U-Adriamycin-owaziwa nangokuthi u-Rubex, i-Doxil, i-doxorubicin ne-Red Devil (i-term informal) -iyisidakamizwa se- chemotherapy . Ngokuqondile, luhlobo lwe-anthracycline antibiotic eliyisidakamizwa esilahlayo. Yenziwe kusukela ku- Streptomyces yebteri.
Sebenzisa i-Adriamycin
I-Adriamycin ingasetshenziselwa ukwelapha isandulela-masinya noma isifo somdlavuza wesifuba se-node-positive, umdlavuza webele we-HER2, nesifo se-metastatic.
Ngezinye izikhathi i-Adriamycin ihlanganiswe ne- Cytoxan kanye / noma i- 5-fluorouracil ukwenza i-cocktail yemithi yokwelapha isifo somdlavuza webele.
Lesi sidakamizwa siphinde sivunyelwe ukwelashwa kwamanye amagciwane, kuhlanganise ne-ovarian, isambiso, izicubu ezithambile kanye ne-sarcoma ye-osteogenic, umdlavuza omncane wamangqamuzana wesifo samaphaphu, i-thyroid ne-gastric cancers, kanye neuroblastoma, i-lymphoma, i-leukemia, i-Wilms tumors kanye ne-sarcoma ye-Kaposi.
Indlela i-Adriamycin esebenza ngayo
U-Adriamycin ulwa nomdlavuza ngokunciphisa noma ukuvimbela ukukhula kwamangqamuzana omdlavuza. Lesi sidakamizwa sifinyelela emangqamuzaneni omdlavuza, singene ngaphakathi kwesakhiwo se-DNA futhi simisa ukuphindaphinda kweseli ngokuvimbela umsebenzi we-enzyme okuthiwa i-topoisomerase-II. I-Adriamycin iphinda idale i-oxygen yama-radicals mahhala, okonakalisa izitho zangasese namaprotheni futhi angathinta inhliziyo.
Indlela i-Adriamycin enikezwa ngayo
Lesi sidakamizwa sinikezwa umjovo ngesikhathi sokukhipha kwamakhemikhali . Uma umthamo we-Adriamycin owunikezwayo ukhulu kakhulu, unganikezwa njengemjovo "push", kunokuba uqhube umgogodla.
Lesi sidakamizwa esibomvu esizobomvu sizohanjiswa esikhwameni esikhulu sepulasitiki, esizoxhunyaniswa nesibhubhe sakho se-catheter, futhi umhlengikazi wakho we-infusion uzokucindezela kancane kancane i-plunger ngesandla, ukufaka i-Adriamycin emithanjeni yakho.
Ngaphambi kokwelashwa kokuqala
Ngenxa yokuthi le mithi ingabangela izinkinga zenhliziyo, kufanele ube nesiskena se- MUGa , i-LVEF (ukuhluleka kwe-ventricular failure) noma ukuhlolwa kwezempilo yenhliziyo okwenziwe ngaphambi kokuqala ukwelashwa.
Lokhu kuhlolwa okuyisisekelo kuzosetshenziselwa ukuqhathanisa nenhliziyo yakho umsebenzi ngesikhathi nangemva kokwelashwa. Okunye ukuhlolwa kwezinso zezinso nesibindi kungase kudingeke.
Izincomo Ngesikhathi Ukwelashwa
- Sebenzisa ukuvimbela ngokweqile - gwema ukukhulelwa
- Phuza amanzi amaningi, ikakhulukazi amanzi, ukugcoba izinso zakho nesibindi
- Gwema ukuphuza udoti kanye ne-caffeine - lezi zicubu zakho zomile
- Ungathathi i-aspirin, ngoba ithokoza igazi lakho
- Ungatholi imithi
Izingozi
- Ukusabela okwenziwe nge-allergen kuya ku-adriamycin
- Kungalimaza ingane, uma ukhulelwa ngenkathi ukwelashwa
- Ukungabikho kokusasa esikhathini esizayo
- Igazi eliphansi libala , ingozi enkulu yezifo
- Kwezinye izimo, kunengozi yokulimala kwenhliziyo
Imiphumela Ezingenakwenzeka
- Umchamo obomvu kuqala ezinsukwini ezimbili emva kokwelashwa
- I-neutropenia (isibalo esincane segazi elimhlophe, ingozi enkulu yokutheleleka)
- I-anemia eyenziwa yi-chemotherapy (inani elibomvu seli-red red)
- I-Thrombocytopenia (inani leplatelet eliphansi )
- Ukulahlekelwa izinwele, noma izinwele ezincane ezipholile
- I-nausea
- Ukuvota
- Uhudo
- Ukukhathala
- I-Mucositis (i-membrane enomsindo emangalisa emlonyeni wakho, esiswini, kanye nomgudu wokugaya)
- I-Amenorrhea (umjikelezo wenyanga ukuya esikhathini)
- Izinguquko ezinzipikili (ezincane noma eziphuzile)
Nini Ukubiza Udokotela Wakho
Uma unayo yalezi zimpawu, shayela udokotela wakho:
- Umkhuhlane we-100.5F noma ngaphezulu
- Ubuhlungu noma ubomvu kusayithi lakho lokujova
- Umchamo wamanzi noma ukujuluka okubomvu
- Iziphazamiso ezingavamile noma ukuphuza okuqhubekayo
- Ukukhwehlela okuqhubekayo, umkhuhlane, umkhuhlane
- Izimpawu zokwelapha: ukuphefumula, ukuvuvukala kwezinyawo noma ama-ankles, ukuqhuma, ukuqhuma komlomo noma ulimi
Sicela wazi ukuthi Extravasation kwenzeka kuphela ngesikhathi ukumnika.
Imithombo
Ukuphathwa kwe-US nokuDrug. I-FDA Doxorubicin Ephakanyisiwe PI Update. Ithebula Elivunyelwe Lokugcina - May 8, 2003.
I-National Cancer Institute. Ulwazi Lwezidakamizwa - Doxorubicin Hydrochloride.
I-Medline Plus. Izidakamizwa & Izithako. I-Doxorubicin.