelela okuningi manje kuthuthukiswa okubhekiswe emathunjini futhi ngokuvamile kufaka izinguquko zokudla nokunciphisa ukucindezeleka. Ukuze uhlanganyele neziguli, amathuluzi edijithali angasiza kakhulu futhi asize ushintsho lokuziphatha, kanye nokusiza kokudla nokushintsha kwendlela yokuphila okudingekayo ukuze bavuselele. Ingqikithi yokuguqulwa kwama-fecal ibuye ibe yindlela enamandla kubantu abathile abanezifo ezivuthayo. Le ukwelashwa isivele isetshenziselwa ukutheleleka kwama-C.difficile okuvamile kanye ne- Irritable Bowel Disease (IBD). Kulindeleke ukuthi izinqubo ezifanayo zizokwakhiwa kwezinye izimo ezihambisana ne-microbiota eguquliwe.
Ukubheka Isizathu Esisisekelo Sesifo Esizimele
Inkulumo ka-TEDx ka-2011, eyanikezwa uDkt. Terry Wahls, yaqala ingxabano ngezifo eziphelele zesifo sokuzimela. U-Wahls, oye waxilongwa nge-multiple sclerosis (MS), wabonisa ukuthi izinkinga zokuzimela zidingeka zibhekiswe ezingeni leselula. Wazinikele ekuhlolisweni kwesayensi ngesifo sakhe, futhi ngenxa yalokho, wakhulisa isimo sakhe ngokuphawulekayo. Ngesikhathi esifanayo, wenza lolu lwazi olubalulekile lutholakale kuwo wonke umuntu. Iziguli eziningi zanquma ukumlandela ziholele ngokuthola izingxoxo zakhe ze-intanethi nezincwadi. U-Wahls uhlele i-protocol-ebizwa ngokuthi i-Wahls protocol-egxile ekusekeleni kokudla okunomsoco kanye nokushintsha kwendlela yokuphila, yena nozakwethu abenza ucwaningo oluqhubekayo ukuze baqinisekise futhi baqhubekele phambili.
Banda nje benza ukuhlolwa okungahleliwe okubonisa ukuthi ukudla kwe-Paleolithic kungathuthukisa ukukhathala, izinga lokuphila kanye nekhono elikhulu lezandla zomsebenzi kubantu abanezinkinga eziqhubekayo ze-sclerosis. UDkt. Wahls kanye neqembu lakhe bakholelwa ukuthi ukudla kwe-Paleo kufanele kubhekwe njengendlela yokwelashwa kwe-multiple sclerosis futhi isetshenziswe ngaphezu kwamanye amayeza atholakalayo.
Abanye ochwepheshe abazimele ngokuzenzakalelayo baphakamisa nokuthi ukuze baqonde imbangela eyinkimbinkimbi yezinkinga ezizimele, iziguli kudingeka zinikele idatha yazo futhi zisebenze ekutholeni izingqikithi ezivamile ezingase zitshengise imbangela.
Ukuphazamiseka kwe-Life Sciences (TLS) yinkampani ebona ukuthi kungenzeka ukwabiwa kwedatha. Isebenzisa amasu ezinkukhuni nokuvula imishado futhi ngokuvamile iyakwazi ukunciphisa izindleko zokuhlolwa komtholampilo ngokucabangela ukufaka kwesiguli. Isu elilodwa inkampani enikezelayo ihlanganisa ukuvivinywa okubonakalayo. Lokhu kunciphisa isidingo sokuvakashela amasayithi omtholampilo okude futhi kwenza wonke umuntu ahlanganyele. I-TLS inezinhlelo eziningi zocwaningo eziqhubekayo, kusukela ekuhloleni ukwemukelwa kwe-telemedicine kwiziguli ezine-IBD ukutadisha imiphumela ye-lisinopril (i-ACE inhibitor) ezigulini ze-MS.
Ukubhala Ukuphumelela Nokunikeza Ithemba
Nakuba abaningi bebhekene nezifo ezizimele ezingenakuphulukiswa, kunezinye eziningi ezithi ziye zathuthukisa kakhulu isimo sabo ngemuva kokusebenzisa izinguquko ezithile zokuphila. Lezi zigwegwe zivame ukubhekwa njengama-anecdotes, engenakho noma yiluphi uhlobo lwesimo sezesayensi. Ubuchwepheshe be-Digital bungasiza ukurekhoda nokutadisha abantu abaphumelelayo futhi basebenzise njengezifundo zocwaningo ezingase ziqiniseke izindlela ezithile zokwelapha izimo ezizenzakalelayo.
Uma abantu abafunda kangcono basesayensi, ososayensi bangakwazi ukuthola ukuthi iziphi izindlela zokuphatha zokwelapha eziphumelelayo. Ngeshwa, izifundo ezimbalwa eziqinile futhi ezibhalwe kahle zihanjisiwe kuze kube manje. Ukucwaninga ngokuzimela ngokwemvelo kuye kwahlukana kakhulu emiphakathini ehlukene, ngakho-ke kudinga ukuba into ehlanganisayo idlulise ama-silos ahlukeneyo futhi alethe ulwazi oluhlangene ndawonye. UDkt. Martha Herbert waseHarvard Medical School unxusa umphakathi wezokwelapha ukuthi uhlole imvelo kanye nokudla kwabagulayo abazimele ngokucophelela, futhi ubone ukuthi kungani ukutakula kwenzeka kwabanye abantu. Umsebenzi wakhe ugxila kakhulu ekuhluphekeni kwegciwane kanye ne-autism (okuye kwaxhunyaniswa nokuvuvukala komzimba) futhi ihlola indima yama-protein asekudleni. Ngokuqoqwa kwedatha, amasu okulungisa okuzenzakalelayo asekelwe ngokuzenzakalela angatholakala futhi athuthukiswe.
> Imithombo
> U-Irish A, u-Erickson C, u-Wahls T, u-Snetselaar L, u-Darling W. Ukuhlolwa kokuhlolwa kwesilingo okusetshenziselwa ukuhlolwa kwe-Paleolithic yokungenelela kokudla ekwelapheni kokubuyiselwa kabusha-ukukhipha isifo se-multiple sclerosis. Izifo ezithathelanayo ze-Neurological and Neuromuscular , 2017; 7: 1-17.
> Kamada N, Seo S, Chen G, Nunez G. Indima ye-microbiota yegciwane ezinkingeni zokuzivikela kanye nokuvuvukala. Ukubuyekezwa Kwemvelo Immunology , 2013; 13 (5): 321-335.
> Kharrazian D, Herbert M, Vojdani A. Reactivity Immunological Ukusebenzisa Ama-Antibodies E-Monoclonal and Polyclonal we-Autoimmune Sites Target Target namaProtheni Okudla. Journal of Research Thyroid, 2017
> Kosiewicz M, Chhabra A, Alard P, Dryden G. Ubudlelwano phakathi kwe-gut microbiota nokuthuthukiswa kwezifo ezihlobene neT. I-FEBS Letters , 2014; 588 (22): 4195-4206.