Uhlolojikelele lwezokwelapha eziningi ze-sclerosis
Imithi yokuguqula izifo kuyisinyathelo esibalulekile sokuqala ekunakekeleni i-MS yakho. Ngenkathi bengeke basize ngqo izimpawu zakho, basebenza ngemuva kwezigcawu ukunciphisa isimo sakho.
Lokhu kuthiwa, kunezinhlobo eziningi zokwelapha ukubhekana nezimpawu zakho eziyinselele ze-MS. Lezi zihlanganisa imithi, amasu okuvuselela, kanye nemithi yokwengeza, njengokuzindla kanye ne-reflexology.
Nakuba kungekho ukwelashwa okwamanje nge-MS, ungahlala kahle nalesi sifo.
Eqinisweni, ukuhlala nokusebenzisana ne-MS kungase kungabonakali amandla angaphakathi ongakaze wazi ukuthi unayo.
Izifo-Ukuguqula Imithi
Ucwaningo lwezesayensi mayelana nemishanguzo yokuguqula izifo ze-MS lithole ukuthi akugcini nje ukwehlisa inani lokubuyiselwa komuntu kodwa nokuthi nokuthi labo ababuyiselwayo baphinde bahlukumezeke kangakanani. Ngaphezu kwalokho, ucwaningo lubonisa ukuthi imishanguzo yokuguqula isifo inciphisa inani nobukhulu bezilonda (njengoba kuboniswe kuMMIs ebuchosheni kanye / noma intambo yomgogodla) futhi kunciphise ukuqhubekela phambili kwe-MS.
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Indlela Antibiotic for Acne Ingasiphatha Ngemitholampilo Isolated Isifo
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Kungani Ukulungisa I-Myelin Sheath Kuyinto Yokugxila Okuyinhloko ku-MS Research
Ngenxa yalezi zifundo, i-National MS Society iluleka ngokuqinile abantu abasanda kutholakala ukuthi banezinhlobo ze-MS zokuqala ukuzolashwa ngesifo sokuguqula isifo ngokushesha. Kukholelwa ukuthi ekuqaleni uqala, kuphakamisa ithuba lakho lokunciphisa umthwalo wakho wesifo.
Kukhona imithi eyishumi nanhlanu evunyelwe yi-United States Food and Drug Administration (FDA) yokwelapha amafomu okubuyiselwa emuva kwe-MS (abantu abane-MS ekubuyiseleni kabusha kanye nabantu abane-MS okuqhubekayo noma eyesibili eyathuthuka). Enye yale mithi iphinde ivunyelwe abantu abane-MS (Ocrevus) eyinhloko eqhubekayo kanye neyodwa evunyelwe ukuba i -MS (Novantrone) encane eqhubekayo.
Izifo
Kukhona imithi eyisishiyagalombili efakwe engxenyeni ye-muscle (yangaphakathi) noma ngaphansi kwesikhumba ibe ngamathishu akho amafutha (ngezansi). Ezinhlanu zala mithi yizokwelapha ze-interferon futhi zifaka:
- I-Avonex
- I-Betaseron
- I-Extavia
- Plegridy
- Rebif
Ama-interferons ama-proteine evame ukukhiqizwa ngumzimba womzimba ngokuphendula isifo sofuba. Kukholelwa ukuthi kubantu abane-MS, izindlela zokwelapha ze-interferon zihlonza ukuphendula komzimba komuntu, okuholela ekunciphiseni ukuhlaselwa okuqondiswa yi-myelin ngaphakathi kobuchopho bomuntu nomgogodla. I-Myelin igxilisa ama-fibre we-nerve futhi, lapho emele noma ebhujiswa (eyenzeka nge-MS), izinzwa azikwazi ukuxhumana komunye nomunye.
Imithi yokwelapha i-Interferon ivame ukubekezelela kahle kodwa ingabangela ubuhlungu noma ubomvu endaweni yesikhumba lapho umuthi ujova khona. Ngaphezu kwalokho, abanye abantu babhekana nezimpawu ezinjenge-flu nelolu hlobo lwezokwelapha, nakuba lokhu kuvame ukuba ngcono ngesikhathi.
Ngokuya nge-interferon ethize oyithathayo, udokotela wakho angabheka umsebenzi wegazi (njenge-isibindi noma ukuhlola kwegazi lesisindo) noma ukubuza imibuzo mayelana nomlando wakho wezokwelapha ngaphambi kokuyibeka.
Ngokwesibonelo, udokotela wakho angase abuze ukuthi unomlando wokucindezeleka-ongadala ukwelashwa kwe-interferon.
