Abesifazane abane-UTIs ejwayelekile bazozuza
Intshisekelo yokugonywa kwe-UTI yavutha ngonyaka wama-1950, futhi kusukela ngaleso sikhathi, abacwaningi bebelokhu befuna umuthi wokugoma ovimbela ama-bacterial E. coli ukuba aqoqe ikhambi bese eqala ukutheleleka. Ngo-Julayi 2017, i-FDA inikeze ukuchithwa kwe-track yokuzivocavoca okusheshayo kaSequoia Sciences 'FimCH. Uma kuvunyelwe, ukugonywa kwe-FIMCH kuyoba umuthi wokuqala wokugoma we-UTI etholakala e-United States.
Ngokusho kwe-FDA:
Ukulandelela okusheshayo kuyinkqubo eyenzelwe ukuthuthukisa ukuthuthukiswa, futhi ukusheshisa ukubuyekezwa kwezidakamizwa ukuphatha izimo ezibucayi futhi ugcwalise isidingo esingavumelani sezokwelapha. Inhloso ukuthola izidakamizwa ezintsha ezibhedlela isiguli. I-Track Track ikhuluma ngobubanzi obuningi bezimiso ezibucayi.
Ingemuva
Kuye kwaba nokwanda kwenani lamabhaktheriya anomelana nama-antibiotic abangela ukutheleleka okunamandla kwamagciwane (UTIs) . Nge-UTI, ukutheleleka kungakhuphuka kusuka kwesibindi (cystitis) zibe izinso (pyelonephritis). Lezi zifo zingakwazi ukuqhubeka zisakaze egazini elibangela ukuphuma kwegazi. Ukulimala kwezinso, ukunakekelwa esibhedlela, ngisho nokufa kungumphumela wokutheleleka okukhulu kwe-UTI okungapheli.
Ngenxa yalokhu kusongela impilo ngabanye kanye nempilo yomphakathi, kube nesithakazelo esikhulu ekwakheni umuthi wokugoma wokuvimbela umuthi wokuvimbela ama-anti-antibiotic (anti-antibiotic) -ukusetshenziswa okuqhubekayo ukuphefumula ukuphikiswa kwemithi elwa namagciwane .
Ngaphezu kwalokho, ukugonywa kwe-UTI kunganciphisa ubuhlungu nokukhathazeka kwabesifazane abaye babhekana ne-UTI-ikakhulukazi labo abahlupheka ngokuphindaphindiwe, noma okungapheliyo, i-UTIs-ngaleyo ndlela bathuthukisa izinga lempilo yezigidi.
I-FimCH Vaccine
Umuthi wokugoma we-FimCH umuthi oqondile-olwa -antigen oqukethe amaprotheni okunamathela kwe-bacterium FimH.
Iproteinyini ye-FimH iyadingeka ku-E. coli ukuze ikhiqize i-urinary tract. Umuthi wokugoma uhola impendulo yomzimba wokuvikela omzimba ukukhomba amaprotheni we-FimH.
Ngenxa yentuthuko ekuhlanjululeni amaprotheni kanye nokuthuthukiswa kobuchwepheshe be-DNA, uma kuqhathaniswa nemigomo egcwele-cell, imithi ethile-imithi e-antigen iye yathandwa eminyakeni yamuva. Ngaphezu kwalokho, imishanguzo ethile ye-antigen ingahlanganiswa.
Ama-antigens asetshenziswe kule migomo angacaciswa ngenye yezindlela ezimbili. Okokuqala, abacwaningi bangasebenzisa amamodeli eseli (ie, in vivo) noma izilwane zezilwane. Okwesibili, ngokusebenzisa i-vaccinology ephindaphindiwe, abacwaningi bangakwazi ukubikezela ukuthi ama-antigens asebenzayo asebenza kahle. Umuthi wokugoma we-FIMCH watholakala usebenzisa izinhlobo zezilwane.
Umuthi wokugoma we-FIMCH awuyena omusha. Ekuqaleni kwakunelayisense yi-Medimmune futhi yangena esigabeni sesi-I nesigaba sesi-II sokuhlolwa kwemitholampilo ngaphambi kokuba ilahlekelwe ekuthuthukisweni. Okubaluleke kakhulu, lo mgomo wawubhekwa sengathi uphephile ngesikhathi sokuhlolwa kwesigaba I. I-Sequioa Sciences yabe iselayisensi umuthi wokugoma, ishintshe i-adjuvant, futhi yangena ekulingweni kwemitholampilo. I-adjuvant ukumiswa okwenziwe ngomgomo futhi isetshenziselwa ukuthuthukisa ukuphendula kwamagciwane.
