Okushiwo yi-Research
Inambuzane yezokwelapha ingxabano-emphakathini, ngokomthetho, nasezombangazwe. Kodwa-ke, ubufakazi besayensi buqhubeka nokuphakamisa ukuthi kungaba ukwelashwa okuphephile futhi okuphumelelayo kwezimo eziningi zobuhlungu, kuhlanganise ne- fibromyalgia .
Sinezinye izinguqulo zokwenziwa kwe-tetrahydrocannabinol (THC) emakethe, okuyizinto ezihlobene ne "phezulu" yensangu.
Kodwa-ke, ukuhlola kusikisela ukuthi ezinye izinhlanganisela ezitshalweni zingaba nezinzuzo zokwelapha.
Ngaphambi kokuxoxa ngemiphumela ethize yezokwelapha kwezokwelapha ku-fibromyalgia, kusiza ukwazi kancane ngokuthi into ebizwa ngokuthi i-endogenous cannabinoid, noma i-endocannabinoid, uhlelo.
Iyini uhlelo lwe-Endocannabinoid?
"Endogenous" ibhekisela kokuthile okuvela ngaphakathi emzimbeni wakho-into engokwemvelo lapho.
"I-cannabinoid" ivela egameni elithi i-cannabis, elibizwa ngokuthi igama lobuchwepheshe lesitshalo se-marijuana, futhi libhekisela ezingxenyeni zomzimba wakho osabela ku-cannabis. Sonke sinezinhlanzi zemvelo emzimbeni wethu, futhi okuningi kungathathwa ngokubhema noma ukungenisa imbuni noma izinguqulo zokwenziwa kwalo.
Uhlelo lwe-endocannabinoid lubandakanyeka ezinkambisweni eziningi, eziningi zazo ezaziwa noma ezichazwa ukuthi zikhubazekile ku-fibromyalgia. Lokhu kufaka:
- I-metabolism yamandla
- Umsebenzi omzimba
- Imemori
- Ukucubungula ubuhlungu
- Ukulala
- Impendulo yokucindezeleka
- Umthetho wokushisa
- Isistimu ye-neon autonomic
Iphepha le-2004 le-endocannabinoid lihlongozwa ukuthi i-fibromyalgia, isifo sofuba esiyingozi, kanye nemibandela ehlobene nayo ibhekwa ngokuthi "i-endocannabinoid insufficiency syndromes". Iphinde ichaze izinkinga zokucwaninga ngokucwaninga ngalesi sibonakaliso ku-schizophrenia, i-multiple sclerosis, isifo sikaHuntington, ezinye izifo zesifo sikaParkinson, ezinye izimo ze-anorexia, nokugula okungapheliyo.
Ukucwaninga komzimba okukhulayo okuphakamisa ukuthi i-fibromyalgia ingase ibandakanye ukungabi nalutho ekupheleni kwe-endocannabinoids iphakamisa umbuzo ocacile: ingabe ukwandisa inani lamakhomikhali emzimbeni kusiza ukuthuthukisa umsebenzi nokunciphisa izimpawu? Uma kunjalo, yiziphi izimpawu ukuthi ingozi yezokwelapha (noma ukulinganisa okulinganayo) kuyosiza ekunciphiseni?
Ucwaningo nge-Marijuana yezokwelapha ne-Fibromyalgia
Ukubuyekezwa kocwaningo lwe-marijuana ngo-2014 ngokuphatha i-fibromyalgia, kanye nezimo ezihlobene nesifo sofuba nesifo samagciwane, okuphakanyisiwe:
- Ukuntuleka kwe-Endocannabinoid kudlala indima kulezi zimo
- I-Marijuana inamandla okuvimbela izindlela zokugulisa umgogodla, ukuphika komzimba kanye nokuphuza emathunjini
- Okuhlangenwe nakho kwemitholampilo kuvumelana nalezi zithole
Ucwaningo lubonisa ukuthi inambuzane ingakwazi kakhulu:
- Nciphisa ubuhlungu (okufaka ubuhlungu obungenayo i-nociceptive, okuyingxenye ye-fibromyalgia)
- Nciphise ukuqina
- Ukuvuvukala okuphansi (okufaka ukuvuvukala kwe-myofascial, okungase kudlale indima ku-fibromyalgia)
- Thuthukisa ukuphumula
- Ukwandisa ukulala
- Ukwandisa imizwa yenhlalakahle
Ucwaningo olulodwa lubuye lwabona ukuthi abasebenzisi be-cannabis babe nenani eliphezulu lempilo yengqondo kunabangewona abasebenzisi. Enye, ebheka umphumela we-synthetic cannabinoid okuthiwa i-nabilone, iphakamisa ukuthi umthamo ophansi ebusuku ungathuthukisa ukulala e-fibromyalgia futhi kungabhekwa njengenye indlela e-amitriptyline ethandwayo yokucindezeleka.