Iminye imithi emibili ye-MS ejoqwayo yokuguqula isifo yi- Copaxone ne-Glatopa (uhlobo olujwayelekile, olubizayo lweCopaxone). Njengokwelapha kwe-interferon, ososayensi abaqiniseki kahle ukuthi i-Copaxone noma i-Glatopa isebenza kanjani, kodwa bakholelwa ukuthi le mithi ifana neprotheyini eyenza i-myelin, ekugcineni ididela isimiso somzimba sokuzivikela ekuhlaseleni i-myelin yangempela.
Umphumela ovamile ovamile we-Copaxone ne-Glatopa uyindlela yokusabela endaweni yokujova, efana ne-interferon therapy. Ukushintshanisa amasayithi okugaya nokusebenzisa i-compress efudumele ngaphambi kokujova kungasiza ekunciphiseni ukusabela okunjalo.
Futhi, amaphesenti angaba ngu-16 abantu abathatha i-Copaxone noma i-Glatopa bahlangabezana nokusabela kokungenwa kwe-post-injection okungabangela izimpawu ezisabekayo njengenhliziyo yokugijima noma ukukhathazeka. Izindaba ezinhle ukuthi lezi zimpawu ngokuvamile zanyamalala zingakapheli imizuzu engu-15 futhi azikho imiphumela yesikhathi eside.
Enye imithi eguqulwa isifo-i- Zinbryta (daclizumab).
Le mithi i-antibody ngokumelene ne-molecule ebizwa nge-CD25 kuma-T-cells, ama-cell-anti-cell cells. I-Zinbryta ikholelwa ukunciphisa izilonda ze-MS ngokunciphisa inani lama-T-cells emzimbeni owaziwayo ukuhlasela i-myelin ku-MS. I-Zinbryta inikezwa kanye ngenyanga, ngaphansi kwesikhumba. Ngenxa yokuthi inamandla okubangela ukonakala okukhulu, izinkinga zesifo esesongela impilo nezinkinga ezihlobene nesistimu ye-immune, iZinbryta zingenziwa kuphela ngohlelo olukhethekile.
I-Oral Therapies
Kunezinhlobo eziyisihlanu zokwelapha ezithathelwana ngesifo se-MS, okuyinto engcono kakhulu kubantu abangakwazi ukubekezelela izijovo noma abantu abane-MS abaqhubeka beqhubeka naphezu kwe-interferon therapy kanye / noma i-Copaxone.
UGilyena (fingolimod) iphilisi ethathwa kanye ngosuku. Ngokuyinhloko isebenza ngokuvimbela amaseli athile omzimba omzimba ukuba angashiyi ama-lymph nodes. Njengoba ama-T-amangqamuzana anamathele ema-lymph nodes, akakwazi ukungena ebuchosheni nasendlini yomgogodla ngakho-ke abangela izilonda .
Kunemiphumela emibi ehlobene noGilyena njengekhanda, umkhuhlane, isifo sohudo, nobuhlungu bomhlane.
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Iyini Impendulo YaseCopaxone Ngokushesha Kwangemva kokuzizwa?
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Amaqiniso kuGilenya Ngaphandle Kokuba Ukwelapha Okuqala Kwe-MS Oral
U-Gilyena angabangela nemiphumela engathí sina kakhulu njengemibono ephikisayo, izinkinga zokuphefumula noma isibindi, kanye nezifo. Ngenxa yekhono likaGilyena lokubangela ukuncipha kwenhliziyo, ukuqapha amahora ayisithupha emva kokuthatha umthamo wokuqala kuleso simo sokunakekelwa kwezempilo.
Enye imithi ye-MS yomlomo i-Tecfidera (dimethyl fumarate) -pilisi ethathwe kabili nsuku zonke. Le mithi ishukumisa indlela emzimbeni ovame ukuvulwa lapho amangqamuzana egcizelelwe. Ngamanye amazwi, kusiza ukuvikela amangqamuzana, nakuba ngokuqondile ukuthi lokhu kusebenza kanjani kumuntu one-MS akucacile.
Imiphumela emibi ejwayelekile ye-Tecfidera iqhuma, i-nausea, isifo sohudo, nobuhlungu besisu. Imiphumela emibi kakhulu ibandakanya ukusabela okunzima kakhulu, ukuthuthukiswa kwe- letifencephalopathy (i-brain-threatening condition condition), kanye nokwehliswa kwamaseli okulwa nokutheleleka komuntu.
I-Aubagio (i-teriflunomide) ithathwa kanye ngosuku futhi ingabangela ukukhanda ikhanda, izinwele ezincibilikayo, isifo sohudo, isicanucanu, noma ukuhlolwa kwegazi okungavamile. I-Aubagio isebenza ngokuvimbela isimiso somzimba sokuzivikela, ngakho-ke singenza abantu bafake izifo.
