Antiinflammatories: Izingozi Nokucabangela
Uma une fibromyalgia (FMS) nesifo esingapheliyo sokukhathala ( ME / CFS ), ungagcina uthatha imishanguzo eminingi ehlukene, kuhlanganise nemithi ejwayelekile yobuhlungu. Nakuba lokho kungakusiza uzizwe futhi usebenze kangcono, kungase kube yingozi. Kukhokhwa ukuqonda ngempela izidakamizwa ezitholakalayo kuwe.
Izinhlobo eziningana zama-painkillers zitholakala ngaphezu kwe-counter (OTC), futhi amaphesenti amakhulu ethu anikwa abanikazi bokugulisa iziguli esikhathini esithile ekuguleni kwethu.
Lezi zidakamizwa zinezingozi zazo kanye nemiphumela emibi, kanti abanye bangakwazi ukusebenzisana kabi neminye imithi.
Enye yezinhlobo ezivame kakhulu zama-painkillers izidakamizwa ezilwa nokuvuvukala. Uhlobo oluvame ukusetshenziswa lwe-anti-inflammatories lubizwa ngokuthi ama-NSAID, okumelela izidakamizwa ezingekho-steroidal ezilwa nokuvuvukala. Ama-OSA ama-NSAID adumile afaka:
- U-Advil, uMotrin (ibuprofen)
- I-Aleve, i-Naprosyn (naproxen)
- Bayer, Bufferin, Excedrin (i-aspirin)
Lezi zidakamizwa nazo zitholakalayo emandleni okugunyazwa. Ama-NSAID kuphela ahlanganisa:
- I-Relafen (nabumetone)
- UFeldene (piroxicam)
- I-Orudis (ketoprofen)
- I-Voltaren (i-diclofenac)
- I-Lodine (etodolac)
- I-celebrex (i-celecoxib)
Abaningi bethu bajwayele ukusetshenziswa kwe-NSAID ukunciphisa ubuhlungu obubangelwa ukuvuvukala. Kodwa-ke, amanye ama-NSAID anganciphisa ubuhlungu ngokuvimbela ama-enzyme athile ayingxenye yomphendvulo womzimba wakho ekuthandeni okubuhlungu. Akucaci ukuthi le ndlela iphumelela yini ngokumelene nezinhlobo ezingavamile zobuhlungu ezihlobene ne-FMS .
Ngenxa yalesi sizathu, ukuthambekela nodokotela ukuhlinzekela ama-NSAID ambalwa futhi kunalokho ukubeka izidakamizwa ezisebenza ohlelweni lwezinzwa, lapho ukukholelwa kwethu kuvela khona. Lokhu ngokusho kocwaningo olwanyatheliswa encwadini ka-2013 ye-European Journal of Medicine.
Ezinye izifundo zibonisa ukuthi ukuvuvukala kudlala indima ebalulekile kuM ME / CFS .
Ingabe i-FMS ivuvukala , noma kunjalo? Ngokuvamile kubhekwa ukuthi akunjalo, kodwa isifundo esibhalwe nguGinevra Liptan, MD, sikhombisa ukuthi kuhilela ukuvuvukala kwe-fascia.
Kungakhathaliseki ukuthi yiziphi izindima ezithile zokuvuvukala kulezi zimo, siyazi ukuthi abantu abaningi bathatha ama-NSAID ngezinhlungu ezihlobene ne-FMS ne-ME / CFS, kanti ezinye lezi zifo nazo zithatha ama-NSAID kwezinye izinkinga zezokwelapha ezibandakanya ukuvuvukala.
Izinhlekelele ze-NSAID
Ngenkathi ungathola ama-NSAID emakhaya amaningi futhi uthenge cishe noma yikuphi, ayenayo izingozi ezinkulu.
Ngokusho kwe-American Journal of Medicine, abantu abangaphezu kuka-100 000 bayiswa esibhedlela ngenxa ye-NSAID minyaka yonke e-US Ukwengeza, abantu abangu-15-20,000 bafa minyaka yonke ezinkingeni ezihlobene ne-NSAID njengezilonda nokugaya kwamathumbu, kanye namaphesenti angama-60 e-NSAID abasebenzisi bangathuthukisa imiphumela emibi yokugaya.
I-NSAID ixhunyaniswe nengozi eyengeziwe yokwehla kwesifo senhliziyo noma isifo sohlangothi. Lezi zidakamizwa zingaholela ezinkingeni zesibindi noma izinso, futhi.
Ukuthatha ama-NSAID amabili ndawonye kuyingozi-isifundo se-2004 esashicilelwe kuyi-European Journal of Clinical Pharmacology sibonise ukuthi kwandisa ingozi yokulimala kwesibindi noma ukwehluleka kwezinso ngamaphesenti angu-500 kuya ku-600 phezu kokusetshenziswa kwe-NSAID eyodwa.
Ukusebenzisa isikhathi eside, njengokungathi ungalindela ngesimo esingapheli, kungandisa lezi zingozi.
