Imvubelo yemvubelo ebomvu (i-RYR) iyinzuzo yokudla eye yadayiswa njengomkhiqizo ongenalo odokotela wokunciphisa i- cholesterol .
I-RYR isetshenziselwe eChina amakhulu eminyaka kokubili ukupheka nokuphatha izifo zokugaya nokugaya ukudla. Kodwa-ke, njengoba isetshenziswe e-US isikhathi esincane kakhulu, senze umehluko omkhulu.
Iyini Rice Rice Yeast?
I-RYR ngumkhiqizo welayisi okwenziwa ngokuvutha irayisi ne- Monascus purpureus isikhunta.
Iqukethe izinto eziningana ezinganciphisa amazinga e-cholesterol, kufaka phakathi i- beta-sterols , i- monounsaturated fatty acids , nesimiso . Igama lekhemikhali le-statin elibonisa i-RYR yi-monocolin K, kodwa liyaziwa kangcono e-US njenge-lovastatin (edayiswa njenge-Mevacor).
Ingabe i-RYR engaphansi kwe-Cholesterol?
Ucwaningo luye lwabonisa ukuthi i-RYR, njengokwenziwa ngokweqile eChina futhi njengoba yayithengiswa njengendlela yokudla eyengeziwe e-US, empeleni inciphisa amazinga e- LDL ama-cholesterol .
Ngokwesibonelo, ekucwaningweni kweziguli ezingama-83 ezine-cholesterol ephakeme, labo abahlukumeziwe ku-RYR banciphise kakhulu i-cholesterol (204 vs. 338 mg / dL) namazinga e-LDL ama-cholesterol (128 vs. 277 mg / dL) ngemva kwamasonto angu-8, uma kuqhathaniswa nalabo abathatha indawo ye-placebo.
Ukuphikisana
Ukuphikisana yiqiniso ukuthi yi-RYR iqukethe i-statin eyenziwe ngokwemvelo. Izitatimende, ngokusho komthetho, ziyizidakamizwa ngakho-ke zihambisana nomthethonqubo.
Ukuphikisana kwaqala ngo-1999, kungekudala ngemva kokuhlolwa kwamakliniki kuqala kwabonisa ukuthi i-RYR ingaba namazinga e-cholesterol aphansi kakhulu. Ngaleso sikhathi i-FDA yabusa ukuthi i-RYR equkethe i-monocolin K yayiyisidakamizwa, ngakho-ke yayala ukuthi isuse emashalofini. Amacala amacala aqhubeka, futhi (emva kwezinqumo ezimbalwa emuva nangaphandle) iNkantolo Yezikhalo Zokudluliswa Kwezifundazwe ezingu-10 yavumelana ne-FDA.
Ngakho-ke, e-US, i-RYR isengathengiswa ngokomthetho, kodwa kuphela uma izinyathelo zithathwa kwinkqubo yayo yokukhiqiza ukususa i-monocolin K.
I-RYR isatholakala njengesengezo sokudla, futhi ikhiqizwa ngabakhiqizi abaningana. Njengengxenye yokudla, ukubunjwa nokuqukethwe kwayo namanje akulawulwa ngokuqinile. Kunzima kakhulu uma kungenakwenzeka ukuthola ukuthi umkhiqizo othile we-RYR ohlezi eshalofini uqukethe.
Ucwaningo
Lapho ebhekene nakho konke lokhu kudideka, ukuhlolwa kwemitholampilo emibili kuvele kubonisa ukuthi ngisho nasesikhathini se-post-FDA, okungenani i-RYR etholakala e-US iphumelela ekunciphiseni amazinga e-cholesterol.
Ngo-2009, isifundo esivela ePennsylvania sabonisa ukuthi ezigulini ezingama-60 okwadingeka ziyeke ukuthatha izidakamizwa ze- statin ngenxa yobuhlungu besisindo esenziwe ngokomzimba, ukuthatha i-RYR nokuqala izinguquko zokuphila kwamaviki angama-24 kakhulu kuncishiswe kakhulu amazinga we-cholesterol angu-LDL, uma kuqhathaniswa nokuthatha indawo ye-placebo okwenza ukuphila okufanayo kuguquke.
Ngo-2010, abaphenyi baseNyuvesi yasePennsylvania babika ukuthi ezigulini okufanele ziyeke ukuthatha izidakamizwa ngenxa yobuhlungu be-muscle, i-RYR yayisebenza kahle njengama-20 mg ngosuku ngosuku lwe-statin drug pravastatin (Pravachol) ekunciphiseni amazinga e-cholesterol. (Bobabili i-RYR ne-Pravachol bakhiqiza kuphela umphumela ophansi kakhulu wezinhlungu zomzimba eziphindaphindiwe.)
Esicwaningweni sika-2009, abaphenyi benza ukuhlaziywa kwamakhemikhali okwenziwe ngomkhiqizo we-RYR abawasebenzisa ekutadisheni kwabo (kusukela eSyvan Bioproducts eKittanning, ePennsylvania). Bathola ukuthi i-RYR isalokhu iqukethe i-monacolin K kanye namanye ama-monacolin ayisishiyagalombili.
Umphumela walokhu kuhlaziywa kwamakhemikhali kubonisa izinto ezimbili. Okokuqala, okungenani i-RYR etholakalayo e-US ngokusobala iqukethe okungenani i-lovastatin, kanti okwesibili, noma ngabe yonke i-lovastatin isuswe ngokuphelele, amanye amakhemikhali afanayo ku-RYR (okungekho i-FDA engakaye - okwamanje ivinjelwe ngokukhethekile) ingasebenza ekunciphiseni i-cholesterol .
Ingabe Kufanele Uthathe I-RYR?
Emkhathini okungenani, ukuthatha i-RYR kubonakala sengathi kunengqondo okucatshangelwayo uma ufuna izindlela ezingavunyelwe zokuncipha kwe-cholesterol. Kodwa-ke, ukuthi yini ongayenza ngempela ithatha inani eliguquguqukayo nelingaziwa lento ethile efana nesimo se-statin. Akunakwenzeka ukutshela, kusuka kumkhiqizi kuya kumakhi, noma ngisho kusuka ebhodleleni kuya ebhodleleni, ukuthi uyithengi ngempela.
Uma ufuna ukunciphisa i-cholesterol yakho ngaphandle kokulahlekelwa ihembe lakho ezinkampanini ezinkulu zezidakamizwa, cela udokotela wakho mayelana nezidakamizwa zesimo esidala. Zitholakala kalula, ezishibhile (mhlawumbe ezishibhile kune-RYR), futhi njengebhonasi, umthamo owutholayo uzokwaziwa empeleni, futhi ungalawulwa futhi ulungiselelwe ukwenza ngcono imiphumela yakho.
Imithombo:
Halbert SC, isiFulentshi B, uGordon RY, et al. Ukwehluleka kwemvubelo yemvubelo obomvu (2400 mg kabili nsuku zonke) ngokuhambisana ne pravastatin (20 mg kabili nsuku zonke) ezigulini ezinokubekezelelana komthetho wangaphambilini. Am J Cardiol 2010; 105: 198-204.
U-Becker DJ, uGordon RY, Halbert SC, et al. Imvubelo yemvubelo ebomvu ye-dyslipidemia kwiziguli ezingenakubekezela. U-Ann Internal Med 2009; 150: 830-839.
UGordon RY, Cooperman T, Obermeyer W, Becker DJ. Ukuhlukahluka kwamazinga e-monacolin kwimikhiqizo ebomvu yemifino yemifino ebomvu: umthengi qaphela! I-Arch Intern Med 2010; 170: 1722.