Njengoba i-Aubagio ingabangela ukuhluleka kwesibindi, udokotela wakho uzohlola ukuhlolwa kwegazi lesibindi ngaphambi kokuqala imithi bese kuthi emva kwesikhathi. I-Aubagio iphinde ibe yisigaba X sokukhulelwa, ngakho ngeke isetshenziswe ngenkathi owesifazane ekhulelwe noma uma ehlela ukuthi akhulelwe.
I-infusions
I-Lemtrada (alemtuzumab) imithi eguqulelwe isifo se-MS esinikezwe izinsuku ezinhlanu ngokulandelana bese izinsuku ezintathu zilandelana ngonyaka owodwa. Ngenxa yokuthi kunezixwayiso eziningi ze-FDA ezixhunywe ku-Lemtrada, zinganikezwa kuphela ngohlelo olukhethekile futhi zigcinwe abantu abane-MS abaye basabela ngokungenele eminye imithi emibili noma ngaphezulu eguqulwa yisifo.
Esinye esibangela imithi yokuguqula izifo nguNovantrone (mitoxantrone), imithi yokwelapha i-chemotherapy enikezwa njalo ngemva kwezinyanga ezintathu. Ngaphandle kokwelapha amafomu e-MS , i-mitoxantrone ingasetshenziselwa ukuphatha i- MS yesibili eqhubekayo . I-Mitoxantrone ingabangela ukulimala kwenhliziyo, ngakho-ke inganikwa inombolo elinganiselwe yezikhathi. Kuye kwahlanganiswa nokuthuthukiswa kwe- acute myeloid leukemia (AML).
Imithi yesithathu eyenziwe nge-MS imishanguzo yokuguqula isifo sikaTysabri (natalizumab) , esinikezwa zonke izinsuku ezingu-28. Kungenziwa kuphela esikhungweni esivumelekile sokukhipha imfucuza ngenxa yengozi yokuthuthukisa i-letifencephalopathy multifocal (PML) eqhubekayo- ukutheleleka okungase kubulawe kobuchopho obuhlobene ne-JC virus .
I-Ocrevus (ocrelizumab) iyindlela yokwelapha ye-MS entsha evunyelwe i-FDA, evunyelwe kokubili ukubuyisela kabusha iMMS kanye ne-MS eyinhloko yokuqhubekayo (owokuqala). Inikezwa njengokwesikhuthaza njalo ezinyangeni eziyisithupha.
Njenge-anti-monoplonal anti-humicised antibody, i-Ocrevus ibopha ekomlekheni ngamaseli e-B okuthiwa yi-CD20, ngaleyo ndlela ukunciphisa inani lamaseli B emzimbeni wegazi lomuntu. Ngaphandle kwamangqamuzana e-T, amaseli B elinye uhlobo lwesistimu yomzimba omzimba olukholelwa ukuthi lidlala indima ekulimaleni nasekulahlekeni kwami.
Izindlela zokwelashwa ezizayo
Izindaba ezinhle ukuthi ososayensi bafunda kabanzi nge-MS usuku ngalunye, okusho ukuthi inoveli, izindlela zokwelapha ezingcono zivela. Ezinye izidakamizwa ezingase zibe khona (njengamanye ama-antibodies) ezizigaba zangaphambili zokutadisha. Ezinye izindlela zokwelashwa, njenge- stem cell transplantation ne- estriol , ziphikisana kakhulu-ikakhulukazi ngoba azikho izifundo ezinkulu zesayensi ukuze zivuselele ukusetshenziswa kwazo.
Okokugcina, indawo eyodwa yokucwaninga iyingxenye yokudla ku-MS, kuhlanganise ne- vitamin D supplementation kanye nama-bacterial gut . Nakuba kungekho ukudla okuqondile (njengokudla kwe- Swank) ukuthi abantu abane-MS kufanele balandele ngokuphelele, ukudla okunempilo okunomsoco ocebile futhi ophansi kumafutha kunconywa yi-National MS Society.
Ukwelapha Izimpawu
Nakuba kubalulekile ukuba ube nemithi yokuguqula isifo se-MS yakho, kubalulekile futhi ukwandisa induduzo yakho nokusebenza kwakho. Eqinisweni, ukubhekana ne-MS kuyinkqubo yansuku zonke kubantu abaningi, okudinga uhlelo olucatshangelwe lokuthi ungaphatha kanjani usuku ngokulinganayo kwesisindo semikhawulo yakho.
