Ama-5-HTP angeke ahlolwe ukuphepha futhi agcine engqondweni ukuthi ukuphepha kwezidakamizwa kwabesifazane abakhulelwe, omama abahlengikazi, izingane, nalabo abanezimo zezokwelapha noma abaphuza imithi akuzange kusungulwe. Ungathola amathiphu ekusetshenzisweni ama-supplements , kodwa uma ucabangela ukusetshenziswa kwe-5-HTP, khuluma nodokotela wakho kuqala. Sicela uqaphele ukuthi lokhu kuphela uhlu oluyingxenye (sicela uxhumane nodokotela wakho ohlwini oluphelele).
Ezinye zezinkinga zokusebenzisana kwezihlahla zemifino zingafaka lokhu okulandelayo.
I-Carbidopa
I-Carbidopa isetshenziselwa ukulawula izimpawu ze- Parkinson's disease ezifana nokuthuthumela, ukuqina nokungahlali kahle. Ngombiko owodwa, i-carbidopa ne-5-HTP ethathwe ndawonye yayikholelwa ukuthi iyabangela ukuthuthukiswa kwesifo se-scleroderma. Ezinye izifundo zithole ukuthi abantu abathwala i-carbidopa kanye no-5-HTP nabo bathole ukuthuthukisa isimo esibizwa ngokuthi inhloso ye-myoclonus.
I-Dextromethorphan
I-Dextromethorphan iyinkinga yokukhwehlela. Akukho ukuxhumana okubikiwe, noma kunjalo, izidakamizwa ezandisa i-serotonin, njenge-serotonin reuptake inhibitors, kuye kwabikwa ukuthi kubangele ukucubungula okubukwayo nokugubha ngokweqile uma kuhlangene.
I-MAO Inhibitor Izidakamizwa
isib Phenelzine, Selegiline, Tranylcypromine
I-MAO inhibitors isetshenziselwa ukwelashwa kokucindezeleka kanye nokuphazamiseka kwesifo kanye nokuvimbela ikhanda. Nakuba kungakaze kube khona ukusebenzisana kwezidakamizwa ezibikwe ngama-5-HTP, ama-inhibitor we-MAO angabangela ukugubha, ukudideka, umkhuhlane, ukukhathazeka, ukugubha, ukucindezela kwegazi okuphakeme, okuthiwa i-serotonin syndrome.
Ucwaningo olwenziwa yi-Hokkaido University lathola ukuthi ingozi ye-serotonin syndrome yayingaphansi kwe-selegiline kunezinye i-MAO inhibitors.
I-Serotonin Reuptake Inhibitors Ekhethiwe (SSRIs)
isib Fluoxetine, Fluvoxamine, Sertraline, Sibutramine
I-serotonin i-reuptake inhibitors ekhethiwe isetshenziselwa ukucindezeleka, isifo se-premenstrual dysphoric syndrome , bulimia nervosa, ukugula okucindezelayo okucindezelayo, nokulahlekelwa isisindo.
I-5-HTP iguqulwa ibe yi-serotonin, ngakho imithi yokwandisa i-serotonin ingandisa ingozi yokuthuthukisa isimo esingavamile kodwa esibi esibizwa ngokuthi izimpawu ze-serotonin syndrome zihlanganisa ukudideka, ukuqina kwemisipha, ukukhanya okushisayo, ukuguqulwa kwengcindezi yegazi nokushaya kwenhliziyo, kanye ne-coma.
I-Triptans
isib Sumatriptan, iZolmitriptan, i-Rizatriptan, i-Naratriptan, i-Almotriptan, i-Eletriptan, i- Frovatriptan
Izidakamizwa ze-Triptan zisetshenziselwa ukwelapha, kodwa zingavimbeli, ziyadlula. Lezi zidakamizwa zisebenza ngokuthinta i-serotonin receptors ebuchosheni. Uma kuthathwe inhlanganisela ne-5-HTP (isithasiselo esithinta amazinga e-serotonin), angandisa ingozi ye-serotonin syndrome.
I-Tramadol
I-Tramadol iyi-analgesic yokulinganisela ebuhlungu obukhulu. Nakuba kungekho ukusebenzisana kwezidakamizwa kuye kwabikwa, i-5-HTP ingayandisa imiphumela ye-Tramadol, yandisa ingozi yokugula noma isifo se-serotonin.
