Yini Ongayilindela Uma Uthatha I-Betaseron
Abantu abane- MS yokubuyisela kabusha, noma i-RRMS, bavame ukwenza izinqumo zabo zokwelapha ngokusekelwe iseluleko sabo nodokotela, kanye nokukhathazeka ngokulula, imiphumela emibi, kanye nezindleko. Okunye ukwelashwa kwe-interferon okuvunyiwe yi-FDA yokuphatha ukubuyela emuva ku-MS yi-Betaseron.
Izisekelo eziseBetaseron Therapy
I-Betaseron (i-Interferon beta-1b) ibilokhu isemakethe isikhathi eside kunanoma yisiphi esinye isifo sokuguqula isifo.
Ihlinzeka ngezinga eliphakeme kakhulu lamasonto onke ama- interferons , ku-250mcg / dose, enikezwa njalo ngosuku. I-subcutaneous (okusho ukuthi ifakwe emanzini ngqo ngaphansi kwesikhumba) futhi ayihambisani ne-PH, ngokuphambene ne-Avonex (i-intramuscular, okusho ukuthi injected into muscle) neRebif (futhi futhi engaphansi, kepha i-acidic, ukujova okunjalo kungaba ebuhlungu). Iningi leziguli zakha izindawo ezibomvu kuma-injection sites with Betaseron, okuyinto, ezimweni ezingavamile, ingaba yizilonda.
I-Betaseron ihambisana nezimpawu ezivamile zokuhlobene ne-interferon, eziwukhuhlane, ikakhulu lapho kuqala ukwelashwa. Njengoba unikezwa njalo ngolunye usuku, lokhu kwenza kube nzima kubantu abasebenza isikhathi esigcwele noma ngokudingekile ukuba babe "ekuhambeni" njalo, ngokungafani ne-Avonex (kanye ngesonto ukulinganisa) noma i-Copaxone (engeyona i-interferon, ngakho-ke akukho mkhuhlane -nemiphumela emibi). Kodwa-ke, iBetaseron iza nesimiso se-titration (okusho ukuthi iziguli ziqala ngomthamo omncane futhi zanda kancane kancane), okuthiwa zinciphisa kakhulu le mibi emibi.
I-Betaseron idinga ukuba iziguli zithole igazi zidonsa njalo ukuze ziqaphe ukusebenza kwesibindi kanye nokubalwa kwamangqamuzana egazi.
Ulwazi Olwengeziwe Olwengeziwe ku-Betaseron Therapy
I-Betaseron yenzelwa abantu abane-RRMS kanye ne-progressive-relapsing MS (i-PRMS). Kuphinde kuvunyelwe ukusetshenziswa kubantu abaye babhekana nomcimbi we-MS ngezimpawu ze-MRI ezihambisana ne-MS.
Ukusebenza kufana nalokho kuzo zonke izidakamizwa ze-CRAB (Copaxone, Rebif, Avonex, Betaseron)-cishe ingxenye yesithathu yokunciphisa ukuphindwa kabusha uma kuqhathaniswa ne-placebo eminyakeni emibili. Ucwaningo lubonisa ukuthi kunobunye ubufakazi bokuthi i-interferons ephezulu-dose (Betaseron neRebif) ingase iphumelele kancane ekuvimbeleni ukubuyela emuva futhi kunciphise izilonda kunomthamo ophansi (i-Avonex). Ngesikhathi seBetaseron, ukuhlolwa kwegazi kudingeke kwenziwe njalo ezinyangeni ezintathu ngonyaka wokuqala ukuhlola isibalo segazi elimhlophe nokusebenza kwesibindi. Ngemuva konyaka, zingancishiswa kanye kanye nezinyanga ezine.
I-Betaseron inikezwa nsuku zonke (izikhathi ezingu-14 ngenyanga) njengesigxobo esingaphansi kwesigqokwane (ngaphansi kwesikhumba), ngokuvamile esenziwe yisiguli ngokwabo noma ilunga lomndeni. Inaliti isifushane kunezindlela zokwelashwa kwe-intramuscular (.5 intshi kuya kokungu-1 kuya ku-1,25 amasentimitha) futhi i-gauge engu-27, elincane kakhulu. I-Betaject 3 idivayisi yokujova ngokuzenzakalelayo inikezwa.
