I-New Class of Future Multiple Sclerosis Therapies
Uma uhlushwa yi-MS noma unomuntu othandekayo owenzayo, cishe uchitha isikhathi esiningi ucabanga, ufisa, noma uthandazela ukwelashwa okungcono, ngisho nokuphulukiswa. Izindaba ezinhle ukuthi kukhona inqwaba yezokwelapha ze-MS ezifundiswa njengamanje, kokubili ebhodini nasezinkingweni zomtholampilo. Omunye othembisayo wokwelashwa kusengaphambili ukuthuthukiswa kwe-MS vaccine.
Ukuhlukanisa i-MS Vaccine kusuka kwezinye izitofu
Uma ucabanga ngemithi yokugoma, iningi lethu licabanga ngokukhipha imikhono yethu ukuze sithole umjovo ozosivimbela ekutholeni izifo eziningi ezimbi, ezifana nomkhuhlane, isirabhu noma i-rubella. Le migomo iqukethe ama-virus noma amabhaktheriya asebuthakathaka noma abulawe ukuze angasenza sigule ngempela, kodwa akhohlise isimiso sethu somzimba sokuzivikela ekukhuliseni impendulo.
Kodwa umgomo wokugonywa kwe-MS ngeke ube yisivikelo. Kunalokho, kuyindlela yokwelapha. Lokhu kusho ukuthi kuzonikezwa ukuvimbela noma ukunciphisa ubunzima bezimpawu ezihlobene ne-MS nezinkinga zezempilo kumuntu osevele ehlolwe ukuthi une-MS.
Omunye umehluko phakathi kwemishanguzo yendabuko kanye nomuntu ovotelwe umgomo we-MS ukuthi imishanguzo yendabuko iklanyelwe ukuvimbela isifo esithathelwanayo - okungukuthi, isifo esiwumphumela wokutheleleka ngezinambuzane ezingaphandle, njengama-virus noma amabhaktheriya.
Nokho, i-MS akuyona isifo esithathelwanayo. Kunalokho, i-MS yisifo esizimele . Ngesizathu esithile, amasosha ethu omzimba ahlasele i- myelin ne-fibre fibers ohlelweni lwethu lwezinzwa zomphakathi . Ngamanye amazwi, i-MS ibangelwa okuthile umzimba wethu owenzela wona uqobo, futhi akubangelwa umbhuli wangaphandle.
Ngakho-ke, izingxenye zezinkampani ze-MS zokugonywa yi-MS azizona izinambuzane ezincane kodwa ezinye izinto zenzelwe "ukusika" amasosha ethu omzimba omzimba ngezindlela ezehlukene ukuvimbela amangqamuzana ethu omzimba omzimba ukuba ahlasele ubuchopho bethu nomgogodla.
Iyini i-MS Vaccines Being Studies?
Nazi izikhala ezine ezihlukile zokuhlolwa kwe-MS ezihlolwayo: Tcelna, NeuroVax, BHT-3009, ne-RTL1000. Ngayinye yale migomo isebenzisa indlela ehlukile yokufinyelela umgomo wayo wokuyeka umsebenzi wokuzimela ngokumelene ne-myelin.
I-Tcelna (eyayiyi-Tovaxin): I- Tcelna-eyayibizwa ngokuthi i-Tovaxin-iyimithi yokugoma e-T-cell, okusho ukuthi iqukethe amaseli e- myelin asebenzayo e-myelin, okumele ahlasele i-myelin kubantu abane-MS, ezibulewe. Ngokufaka ijubane elikhulu lalawo angena kumuntu, i-Tovaxin ithola isimiso somzimba sokuzivikela sokubhubhisa wonke amanye lawa maseli ekusakazeni ngaphandle kokuthinta wonke amasosha omzimba.
Lo muthi utholakale ukuthi uphephile kepha awunciphisi kakhulu inani elingu-gadolinium-enhancing MS lesions ekutadisheni iziguli ezingu-150 ngo-2008. Manje sesibhekene novivinyo olusha lomtholampilo olwethulwe ngo-2012 ngaphansi kwegama elithi Tcelna, ukuze lihlolwe indima ekunciphiseni ubuchopho be-brain and delaying the disabled.
