Ingabe i-Xopenex ingcono kune-Albuterol?
I-Xopenex (i-levalbuterol) imithi ephazamisekile yokwelapha izimpawu ezinzima ze- asthma , kuhlanganise ukukhwehlela, ukushisa, ukuphefumula nokuqina kwesifuba. I-Xopenex isebenza ngokuphumula imisipha ebushelelezi emaphashini, ngokuvamile phakathi nemaminithi ambalwa ukuthatha imithi. I-Xopenex itholakala kokubili njenge-inhaler kanye nesifomula esinikezwa ngomshini we- nebulizer .
I-Xopenex yi- isomer esebenzayo ye- albuterol (ebizwa nge-R-albuterol noma i-levalbuterol). Izakhi zamakhemikhali zemithi zikhona njengengxube yesithombe esibukweni somunye nomunye (okubizwa ngokuthi ingxube ye-racemic ), futhi eyodwa kuphela yalezi zindlela imithi esebenzayo. Ifomu elingasebenzi (elibizwa nge-S-albuterol noma le-dextroalbuterol) alisebenzi lutho ngaphandle kokuthi "liya endleleni" yefomu elisebenzayo futhi lingase libe nomthelela emibikweni. Lokhu kwakuyisizathu sokuthi kungani i-Xopenex yasungulwa - ukuthuthukisa umsebenzi we-albuterol ngenkathi kunciphisa imiphumela emibi.
Ingabe i-Xopenex Better kune-Albuterol ye-Asthma?
Akucaci ngokuphelele. Lapho i-Xopenex iqala ukuthuthukiswa, izifundo zezilwane zaphakamisa ukuthi i-S-albuterol ibangele ukuvuvukala emaphashini, okungase kube nakakhulu ukulimaza i-asthma. Kwacatshangwa ukuthi njengoba i-albuterol engaphezu kwe-racemic (ingxube ye-R ne-S-albuterol isomers) ithathwe, i-S-albuterol isomeroma yayiyobuthelwa ngaphakathi kwamaphaphu futhi ibangele ukuchotshozwa kwemisipha ebushelelezi emaphashini, ngaleyo ndlela ibe nzima kakhulu izimpawu ze-asthma .
Ngakho-ke, i-Xopenex kulindeleke ukuthi isebenze kangcono ekwelapheni izimpawu ze- asthma kune-albuterol ye-racemic.
Izifundo zakuqala zabonisa ukuthi i-Xopenex yayingcono ekwelapheni i-asthma kune-albuterol, ngoba i-Xopenex encane yayidingeka ukuze kutholakale ukulawulwa kwempawu ze-asthma kunamanani afana ne-albuterol. Njengoba i-Xopenex yisigamu esisebenzayo se-albuterol, umuntu angalindela ukuthi isigamu umthamo we-Xopenex uzolingana ne-dose ye-albuterol; Kodwa-ke, lezi zifundo zacacise ukuthi kuphela eyodwa-yesine yomthamo we-albuterol owadinga ukufezekisa umphumela ofanayo uma usebenzisa i-Xopenex.
Lokhu kwakucatshangwa ukuthi kungenxa yokuntuleka kwe-S-albuterol isomero ku-Xopenex, eyayisebenza ngokumelene ne-R-albuterol isomerom.
Idatha yakamuva ku-Xopenex, noma kunjalo, kanye nokubukeza konke kwedatha etholakalayo, iphakamisa ukuthi i-Xopenex ayikho kangcono ekwelapheni i-asthma kunokuba ingalindelwe. Umthamo we-Xopenex odingekayo ukufezekisa umphumela ofanayo wokwelapha i-asthma kubonakala sengathi uyingxenye eyodwa kwesigamu, yilokho okulindelwe ngoba liqukethe isomerom esebenzayo (i-albuterol). I-S-albuterol isomerom ibonakala sengathi ivulekile, okusho ukuthi ayikwenzi noma imelene nokuphathwa kwezimo ze-asthma.
Ingabe i-Xopenex inezimbalwa ezingezansi kune-Albuterol?
U-Albuterol uyaziwa ngokubangela imiphumela ethile yemiphumela, kufaka phakathi ukuthuthumela kwemisipha, ukujula, ukuguqulwa komzimba kanye nokwanda kwenhliziyo. Ucwaningo oluqala ngo-Xopenex luphakamisa ukuthi ngenxa yokuthi kwakudingeka imithi encane kakhulu ukuze kufinyelele inzuzo efanayo njenge-albuterol, imiphumela emibi ingase ibe khona. Ukwengeza, ekuqaleni kwakucatshangwa ukuthi i-S-albuterol isomerom yayiyinhloko enkulu yemiphumela emibi ye- albuterol, ngakho-ke i-Xopenex, engenayo i-S-albuterol isomerom, ingabangela imiphumela embalwa emibi.
Ucwaningo lwamuva luveza ukuthi imiphumela emibi ye-Xopenex ilingana ne-albuterol ngoba empeleni i-R-albuterol isomerom enomthwalo wemiphumela emibi ye-albuterol.
I-S-albuterol isomer is inert, okusho ukuthi ayinayo emibikweni emibi. Ukufaka iphakethe ye-Xopenex ithi izinga lemiphumela emibi ekhonjwe ngenhla lifana nezilinganiso ezilinganayo ze-Xopenex ne-albuterol.
Funda ukuthi ungayisebenzisa kanjani futhi uhlanze i-Xopenex inhaler .
Imithombo:
Faka iphakethe le-Xopenex [PDF]. I-Sepracor corporation. Ifinyelele ngoJanuwari 13, 2011.
U-Ahrens R, Weinberger M. Levalbuterol no-Racemic Albuterol: Ingabe kukhona ukungafani kokwelapha? J Allergy Clin Immunol. 2001; 108: 681-4.
UMilgrom H, uSkoner DP, uBensch G, et al. I-Levalbuterol Ephansi-Izingane Ezine-Asthma: Ukuphepha Nokusebenza Ngokuqhathanisa ne-Placebo no-Racemic Albuterol. J Allergy Clin Immunol. 2001; 108: 938-45.
Lötvall J, Palmqvist M, Arvidsson P, et al. Ukulinganisa Kwezokwelapha kwe-R-Albuterol kufaniswa nalokhu kwe-RS-Albuterol ezigulini ze-Asthmatic. J Allergy Clin Immunol. 2001; 108: 681-4.