Iyini i-Glutamate?
Incazelo:
I-Glutamate uhlobo lomuthi wezobuchopho okuthiwa i- neurotransmitter , okusho ukuthi kuyasiza ukudlulisa imiyalezo emayelana nobuchopho. Ngokuvamile kuhilelekile ekufundeni nasekukhunjweni. I-glutamate nayo ihileleke ezinhlokweni eziningi zezinzwa.
Futhi ebizwa ngokuthi: L-glutamic acid, i-glutamic acid, i-L-glutamate
Ngokuvamile Udidekile Nge: Glutamine
I-Glutamate yenza imisebenzi edingekayo ebuchosheni bakho.
Ibhekwa njenge-neurotransmitter ye-excitatory, okusho ukuthi ivuselela izindawo zobuchopho noma ezinye izingxenye zesimiso sezinzwa. Lolu hlobo lokuvuselela luyingxenye ebalulekile yenqubo yokufunda, ngakho ngaleyo ndlela, i-glutamate yinto enhle.
Nokho, eziningi ze-glutamate akuyona into oyifunayo. Kwezinye izimo, kungaba yilokho okubizwa nge-excitotoxin. "I-Toxin" ayidabuli igama elihle, futhi ngokuqinisekile alilungile kulokhu. Engxenyeni yayo njenge-excitotoxin, i-glutamate ingadlula ngaphezu kwamangqamuzana akho obuchopho.
Uma amazinga aphakeme engahambelwanga, lo mqondo we-neurotransmitter ungadlula kakhulu lawo maseli kuze kube yilapho ethatha isenzo esikhulu futhi enza ukuzibulala kwamaselula ukuze avikele amaseli azungezile. (Cabanga njengokuthatha izinyo ezibolayo ukuze ukubola kungakafiki emazinyo eduze kwalo.)
Amaseli emzimbeni wethu afa ngaso sonke isikhathi, futhi iningi lawo lingashintshwa. Nokho, labo abashayela i-glutamate bazibulala, kuyi-neurons.
Ubuchopho bakho abukwazi ukwenza amasha ukuthi athathe isikhundla salowo olahlekile, ngakho-ke kubalulekile ukuwagcina enempilo futhi ephephile.
Indima ye-glutamate njenge-excitotoxin ikholelwa ukuthi ihileleke ezinhlobonhlobo ezihlukahlukene ze-neurodegenerative ezifana ne-multiple sclerosis, isifo se-Alzheimer kanye ne- amyotrophic lateral sclerosis (eyaziwa njenge-ALS noma isifo sikaLou Gherig).
I-glutamate dysregulation nayo icatshangwa ukuthi iyisici se- fibromyalgia nesifo esingapheliyo sokukhathala , nakuba lezi zimiso zingabhekwa njenge-neurodegenerative.
I-glutamate ne-Fibromyalgia
Ucwaningo lubonisa ukuthi abantu abane-fibromyalgia banezinga elingavamile kakhulu le-glutamate endaweni yechungechunge okuthiwa i-insula noma i-cortex e-insular. I-insula ihileleka kakhulu ekwenzeni kokubili ubuhlungu nemicabango. Amazinga aphezulu e-glutamate awuphawu lokuthi lesi sifunda sobuchopho singase sigxile kakhulu kule nkinga.
I-insula nayo ihileleke ku:
- izinzwa
- ukukhathazeka
- amakhono emoto
- izifiso
- ukuphazamiseka kokudla
- umlutha
Ku-fibromyalgia, ukungena kwe-sensory kungakhuliswa, okuholela ekugqibeleni . Ukukhathazeka yisimo esibonakalayo / isimo esidlulayo. Amakhono emoto angase aphelelwe amandla, okuholela ekubhekaneni nezinkinga nokuwa phansi . Ukuphazamiseka kokudla kungase kuvame kakhulu kubantu abane fibromyalgia, futhi.