Ucwaningo olwenziwa ngo-2012 lubheke ukusabalala kokusetshenziswa kwensangu ku-fibromyalgia. Abacwaningi bathola ukuthi cishe amaphesenti angu-13 abahlanganyeli basebenzisa lesi sidakamizwa ukusiza ukukhulula izimpawu zabo. Kulezi, amaphesenti angaphezu kwangu-80 ayisebenzisa ngokungemthetho.
Abacwaningi bathola nokuthi ukusetshenziswa kwamanoni kwakungenzeka kakhulu kwiziguli ze-fibromyalgia ezinokugula kwengqondo ezingazinzile. Ubuhlobo phakathi kokusetshenziswa kwamagciwane nokugula kwengqondo kuleli qembu akuwaziwa.
Ukusetshenziselwa i-Marijuana kwakunabantu abaningi, abahlanganyeli abangasebenzi, nalabo abathola izinkokhelo zokukhubazeka.
Okuqhamuka uma udla imishanguzo
Ukubuyekezwa kuka-2011 kuchaza ukuthi ama-cannabinoids avela ephephile futhi ahlotshaniswa nemiphumela emibi engalingani noma elinganisiwe eyayivame ukubekezelela kahle, nokuthi izinga lokudonsa ngenxa yemiphumela emibi laliphansi.
Imiphumela emibi ebikiwe ifakiwe:
- Isizungu
- I-nausea
- Umlomo omile
- I-Ataxia (ukulawulwa okunciphise ukunyakaza komzimba)
Kodwa-ke, ukutadisha kuka-2014 kubonisa ukuthi sidinga izifundo zesikhathi eside ukuze ukwazi ukuthi imiphumela emibi yesikhathi eside ingaba yini, kanye nezingozi ezingase zibe khona zokusebenzisa kabi izidakamizwa nokulutha.
Ukwelashwa Okusekelwe Emanzini
Ezinye izinhlobo zokwenza inambuzane zisemakethe e-US Lezi zidakamizwa zihlanganisa:
- I-Marinol (i-dronabinol)
- I-Cesamet (nabilone)
Ubuthi lwezokwelapha busemthethweni emazweni amaningana. Leli fomu lezidakamizwa lingabhema, lidliwe (njengezimpahla ezibhaka), noma liphefumlelwe ngamanzi. Amafomu okudla noma aphefumulelwe angase aphephe futhi alula kwabanye abantu ukubekezelela.
Ngenxa yokutholakala kwayo njengesidakamizwa sokuzilibazisa, abanye abantu bakhetha ukuzithokozisa ngamanoni ngokungemthetho. Lokhu kuza nezingozi zayo siqu, kufaka phakathi:
- Ukuboshwa, icala futhi ulahlwe yicala
- Ukuthola inambuzane ngezinto ezingase zibe yingozi ezifakiwe
- Ukuthola umkhiqizo ongaphansi
Abantu abasebenzisa inambuzane ngokungemthetho bangase banqabe ukutshela abahlinzeki babo bezempilo ngalokhu. Lokhu kungaholela ezinkingeni zokusebenzisana kwezidakamizwa noma, uma kwenzeka ukusabela okubi kakhulu, kubangelwa odokotela ukuba bangaziqondi kahle le nkinga. Ukuze uthole ukuphepha kwakho, kufanele njalo utshele udokotela wakho kanye nemithi mayelana nayo yonke imithi oyithathayo.
