I-Lipitor (atorvastatin) imithi yokwehliswa kwe-cholesterol engokwesigaba se- statin yezidakamizwa. Isetshenziselwa ukwelapha amazinga aphezulu we-cholesterol, i-LDL cholesterol, i-triglyceride, namazinga we-apolipoprotein B kubantu abathintekayo abane-primary hyperlipidemia noma i-dyslipidemia exubekile ezimweni lapho ukudla, izinguquko zendlela yokuphila, noma iminye imithi ayinciphisi ngokuphelele amazinga e-lipid.
Ukwengeza, i-Lipitor isetshenziselwa ukunciphisa ingozi yokuba nesifo senhliziyo nokushaywa yisifo kubantu abanesifo senhliziyo noma abangenayo isifo senhliziyo kanye nabantu abane-angina noma uhlobo lwesifo sikashukela esinesifo esithile senhliziyo.
I-Lipitor ingenye yesimiso esinamandla kakhulu emakethe. Ucwaningo olubalulekile oluhlolisisa umphumela we-Lipitor kumazinga omlomo we-lipid lubonise ukuthi i-Lipitor 10 mg ethathwe nsuku zonke inga:
- I-cholesterol ye- LDL engaphansi kwezingu-29%.
- Amazinga we-cholesterol esezansi ngokwesilinganiso sama-36%.
- I- triglycerides engaphansi nge-19%.
- Ukwandisa amazinga we- HDL ye- cholesterol okungenani u-6%.
- I-apolipoprotein B engezansi iyancipha yi-34%.
I-Lipitor nayo iboniswe ezincwadini zokunciphisa ingozi yokubhekana nemicimbi emikhulu ye-cardiovascular by 37% uma kuqhathaniswa ne-placebo.
I-Lipitor yavunyelwa ukusetshenziswa e-United States yi-Food and Drug Administration (FDA) ngoDisemba ka-1996.
I-Lipitor isebenza kanjani?
I-Lipitor isebenza ngokuvimbela - i-3-hydroxy-3methylglutaryl coenzyme A (HMG CoA) yokunciphisa - i- enzyme emzimbeni odlala indima ebalulekile ekwenzeni i-cholesterol esibindi.
Lesi senzo sinciphisa inani le-cholesterol emzimbeni.
Kumelwe kuthathwe kanjani i-Lipitor?
I-Lipitor iyatholakala kwifomu yethebhulethi futhi ingathathwa noma ngaphandle kokudla kanye ngosuku, njengoba iqondiswa umhlinzeki wakho wezempilo. Nakuba ama-dose atholakalayo kusuka ku-10 ukuya ku-80 mg, umhlinzeki wakho wezempilo uyoqala ngawe ngomthamo ophansi bese ukwandisa umthamo wakho kancane kancane, ngokusekelwe emazingeni akho e-LDL kanye nempendulo yakho emithini.
I-Lipitor kufanele ithathwe ngokuhambisana nokudla ukuze unciphise i-cholesterol yakho ne-triglycerides. I-Lipitor ivame ukushiwo lapho impilo yakho ishintsha noma iminye imithi ayiphuli kahle i-lipids yakho.
Kumele uqiniseke ukuthi uhambela izinkampani zakho zokuqashwa kwezempilo njalo ngoba uzodinga ukuqapha amazinga akho e-lipid, kanye neminye imingcele, ngenkathi uthatha le mithi.
Ubani Ongayithathi I-Lipitor?
Uma unezinye zezimo zezokwelapha ezibalwe ngezansi, akufanele uthathe i-Lipitor. Kulezi zimo, umhlinzeki wakho wezempilo uyokubeka ekwelapheni okuhlukile ukwehlisa lipids yakho:
- Amagciwane. Uma ngabe uke waphelela i-Lipitor noma yiziphi izithako zalo, akufanele uthathe le mithi.
- Isifo sesibindi esisebenzayo. Uma unezifo zesibindi esebenzayo noma ezingakaze zichazwe, amazinga enzyme aphakeme angabonakali, i-Lipitor akufanele ithathwe.
- Ukukhulelwa. I-Lipitor ihlukaniswe ngokuthi Isigaba sokukhulelwa i-X. Lipitor siboniswe ukuthi sidlule isivinini esisezingeni eliphansi emagatsheni kanti kuye kwaba nemibiko yokungaziphathi kahle nokukhubazeka okungenasisindo ezifundweni zesilwane. Ngaphezu kwalokho, lokhu kuye kwabikwa nakwabesifazane abakhulelwe bethatha imithi yesimiso. Uma uhlela ukukhulelwa noma usuvele ukhulelwe futhi uthatha i-Lipitor, umhlinzeki wakho wezempilo uzothola izinzuzo zokuthatha imithi empilweni yakho kanye nezingozi ezinganeni yakho.
- Ubuhlengikazi. I-Lipitor iboniswe ukuthi iwele ubisi lwebele. Ayaziwa ukuthi yiluphi uhlobo lomphumela lokhu okungaba nalo kumntanakho.
Yiziphi Izimo Okudingeka Zibukwe Ngesikhathi Kuthatha Lipitor?