Inothi, izivivinyo zesigaba se-I ziyizinfundo ezifaka phakathi kwabahlanganyeli abangu-20 no-100 ukuhlola ukuphepha nokulinganisa komuthi.
Izivivinyo zesigaba sesibili ze-Phase II zifaka abantu abangamakhulu amaningana futhi zihlolisise imiphumela esebenzayo kanye nemiphumela emibi yomuthi. Izivivinyo zesigaba se-Phase III zingabandakanya izinkulungwane zabahlanganyeli futhi zihlolisise ukusebenza nokuqapha imiphumela emibi.
Ngokusho kwemibiko yabezindaba, ngesikhathi sokuhlolwa kuka-Sequoia I-I I-vaccine ye-FIMCH, umgomo wawubekezelela kahle futhi wathonya impendulo evikela omzimba. Ngokuqondile, abesifazane abangu-67 bathola umgomo. Kulaba besifazane, 30 babenomlando we-UTI ophindaphindiwe owahlala iminyaka emibili. Ngokuphawulekayo, imiphumela yalezi zivivinyo zezokwelapha zesigaba I azizange zishicilelwe ngokomthetho ezincwadini.
Ngubani okufanele athole igciwane?
Abesifazane abahlangabezana ne-UTIs ephindaphindiwe bangabantu abakhethiweyo be-UTI.
I-Cystitis, noma ukutheleleka kwesinye, kufana namaphesenti angu-90 azo zonke i-UTIs. Phakathi kwamaphesenti angu-20 kuya kwangu-30 alaba besifazane abhekana nokuphindaphinda phakathi kwezinyanga ezintathu noma ezine. Umphumela we-UTIs ovame ukwenzeka ekukhungeni okuphuthumayo nobuhlungu nokufaka isandla ekuphikisweni kwama-antibiotic ngoba abesifazane abanayo nabo bavame ukuthatha ama-antibiotic phakathi nonyaka.
Uneminye imishanguzo ivivinywa maduzane?
I-GlycoVaxyn neJanssen Pharmaceuticals nayo isebenza kwenye imithi ye-UTI ebizwa ngokuthi i-ExPEC4V, okuyi-candidate ye-vaccination e-coli bioconjugate e-tetravalent. NgoFebruwari 2017, uHuttner kanye nabalobi ababambisene nabo bakhipha iziphumo ezivela ezivivinyweni zesigaba se-I emtholampilo kulomuthi wokugoma.
Sekuphelele, abesifazane abangu-93 bathola umgomo kanti abesifazane abangu-95 bathola i-placebo. Abahlanganyeli babephakathi kweminyaka engu-18 no-70 ubudala futhi babe nomlando we-UTIs ophindaphindiwe. Umgomo wawubekezelela kahle abamukeli. Ngaphezu kwalokho, lo mgomo waba nomphumela obalulekile wokuzivikela omzimba, futhi abesifazane abathola umgomo babenezindlela ezimbalwa ze-UTIs ezibangelwa u-E. coli.
Ekuphetheni, ngesikhathi sokuhlolwa kwemitholampilo, ukugoma kwe-FIMCH kubonise isithembiso ekuvimbeleni i-UTIs ebangelwa u-E. coli. Njengamanje, isinqumo sokuvuma lo mgomo sihanjiswe yi-FDA. Uma kuvunyelwe, lo mgomo uzovimbela ama-UTIs angamelana namagciwane futhi kuzosiza ikakhulukazi abesifazane abane-UTIs ephindaphindiwe.
> Imithombo:
> FDA. Ukulandelela okusheshayo. www.fda.gov
> I-Gupta K, i-Trautner BW. Izifo Zama-Urinary Tract, i-Pyelonephritis, ne-Prostatitis. Ku: Kasper D, Fauci A, Hauser S, Longo D, Jameson J, Loscalzo J. eds. I-Harrison's Principals of Medical Internal, 19e eNew York, NY: McGraw-Hill.
> Huttner, A, et al. Ukuphepha, ukuzivivinya umzimba, kanye nokusebenza kahle komtholampilo wokuvikela umgomo wokulwa nesifo sofuzo esibhekene ne-pathogenic Escherichia coli kwabesifazane abanomlando wokutheleleka okuvame ukuvuthwa kwe-urinary isilingo 1b esingahleliwe, esingaboni kahle, esingaboni kahle. Izifo ezithathelwanayo zeLancet. 2017; 17 (5): 528-537.
> O'Brian, VP, et al. UkuThuthukiswa kwezidakamizwa kanye nokuKhulelwa komuthi wokuThola ukwelashwa nokuVimbela izifo eziHlangene neziNdaba ze-Urinary. I-Microbiology Spectrum. 2016.