Ezinye izidakamizwa
isib Venlafaxine, i-Nefazodone, i-Trazodone
Eminye imithi ethinta ukutholakala kwe-neurotransmitter serotonin ingase iholele ku-serotonin syndrome lapho isetshenziselwa ndawonye ne-5-HTP.
I-Zolpidem
I-Zolpidem isetshenziselwa ukuphumula kwesikhashana sokulala. Nakuba ukusebenzisana kwezidakamizwa kungakabikwa nge-5-HTP, i-Zolpidem kanye nezidakamizwa ezithinta amazinga e-serotonin ayekholelwa ukuthi kubangela ukucubungula okubukwayo, ukuphefumula kancane nokukhuluma, nokusebenzisana kabi.
> Imithombo:
> Coleman DE no-Ota K. "Ama-hallucinations nge-ajpidem ne-fluoxetine kumshayeli okhubazekile." Journal of Science Forensic . 49.2 (2004): 392-3.
> Elko CJ et al. "I-Zucpidem-ezihlotshaniswayo kanye ne-serotonin kabusha yokuvimbela: ukuxhumana okungenzeka." Journal of Toxicology - Toxicology Clinic . 36.3 (1998): 195-203.
> Griffith, H. Winter. Isiqondiso Esiphelele Sokubhaliswa Kwezincwadi Ezibhalwe Ngomthetho kanye Nezingekho Emthethweni 2006. I-New York: I-Perigree, ngo-2005.
> Ezempilo. Umhlahlandlela we-AZ we-Drug-Herb-Vitamin Interaction. I-New York: I-Three Rivers Press, ngo-2006.
Izumi T et al. "Imiphumela ye-co-administration ye-serotonin e-reuptake inhibitor ne-monoamine oxidase inhibitors ekuphatheni okuhlobene no-5-HT kuma-rats." Journal European of Pharmacology . 532.3 (2006): 258-64.
> I-Navarro A > wt > al. "Icala le-serotonin syndrome linyanyiswe ngokuhlukunyezwa kwe-remtic remedy dextromethorphan ngesifo sofuba-bipolar esiphathwa nge-fluoxetine ne-lithium." I-General Hospital Psychiatry. 28.1 (2006): 78-80.
> Rybacki, uJames J. Umhlahlandlela Owusizo Wokusetshenziswa Kwezidakamizwa Zomuthi 2006. New York: Collins, 2006.
I-Sternberg EM et al. "Ukuthuthukiswa kokugula okufana nesifo se-scleroderma ngesikhathi sokukwelashwa nge-L-5-hydroxytryptophan ne-carbidopa." I-New England Journal of Medicine . 303.14 (1980): 782-7.
> Thal LJ et al. "Ukwelashwa kwe-myoclonus nge-L-5-hydroxytryptophan ne-carbidopa: ukuhlolwa kwemitholampilo, i-electrophysiological, ne-biochemical." Ama-Annal of Neurology. 7.6 (1980): 570-6.
I-Toner LC et al. "Imizwa emibi yesimiso esiyinkimbinkimbi ehlobene nokuphathwa kwe-ajpidem." I-Neuropharmacology yezokwelapha. 23.1 (2000): 54-8.
> Tsai MJ et al. "Iphethini lomtholampilo lomlando we-hallucination ebonakalayo ngemva kokusebenzisa i-zolpidem." Journal of Toxicology - Toxicology Clinic . 41.6 (2003): 869-72.
> Van Woert MH et al. "Ukwelapha isikhathi eside kwe-myoclonus nezinye izinkinga ze-neurologic ne-L-5-hydroxytryptophan ne-carbidopa." I-New England Journal of Medicine. 296.2 (1977): 70-5.
Ukwaziswa okuqukethwe kule sayithi kuhloswe ngezinhloso zemfundo kuphela futhi akusilo esikhundleni seseluleko, ukuxilongwa noma ukwelashwa udokotela olayisensi. Akuhloswe ukumboza zonke izinyathelo zokuphepha, ukusebenzisana kwezidakamizwa, isimo noma imiphumela emibi. Kufanele ufune ukunakekelwa okusheshayo kwezokwelapha kunoma yiziphi izinkinga zezempilo bese uthintana nodokotela wakho ngaphambi kokusebenzisa enye imithi noma wenze ushintsho ohlelweni lwakho.