Izindaba ezinhle ukuthi kunezindlela zokwelapha eziningana zokusiza umuntu one-MS noma othandekayo wakhe azizwe kahle futhi aphathe izimpawu ezingakhululekile noma ezinzima. Lezi zindlela zokwelapha zihlanganisa:
- Imithi
- Izindlela Zokuphila
- Amasu okuvuselela
- Ukwelashwa okuhambisanayo
Isibonakaliso esisodwa esibucayi kakhulu kubantu abaningi abane-MS ukukhathala- konke okuhlanganisa, ukukhathala okunobunzima okungenza imisebenzi elula efana nokugqoka ekuseni noma ukugxila enkampanini enzima futhi engathandeki. Kodwa kunezinhlobo eziningi zokulwa nalo, kuhlanganise:
- Ukuzivocavoca nsuku zonke kuhlolwe ngezidingo zakho ngosizo lomuthi wezinto eziphilayo
- Imithi yomzimba yengqondo efana ne-yoga
- Imikhuba emihle yokulala ifana nokugcina isimiso esifanayo sokulala nsuku zonke
- Ukugwema ukushisa
- Imithi efana ne- Symmetrel (i-amantadine) , i- Provigil (i-modafinil) , noma i-Ritalin (i-methylphenidate)
Njengokukhathala, kunezinhlobo ezihlukahlukene zokwelapha kwezinye izimpawu ezihlobene ne-MS. Isibonelo, ukuzindla kokwelashwa okuhambisanayo kungasetshenziswa ekwelapheni ubuhlungu obuhlobene ne-MS njengoba kungaba nemithi efana ne-gabapentin ngezinhlungu ezihlobene nesifo senzwa kanye nokuphumula kwemisipha ebuhlungu obuhlobene nemisipha ( spasticity ).
Ukubona isazi kungasiza futhi ekulawuleni izimpawu zakho. Udokotela wezokwelapha noma umjozi wezinkinga zokubeletha angakwazi ukwelulekwa noma ukuhlinzeka ngezindlela zokwelapha ekulawuleni ukungasebenzi komzimba okuhlobene ne-MS, njengokungasebenzi kahle kwe-erectile kumadoda noma ukunciphisa ubuhlungu besisu / i-clitoral kwabesifazane. Isazi sezinzwa zegazi singasiza umuntu olwa nokuhlukunyezwa kwengqondo . Kubantu abane-MS abadinga amadivaysi okuhamba okusizayo, uchwepheshe wezempilo nomzimba angasiza ekukhuliseni ukuzimela nokusebenza ngaphakathi kwekhaya lakho nasemsebenzini.
Izwi elivela
Zama ukubekezela njengoba wena kanye nethimba lakho lokunakekelwa kwezempilo le-MS ukhipha uhlelo oluhle kakhulu lwezokwelapha-ibhalansi enesibindi phakathi kokunciphisa i-MS yakho ngenkathi unciphisa imiphumela emibi futhi unciphisa indlela ozizwa ngayo. Khumbula i-MS yisifo esiyingqayizivele, ngakho-ke lokho okusebenza kumngane noma othandekayo kungase kungabi ngcono kuwe.
Futhi, njengoba isifo sakho sithuthuka noma sithuthuka ngemva kokubuyela emuva, izimpawu zakho kanye nezinqumo zokwelashwa zingashintsha. Zama ukuhlala uzivumelanisa nezimo futhi uxoxe ngemicabango yakho kanye nokukhathazeka nge-neurologist yakho. Qhubeka uhlale uqinile emoyeni wakho we-MS.
> Imithombo:
> Bloomgren G et al. Ingozi ye-lealiencephalopathy ehambisana ne-natalizumab ehambisana ne-multifocal. N Engl J Med . 2012 Meyi 17; 36620): 1870-80.
> Burness CB & Deeks ED. I-dimethyl fumarate: ukubuyekezwa kokusetshenziswa kwayo ezigulini ezine-sclerosis ephindaphindiwe. I-CNS Izidakamizwa . 2014, 28 (4): 373-87.
> Fazekas F et al. I-fingolimod (Gilyena) ingabe i-algorithm yokwelashwa yokuvuselela kakhulu ukubuyisela emuva-ukubuyisela izifo eziningi? Ngaphambili Neurol . 2013; 4: 10.
> I-Lycke J. Monoclonal antibody zokwelashwa zokwelashwa kokubuyiselwa kabusha-ukulungisa izifo eziningi: ukuhlukanisa izindlela kanye nemiphumela yomtholampilo. I-Ther Adv Neurol Disord . 2015 Nov; 8 (6): 274-293.
> National MS Society. Izifo-Ukuguqula Imithi Ye-MS .
> Namjooyan, F., Ghanavati, R., Majdinasab, N., Jokari, S., & Janbozorgi, M. (2014). Ukusetshenziswa kwemithi ehambisanayo neyehlukile ku-multiple sclerosis. I-Journal of Medicine Complementary Medicine , Jul-Sep; 4 (3): 145-52.