Ukwanda kwamathambo e-rheumatoid kwenyuka phakathi kwabesifazane
I-arthritis ithinta abesifazane kaningi kunamadoda. Lokhu kuyiqiniso eziningi - kodwa hhayi zonke izinhlobo ze-arthritis . Ngemuva kweminyaka engamashumi eminyaka, ukwehla kwamathambo e- rheumatoid kwenyuka phakathi kwabesifazane. Kungani abesifazane besithinteka kakhulu yi-arthritis?
Okwenza Abesifazane Abaningi Kunabantu Abano-Arthritis
Sabuza isazi sezinshukela uScott J. Zashin, MD, ukuthi kungani abesifazane abaningi kunamadoda abane-arthritis.
UZashin wathi:
Izifo ezizenzakalelayo zivame kakhulu kubantu besifazane. I-Lupus isibonelo esihle salesi senzakalo. Abesifazane ngaphambi kokuya esikhathini bangase babe nezintambo ezingu-15 zandisa ingozi ye-lupus uma kuqhathaniswa namadoda. Noma kunjalo, ngemva kokuya esikhathini, leyo ngozi iyancipha ngamaphesenti amabili kuphela, okusikisela ukuthi ama-hormone wesifazane angakhuphula ingozi ye-lupus. Ngaphezu kwalokho, kucatshangwa ukuthi ama-estrogens amaningi asetshenziselwa ukwelashwa ngomlomo esikhathini esidlule kungenzeka ukuthi wadlala indima ekwenzeni umsebenzi we-lupus noma lupus.
I-estrogen ephansi emisha iyabonakala ivikelekile kulokhu uma isiguli singenayo ingozi yezingxube zegazi (njengama-anti-phospholipid antibodies). Ngakolunye uhlangothi, izifundo zezilwane ziye zabonisa ukuthi ama-hormone wesilisa anganciphisa lesi sifo kumagundane. Kungani ithonya le-hormone lidlala indima kulezi zimo akucacile. Enye inkolelo yokuthi i-estrogen idlala indima ekuthinteni amangqamuzana e-B ne-T ahileleke ekuphenduleni komzimba.
Ku-arthritis ye-rheumatoid, abesifazane baphindela izikhathi ezintathu ukuthuthukisa isimo kunamadoda. Kuyathakazelani ukuthi abesifazane abaningi abane-arthritis ye-rheumatoid baya ekuxoxweni ngesikhathi sokukhulelwa. Kuze kube manje, akekho oye wakwazi ukucacisa isizathu esiqondile salomphumela omuhle, kodwa enye inkolelo ukuthi ukuguqulwa kwamazinga e-hormone kungabangela izinga lamaprotheni egazini elifaka isandla ekuvukeni.
I-Arthritis Ye-Rheumatoid Iphakeme Phakathi Kwabesifazane
Ngokwe-Mayo Clinic Study, emva kweminyaka engama-40 yokuncipha (phakathi neminyaka ka-1955 kuya ku-1994), izigameko (imvamisa yezinto ezenzekayo) kanye nokusabalalisa (isibalo esiphelele samacala endaweni esinikeziwe) se-arthritis ye-rheumatoid phakathi kwabesifazane senyukela. Kusukela ngo-1995 kuya ku-2005, isifo samathambo esifubeni phakathi kwabesifazane sasingama-54 ku-100 000 uma kuqhathaniswa nama-36 kwangu-100 000 eminyakeni eyishumi edlule.
Kwabesilisa, lesi sigameko sagxilile ku-29 kwabayi-100 000. Abacwaningi baphetha ngokuthi isimo esingokwemvelo singachaza ukuguquguquka komkhuba kubantu besifazane.
Imithombo:
I-Arthritis Ye-Rheumatoid ingase iqhubeke nokuvuka kwabafazi. UGabriel S. et al. I-American College of Rheumatology.
http://www.rheumatology.org/press/2008/2008_press_12.asp
UDkt. Zashin uprofesa wothisha osebenza emtholampilo e-University of Texas Southwestern Medical School kanye nodokotela ozofika esibhedlela sasePresbyterian eDallas nasePlano. UDkt Zashin ungumbhali we- Arthritis Ngaphandle Kokuhlungu - Ummangaliso Wama-Blockers we-TNF . Le ncwadi iyasiza kunoma ubani kwenye yezidakamizwa ze-biologic noma ucabangela izidakamizwa ze-biologic.