Ucwaningo luye lwabonisa ukuthi ukwelashwa nge-iodine e-radioactive yomdlavuza we-thyroid ehlukene kahle kuhloswe ngengozi eyengeziwe yokwelashwa kwegazi ezimbili: i-myeloid leukemia ekhulayo kanye ne-lemonemia engapheliyo.
"Ukuhlukahluka" umdlavuza we-thyroid ubhekisela ekubukeni nasekuziphatheni kwamangqamuzana omdlavuza, futhi kumdlavuza we-thyroid ohlukanisiwe kahle, amangqamuzana abukeka futhi asebenze njengamaseli avamile wegciwane.
Izinhlobo zomdlavuza we-thyroid ezihlukanisa kahle zihlanganisa i-papillary thyroid. i-carcinoma, i-follicular carcinoma ye-thyroid, ne-Hürthle cell carcinoma (i-HCC).
Iodine yomsakazo iqhutshwa njalo njengengxenye yokwelashwa komdlavuza wegciwane , ngokuvamile emva kokuhlinzwa ukukhipha igciwane le-thyroid. Iodine ye-radioactive, eyaziwa nangokuthi i-RAI, inikezwa ukusiza ukubhubhisa noma yiziphi izicubu ze -roid ezisele ngemuva kokuhlinzwa, njengendlela yokuvimbela ukuphindaphinda komdlavuza we-thyroid ongase uthuthuke ekusekeni izicubu ze-thyroid.
Ngenkathi ucwaningo lubonise ukuthi abasindile bomdlavuza we-thyroid abaye bahlangabezana ne-RAI babhekana nengozi enkulu yamanqamuzana wesibili , lokhu okokuqala ukuthi ubudlelwano obuphawulekayo nobubonakalisiwe buye lwafunyanwa phakathi kwe-iodine ye-radioactive ngomdlavuza wegciwane kanye nengozi eyengeziwe yokubili komzimba kanye ne-lemonemia engapheliyo.
Mayelana neMyeloid Leukemias
I-myeloid leukemia (AML) enamandla, eyaziwa nangokuthi i-acute myelogenous leukemia, iyindlela engathà sina yomdlavuza wegazi oqhubekayo ngokushesha futhi ingaba yingozi uma ingelashwa.
I-AML ingasakazeka nakwezinye izingxenye zomzimba kufaka phakathi izilonda ze-lymph, isibindi, uhlangothi, ubuchopho, intambo yomgogodla kanye namagundane. I-American Cancer Society ilinganisela ukuthi kuzoba namacala angaphezu kuka-21 000 amasha we-AML ngo-2017, kanye nokufa kwabantu abangu-10 600 kusukela ku-AML. I-AML ayidlame ngaphambi kokuba ineminyaka engu-45, kanti isilinganiso seminyaka yesiguli se-AML sinama-67.
Inani leminyaka emihlanu lokusinda kwe-AML ngamaphesenti angu-26.
I-myeloid leukemia engapheli (CML), eyaziwa nangokuthi i-leukemia engapheli, iwuhlobo olungapheli lomdlavuza wegazi. I-American Cancer Society ilinganisa ukuthi cishe amacala angu-9 000 amasha we-CML azotholakala ngo-2017, anezingu-1,110 zokufa. Isilinganiso seminyaka esixilongwa ngayo singama-64. Inani leminyaka emihlanu yokusinda kwe-CML lingamaphesenti angama-75.
Abacwaningi bachaza iqembu labafundi labahlolwayo elihlukanisa umdlavuza we-thyroid ukuze babala izingozi zabo zamagciwane egazi. Esicwaningweni, iziguli ezingu-148.215 ezinomdlavuza we-thyroid ezahlukaniswa kahle zahlolwa. Ngokonke amaphesenti angu-53 weziguli, ukwelashwa kwabo kuphela kwakuyi-thyroidectomy, ukuhlinzwa ukukhipha igciwane le-thyroid. Ingqikithi yamaphesenti angu-47 yayine-thyroidectomy, kanye nokwelashwa kwe-iodine okusasazwa kwe-restlation.
Phakathi kwesiguli sesiguli esifundwe, iziguli ezingu-783 zathuthuka umdlavuza wegazi wesibili ngaphezu kwesikhathi sesifundo seminyaka engu-6.5.
Uma kuqhathaniswa neziguli ezine-thyroidectomy kuphela, iziguli ezaba ne-iodine ye-radioactive zanda kakhulu ingozi yokuqala noma i-leukemia noma i-chronic myeloid leukemia.
Ingozi yayiyinto efanayo uma isiguli sinesifo esincane, esiphakathi noma esiphakeme.
Phakathi kwalabo abasindiswa umdlavuza we-thyroid owaqala i-AML, ukusinda kwemithombo yeminyaka eyi-1.2 kwakuncane kakhulu kunomphakathi oneminyaka engu-2.9 wabantu abangakaze baphathe ukwelashwa kwe-iodine.
Izwi elivela
Lolu cwaningo lubonisa ukuthi iziguli eziye zahlukanisa umdlavuza we -roid njenge-papillary, follicular, noma i-Hurthle umdlavuza wamangqamuzana, futhi zithola ukwelashwa kwe-iodine ye-iodine asele emsakazweni, zanda ingozi yokuqala yokwelapha i-myeloid leukemia ne-myeloid leukemia engapheli. I-myeloid leukemia evumayo ibuye ibe nesifo esibi emalini emva kokwelapha i-iodine.
Abacwaningi bancoma ukuthi kuphela iziguli ezinezifo eziphezulu kakhulu zesifo eziphathekayo eziphathekayo eziphathekayo zizophathwa nge-iodine yama-radiac for cancer cancer.
Uma uthola ukuthi unomdlavuza we-thyroid ohlukaniswe kahle futhi udokotela wakho uncoma ukwelashwa kwe-iodine e-radioactive, cabanga ukuthola umbono wesibili komunye udokotela.
Uma ngabe ube ne-iodine yomsakazo esikhathini esidlule, noma unayo esikhathini esizayo, qiniseka ukuthi ukuqapha ngezikhathi ezithile nokubhekwa kwalezi zomshukela wegazi kuyingxenye yokunakekelwa kwezempilo okuqhubekayo. Ungahlolwa ngezikhathi ngezivivinyo zegazi, kanye nokuhlolwa kwe-chromosomal nokuhlolwa kofuzo.
Futhi, yilokhu ubheka izimpawu ze-leukemia eziyingozi futhi ezingapheli, ezihlanganisa ukukhathala, ukuzwa izimpondo, ukunciphisa amandla okuzivocavoca, ukutheleleka okulula, ukulimala okulula, ukushisa, ukulahlekelwa ukudla, ukuphefumula, ukulahlekelwa isisindo, ukujula ebusuku, ugozi, izinsini eziphaphayo, iziphuzo ze-noseblees, izikhukhula zesikhumba
> Umthombo:
> Molenaar, Remco J. et al. "Ingozi ye-Hematologic Malignancies Ngemuva kokunakekelwa kwe-Radioiodine ye-Cancer Differentiated Cancer," Journal of Clinical Oncology, http://ascopubs.org/doi/abs/10.1200/JCO.2017.75.0232?journalCode=jco