I-Zocor (i-simvastatin) imithi yokwehliswa kwe-cholesterol eyingxenye yesigaba se- statin yezidakamizwa. Isetshenziselwa ukwelapha amazinga aphezulu we-cholesterol, i-LDL cholesterol, i-triglyceride, namazinga we-apolipoprotein B kubantu abathintekayo abane-primary hyperlipidemia noma i-dyslipidemia exubekile ezimweni lapho ukudla, izinguquko zendlela yokuphila, noma iminye imithi ayinciphisi ngokuphelele amazinga e-lipid.
Ukwengeza, iZocor isetshenziselwa ukunciphisa ubungozi bokuhlaselwa kwenhliziyo nokushaywa isifo kubantu abanezinkinga zesifo senhliziyo.
Ucwaningo olubalulekile oluhlola umphumela kaZocor 20 kuya ku 40 mg lubonile okulandelayo okutholakala ngeZocor:
- Kunganciphisa i- cholesterol ye- LDL ngokwesilinganiso sama-35%.
- Kunganciphisa amazinga e-cholesterol angama-25%.
- Kunganciphisa i-triglyceride ngokulinganiselwa kwe-10%.
- Kungandisa ama-HDL ama-cholesterol amazinga ngo-8%.
UZocor ubuye waboniswa ezifundweni zokunciphisa ukufa ngenxa yesifo senhliziyo ngenxa yezingu-42%
I-Zocor yavunyelwa ukusetshenziswa nguDrug Administration (FDA) ngoDisemba ka-1991.
Zocor Isebenza Kanjani?
I-Zocor ibophezela futhi ivimbele i-enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) yokunciphisa, i-enzyme enkulu emgwaqweni we-cholesterol, Lesi senzo sinciphisa inani le-cholesterol elenziwe esibindi.
Kufanele Zocor Ithathwe Kanjani?
I-Zocor ithathwa ngomlomo, noma ngaphandle kokudla kanye ngosuku, njengoba iqondiswa umhlinzeki wakho wezempilo.
Nakuba izilinganiso ezijwayelekile ezisetshenziselwa ukwelapha i-lipids yakho ziqala kusuka ku-5 kuya ku-40 mg, umhlinzeki wakho wezempilo uzokuqala ngomthamo ophansi bese wandisa kancane umthamo wakho, ngokusekelwe emazingeni akho e-LDL kanye nempendulo yakho kumuthi. I-Zocor 80 mg ingabangela ubuhlungu obukhulu be-muscle - kubandakanya i-rhabdomyolysis - ngakho-ke leli dose alisetshenzisiwe ngaphandle kokuthi ubekezelele isikhathi esingenayo imiphumela emibi.
Ukudla okunciphisa umzimba kufanele kulandelwe ngenkathi uthatha iZocor.
Ubani Akufanele Awathathe Zocor?
Uma unezinye zezimo zezokwelapha ezibalwe ngezansi, akufanele uthathe iZocor. Kulezi zimo, umhlinzeki wakho wezempilo uyokubeka ekwelapheni okuhlukile ukwehlisa lipids yakho:
- Amagciwane. Uma ngabe uke wangena kuZocor noma yiziphi izithako zalo, akufanele uthathe le mithi.
- Isifo sesibindi esisebenzayo. Uma unezifo zesibindi esebenzayo noma ezingachaziwe, amazinga e-enzyme yesibindi aphakeme ngokungavamile, akufanele kuthathwe uZocor.
- Imithi ethile. Uma uthatha i-cyclosporine, i-gemfibrozil, i-danazol, noma iminye imithi evimbela kakhulu indlela yokusebenzisa umzimba, i-CYP3A4, akufanele uthathe iZocor.
- Ukukhulelwa. I-Zocor ihlukaniswe njengeSigaba sokukhulelwa X. I-Zocor iboniswe ukuthi iwele umgoqo ophazamisayo emagatsheni kanti kuye kwaba nemibiko yokungaziphathi kahle nokukhubazeka okungezansi kokuhlolwa kwezilwane. Ngaphezu kwalokho, lokhu kuye kwabikwa nakwabesifazane abakhulelwe bethatha imithi yesimiso. Uma uhlela ukukhulelwa noma usukhulelwe kakade futhi uthatha uZocor, umhlinzeki wakho wezempilo uzothola izinzuzo zokuthatha imithi empilweni yakho kanye nezingozi ezinganeni yakho.
- Ubuhlengikazi . I-Zocor iboniswe ukuthi iwele ubisi lwebele. Ayaziwa ukuthi yiluphi uhlobo lomphumela lokhu okungaba nalo kumntanakho.