Uma uthatha i-Lipitor, umhlinzeki wakho wezempilo uzodinga ukukuqapha eduze uma unezimo ezithile zezokwelapha ezingase zithuthukiswe ngokuthatha imithi. Uma unemibandela elandelayo ngezansi, umhlinzeki wakho wezezempilo anganquma ukukuqala ku-Lipitor ngesilinganiso esincane, futhi kuzodingeka akuqaphele ukuthi unqume noma ungayithathi yini i-Lipitor kuyoba yingozi kuwe. Lezi zimo zezokwelapha zihlanganisa:
- Ama-enzyme we-fox ephakeme. Ezicwaningweni, i-Lipitor yandisa ama-enzyme ye-aspartate aminotransferase (AST) ne-alanine aminotransferase (ALT) kwizifundo. Nakuba ezimweni eziningi lokhu kwanda kungokwengqayizivele, umhlinzeki wakho wezempilo uyoqapha la mazinga ukuze aqiniseke ukuthi ama-enzyme akho webindi aphakanyisiwe kumazinga ayingozi.
- Amazinga wegazi we-glucose ephakeme. Ucwaningo luye lwabonisa ukuthi i-Lipitor ingase ikhulise i-hemoglobin A1C nokuzila ukudla kwe-glucose. Uma unesifo sikashukela, umhlinzeki wakho wezempilo uyoqapha lezi zakhi egazini lakho bese ulungisa umthamo wakho we-Lipitor.
Yiziphi izinhlobo zemiphumela emibi eyokwenza i-Lip Lipitor?
Imiphumela emibi kakhulu ehlanganisa ukunxanxwa, isifo sohudo, ubuhlungu be-muscle, nokwanda kwama-enzyme yesibindi. Ezinye imiphumela emibi, kuhlanganise nesifo sohudo, i-nasopharyngitis, kanye nobuhlungu obuhlangene, nazo zaphawulwa ezincwadini. Uma uhlangabezana nanoma yimiphi imiphumela emibi ekuthatheni i-Lipitor ehlala isikhathi eside noma ephazamisayo, kufanele uvumele umhlinzeki wakho wezempilo ukuthi azi.
Njengamanye ama-statins, umphumela wecala ongajwayelekile - i-rhabdomyolysis - ingenzeka nakwabantu abathatha i-Lipitor. Izimpawu ze-rhabdomyolysis zifaka imisipha ebuhlungu kanye nobuthakathaka, kanye nomchamo ombala we-soda. Ingozi yakho yokubhekana nale miphumela emibi ingenzeka uma uthatha ezinye izidakamizwa, iminyaka ekhulayo, nezinye izimo zezokwelapha. Uma uthola noma yiziphi izimpawu ze-rhabdomyolysis, kufanele usheshe wazise umhlinzeki wakho wezempilo.
Zikhona Imithi Engayisebenzisa Ne-Lipitor?
Imithi elandelayo ingasebenzisana ne-Lipitor, ikhulise amathuba okuba nemiphumela emibi (ikakhulukazi i-myopathy). Ngaphandle kwezidakamizwa ezinciphisa i-cholesterol ezibalwe ngezansi, lezi zidakamizwa zingandisa ama-Lipitor emzimbeni wakho.
- Izidakamizwa ezinciphisa i-cholesterol (i- nicotinic acid , i-fibrates)
- I-Clarithromycin
- I-Cyclosporine
- Ama-protease inhibitors
- I-Colchicine
- Ukukhulelwa komlomo
- Utshwala
- Ijusi lamagilebhisi
- Itraconazole
Lokhu akulona uhlu oluphelele. Kufanele uvumele umhlinzeki wakho wezempilo ukuthi azi yonke imithi - kuhlanganise imithi yemithi kanye nezidakamizwa ezingaphezu kwe-counter - ukuthi uthatha ngenkathi uthatha i-Lipitor. Lokhu kuzosiza umhlinzeki wakho wezokunakekelwa kwempilo ukuthi akuqaphele ukusebenzisana kwezidakamizwa lapho uthola imithi. Uma kudingeka ukuba uthathe esinye sezidakamizwa ezibalwe ngenhla, umhlinzeki wakho wezempilo uzodinga ukulungisa umthamo wakho, ukuqapha eduze nemiphumela emibi, noma ukuyeka esinye sezidakamizwa.
Okubalulekile
I-Lipitor ingenye yemithi ethandwa kakhulu ye-lipid e-United States - hhayi nje ngenxa yokuthi ikhono layo lokuthinta kahle zonke izici zephrofayela yakho ye-lipid kodwa futhi ngenxa yokuthi ikhono layo lokunciphisa ingozi yokubhekana nesifo senhliziyo - enjalo inhliziyo ukuhlaselwa noma ukushaya. Ngenxa yezinkinga ezingase zibe nezinye izimo zezokwelapha kanye nokusebenzisana kwezidakamizwa, kufanele uqiniseke ukuthi uhambela wonke ama-aphoyintimenti omhlinzeki wezempilo ukuze akwazi ukukuqapha ngezinkinga ezingenzeka ngenkathi ethatha i-Lipitor.
Imithombo:
Lipitor [iphakheji efakiwe]. I-Pfizer: eNew York, eNew York. 3.2015.
I-Micromedex 2.0. I-Truven Health Analytics, Inc. I-Greenwood Village, CO. Itholakala ku-: http://www.micromedexsolutions.com. Ifinyelele ngo-Februwari 10, 2016