Funda kabanzi mayelana nohlobo lwe-Paenibacillus lwe-VT 400
Ehlobo lika-2016, emhlanganweni waminyaka yonke we-American Society for Microbiology, ososayensi babuthana ukuze babelane futhi baxoxe ngeziphumo ezihlobene nezwe lama-bacteria nempilo yabantu.
Phakathi kokutholakala, iqembu libika lonke i-genome, noma iqoqo eliphelele lezakhi zofuzo, ngoba ibhethri ebizwa ngokuthi i-Paenibacillus i-VT 400 (PVT400). Lawa ma-bacteria ayengatholakali ngaphambili ematheni wesiguli sezingane nge- acute lymphoblastic leukemia (KONKE).
Ukwaziswa okuningiliziwe kulezi zifundo kanye nezifundo ezizayo kuzosiza ososayensi bafunde ukuthi ngabe lezi zingqimba zingabamba iqhaza ezithombeni zabantu, ikakhulukazi kubantu abane-leukemia ekhulayo abahlakulela i-pneumonia noma izifo zegazi.
I-Pneumonia kubantu abane-Cancer
I-pneumonia yiyona imbangela eholela ekufeni ekuguleni iziguli ezine-neutropenia, ikakhulukazi labo abane-leukemia ephawulekayo. I-neutropenia yi-count ephansi ye-neutrophils ema-neutrophils wegazi amhlophe amangqamuzana egazi abalulekile ekusizeni umzimba ukulwa nokutheleleka .
Izifo ezithathelwanayo zokuphefumula zivame kakhulu phakathi kweziguli zomdlavuza, kanye neminye imibiko ebonisa ukuthi iziguli ezingu-13 kuya ku-31 zamagciwane e-leukemia zithola i-chemotherapy futhi amaphesenti angama-80 we-hematopoietic stem cell transplant abamukeli bayothola okungenani isiqephu esisodwa se-pneumonia.
I-pneumonia ye-Neutropenic ingaba izifo ezisongela ukuphila. Ezimweni ezinjalo, odokotela baqala ukwelashwa kwama-antibiotic ngokushesha, ngaphandle kokulinda imiphumela ye-laboratory ukuqinisekisa futhi ucacise uhlobo lokutheleleka kwebhaktheriya-ngoba kubaluleke kakhulu ukuqala ukwelashwa ngesikhathi esisodwa, ukunciphisa ingozi ukuthi isiguli sizothola ukutheleleka.
Eqinisweni, ukwelashwa kokuvimbela kusetshenziselwa izimo ezithile, okuchazwe ngezansi.
Ukuthuthukiswa kwamuva ekuphathweni kwe-neutropenic pneumonia kukhuthaza ithemba lemiphumela engcono. Izinhlangano eziningi zezokwelapha ziye zakhipha imihlahlandlela evuselelwe yokwelashwa kwama-antibiotic we-pneumonia ye-neutropenic.
Futhi kungenzeka ukuthi amanxusa amasha akhuthaza izimpendulo zomzimba ekuthelelekeni angathuthukisa umsebenzi we-antibiotics.
Ukugxila kuma-Pathogens kwiziguli ezine-neutropenia
Izinkombandlela ezivela eMelika Society of Clinical Oncology (ASCO) zincoma ukuthi odokotela bazama ukuvimbela ukutheleleka ezigulini eziphuthumayo nge-neutropenia ejulile kodwa akukho fever. Ukwelashwa kwe-antibacterial kanye ne-antitifungal kunconywa uma ngabe i-neutrophils ilindeleke ukuthi ihlale ingaphansi kwe-100 / μL izinsuku ezingaphezu kwesikhombisa. Isiqondiso sithi i-ejenti ekhethiwe yokwelashwa okuvimbela ukulwa nokulwa nomzimba yi-fluoroquinolone yomlomo, kanti lokho okwelapha i-antifungal kuyinto i-triazole yomlomo.
Iziguli ezine-neutropenia zitholakala ezinhlobonhlobo ezihlukahlukene kakhulu ze-pathogens kunezihlobo zabo. Kungaba usizo odokotela ukucabangela lapho amabhaktheriya avela khona ekubikezeleni ukuthi yimiphi imithi elwa namagciwane okungenzeka ukuthi ayimelana nayo, ngakho-ke yiziphi amasu angase aphumelele kakhulu.
Izinhlobo ze-Paenibacillus
Ngalolu daba, ososayensi bebelokhu befunda i-PVT400, amabhaktheriya amasha ahlukaniswe nesiguli se-leukemia, ilungu le-Paenibacillus-uhlobo lomuthi wezinhlobo ezibizwa ngokuthi i-rod. Izinhlobo ezihlukahlukene kuleli qembu ziye zahlukaniswa nomhlabathi, amanzi, izitshalo, ubisi nezinye izingosi.
Noma kunjalo, izinhlobo zePaenibacillus aziwazanga ukudala izifo zabantu. .. kuze kube yilapho imibiko yamuva ibonisa ukubandakanyeka kwezinhlobo ezintathu zePaenibacillus ezihlukene ngezifo zabantu.
Ngemuva kokuthi i-PVT 400 yayingasetshenziswanga nesiguli sesiguli sezingane esine- acute lymphoblastic leukemia , izifundo zakuqala zabonisa okufana nalezi zihlukanisi nezinhlobo ze-amylolyticus, ezitholakala ku-hindgut endizayo yezindiza; Kodwa-ke, kuze kube yimanje, kuseyiqiniso ukuthi i-P. amylolyticus ayitholakali kubantu, futhi izifundo ezengeziwe zabonisa umehluko phakathi kwamagciwane a-VT 400 atholakala esigulini somdlavuza kanye namanye ama-P.
amylolyticus.
Ngakho-ke, lapho abaphenyi beyifunde yonke i-gen 400 ye-genome, kwakunokutholakala okuningana okuthakazelisayo. Kwakukhona ama-genes akhiphe izindlela zokumelana nezidakamizwa zamakhemikhali , njenge-tunicamycin ne-bleomycin. Babuye bathola amagciwane ngamapompo e-bacteria ahlobene nokuphikiswa kwezidakamizwa, kanye namajezi okufaka ukumelana nemithi elwa namagciwane, kuhlanganise ne-vancomycin, i-fosmidomycin, i-tetracycline kanye nemithi efana ne-penicillin, noma i-beta-lactam.
Abalobi be-genome-study baqaphele ukuthi ukulandelana okuphelele kwe-genome ka-Paenibacillus sp. i-VT 400 iyasiza ukucacisa indima yezinhlobo ze-Paenibacillus ezifweni zabantu futhi ihlinzeke ngokucacile ekubunjweni kwamagciwane ajwayelekile ahlala ezigulini ezinegazi legazi.
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