Okunye Ukwelashwa Kwesistimu ye-Endocannabinoid
Ukucwaninga kusikisela ukuthi ezinye izidakamizwa eziningi, kokubili imithi kanye ne-over-the-counter, zithinta uhlelo lwe-endocannabinoid. Lokhu kufaka:
- Ama-Painkillers (i- acetaminophen , i- NSAID , ama-opioid , i-glucocorticoids)
- Ama-antidepressants ( amitriptyline , duloxetine )
- Antipsychotics
- Ukukhathazeka ngezidakamizwa
- Izidakamizwa zokulwa ne-Anti-seizure ( pregabalin , gabapentin)
Ukwelashwa okungewona izidakamizwa okungase kuphumelele kufaka:
- Ukushisa
- Ukuxhaphazwa kwamagciwane
- I-Acupuncture
- Izithako
- Imithi yamagciwane
Izindlela zokuphila ezihlanganisa nokudla nokuzivocavoca zingase zenze nezinguquko ohlelweni lwe-endocannabinoid. Njengoba kunoma iyiphi indlela yokwelashwa noma yokuphatha, kufanele ukhulume nodokotela wakho ngokuthi yini ongakhetha ngayo.
Imithombo:
UBenyamina A, Reynaud M. La revue du praticien. 2014 Feb; 64 (2): 165-8. (Isihloko ngesiFulentshi. Abstract ekhonjisiwe.) Ukusetshenziswa kokwelashwa kwezidakamizwa ze-cannabis.
Fiz J, et al. PLoS One. 2011 Apr 21; 6 (4): e18440. I-cannabis isebenzisa iziguli ezine-fibromyalgia: umphumela wokukhululeka kwezimpawu kanye nekhwalithi yokuphila ephathelene nempilo.
ULynch ME, uCampbell F. British Journal yemithi yezokwelapha. 2011 Nov; 72 (5): 735-44. I-cannabinoids ekwelapheni ubuhlungu obungapheli bomdlavuza obungapheli; ukubuyekezwa okuhlelekile kokuhlolwa okungahleliwe.
I-McPartland JM. I-Journal of bodywork kanye nokunyakaza kwemithi. 2008, 12 (2): 169-82. Ukuveza uhlelo lwe-endocannabinoid ku-fibroblasts nama-myofascial tisses.
McPartland JM, Guy GW, Di Marzo V. PLoS One. 2014 Mar 12; 9 (3): e89566. Ukunakekelwa nokudla kwesimiso se-endocannabinoid: ukubuyekezwa okuhlelekile kokungenelela okusemtholampilo okuphakamisa uhlelo lwe-endocannabinoid.
Russo EB. Izincwadi ze-Neuro endocrinology. 2004 Feb-Apr; 25 (1-2): 31-9. Ukwelashwa kwe-endocannabinoid yomtholampilo (i-CECD): ingabe lo mqondo ungachaza izinzuzo zokwelapha ze-cannabis ku-migraine, i-fibromyalgia, i-irritable bowel syndrome kanye nezinye izimo ezingamelana nemithi?
Smith SC, Wagner MS. Izincwadi ze-Neuor endocrinology. 2014; 35 (3): 198-201. Ukuntuleka komtholampilo we-endocannabinoid (CEC D) ubuyekezwa: ingabe lo mqondo ungachaza izinzuzo zokwelapha zokudla i-cannabis ku-migraine, i-fibromyalgia, i-irritable bowel syndrome kanye nezinye izimo ezingamelana nemithi?
Ste-Marie PA, et al. Ukunakekelwa kwe-Arthritis nokucwaninga. 2012 Aug; 64 (8): 1202-8. Inhlangano ye-herbal isnabis isebenzisa imingcele engafanele yengqondo kwiziguli ezine-fibromyalgia.
Ware MA, et al. I-anesthesia ne-analgesia. 2010 Feb 1; 110 (2): 604-10. Imiphumela ye-nabilone ekulele e-fibromyalgia: imiphumela yesilingo esilawulwa ngokungahleliwe.