Ingxenye 2 kwezingu-3
Njengoba sifunde ingxenye eyodwa, Kuyini i-Post-Exertional Malaise, abantu abane- syndrome engapheliyo ( ME / CFS ) abone ukukhuphuka okuphawulekayo okubonakalayo ngemva kokusebenza. Lesi yisibonakaliso esibonakalisiwe sesi sifo futhi abacwaningi bebelokhu bezama ukuthola iminyaka. Sisenokuningi okumele sikufunde ngalesi sibonakaliso, kodwa siyazi ukuthi izimo eziningi ezingokwemvelo zihlobene ne-malaise emva kokucindezela (PEM).
Ukungahleleki Kwemvelo
Abacwaningi baye baqaphela ukungalingani okuhlobene nokuzivocavoca kwezimo eziningi, kuhlanganise nesistimu yomzimba, isimiso sezinzwa esiyinhloko nesimiso senhliziyo. Kuze kube manje, abazange bakwazi ukuphetha ngokuthi lezizinto ezingavamile ziyisizathu (s) se-PEM. Ukubuyekezwa kuka-2014 kwezincwadi zezokwelapha ezikhomba izimpendulo eziningana zokuguqula izivikeli mzimba eM ME / CFS, eziningi zazo ezaziboshwe ekuzivocavoca kanye ne-PEM. Lezi zihlanganisa:
- Impendulo ekhulunywe ngokwengeziwe esimisweni sokuxhaswa (ingxenye yamasosha omzimba asiza izifo ezilula ezivela emzimbeni wakho),
- Ukwenyuka kokucindezeleka okwenziwe nge-oxidative (uhlobo lomonakalo wamangqamuzana) kuhlangene nomphendvulo omncane we-antioxidant,
- Ukuguqulwa kwiphrofayli yegciwane lesigenjana segciwane lesigciwane.
Olunye ucwaningo (i-Morris 2014) luye lwahlola okungavamile okuphathelene nomuthi okuthiwa i-adenosine triphosphate (ATP), okuyinto ifomu lamandla eselula. I-ME / CFS ikholelwa ukuthi ihlotshaniswa nekhono elingakwazi ukudala i-ATP ezingeni le-mitochondrial.
(I-Mitochondria yizinhlaka kumaseli akho eziguqula izakhi zibe i-ATP.)
Ukutadisha kuka-2015 usebenzisa imodeli ye-computer yesifo (Lengert) ubukele amazinga aphansi a-ATP, okuvame ukuholela ezingeni eliphezulu lokufa kweseli. Ukusabela kwe-chain kokuqala nge-ATP ephansi kuholele ekutheni ukucindezeleka kwe-immunological nokucindezeleka kwe-oxidative, ngokusho kohlobo.
Abacwaningi bathi ukuzama ngokuphindaphindiwe kwenza isimo sibe sibi nakakhulu. Ngo-2012, iphepha elihlola umsebenzi we-mitochondrial kanye ne-ME / CFS (i-Morris) lixoxe ngezinto eziningi ezingavamile, kuhlanganise:
- Kwasungula izindlela zokuzivivinya umzimba,
- Amazinga akhula ama- cytokines anama -pro-inflammatory,
- Izinga elikhulayo le-nuclear factor-kB,
- Ukubheka emisebenzini ye-mitochondrial, kufaka phakathi ukukhiqizwa okuphansi kwe-ATP.
Abacwaningi bathi lezi zici zingase ziholele ekukhatheni kwemithichondrial, okungenani ingxenye, okusho ukuthi lapho umzimba udinga amandla (ngendlela ye-ATP), amandla asuke engekho.
Olunye ucwaningo luka-2015 lwalusebenzisa uhlobo lokuskena oluthiwa yi-near-infrared spectroscopy ukukala ukusetshenziswa kwe-oxygen ngesikhathi sokuvivinya umzimba. Uma kuqhathaniswa nabantu abanempilo eqenjini lokulawula, abahlanganyeli abane-ME / CFS batholakala ukuthi banezinguquko ezingavamile okwenziwe umoya-mpilo we-hemoglobin (iprotheni elayini elibomvu legazi elihambisa i-oksijini emaqenjini wakho) ngemuva kokusebenza.
Noma yikuphi ukuhlanganiswa kwalezi zici kungase kube negalelo lokufaka isandla ku-PEM. Noma kunjalo, abacwaningi banomsebenzi omkhulu ngaphambi kwabo. Abanye abacwaningi basikisela ukuthi ezinye izinto ezingavamile zingasetshenziswa njengenhloso yokuhlonza i-ME / CFS ngenkathi abanye bakholwa ukuthi i-PEM ingaba yindlela ewusizo odokotela bokulinganisa ubuhlungu bokugula.
Okubaluleke nakakhulu, lapho sifunda okwengeziwe ngalokho okuqhubekayo emzimbeni ngesikhathi se-PEM, sisondelene kakhulu nokuqonda ukuthi singayiphatha kanjani.
Funda kabanzi
Imithombo:
Lengert N, Drossel B. I-chemical chemistry. 2015 Jul; 202: 21-31. Ukuhlaziywa kwe-silico kokungabekezelelani ngokweqile ku-myalgic encephalomyelitis / chronic fatigue syndrome.
UMiller RR, et al. I-Journal yemithi yokuhumusha. 2015 Meyi 20; 13: 159. Ukuhlolwa kokuvivinya umzimba okuncane kakhulu nge-spectroscopy eseduze-ye-infrared in syndrome ye-myalgic encephalomyelitis / chronic fatigue syndrome uma kuqhathaniswa nokulawulwa okunempilo: isifundo esilawulwa ngecala.
UMorris G, ama-Maes M. Medical Hypotheses. 2012 Nov; 79 (5): 607-13. Ukwanda kwe-nuclear factor-kB nokulahlekelwa kwe-p53 yizinqubo ezibalulekile ku-myalgic encephalomyelitis / chronic fatigue syndrome (ME / CFS).
UMorris G, Maes M. Izifo zobuchopho zobuchopho. 2014 Mar; 29 (1): 19-36. Izidakamizwa ze-mitochondrial ku-myalgic encephalomyelitis / chronic tiredness syndrome echazwe ngezindlela ezicindezelayo zokugonywa kwe-immuno-inflammatory, oxidative ne nitrosative.
I-Nijs J, Nees A, et al. Ukuzivocavoca ukuhlolwa kwe-immunology. 2014; 20: 94-116. Impendulo ye-immune eguqulekile ekusebenziseni iziguli ezinesifo esingapheli syndrome / myalgic encephalomyelitis: ukubuyekezwa kwezincwadi ezihleliwe.