Imiphumela emibi ye-Betaseron Therapy
Imiphumela emibi ye-Betaseron ifana neyenye imithi yokwelashwa e-interferon ngaphandle kwe-Avonex, engabangeli ukuphendula okuningi kwesayithi.
- Izimpawu ezinjenge-Flu: Umphumela oqakathekile kunazo zonke izimpawu ezinjenge-flu. Lokhu kufaka phakathi umkhuhlane, izikhukhula, ukujuluka, ama-muscle aches nokukhathala, okugcina amahora angu-24 kuya kwangu-36. Lo mphumela ohlangothini uvame ukubi kakhulu emva kokujova kokuqala futhi uhlise kancane kancane ngomjovo ngamunye ukuze abantu abaningi bazibonele noma bebekezeleleke ngemva kwezinyanga eziyisithupha. Kungabuye kuncishiswe ngokuqala ngomthamo ophansi futhi ukwandise umthamo ogcwele kancane kancane, ngaphezu kwamasonto ambalwa. Ukuthatha ibuprofen noma i-acetaminophen amahora ambalwa ngaphambi nangemva kungasiza ngalomphumela ohlangothini.
- Izindawo ezibomvu: Lezi zivame ukuvela esakhiweni somjovo, okungase kuphele amasonto ambalwa. Lezi zingakwazi ukwehla zibe izilonda (injection-site necrosis) ngamaphesenti angu-4 amacala. Ukushintshaniswa kwamasayithi nokufaka ukucindezela okufudumele kwisayithi ngaphambi kokujova kuyo kungasiza ukunciphisa lezi zindawo ezibomvu.
- Ukulimala kwesibindi: Ukulimala kwe- Hepatic kufaka phakathi amazinga e-enzyme ephakeme wegazi nesifo sofuba esibikiwe. Ukuqapha okuvamile kuyadingeka ukuvimbela umonakalo onjalo ungenzeki noma uthuthuke.
- I-Blood Counts: I- Betaseron ingabangela ukwehla kwezinombolo zamaseli abomvu namhlophe, kanye nokunciphisa inani lamaplatelet egazini.
- Ukucindezeleka Nezimpikiswano: I- Betaseron kufanele isetshenziswe ngokucophelela ezigulini ezinezinkinga nokucindezeleka-lezi ziguli zidinga ukuqapha okungaphezulu.
Ngingathatha I-Betaseron Lapho Ngikhulelwe?
I-Betaseron yisigaba C sokukhulelwa, okusho ukuthi kubangele ukulimala kumatfusi ezifundweni zesilwane, kodwa umphumela kubantu awuziwa. Uma uhlela ukukhulelwa, sicela uzise udokotela wakho ngokushesha ukuze ukwazi ukuhlela uhlelo ndawonye ngesikhathi sokumisa. Akunconywa ukuba ancelise ngenkathi ethatha i-Betaseron.
Ulwazi lokuxhumana lwe-Betaseron
I-Betaseron yenziwa yi-Bayer HealthCare Pharmaceuticals Inc. Uhlelo loxhaso lwesiguli lweBetaseron lubizwa nge-MS Pathways. Zingafinyelelwa ngocingo ngo-1-800-788-1467, lapho ungaxoxa ngemibuzo onayo ngeBetaseron nomhlengikazi (obizwa ngokuthi umhlengikazi we-BETA).
Imithombo:
I-Bayer Health Care. Umhlahlandlela wemithi: Betaseron .
I-Durelli L, i-Verdun E, i-Barbero P, et al. I-interferon i-beta-1b yansuku zonke-enye ngokuphikisana ne-interferon beta-1a yama-multiple for sclerosis amaningi: imiphumela yocwaningo lweminyaka eminingi elandelanayo engahlosiwe (INCOMIN). Lancet 2002; 359: 1453-1460.
Kappos L, Polman CH, Freedman MS, et al, for the BENEFIT Study Group. Ukwelapha nge-interferon beta-1b ukuguqulwa kokuguqulwa ukuguqulwa komtholampilo kanye noMcDonald MS ezigulini ezinezifo ezihlukumezekile emitholampilo. I-Neurology 2006; 67: 1242-1249.
I-National MS Society. (2015). Imishanguzo ye-MS Yokuguqula Imishanguzo .