I-Glutamate ikhona ezindaweni zomzimba ngaphandle kwesistimu yezinzwa, lapho isebenza njenge-hormone. Kule ndima, kungabangela ubuhlungu.
Ucwaningo lwango-2016 lubonisa ukuthi ukuvivinya umzimba kunganciphisa ubuhlungu obuhlobene ne-glutamate kubantu abane-fibromyalgia, engasiza ukuchaza ukuxhumana okungaqondakali phakathi kwalesi simo nokuzikhandla .
I-glutamate ku-Chronic Fatigue Syndrome
Izifundo zihlukaniswa ngokuthi i-glutamate dysregulation idlala indima ekudleni okungapheliyo ukukhathala, isimo esibandakanya nokuxoshwa kokukhathazeka, ukukhathazeka, nokunyakaza / ukulinganisela .
Ngokuphambene ne-fibromyalgia, ucwaningo lubonisa ukuthi amazinga e-glutamate angase aphansi ezindaweni ezithile zobuchopho. Lokho kunengqondo uma ucabangela ubuchopho obuchopho obuhlobene nalesi sifo, okufaka izinkinga zokufunda.
Siphinde sibe nobufakazi bokuthi lesi sifo esingapheliyo sokukhathala singabandakanya izakhi zofuzo ezihlobene ne-glutamate dysregulation.
I-Monosodium Glutamate
Njenge-amino acid, i-glutamate iyisici se-monosodium glutamate (MSG), esetshenziselwa imithi ethile futhi njengesengezo sokudla.
Kungase kuhlotshaniswe nezinye izinto ezimbi ezithinta impilo.
Abanye odokotela bezempilo bakholelwa ukuthi i-MSG ingaba yingozi kubantu abane-fibromyalgia, kanti abanye bakholelwa ukuthi akunjalo. Abanye abantu bathi ukuqeda i-MSG ekudleni kwabo kusize ukunciphisa izimpawu ze-fibromyalgia nesifo esingapheliyo sokukhathala, kodwa lezi zimangalo aziqinisekiswa yisayensi yezokwelapha.
I-Glutamate & Neurotransmmitter Eminye
Ungase uzibuze ukuthi ubuchopho bakho busebenzelana kanjani namazinga aphezulu e-glutamate. Inesisombululo-enye i-neurotransmitter ebizwa nge-GABA. Umsebenzi we-GABA uwukuzolalisa ubuchopho bakho emva kokuba i-glutamate ithole konke.
Kubalulekile ukuthi ama- GABA namazinga a-glutamate ahlelwe ngokulinganayo , kepha lokho akuvamile ukugula okuhlobene ne-glutamate.
Amanye ama-neurotransmitters ahilelekile kulezi zimo afaka:
- i-serotonin
- melatonin
- i-norepinephrine
- i-dopamine
UHannestad U, Theodorsson E, Evengård B. Iphephabhuku lamazwe omhlaba wemithi yamakhemikhali. 2007 Feb; 376 (1-2): 23-9. i-beta-Alanine ne-gamma-aminobutyric acid e-syndrome engapheliyo yokukhathala.
I-Harris RE, et. al. I-arthritis ne-rheumatism. 2009 Okthoba; 60 (10): 3146-52. Ukuphakama kwe-glutamate e-fibromyalgia kuhlotshaniswa nobuhlungu bokuhlola.
Kuratsune H, Yamaguti K, Lindh G, et al. I-NeuroImage. > 2002 Nov; 17 (3): 1256-65. Izifunda ze-Brain ezihilelekile ekuzweleni ukukhathala: kuncishiswe ukunciphisa i-acetylcarnitine ebuchosheni.
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U-Smith AK, uFang H, u-Whistler T, et al. I-Neuropsychobiology. > 2011; 64 (4): 183-94. Izinguquko zokuguqula izifo zikhomba ukubambisana kwe-GRIK2 ne-NPAS2 ene-syndrome engapheliyo yokukhathala.