I-HMGB2 Imayelana nokuguga nokuguqulwa kwamathambo
Isizathu Sokuqedwa Kwe-Cartilage
Sekuyisikhathi eside abacwaningi bezama ukuthola ukuthi yini ebangelwa ukubola kwesifo se- cartilage ehambisana ne- osteoarthritis . Ukuphumelela koososayensi kubonisa ukulahlekelwa kwesiprotheni esithile esivela emgqeni we-cartilage emajoyini. Leyo phrotheni, ebizwa ngokuthi i-HMGB2, ibonakala idlala indima ebalulekile ekuqothulweni kwamathambo.
Nakhu Okukwenzeka Kokuqothulwa Kwe-Cartilage
I-carticlage ye-articular yizinambuzane ezinzima kodwa ezilulekayo ezifaka amathambo ngaphakathi kwe-joint, evumela ukunyakaza okushelelayo.
I-cartilage ikhiqizwa futhi igcinwe ngamaseli e-chondrocyte, futhi ihlanganisa i-collagen ene-fibrous ne-mesh-like proteoglycans.
I-osteoarthritis iqala uma kunokuphazanyiswa emgqeni wobuso we-cartilage - futhi ubizwa ngokuthi indawo engaphandle. Isendlalelo esingaphansi kwesibhakabhaka siyona ebaluleke kunazo zonke izingxenye ezine ze-cartilage ngokuhlanganyela, ngokuhambisana nokuhambelana okuhambisanayo. Amajoyina avamile ane-layer ebusayo ye-cartilage evumela ukuthi amalunga agxilane. I-cartilage iphinda iqinise amalunga futhi ithatha amandla. Uma isendlalelo sokuqala seqala ukuwohloka, noma kunjalo, i-osteoarthritis iqala ukuthuthukisa futhi inqubo engenakuguqulwa iqaliswa ukuthi ekugcineni ibhubhise izingxenyana ezingaphansi kwe-cartilage kuze kube sekupheleni kwesiteleka: ithambo lixubha ngethambo elihlangene.
Abacwaningi bazi ukuthi isigaba sokuqala se-osteoarthritis sasihlotshaniswa nokuwohloka kwe-cartilage emgqeni ongaphezulu. Lokho abacwaningi abakwaziyo manje ukuthi ngisho nangaphambi kokubhujiswa kokungqimba komhlaba, kukhona ukulahlekelwa amaprotheni okubopha i-DNA, i-HMGB2.
Okuningi mayelana ne-HMGB2 kanye nendima yayo ku-Cartilage Health
Esikhathini esingqimba se-cartilage emajoyini, i-HMGB2 isekela ukusinda kwe-chondrocyte. Ama-Chondrocytes yiwona kuphela amangqamuzana atholakala ku-cartilage - empeleni akhiqiza i-cartilage. Kulula nje, ukulahlekelwa kwe-HMGB2 kuhlotshaniswa nokuguga futhi ama-chondrocytes anganciphisa noma aqedwe ku-layer layer of cartilage.
Uma i-HMGB2 yi-chondrocytes ephilile, ikhomba indlela yokuthuthukisa ukwelashwa okusha ukugcina isifo somzimba futhi kuvimbele ukuwohloka kwayo.
Lokho Lokhu kuqhuma kusho ikusasa
Kuyini ukubaluleka kokuthola? Kwavela ngokubambisana phakathi kwabacwaningi abavela eScripps Research Institute eLa Jolla, eCalifornia; I-San Raffaele University e-Milan, e-Italy; ne-Kogoshima University eJapane.
Izindlela ezingase zibe khona esikhathini esizayo zocwaningo zingahamba ngezindlela ezimbili. Babengabheka ama-molecule ayeyoyeka ukulahlekelwa yi-HMGB2 futhi ayenze ibe yimithi yokwelapha. Bangabheka izindlela zokugqugquzela ukukhiqizwa kwe-HMGB2, ikakhulukazi kubantu asebevele benesifo se-cartilage, ukulungisa i-cartilage. I-osteoarthritis ingacabanga ukuthi ngolunye usuku ingavinjelwa noma iguqulwe. Ukutholakala kwendima ye-HMGB2 ku-osteoarthritis kungathinta nokuthi amangqamuzana amancane asetshenziselwa kanjani ukuvuselelwa kwezicubu esikhathini esizayo.
Kungase kuvele ukuthi i-HMGB2 ingxenyana encane yesithombe sokuqothulwa kwe-cartilage. Ucwaningo luvame ukuveza ulwazi oluthakazelisayo oluzophela ekupheleni kokufa. Kungenzeka akunakwenzeka ukuthola isidakamizwa esithinta i-HMGB2 ngendlela edingekayo yokulungisa nokwakha uqwanga. Kodwa isixhumanisi ngasinye esisha kanye nesixhumanisi esisha kulesi chungechunge kungaholela ekuthuthukeni ekuvimbeleni nasekwelapha i-osteoarthritis.
Umthombo:
Ukulahlekelwa okuhlobene nokuguga kwesiprotheni se-chromatin i-HMGB2 ku-carticlage ye-articular kuhlotshaniswa neselula esinciphile kanye ne-osteoarthritis. Tanaguchi N et al. I-PNAS.