Ukuqonda imithi ephuthumayo nephephile yomshuwalense
Ngenxa yokuthi i-high blood pressure ne- asthma yizifo ezivame kakhulu, kuvamile ukuthi abantu babe nombili ngesikhathi esisodwa. Nakuba lokhu kuhlanganiswa akuyona ingozi engavamile, kungabonisa izinselelo ezinzima zokwelashwa. Ngenxa yokuthi imithi ye-blood pressure esebenzayo futhi eqinisekisiwe iyaziwa ukuthi ibangele imiphumela emibi kubantu abane-asthma, kunakekelwa okudingekayo ekwakheni izinhlelo zokwelashwa eziphumelelayo.
Izidakamizwa ze-Hypertension ezinzima
Phakathi kwezidakamizwa eziningi ezitholakalayo zokwelapha umfutho wegazi ophezulu, i-beta blockers kanye ne-angiotensin-ukuguqula i-enzyme (ACE) inhibitors inamandla kakhulu okubangela izinkinga ezigulini ze-asthmatic.
Kungani iBeta-Blockers Inenkinga
Abavimbela i-Beta bangabangela inkinga ngenxa yokuba khona kwe-beta receptors kumavesi okuphefumula. Ngenkathi ukuvimbela isenzo se-beta receptors emithanjeni yegazi kuyimpumelelo efunwayo lapho ukwelapha umfutho wegazi ophezulu ngoba kubangela ukuthi imithi yegazi ivuleke, ukuvimbela ama-beta receptors kumavesi okuphefumula kubangela ukuthi imimoya yomoya ingenele futhi ingaholela emiphumeleni eyingozi.
Abavimba be-beta asetshenziselwa ukwelapha umfutho wegazi ophezulu abakhethi, ngakho-ke abawenzi umsebenzi omuhle okwehlukanisa phakathi kwezinhlobo ezahlukene ze-receptors emithanjeni yegazi kanye namavesi okuphefumula. Lokhu kuqhathaniswa ne-beta-agonist noma ivuselela, izidakamizwa ezisetshenziselwa ukwelapha i-asthma, njenge-albuterol, ejwayele ukubhekela kuphela ama-receptors kumavesi okuphefumula.
I-Beta-1-i-Beta Blockers Ekhethiwe
Ngenxa yokuthi abakwa-beta blockers baphumelela kakhulu ekwelapheni umfutho wegazi ophakeme, kwenziwa umzamo wokwakha izinguqulo ezenza umsebenzi ongcono phakathi kwezimpawu zegazi namaphesenti okuphefumula. Lezi zidakamizwa, ezibizwa nge-blocka-1-block blockers, ziye zahlolwa ezinhlobonhlobo zokuhlolwa kwemitholampilo ukuze zithole ukuphepha kwabo kuziguli ze-asthmatic.
Ukuhlola nokuhlolwa kwemitholampilo kubonise ukuthi ngenkathi i-beta-1-blockers ivikelekile iziguli zesifo se-asthmatic, zisabonisa ukuthambekela kokuvimbela imibhalo yokuphefumula kwabanye abantu. Ngenxa yalesi sizathu, ngisho nalezi zidakamizwa ezikhethiwe zivame ukushiwo abantu abane-asthma.
Okwenza i-ACE Inhibitors ingaba yinkinga
Kanye ne-beta blockers, i-ACE inhibitors ingabonisa ezinye izinkinga uma une-asthma. Omunye wemiphumela emibi kakhulu ye-ACE inhibitors iphikelela, ukukhwehlela owomile, okwenzeka kuma-20% abantu. Ucwaningo luye lwabonisa ukuthi lokhu kukhwehlela kubangelwa uhlobo lomsebenzi wokuphefumula okuthiwa "ukulingana kwe-asthma," okusho ukuthi umsebenzi ngaphakathi kwezingxenye zokuphefumula ulingisa imiphumela ye-asthma. Nakuba ukusabela okujulile kuma-inhibitors e-ACE akuvamile kubantu abane-asthma, kubikiwe. Ngenxa yalezi zizathu, i-ACE inhibitors ngokuvamile ayicatshangwa njengesiyaluyalu sokuqala (okuqala) sokuzikhethela, nakuba singase sisetshenziswe uma nje udokotela wakho echaza ngokucophelela imiphumela yabo.
Izidakamizwa eziphephile ze-Hypertension
Izidakamizwa eziningi zokwelapha umfutho wegazi ophezulu ziphephile ukusebenzisa iziguli ezine-asthma, kufaka phakathi:
Ama-blockers wesiteshi se-Calcium nama-ARB awabonwanga ukuthi angabangela ingozi enkulu noma engavamile ezigulini ze-asthmatic, futhi lezi zidakamizwa zikhetha ukwelashwa okuhle kakhulu. Ama-blockers wesiteshi se-calcium avame ukusetshenziswa kuqala ngenxa yerekhodi labo elide nezindleko eziphansi.
I-Diuretics Ingabangela I-Potassium Ephansi
Omunye umphumela ohlangothini wezokwelapha okuzithokozisa-kuzo zonke iziguli, hhayi nje labo abane-asthma-i-potassium ephansi, okuthiwa i-hypokalemia. Yize noma zonke iziguli eziphathwa nge-diuretics zineengozi yokuthuthukisa i-hypokalemia, le ngozi ingcono nakakhulu uma usebenzisa izidakamizwa eziphefumulayo ze-asthma. Imithi ye-asthma inomkhuba wokuphoqa i-potassium ngaphandle kwegazi lakho nasemangqamuzaneni akho, lapho engatholakali khona ngokukhululekile.
Ukuthambekela, okuhlanganiswe nemvelo ye-potassium-sapping ye-diuretics, kusho ukuthi uma usebenzisa lezi zinhlobo ezimbili zezidakamizwa ngesikhathi esisodwa, kuzodingeka ukuthi amazinga akho e-potassium ahlolwe njalo. Ukwengeza, udokotela wakho cishe uzokubeka emthamo ophansi we-diuretic ukunciphisa ingozi ye-hypokalemia.
Ezinye izidakamizwa ze-Hypertension
Ezinye izidakamizwa ze-hypertension zibhekwa njengeziphephile noma zingaphephile zokusetshenziswa kubantu abane-asthma. Ngokuvamile, lesi simo esingachaziwe ngoba izidakamizwa azifundwanga ngokuqondile kubantu abanezimpikiswano eziphakeme zegazi kanye nesifo se-asthma. Eqinisweni, iningi lalezi zidakamizwa-kuhlanganise ne- clonidine ne-hydralazine-zivame ukuba zisetshenziswe noma kunjalo, okwenza umqondo wokuphenya ngokusetshenziswa kwabo kweziguli ze-asthma ungathandeki.
> Umthombo:
> Weinberger SE, Kaplan NM. Ukwelashwa Kwe-Hypertension ku-Asthma ne-COPD. Kusesikhathini. Kubuyekezwe ngo-Februwari 1, 2016.