Abacwaningi baveza ukuthi kunzima ukuqhubekela phambili ku-AIDS eminyakeni emithathu
Ngenkathi kungekho ndlela ehleliwe ngendlela i- HIV eqhubeka ngayo ukusuka komunye umuntu kuya kwesinye, kunezinkinga (ezihlukile) ezihambisana nokuqhubekela phambili okusheshayo. Lezi zinhlobonhlobo zibangelwa ukuguqulwa kwezakhi zofuzo ezivame ukukhula ngaphakathi kwesifunda esithile, ngokuvamile zihlakazeka ngaphesheya kwaleso sifunda ukuze zibe yinkinga enkulu-uma kungenjalo.
Ucwaningo olwanyatheliswa encwadini yezokwelapha e- EBioMedicine libike ukuthi okunye okuhlukile kuye kwahlukaniswa eCuba, okuyaziwa ukuthi i- AIDS ingakapheli iminyaka emithathu kokutheleleka kokuqala-okwenza kube sengathi yiyinkinga enobudlova obhekene nesikhathi esaziwayo.
Ngokombiko, abacwaningi abavela eNyuvesi yaseLeuven eBelgium baye baphawula kahle ukuthi lolu hlobo luyi-CRF19 , okuhlukile okuhlukile kwe-HIV okuhlanganisa ama-subtypes amathathu ahlukene , A, D, no-G.
Lapho i-HIV ivame ukuqhubeka nengculazi eminyakeni emihlanu kuya kweyishumi ngaphandle kokwelapha, i-CRF19 ibonakala iqhubekela phambili ngokushesha njengokubeka umuntu engozini enkulu yokugula nokufa ngaphambi kokuba kuqalwe ukwelashwa .
Okufundwayo Okufundwayo
Iziguli ezingamashumi ayisikhombisa zaziwa ngabacwaningi njengabaqhubekela phambili ngokushesha (RP), zibonisa ukwehla okunamandla emtheni wabo we- CD4 kuya ezingaphansi kwamangqamuzana angama-200 / mL noma kubonisa isimo esichaza i- AIDS (noma kokubili).
Isikhathi esiphakathi kweziguli sasingama-34, kanti isibalo sama-CD4 isilinganiso ngesikhathi sokuxilongwa sasingama-276 cells / mL. Ngokuphambene nalokho, iqembu elilinganayo leziguli ze-HIV ngaphandle kokuhluka kwe-CRF19 kwakune-CD4 count ephakathi kuka-522 no-577 ngesikhathi sokuxilongwa.
Ngaphezu kwalokho, abaqhubekela phambili bahamba phambili banesisindo se- HIV esisodwa-kuya kwezi-ezintathu eziphakeme kunabathuthuki abangekho ngokushesha.
Ngenxa yalokho, iziguli eziqinisekisiwe i-CRF19 zinesikhathi esiphakathi phakathi kwe- seroconversion ne-AIDS engama-1.4 kuphela uma kuqhathaniswa neminyaka engu-9.8 ngenxa yabalingani babo abangewona ama-CRF19.
Izincazelo zokuqhubekela phambili okusheshayo
Abacwaningi bakwazi ukukhipha ama-co-factors ambalwa angase achaze ukuthuthuka okusheshayo kwe-AIDS. Ngokwezibalo zabantu, kwakukhona ukuthuthuka okusheshayo kokushayisana phakathi kwabantu abangenazikhathi eziphuthumayo (49% vs28%). Ukwengeza, akukho ukungafani kokuthola i-HIV ngemisebenzi yezocansi (isibalo, ubulili).
Ngokusekelwe ekutholeni kwabo, abaphenyi bakholelwa ukuthi izinguquko eziphuthumayo ezihlukahlukene ze-CRF19 zingachaza lesi simo.
Ngokuvamile, kunezinhlobo ezimbili ze-co-receptors ebusweni bamangqamuzana egazi amhlophe avumela ukungena kwegciwane lesandulela ngculazi esitokisini: CCR5 neCXCR4 . I-CCR5 yi-co-receptor eyenziwa yi-HIV ngokujwayelekile ekutheleleni kwesandulela-ngculaza, kanti i-CXCR4 iyona esetshenziselwa ukutheleleka kamuva.
Ngokwehlukahluka kwe-CRF19, igciwane liyashintsha ukusuka ku-CCR5 kuya ku-CXCR4 ngokusheshisa kakhulu kunezinye izinkinga ze-HIV . Ngokwenza kanjalo, ukuqhuma kwesifo kubuye kuphuthumise, okuholela ekuthuthukiseni ingculaza ngaphambi kwesikhathi.
Lokhu okutholayo kuzodinga ukwanda kwe-HIV ukubhekwa kwe-HIV eCuba, okwamanje inezinga lokusakazwa kwe-0.2% (kuqhathaniswa ne-0.9% e-US) futhi kungaphezu kwezigidi eziyizinkulungwane eziyisithupha eziqinisekisiwe.
Okuphathelene nalokhu ukuthi, ngesilinganiso esiphakathi kokutheleleka kuya ekuxilongweni kusuka ezinyangeni ezingu-37 kuya ezinyangeni ezingu-55, iziphathimandla zezempilo zomphakathi zingase zingakwazi ukukhomba abantu abane-CRF19 ehlukile ngokushesha ukuze bagcine ukusabalalisa okusheshayo kwegciwane.
Ngenkathi ama-alamu ezempilo yomphakathi ekhuliswe manje kuphela, ukuhlukahluka kwakunqanyuliwe eCuba njengasekuqaleni kuka-2005 futhi kungenzeka ukuthi kwavela eCentral Africa, lapho kwabikwa khona ukuhlakazeka kwamacala e-Angola, eBurkina Faso, Cameroon naseTogo.
Imithombo:
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