Ukwahlukana Kwama-Transplants Amancane kanye Nokukhula Ngokwe-Malignancy Effect
Ukuguqulwa kwe-non-myeloablative stem cell, noma "ukuhamba okuncane," kuyihlobo olusha oluthile lwe-allogeneic peripheral stem cell transplant engadingi ukuchithwa (ukusula) umnkantsha kuze kube semkhakheni wokuguquka kwesiguli se-stem cell.
Indlela Abasebenza ngayo
Ezikhathini zendabuko ye-stem cell, iziguli zinikezwa kakhulu ukulinganisa okuphezulu kakhulu kwe-chemotherapy, noma ngaphandle kwemisebe, ukusula noma "ukubhubhisa," umnkantsha.
Bese banikezwa ukumnika kwamaseli ama-donor stem ukuze avuselele ukukhiqizwa kwamangqamuzana egazi ne-immunity.
Ucwaningo luye lwabonisa ukuthi ukulinganisa okujulile kwe- chemotherapy kanye nemisebe enikezwe ekuguquleni kwe-stem cell kungase kungabi yinto ebhekene nempumelelo yabo emkhatsini we-cancer. Ukuguquguquka kwe-stem cell cell okungenayo i-myeloablative isebenzisa amanani amancane kakhulu we-chemotherapy ukuze athole umphumela omuhle.
I-Graft vs. Malignancy
Isimiso esivela empumelelweni engaba khona yalolu hlobo lokufakelwa libizwa ngokuthi "ukuxhunyelelwa-ukuhlambalaza" (i-GVM), "ukuhlukumeza-ukuphikisana," noma "umthelela we-graft-to-leukemia". Lapho ama-stem cell asetshenziselwa ukungena kumuntu owamukelayo, isimiso somzimba sokuzivikela "esisha" siyaqaphela ukuthi noma yimaphi amangqamuzana omdlavuza awavamile futhi awabhubhisa.
Umehluko Kusuka ku-Myeloablative Transem Cell Cell Transplants
Ukuguqulwa okungezona okwenziwe ngesimiso esincane kunokuhluka ngokuyinhloko kulokho okwenzeka ngaphambi kokufakelwa. Uma kuqhathaniswa nokuguqulwa kwe-myeloablative, ama-mini-transplants asebenzisa amanani aphansi kakhulu futhi angaphansi kwesifo samakhemikhali kanye nomswakama, okulandelwa ukukhipha kwamangqamuzana e-donor stem.
Le nqubo isebenzisa ngokunenzuzo umthelela we-graft nge-malignancy effect ngenkathi ungaphansi kobuhlungu kumamukeli.
Njengama-stem cell transplants, ama-mini-transplants nawo afaka ingozi yokufakelwa kwesibhamu ngokumelene nesifo esibambileyo , lapho amangqamuzana afakwe khona abona amaseli akho angaphandle futhi ahlasela.
Ukusetshenziswa
Lolu hlobo lokufakelwa kabusha lungaba yindlela enhle kulabo abakhulile ubudala noma abanezinye izimo zezokwelapha ezizobenza bangakwazi ukubekezelela imithi yoketshezi ye-chemotherapy yokuguquka okuvamile.
Ukufakelwa kwe-non-myeloablative cell stem cell kungase kube nendima ekwelapheni iziguli ezisemtholampilo onomdlavuza ophezulu, njenge -leukemia esilula kakhulu , noma obhekene nokuphindaphinda ngemva kokufakelwa kwe-stem cell cell.
Abacwaningi babheka nokuphumelela kokufakelwa kwe-non-myeloablative stem cell cell kwizigulane ezinomdlavuza we-tumor oqinile, njengebele nezinso, kanye nezinye izimo zezokwelapha ezifana ne-multiple sclerosis.
Njengoba kuthatha isikhashana ukuthi amangqamuzana anikelwe ukuvuthwa, lezi zintambo azivame ukusetshenziswa uma umdlavuza usezigaba zawo eziphambili kakhulu.
Ukuphumelela
Ukuguqulwa okungewona okwenziwe ngesimiso esibucayi kuye kwasetshenziselwa ukuphatha izinhlobo ezahlukene zegazi lomdlavuza, kuhlanganise neHodgkin ne-non-Hodgkin lymphoma, i- myeloma , ne-leukemia. Izinga lokuphendula liye lahluka ngezifundo.
Le nqubo entsha kakhulu, kanti owokuqala kwenziwa ngaphansi kweminyaka engama-20 eyedlule, ngakho-ke kukhona ukucwaninga okulinganiselwe kwesikhathi eside okutholakala izinzuzo nezingozi ezihambisana nalolu hlobo lokufakelwa. Kodwa-ke, imiphumela yokuqala eyithembisayo inikeza ithemba ezigulini ezingenakwazi ukuthola ukufakelwa kwe-cell stem , ikakhulukazi labo abaphakathi kweminyaka engama-50 no-75.
Imithombo:
Neiss, D., Duffy, K. "Imiqondo Eyisisekelo Yokutshala Izihlahla" e-Ezzone, S. (2004) I-Hematopoietic Stem Transplantation Cell: I-Manual for Practice Practice. I-Oncology Society Nursing. Pittsburg, PA (pp.13-21).
I-Duke Medicine. Igazi le-Adult and Marrow Transplant. I-Handbook ye-Allogeneic Patient Transplant Handbook. https://www.dukemedicine.org/sites/www.dukemedicine.org/files/nonmyeloablative_allogeneic_transplant_patient_handbook.pdf
Kasamon, Y., Bolanos-Meade, J., Prince, G. et al. Imiphumela yegazi elingenayo i-HLA-I-Haploidentical Blood noma i-Marrow Transplantation ne-High-Dose Post-Transplantation i-Cyclophosphamide ku-Older Adult. I-Journal ye-Clinical Oncology . Agasti 10, 2015. (Ishicilelwe ku-intanethi ngaphambi kokuphrinta).