I-Oral Flupirtine: Efile Emanzini?
Awukho isikhathi eside kuPayipi?
Isidakamizwa esibizwa ngokuthi i-oral flupirtine sasibonisa isithembiso njengendlela yokwelashwa okusha kwe- fibromyalgia emuva ngo-2008, lapho kubonakala sengathi izidakamizwa zizoqala ukuhambisa indlela eya ku-FDA imvume. Nokho, kusukela ngaleso sikhathi, kubonakala sengathi iwile ku-radar.
I-Oral flupirtine itholakale eYurophu kusukela ngawo-1980. Lapho, isetshenziselwa ukuphatha ubuhlungu obuvela emithonjeni eminingana, kuhlanganise nokuhlinzwa, umdlavuza, ukuhlukumezeka nesifo sesibindi.
Unomlando omude wethrekhi njengomuthi ophephile futhi osebenza kahle.
I-US FDA inikeze i-Adeona Pharmaceuticals isicelo soPhenyo olusha lweDrug ukuze kuqalwe ukulingwa ku-fibromyalgia. Igama elithi Brand Effirma libhaliswe kulo.
I-Adeona inkontileka nePipex Pharmaceuticals ukuze isebenzele ekufakeni i-FDA, kodwa i-website yangaphambili ye-Pipex isiphelile manje. U-Adeona ekugcineni washintsha igama layo waba yi-Synthetic Biologics, kanti u-Effirma akashiwo noma yikuphi ku-website ye-Synthetic's. Akukho lutho olufakwe ku-FDA, futhi akukho zinshumo ezintsha ezishicilelwe.
Okwamanje, kubonakala sengathi le mithi ifile emanzini e-US Lokho kuyisibi, ngoba ihluke kwezinye izidakamizwa kanye nezidakamizwa ze-fibromyalgia ngezindlela ezithakazelisayo nezingazuzisa.
Indlela i-Oral Flupirtine isebenza ngayo
I-Oral flupirtine ayiyona i- opiate / i-narcotic , futhi akuyona imithi yokucindezeleka noma i- anti-seizure , okwenza ihluke kakhulu kwezinye izidakamizwa ezisetshenziselwa ukwelapha i-fibromyalgia .
U-Adeona uthe uthembele ukukhombisa ukuthi izidakamizwa ziphathwe ngaphezu kobuhlungu be-fibromyalgia, kodwa futhi zithuthukisa imizwa, ukukhathala, izinkinga zokucabanga, ukuphazamiseka kokulala nokusebenza jikelele.
I-oral flupirtine isebenza ngendlela ehlukile kunemithi ejwayelekile yokuhlunguphazwa ngenxa yokuthi ihlose izindlela ezibuhlungu ebuchosheni.
Ama-opiate , ahlale engasebenzi kubantu abane-fibromyalgia, phakamisa izinga lakho le-dopamine, okubangela ukuba ujabule. Esikhundleni sokuvimbela ubuhlungu, ama-opiates akukhathalela kancane ngobuhlungu.
I-Oral flupirtine, ngakolunye uhlangothi, inomphumela omuhle kwezinye izakhiwo zobuchopho okuthiwa yi-NMDA receptors futhi, ngenxa yalokho, ihlisa izinga lakho le- glutamate . I-Glutamate yi-neurotransmitter eyenza amangqamuzana akho obuchopho asebenze.
Izifundo ezanyatheliswa ngo-2008 no-2009 (i-Harris) zibonisa ukuthi abantu abane-fibromyalgia bangaba namazinga aphezulu okuthiwa i-glutamate ezindaweni ezithile zobuchopho nokuthi uma amazinga e-glutamate ehla, kunjalo namazinga obuhlungu. Lokhu kwenza uketshezi komlomo kube ngumuntu okhangayo okhangayo kithi.
Abantu abane-fibromyalgia banezikhathi ezinzima kakhulu zokubekezelela imithi. Imithi yokwelashwa esetshenziswa njalo ukusiphatha, okwamanje, inezinhlu ezindala zemiphumela emibi futhi kungaba nzima kakhulu ukubekezelela. I-Oral flupirtine irekhodi yaseYurophu njengesidakamizwa esiphephile esinemiphumela embalwa yocala futhi yenza kube mnandi. Futhi akudingeki ukuba ugxile kancane kancane kulowo muthi, noma, njengoba wenza ngezinqubo eziningi zamanje zokwelashwa kwe-fibromyalgia.
Yini Manje?
Kubonakala sengathi sithemba lethu kuphela manje ukuthi i-Synthetic noma enye inkampani inquma ukuqala ukucwaninga ngomlomo we-oral flupirtine.
Ngisho noma kungenxa yesinye isimo, kuyosizuzisa - ukugunyazwa kwe-FDA kungasho ukuthi kuyoba emakethe e-US kanye nodokotela bangasichazela yona ngelebuli.
Noma kunjalo, leyo nqubo ithatha iminyaka. Ngakho-ke ngaphandle uma ufuna ukuthuthela eYurophu, akubukeka sengathi uzokwazi ukuthatha umlomo we-flupirtine nganoma isiphi isikhathi maduzane.
Imithombo:
U-Harris RE, et al. I-arthritis ne-rheumatism. 2008 Mar; 58 (3): 903-7. Amazinga anamandla we-glutamate ngaphakathi kwe-insula ahlobene nokuthuthukiswa kwezizinda eziningi zobuhlungu ku-fibromyalgia.
U-Harris RE, et al. I-arthritis ne-rheumatism. 2009 Okthoba; 60 (10): 3146-52. Ukuphakama kwe-glutamate e-fibromyalgia kuhlotshaniswa nobuhlungu bokuhlola.