6 I-Virus engabangela umdlavuza

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I-Minority Infections Iyakhathaza

Ayikho uhlobo olulodwa lwegciwane elidala umdlavuza. Amagciwane ayisithupha ahlukene angabangela umdlavuza avela emindenini ehlukene yegciwane, ahlukahlukene ama-genomes, futhi abe nemijikelezo yokuphila ehlukile.

Ngokuvamile, ukutheleleka nganoma yikuphi kulaba magciwane kuvamile kakhulu. Ngenhlanhla, kuphela abantu abambalwa abanesifo samagciwane abaqhubeka behlakulela umdlavuza. Futhi uma umdlavuza wawuzokhula, kungathatha iminyaka noma amashumi eminyaka ukubamba. Ngaphezu kwalokho, ama-virus ngokwawo ayanele ngokwanele ukudala umdlavuza futhi kufanele ahambisane nokuguquka kwamagciwane, ukuguquguquka kwesimo somzimba, ukuguqula izakhi zofuzo, kanye nokwehliswa kwama-carcinogens.

Nazi izinhlobo eziyisithupha zamagciwane abangela umdlavuza (ama-virus omzimba we-aka)

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I-Hepatitis C

I-Hepatitis C iyigciwane le-RNA. Lokhu kubangela kokubili ukushisa kwesibindi nesifo esingapheli. Ukutheleleka okungapheli nge-hepatitis C kubangela ukushisa kwesibindi noma ukubhuka kwesibindi. Emaphesenti angu-1 kuya kwangu-2 alabo abathintekile, le-cirrhosis ingagcina ibangela umdlavuza we-hepatocellular (isibindi). I-Hepatitis C nayo ixhunywe ne- non-Hodgkin's lymphoma .

Nakuba abacwaningi bengakakhulumi umuthi wokugoma we-hepatitis C, kunezokwelapha eziphumelelayo zesifo, kuhlanganise no-Olysio, Sovaldi, neHarvoni .

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I-hepatitis B

Nakuba i-hepatitis C iyigciwane le-RNA, isibindi B isifo se-DNA. Naphezu kokuba isigaba segciwane ehlukile, isifo sofuzo esibangelwa yi-B sibangela ukutheleleka ngekliniki efana ne-hepatitis C: i-hepatitis, i-cirrhosis ne-hepatocellular.

Umdlavuza we-hepatocellular ngumdlavuza ohlukumezayo obulala unyaka owodwa noma amabili emva kokutheleleka. Ukwelashwa komdlavuza we-hepatocellular kugcina ukuthengiswa kokuhlinzwa kwesibindi noma ukufakelwa kwesibindi.

Ngenhlanhla, sinomgomo wokushisa kwesibindi B.

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I-Human Papilloma Virus (HPV)

I-HPV iyi-virus encane ye-DNA edala izimpi zobulili. Ukutheleleka okuphindaphindiwe abane-highty risk subtypes ye-HPV kungabangela umdlavuza wesibeletho. Ngaphezu kwalokho, ukutheleleka kwe-HPV okuqhubekayo kuye kwacatshangelwa ekuthuthukiseni ezinye izinhlobo zomdlavuza, kufaka phakathi izikhwehlela zekhanda nentamo, izikhonda zesikhumba ezigulini ezingenakuzivikela (cabanga nge-AIDS), kanye ne-anogenital cancers.

Ngenhlanhla, ngenxa ye-PAP smear, sinesivivinyo esiphumelele kakhulu somdlavuza wesibeletho.

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Uhlobo lwe-T Lymphocyte Virus Uhlobo 1 (HTLV-1)

I-HTLV-1 iyi-retrovirus ye-RNA. Emhlabeni wonke, abantu abayizigidi ezinhlanu kuya ku-25 banesifo sengculazi; Nokho, abambalwa kuphela (amaphesenti angu-5) athuthukisa izimpawu. I-HTLV-1 ine-tropism noma ikhanga kuma-CD4 cells, i-leukemia clonal cell. Eminyakeni engamashumi amabili kuya kwengamashumi amathathu emva kokutheleleka nge-HTLV-1, i-adult T-cell leukemia ingaqala.

I-chemotherapy ingasetshenziswa ekutholeni ukwelapha i-T-cell leukemia yabantu abadala futhi ibangele ukukhululwa kwesikhashana okulandelwa ukulandelwa okusheshayo kwesifo. Isikhathi sokusinda (esiphakathi) emva kokuthuthukiswa komuntu omdala we-T-cell leukemia yizinyanga ezingu-8.

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I-Epstein-Barr Virus

I-EBV iyigciwane elijwayelekile lapho sonke siyazi-lidala i- mononucleosis . Nakuba amaphesenti angu-95 abantu anesifo se-EBV emzimbeni we-throat, ukutheleleka okuningi kunesifo esincane, kanti kunabantu abambalwa abakhula izifo zomtholampilo.

I-EBV ixhunywe ezinhlobonhlobo zamanqamuzana kuhlanganise ne-B-and-T-cell lymphomas, i-leiomyosarcomas, i-nasopharyngeal carcinomas, isifo sikaHodgkin, kanye nesifo se-post-transplant lymphoproliferative.

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HHV-8 noma i-Kaposi Sarcoma Herpesvirus

Ngo-1994, i-HHV-8, noma i-Kaposi sarcoma herpesvirus, yathinteka ekuthuthukiseni i -sarcoma yeCapasi , umdlavuza obangela izikhumba zesikhumba nomlomo kulabo abane-AIDS. Kodwa-ke, kulabo abanamasosha omzimba anamandla, i-HHV-8 ayidabuli kabi.

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Izikhombisi-ndlela zokwelashwa zesikhathi esizayo zeVirus Tumor Viruses

Izindlela ezintsha zokwelapha zomdlavuza obangelwa amagciwane we-tumor womuntu zigxile kwimikhiqizo yegciwane lesandulela ngculaza ecacile kumangqamuzana e-tumor abangelwa igciwane. Ngokuhlakulela ukwelashwa okubhekiswe ikakhulukazi amangqamuzana aphethwe amagciwane, izinketho zokwelapha esikhathini esizayo zingasindisa amangqamuzana omzimba omzimba. Njengamanje, ukwelashwa okufana ne-chemotherapy kanye ne-radiotherapy kubulala wonke amangqamuzana, achaza imiphumela yabo embi futhi embi kakhulu.

Njengamanje, indlela engcono kakhulu yokuvimbela umdlavuza wesibili kumagciwane omuntu (nakuba kungavamile) ukuvimbela ukuvezwa kwezifo ze-tumor yomuntu. Nakuba ezinye zalezi zinambuzane zikhona, singavimbela ukutholakala kwezinye izigciwane ezifana ne-hepatitis B no-C. Kukhona nokugoma kwe-hepatitis B ne-HPV etholakalayo.

_Imithombo:

_{Liao JB. Amagciwane kanye neCancer Cancer. Yale Journal of Biology and Medicine . http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1994798/}

_{I-Mazzaro C et al. I-virus ye-Hepatitis C ne-non-Hodgkin's lymphoma eminyakeni eyishumi kamuva. Izifo zesibindi sokugaya . https://www.researchgate.net/publication/7948031_Hepatitis_C_virus_and_non-Hodgkin's_lymphoma_10_years_later}