Kunezigaba ezimbili eziyinhloko ze-arthritis engavamile, evuthayo. Okokuqala, i- osteoarthritis , ngokuvamile ibhekwa njengomphumela ongenakugwemeka wokugqoka nokudabuka ekuhlanganyeleni ukuguga noma ngemva kokulimala. Owesibini yi-arthritis yokuvuvukala okuzenzakalelayo, okuyi- arthritis ye-rheumatoid (RA) evamile kakhulu. E-RA, amangqamuzana omzimba omzimba kanye nezithunywa zawo ezikhishwe (ama-cytokines angesinye isibonelo), ahlasele izicubu ngaphakathi kwamalungu adala ukuvuvukala.
Bobabili kungabangela ukulimala okuhlangene nokukhubazeka-okuningi kangangokuthi kuthinta izinga lempilo yabantu. Kodwa uma une-arthritis, cishe uyazi kahle leyo ngxenye yokugcina. Okungenzeka ukuthi ungajwayele wena, noma kunjalo, ukuthi izinhlobo zombili zesifo samathambo zibandakanya okuthiwa ukucindezeleka kwe-oxidative kumalunga-futhi lokhu okubangela ukulimala okuhlangene kuyinto ongayithonya.
Ukuqonda ukucindezeleka kwe-Oxidative
Ukucindezeleka okwenziwe nge-oxidative yinkqubo evamile kakhulu ephuma ekusebenzeni komzimba wakho kwansuku zonke. Njengoba amaseli akho enza umsebenzi wawo, enza ama-radicals amahhala, engicabanga ngokuthi "izinhlansi" noma imililo encane. Khona-ke isimiso somzimba wakho wokuzivikela we-antioxidant siwabeka ngaphandle, kufana ne-hose yomlilo ephonsa amalangabi.
Amazinga aphansi okucindezeleka okwenziwe nge-oxidative empeleni awusizo emisebenzini yakho yesimiso. Ngoba ukuvala ama-radicals mahhala kuyindlela evamile, imvelo yasinika inqwaba yama-antioxidants ekudleni esikudlayo-ama-compounds atholakala ezitshalweni nemifino-ezihlukahlukene ezimelelwa yizo zonke imibala ekhanyayo kanye ehlukahlukene yalezi zokudla.
Nsuku zonke, kufanele udla ukudla okuvimbela i-antioxidant ukuze unike umzimba wakho nge-antidote kula ma-radicals mahhala. Kodwa-ke, uma ungalethi ama-antioxidants anele emzimbeni wakho ukuze uqhubeke nazo zonke izinhlansi ezidalwa, ekugcineni ama-radicals azothola, ama-sparks abe umlilo futhi umlilo uvutha ukuvuvukala, ukulimala kwezicubu, kanye nokugcina izifo.
Ukucindezeleka okwenziwe nge-oxidative kungathinta amangqamuzana omzimba wakho omzimba, ikakhulukazi, ngoba akhuthele kakhulu, futhi adale futhi akhulula ama-radicals mahhala lapho enza umsebenzi wabo wansuku zonke ukuvikela wena. Lokhu kuyindlela futhi esikholelwa ngayo i-RA nezinye izimo zamathambo ezivuvukalayo, kuhlanganise ne-osteoarthritis, ithatha futhi ihlume.
I-Connection kuya ku-Arthritis
Ucwaningo oluningi luye lwabonisa ukuthi abantu abane-RA banyukile amazinga e-molecule abizwa ngokuthi ama-oxygen asebenzayo kakhulu (ROS), ama-radicals mahhala angakwazi ukulimaza i-lipids, amaprotheni kanye ne-DNA emathisini ahlangene.
Ngaphansi kwezimo ezivamile, i-ROS ilawulwa yizinhlelo ezihlukahlukene zokuzivikela komzimba wakho we-antioxidant. Kulabo abane-RA, noma kunjalo, i-antioxidants ayikwazi ukuqhubeka futhi ama-radicals akhululekile akwazi ukuqhuba i-amok futhi abangela ukulimala kwezicubu. Uma kuhlangene nokuhlaselwa okuqhubekayo kumajoyini akho nge-immune system yakho, lelizinga eliphakeme lokucindezeleka okwenziwe nge-oxidative liyaqhubeka nokuvutha ukuvuvukala. Inqubo yonke ingabangela ekubhujisweni kwamathambo, amalunga, kanye ne-articular cartilage.
Lapho abacwaningi abavela e-Aligarh Muslim University eNdiya beqhathanisa ukucindezeleka okwenziwe yi-oxydative kubantu ababhekene ne-RA kubantu abangenawo lesi sifo, abagulayo be-RA babe namazinga aphezulu wokucindezeleka okwenziwe nge-oxidative, kuhlanganise nokukhuphula ukukhiqizwa kwe-ROS, ukulimala kwe-DNA, izinhlelo zokuzivikela zokuvimbela i-antioxidant, nezinye izimpawu.
Futhi babe namazinga aphansi ama-antioxidants amabili: i-glutathione ne-vitamin C. I-Glutathione cishe i-antioxidant ebaluleke kakhulu emzimbeni ngoba isebenza ngaphakathi kuwo wonke amaseli wakho ukuvikela umzimba wakho kumonakalo we-ROS. Ngokuthakazelisayo, abagulayo abane-RA ababenokuhlukumezeka nokukhubazeka okungaphezulu futhi abanama-RA omude kunamazinga aphakeme kakhulu okucindezeleka okwenziwe nge-oxidative namazinga aphansi ama-antioxidants. Izifundo zivuselela njalo lokhu kuxhumana phakathi kwamanethiwekhi aphansi ama-antioxidants akhethekile kanye namanothi akhudlwana wama-radicals mahhala kubantu abane-RA.
