Imishanguzo Emisha Ngaphambi Kokuqhathaniswa ne-Placebo
Uma imishanguzo emisha itholakala, kuyimvelo ukubuza ukuthi ingaqhathanisa kanjani nokuphumelela kulawo mayeza asevele atholakalayo. Endabeni ye- Hetlioz , ethengiswa ngaphansi kwegama elithi generimette, kubalulekile ukuhlola ukuwusizo kwalo ekuphatheni ukungasebenzi kwe- Non-24-Sleep Sleep-Wake (okungewona-24) . Ingafani kanjani ne- melatonin , ukwelashwa okujwayelekile kwalesi sifo?
Ukuqhathaniswa kocwaningo Phakathi kukaHetlioz noMelatonin
Kubekho ukuhlolwa kocwaningo lwezokwelapha okuqhathanisa nokusetshenziswa kwe-Hetlioz ne-melatonin ngendlela ekhanda kuya phezulu. I-US Food Administration and Drug Administration (FDA) evunyelwe i-Hetlioz esekelwe ukuhlolwa kwe-placebo. Lokhu kusho ukuthi u-Hetlioz, osebenza kuma-receptors ebuchosheni nge-melatonin, wawuphumelela kakhulu ekuphatheni okungewona ama-24 kunamaphilisi e-placebo. Ukuphumelela kwalo akuzange kube khona kuleli phuzu kuqhathaniswa ngqo nokuthatha i-melatonin engaphezu kwe-counter, eyake ibe yinkinga yokunakekelwa kwalesi simo.
Izincomo ezijwayelekile zokwelashwa
Emihlahlandleleni yayo yokugcina kusukela ngo-2007, ngaphambi kokutholakala kweHetlioz, i-American Academy of Sleep Medicine (AASM) uncoma ukusetshenziswa kwe-melatonin ekwelapheni okungewona u-24. Ukuze kuqinisekiswe izilinganiso ze-circadian ezihloswe ngokofuzo ezingaholela ekujikelezeni ukulala nokulala ngokweqile , i-melatonin ingaba yimpumelelo kakhulu.
Lokhu kuqiniswa kubizwa ngokuthi ukuxhaswa. Izinga lokulala nokuvusa abantu abayizimpumputhe zingaqondaniswa, noma ziboshwe, kumaphethini emini yelanga.
Lokhu kungenziwa ngezinga elincane kakhulu le-melatonin engaphezu kwe-counter. Kubalulekile ukukhetha umkhiqizi ohloniphekile oqinisekisa ukuthi izinga lomkhiqizo lihambisana nobunikazi.
Ngokuvamile, amanani amancane (0.3 mg) angasetshenziselwa ukuqhutshwa kwabantu abayizimpumputhe abangenazo 24. Uma kuqhathaniswa, imikhiqizo eminingi yokwengeza ngokuvamile iqukethe 3 mg we-melatonin (izikhathi ezingu-10 okudingekayo) noma ngaphezulu. Le melatonin ngokweqile ingase ikhukhumeze uhlelo, ihambisane nezinzuzo futhi ingase iholele emiphumeleni emibi.
Isikhathi somthamo we-melatonin sibalulekile. Kungadinga usizo lomchwepheshe wokulala ukuze kuqinisekiswe ukuthi inani lomthamo kanye nesikhathi kufanelekile.
Ukuhlola Imiphumela Yokwelapha
Uyazi kanjani ukuthi ukwelashwa kusebenza? Ngaphandle kokuthuthukiswa okuphawulekayo, kungasiza ukulandelela ukusebenza kokwelapha kwezinye izindlela zomgomo. Izingolo zokulala kanye nezindlela zokuhlola ze-laboratory zezigaba zesigaba se-circadian zingasiza.
Okubaluleke kakhulu, kubantu abane-Non-24 abangaboni kahle, ukuvezwa kokukhanya okufinyelelwe isikhathi kungase kube yindlela yokwelapha ewusizo.
Sethemba ukuthi ucwaningo oluthe xaxa luzokwenza ukufaniswa okuqondile phakathi kweHetlio ne-melatonin, kodwa okwamanje ungacabangela ukuxoxa ngezinketho zokwelashwa ngezobuchwepheshe bakho bokulala ukuze ubone ukuthi ungakhetha kanjani.
Imithombo:
Arendt, J et al . "Ukuvumelanisa umjikelezo wokulala ophazamisekile kumuntu oyimpumputhe ukwelashwa kwe-melatonin." I- Lancet .
1988; 1: 774-773.
I-Morgenthaler TI et al . "Imikhawulo yokuzikhandla yokuhlolwa kwemitholampilo nokwelashwa kwezidakamizwa zokulala eziphakathi komzimba: Umbiko we-American Academy of Sleep Medicine." Ukulala . 2007; 30: 1445-59.
Lewy, AJ et al . "Amanani aphansi, kodwa hhayi aphezulu, ayenziwa nge-melatonin aqeqesha umuntu oyimpumputhe ongekho mahhala okwesikhashana eside." I- Chronobiology International . 2002; 19: 649-658.
Tzischinsky, O et al . "Ukubaluleka kokwenza isikhathi ekuphathweni kwe-melatonin kumuntu oyimpumputhe." I- Journal ye-pineal ucwaningo . 1992; 12: 105-108.
Isaka, RL et al . "Ukuxoshwa kwemigqa ye-circadian free-run by melatonin kubantu abayizimpumputhe." NEJM .
2000; 343 (15) 1070-1077.
Isaka, uRL noLeyy AJ. "Izimpikiswano zokulala ze-circadian: izifundo ezivela ezimpumputhe. 2001; 5 (3): 189-206.