Ezinye zezinkinga ezivela ekusetshenzisweni kwe-NSAID zingase zibe ngenxa yokucabanga kwabantu mayelana nezidakamizwa ze-OTC. Bangase bacabange ukuthi akubalulekile noma kuyingozi futhi ngakho-ke ungabiki udokotela noma umuthi wezokwelapha. Kubalulekile ukuthi laba ochwepheshe bezempilo bazi konke okuthathayo, kuhlanganise nezidakamizwa ze-OTC nezithako zokudla, ngakho bangakusiza ukuba ugweme izinkinga ezinkulu.
I-NSAID Imiphumela Yecala Nokusebenzisana
Ngaphandle kwezingozi ezingenhla, ama-NSAID angabangela imiphumela emibi emibi. Okuvamile kakhulu:
- I-nausea
- Ukuvota
- Uhudo
- Ukuqokwa
- Ukuncipha kokudla
- Rash
- Isizungu
- Izinwele
- Ukulala
Eminye yemiphumela emibi (izinkinga zokugaya ukudla, isizungu, ukukhanda ikhanda, ukulala) nazo izimpawu ezivamile ze-FMS ne-ME / CFS. Uma uqala ukuthatha i-NSAID entsha, kubalulekile ukuphawula noma yikuphi ukuguqulwa kwezimpawu ezingase zibe ngenxa yemithi.
Ama-NSAID angahlanganyela ngokungafani nezinye izidakamizwa eziningana, ngakho-ke qiniseka ukuthi ukhuluma nodokotela wakho kanye nemithi mayelana nemithi yakho yonke.
Ngenxa yokuthi ama-NSAID anciphisa ikhono lakho legazi lokugqoka, kungaba yingozi ukuwahlanganisa nama-anticoagulants (igazi elincane) njengeCoumadin (warfarin).
Uma uphathwa nge- hypertension (high blood pressure), udinga ukwazi ukuthi ama-NSAID angenza imithi yakho ingasebenzi kahle.
Ukunciphisa Ingozi Yakho
Ngokusho kwe-FDA, ukuvikela impilo yakho kufanele usebenzise ama-NSAID kuphela njengoba ushiwo, ngenani eliphansi kunazo zonke, futhi njengesikhathi esifushane ngangokunokwenzeka.
Uma ubuhlungu bakho bungapheli, leso sincomo sokugcina kunzima ukulandela. Qiniseka ukubika noma yimuphi ukwanda kwemiphumela emibi kudokotela wakho. Udokotela wakho angase afune ukuqapha izimpawu zesifo semibindi uma uthatha ama-NSAID isikhathi eside.
Ukubhema ugwayi nokuphuza utshwala kungandisa ingozi yezilonda ezihlobene ne-NSAID noma izinkinga zokuphuma kwegazi, zombili zazo ezingabangela isiteleka ngaphandle kokuxwayisa futhi zingakubulala. Qinisekisa ukuthi udokotela wakho uyazi ngokubhema nokusetshenziswa kotshwala.
Izwi kusuka
Wena nodokotela wakho kufanele nithathe isinqumo ndawonye ukuthi ngabe ama-NSAID afanelekile yini, ngokususelwa ekuhloleni kwakho, izimpawu, impilo yonke kanye nezici zokuphila. Kubalulekile ukuqaphela ukuthi i-NSAID eyodwa ingase ikusebenze kangcono kunabanye, ngakho-ke kungathatha ukuhlolwa ngezidakamizwa ezahlukene ukuze kufeze imiphumela emihle kakhulu.
Uma ungaboni ukuthi ama-NSAID asebenza kahle ekunciphiseni ubuhlungu bakho, khuluma nodokotela wakho mayelana nezinye izindlela ezingenzeka futhi ulinganise ingozi ngezinzuzo.
Imithombo:
I-Carruthers BM, et. al. Umbhalo wezokwelapha zangaphakathi. 2011 Oct; 270 (4): 327-38. i-doi: 10.1111 / j.1365-2796.2011.02428.x. I-myalgic encephalomyelitis: Izilinganiso zamazwe ngamazwe okuvumelana.
Cindezela F, futhi. al. Umagazini waseYurophu wemithi yokwelashwa. 2004 Jun; 60 (4): 279-83. Inhlangano ephakathi kokusetshenziselwa ukusebenzisana kweziNSAID eziningana zesistimu kanye nengozi eyingozi yokuphendula izidakamizwa ezimbi. Icwaningo / icala elingekho-cala kusukela ku-French Pharmacovigilance system database.
I-Kovac SH, et. al. I-arthritis ne-rheumatism. 2008 Feb 15; 59 (2): 227-33. Uhlobo lwezinga eliphezulu lokuphila elihlobene nempilo kanye nokusetshenziswa kabili kwemithi yesidakamizwa kanye ne-over-counter-anti-anti-inflammatory drugs.
Liptan GL. I-Journal of bodywork kanye nokunyakaza kwemithi. 2010 Jan; 14 (1): 3-12. UFascia: isixhumanisi esingekho ekuqondeni kwethu ukugula kwe-fibromyalgia.
U-Wolfe F, et al. Umagazini weYurophu wezinhlungu. 2013, 17 (4): 581-6. Amaphethini ase-longitudinal we-analgesic kanye ne-central central abasebenzisa izidakamizwa kanye nokusebenza okuhambisanayo ku-fibromyalgia.