I-NeuroVax: I- NeuroVax iyigciwane le-T-cell receptor peptide, okusho ukuthi lenziwe ngezicucu zamaprotheni ezifana nezingxenye ze-T-cell ezinama-pathogenic ezihlasela i-myelin. Yenzelwe ukugqugquzela umzimba ukuba wenze okungaphezulu kwe-T-cell elawulayo elawula umsebenzi walezi zinambuzane, noma "ama-T" amangqamuzana.
I-Neurovax ifakwe emisipha njalo ngemva kwamasonto amane. Izivivinyo zokwelapha zesigaba sesi-2 ze-multiple progressive sclerosis eziqhubekayo okwamanje ziyakhiwa kulo mgomo wokuhlola.
I-BHT-3009: Lo mgomo wenziwa nge-DNA ezakhiwe ngezifo ezifana neprotheyini e-myelin ukuthi amasosha ethu omzimba ahlasela, okuthiwa i-myelin amaprotheni ayisisekelo.
Inhloso yalo ukuhlanganisa "inkinobho" elawula ukumelana nomzimba, empeleni "ukuvuselela kabusha" amasosha omzimba ahlasela i-myelin sheath kubantu abane-MS.
Ucwaningo lwezesayensi lubonisa ukuthi umgomo uphephile futhi uvunyelwe kahle futhi ungangena ekuhlolweni kwesigaba se-Phase III maduzane.
I-RTL1000: "RTL" ifushane "emigqeni ye-T-cell receptor" ephindaphindiwe, okuyizinhlayiya ezibophezela kumamukeli we-T-cell ezilimaza i-myelin kubantu abane-MS. Ngokuhlanganisa lezi receptors, ama-T-amaseli akakwazi ukwenza umonakalo. Abanye ochwepheshe abafaki nalokhu emigqeni "yokugoma" ngenkathi abanye benza.
I-RTL1000 itholakala ukuthi iphephile futhi ibekezelelwe kahle njengendlela yokuphatha okungeyona eyodwa ekuhlolweni okuncane kweSigaba 1. Abacwaningi bahlela ukuqhubekela phambili ukuhlola ukuphepha nokusebenza kwayo njengama-infusions amaningi ngenyanga ngenyanga yesilingo sesiGaba sesi-2.
Izinyathelo Ezijabulisayo E-Multiple Sclerosis
Lezi zincithakalo ezikhona zinganikeza abaningi bethu ithemba. Yebo, basesekuvivinyweni futhi kude nokutholakala kuningi lethu. Nokho, zijabulisa kakhulu. Cabanga ngokuxoxa nabo nodokotela wakho futhi ulandele izilingo kwiDatayela yeZilingo Zezokwelapha.
Imithombo:
I-Correale J, uFarez M, uGilmore W. Imishanguzo ye-sclerosis eminingi: inqubekela phambili kuze kube yimanje. I-CNS Izidakamizwa. 2008; 22 (3): 175-98.
I-Correale J & Fiol M. BHT-3009, i-plasmid yamaprotheni eyisisekelo ye-myelin yokwelashwa kwe-multiple sclerosis. I-Curr Opin Mol Ther . 2009 Aug; 11 (4): 463-70.
I-Multiple Sclerosis Association of America. (2013). Imithi Yokuhlola: Tcelna (owawuyi-Tovaxin) ngaphambili. Ibuyiselwe ngoJanuwari 10th 2015.
I-Multiple Sclerosis Association of America. (2013). Imithi Yokuhlola: BHT-3009. Ibuyiselwe ngoJanuwari 19th 2015.
Yadav V et al. I-Recombinant Receptor Ligand (RTL) yokwelashwa kwesifo sobunzima: I-double blind-blind, i-placebo-elawulwayo, isigaba 1, isifundo sokukhuphuka kwesisindo. I-Autoimmune Dis . 2012; 2012: 954739.