I-osteoarthritis (OA) ixhunyaniswe namazinga aphezulu wokucindezeleka okwenqunyiwe, futhi. Kukholelwa ukuthi abantu abakhuluphele noma abanamafutha omzimba okweqile (uhlobo lwamafutha oluphakathi kwesisu sakho, ukumboza ezungeze izitho zakho zangaphakathi) banokucindezeleka okungaphezulu kwegazi okwenziwa emzimbeni wabo, futhi kukhona ukuxhumana okuqinile phakathi kokukhuluphala no-OA.
Kukholelwa ukuthi ukuvezwa okuqhubekayo kuma-radicals amahhala kubangela ukuthi ama-chondrocytes (amangqamuzana enza i-cartilage) akhiqize izinhlobo ze-oksijeni esebenzayo (ROS), futhi lezi zilimaza ngokuqondile i-cartilage i-collagen futhi zishintshe amakhemikhali angaphakathi ngaphakathi ngokuzenza zibe mncane futhi zivikeleke kancane. Ucwaningo lubonisa ukuthi amazinga aphansi kavithamini C ahlobene nengozi ephakeme yamadolo i-OA nokuthi ukwandisa ukungenisa kwakho kungagcina i-OA idolo lobuhlungu nobuhlungu bube bubi nakakhulu. Izindaba ezinhle ukuthi izifundo zibonisa ukuthi ukulahlekelwa amafutha omzimba kuzoholela ekunciphiseni ubuhlungu obuhlangene nokuvuvukala.
Indlela Ongayithatha Isinyathelo
Ukusebenzisa ukudla njengemithi njalo kuyisinyathelo sokuqala sokunciphisa ukuvuvukala nokucindezeleka okwenzakalayo. Lapha sigxila ekuthuthukiseni umsebenzi we-antioxidant emzimbeni wakho. Isistimu yakho ye-antioxidant isebenzisa ama-enzyme amaningi ahlukene ukuphatha ukucindezeleka okwenziwe nge-oxidative, njenge-superoxide dismutase (i-SOD), futhi la ma-enzyme adinga amavithamini, amaminerali, nama-amino acid ukuze benze umsebenzi wabo omuhle kakhulu.
Ukuqeda ama-radicals amahhala, ama-antioxidants ekudleni nawo asemqoka, futhi afaka amavithamini awaziwa njenge-beta-carotene namavithamini A, E, no-C, kanye ne-powerhouse polyphenols egcwele kakhulu imifino nezithelo ezimibalabala, nemifino eluhlaza Kufanele udle nsuku zonke, nazo zonke izidlo.
Ngaphezu kokuthuthukisa ukudla kwakho kwe-antioxidants, ukubuyisela emuva ngempela nokuphulukisa i-arthritis yakho, kufanele futhi ulungise ukuchayeka kwemvelo kanye nezimbangela okungenzeka ukwengeze ukucindezeleka kwe-oxidative ohlelweni lwakho. Lezi zinkinga zihlanganisa ukungena kwe-gut dysbiosis (ukuguqulwa kwe-microbiome yegciwane), ukutholakala kwezidakamizwa, ukutheleleka, kanye / noma amanoni amaningi kakhulu.
Ukwelapha i-microbiome yegciwane kanye nokugwinya okungenalutho kunesisombululo esiningi ngemuva kwayo njengesindlela esisekelwe ekusunguleni i-arthritis ngoba kubonakala sengathi ukucindezeleka kwe-oxidative nokuvuvukala kuvame ukuqala lapho bese uhamba ezindaweni ezikude zomzimba wakho, kuhlanganise namalungu akho.
Khumbula, i-arthritis yisimo se-system-wide, futhi ubuhlungu obuzwayo bubangelwa ukuvuvukala nokucindezeleka okwenziwe oxidative okuvela kwenye indawo emzimbeni wakho. Uma uthola futhi uphathe umthombo, uzozizwa ungcono ngaphandle kwemithi. Futhi yilona umgomo.
UDkt. Blum ungumbhali we-"Healing Arthritis," ekhuluma ngendlela yokuphulukisa ukugulisa nokuphatha izimbangela zokucindezeleka okwenziwe nge-oxidative (Scribner 2017).
> Imithombo:
> Hani M. Khojah, Sameh Ahmed, Mahran S. Abdel-Rahman, Al-Badr Hamza, izinhlobo eziphilayo zomoya ne-nitrogen ezigulini ezine-arthritis ye-rheumatoid njengezinto ezibonakalayo ezenza umsebenzi wezifo kanye nendima yama-antioxidants. I-Biology Yama-Radical Free and Medicine, Volume 97, Agasti 2016.
> Mateen S, Moin S, Khan AQ, Zafar A, Fatima N (2016) Ukwandiswa Kwezinhlobo Eziphilayo Zama-oksijeni Ukwenza Nokucindezeleka Oxidative ku-Rheumatoid Arthritis. PLoS ONE 11 (4): e0152925. i-doi: 10.1371 / iphephandaba.pone.0152925
> Musumeci G, Aiello FC, Szychlinska MA, Di Rosa M, Castrogiovanni P, et al. (2015). I-osteoarthritis ekhulwini lama-XXI: izici zengozi kanye > nezenzo zokuziphatha > ezithonya ukugula nokuqala. I-International Journal of Molecular > Sciences, > 16 (3): 6093-112.
> I-Quiñonez-Flores CM, i-González-Chávez SA, i-Del Río Nájera D, i-Pacheco-Tena C. Ukucindezeleka Okucindezelayo Kwama-Pathogenesis We-Arthritis Ye-Rheumatoid: Ukubuyekezwa Okuhlelekile. I-BioMed Research International. 2016; 2016: 6097417. i-doi: 10.1155 / 2016/6097417