Izimo Ezidinga Ukuqapha
Uma uthatha uZocor, umhlinzeki wakho wezempilo uyokwazi ukukuqapha eduze uma unezimo ezithile zezokwelapha. Uma unemibandela elandelayo ngezansi, umhlinzeki wakho wezezempilo anganquma ukuqala kuZocor kumthamo ophansi futhi kuzodingeka akuqaphele ukuze anqume ukuthi noma ukuthatha iZocor kungakulimaza yini. Lezi zimo zezokwelapha zihlanganisa:
- Ama-enzyme we-fox ephakeme. Ezicwaningweni, uZocor wandisa ama-enzyme ye-aspartate aminotransferase (AST) ne-alanine aminotransferase (ALT) kwizifundo. Nakuba ezimweni eziningi lokhu kwanda kungokwengqayizivele, umhlinzeki wakho wezempilo uyoqapha la mazinga ukuze aqiniseke ukuthi ama-enzyme akho webindi aphakanyisiwe kumazinga ayingozi.
- Amazinga wegazi we-glucose ephakeme. Ucwaningo luye lwabonisa ukuthi iZocor ingandisa ukwanda kwe- hemoglobin A1C nokuzila ukudla kwe-glucose. Uma unesifo sikashukela, umhlinzeki wakho wezokunakekelwa kwezempilo angabheka lezi zakhi egazini lakho futhi alungise umthamo wakho weZocor.
- Izifo Zezinso. Umhlinzeki wakho wezempilo uzokuqala kumthamo ophansi futhi akuqaphele eduze.
Okuqhamuka uma udla imishanguzo
Imiphumela emibi kakhulu efaka phakathi ikhanda, ubuhlungu besisu, isisulu sokuqhwabanisa, ukuqothulwa, kanye nezifo ezingaphezulu zokuphefumula. Uma uhlangabezana nanoma yimiphi imiphumela emibi ekutheni u-Zocor ohlala isikhathi eside noma ophazamisayo, kufanele uvumele umhlinzeki wakho wezempilo ukuthi azi.
Njengamanye ama-statins, umphumela wecala ongajwayelekile - i-rhabdomyolysis - ingenzeka nakwabantu abathatha iZocor. Izimpawu ze-rhabdomyolysis zifaka imisipha ebuhlungu kanye nobuthakathaka, kanye nomchamo ombala we-soda. Ingozi yakho yokuthola lemiphumela emibi ingenzeka uma uthatha ezinye izidakamizwa, ukwanda kweminyaka, ukuthatha umthamo we-80 mg weZocor, nezinye izimo zezokwelapha. Uma uthola noma yiziphi izimpawu ze-rhabdomyolysis, kufanele usheshe wazise umhlinzeki wakho wezempilo.
Imithi Engahlangana NoZocor
Ngaphandle kwe-cyclosporine, i-gemfibrozil, neminye imithi ekhulunywe ngenhla, izidakamizwa ezilandelayo zingase zihlanganyele noZocor - zandisa amathuba okuba nemiphumela emibi. Imithi elandelayo ingakhuphula amazinga eZocor noma eminye imithi emzimbeni wakho:
- Izidakamizwa ezinciphisa i-cholesterol (i- nicotinic acid , i-fibrates)
- Imithi ethile yezinhliziyo - njenge-verapamil, i-diltiazem, i-amiodarone, i-amlodipine
- Ama-protease inhibitors
- I-Colchicine
- I-Coumadin (i-warfarin)
Njengoba lokhu akulona uhlu oluphelele, kufanele uvumele umhlinzeki wakho wezempilo ukuthi azi yonke imithi - kuhlanganise imithi yemithi kanye nezidakamizwa ezingaphezu kwe-counter - ukuthi uthatha ngenkathi uthatha iZocor. Uma kudingeka ukuba uthathe esinye sezidakamizwa ezibalwe ngenhla, umhlinzeki wakho wezempilo uzodinga ukulungisa umthamo wakho, ukuqapha eduze nemiphumela emibi, noma ukuyeka esinye sezidakamizwa.
Okubalulekile
I-Zocor imithi evame ukushicilelwa kulokho isetshenziselwa ukuthuthukisa iphrofayili yakho ye-lipid futhi unciphise ingozi yokufa ngesifo senhliziyo noma isifo sohlangothi. I-Zocor itholakale ngendlela ejwayelekile, ikuvumela ukuba uthole le mithi ngezindleko ezishibhile uma kuqhathaniswa nemithi yegama lomkhiqizo. Nakuba kuphumelele, kuneminye imiphumela emibi kanye nokusebenzisana kwezidakamizwa okufanele uqaphele lapho uthatha iZocor. Ngakho-ke, kufanele uqiniseke ukuthi ugcina ama-aphoyintimenti wakho nomhlinzeki wakho wezempilo ukuze akwazi ukuqapha intuthuko yakho emithini.
Imithombo:
I-Zovor (i-Simvastatin) [iphakheji]. I-Merck: I-Whitehouse Station, NJ. Kubuyekeziwe 3.2015.
I-Micromedex 2.0. I-Truven Health Analytics, Inc. Greenwood Village, CO. Itholakala ku-http: //www.micromedexsolutions.com.
Ama-4S Study Authors. Ukuhlolwa Okungahleliwe Kwe-Cholesterol Ukwehla Ku-4444 Iziguli Eziphethwe Yizifo Zenhliziyo YaseCoronary: Isifundo SokuSinda eScandinavian Saving Survival Study. Lancet 1994 Nov 19; 344 (8934): 1383-9.