I-Angiogenesis ne-Inhibitors e-Cancer Treatment
Incazelo: i-Angiogenesis
I-Angiogenesis ibhekisela ekwakheni imithwalo yegazi emisha emzimbeni. Kuyindlela ejwayelekile yomzimba yokuphulukisa kodwa futhi idlala indima ekukhuleni komdlavuza.
Angiogenesis in Health and Healing
I-Angiogenesis yindlela evamile eyenzeka emzimbeni kunoma yisiphi isimo lapho kudingeke khona ukukhula kwemithambo emisha yegazi.
Ngakho-ke, kubalulekile ukuthi izingane zikhule, ngoba ubunikazi bebelethi bukhula ngenyanga ngayinye kubesifazane besandulelausal, futhi ngamanxeba okuphulukisa.
I-Angiogenesis ku-Cancer ne-Metastasis
I-Angiogenesis inesithakazelo emdlalweni ngoba umdlavuza udinga ukwakhiwa kwemithambo yegazi entsha ukuze ikhule futhi ihambisane nemisipha. Ukuze umdlavuza ukhule ube mkhulu kune-millimeter (1 mm) i-angiogenesis idinga ukuthi yenzeke. Amakhambi enza lokhu ngokufihla izinto ezikhuthaza i-angiogenesis, ngakho-ke, ukukhula komdlavuza.
Ngaphandle kokuba inqubo edingekayo ukuze umdlavuza ukhule futhi uhlasele izicubu eziseduze, kuyadingeka ukuba imetastasis ivele . Ukuze amangqamuzana omdlavuza ahambe futhi ahlele ikhaya elisha endaweni ethile ngaphandle kokuvela kwawo, lawa maseli adinga ukuletha imisha yegazi entsha ukusekela ukukhula ezindaweni zabo ezintsha.
I-Angiogenesis ne-Vascular Endothelial Growth Factor (i-VEGF)
Izitsha zegazi zakhiwa ngamaseli abizwa ngokuthi i-endothelial cells ngaphakathi ngaphakathi kwezitsha.
Izinto eziziwa ngokuthi izimbangela zokukhula ze-vascular endothelial, i-VEGF emfishane, zikhonza njengezimpawu ezivumela amangqamuzana ekugcineni ukuba akhule futhi adale imishaya yegazi entsha. Ngamanye amazwi, yi-activators. Ukwakheka kwezimpahla zegazi emzimbeni, njengemisebenzi eminingi, kungumkhawulo wokusebenza nokuvimbela imiphumela.
Angiogenesis Inhibitors
I-Angiogenesis inhibitors yindlela yokuthola imithi , okusho ukuthi ngokuqondile ihlose amaseli omdlavuza noma amaseli adingekayo ekukhuleni noma ekusakazeni komdlavuza.
Le mithi ingaphazamisa inqubo ye-angiogenesis kumaphuzu amaningana ahlukene. Eminye yalezi zivimbela ngokubophezela ekukhuleni kwe-vasothecular endothelial factor (VEGF) ukuze ingabe isakwazi ukukhombisa ukuthi amangqamuzana ekugcineni akhule, ngakho-ke ayeka ukwakheka kwemithambo yegazi entsha.
Izibonelo ze-Angiogenesis Inhibitors
Ezinye i-angiogenesis inhibitors ezitholakalayo okwamanje zokwelapha umdlavuza zihlanganisa:
- I-Avastin (i-bevacizumab)
- I-Nexavar (sorafenib)
- I-Sutent (i-sunitinib)
- I-Votrient (pazopanib)
- Afinitor (everolimus)
Funda kabanzi mayelana ne- immunotherapy nokuthi i-angiogenesis inhibitors isebenza kanjani ukuphatha umdlavuza.
Angiogenesis Inhibitors Plus Chemotherapy
Umbuzo ovamile wukuthi kungani abantu bezodinga ukwelapha ngamakhemikhali ngaphezu kwe-angiogenesis inhibitors. Ukubuka indlela i-angiogenesis inhibitors esebenza ngayo kusiza ukuchaza lokhu. I-Angiogenesis inhibitors ayibulali umdlavuza, ivele isebenze ukuvimbela ekukhuleni okukhudlwana nokusabalalisa (imetastasizing), ngakho-ke ukuze kukhishwe isisu, i-chemotherapy kufanele isetshenziswe ngokuhambisana nama-angiogenesis inhibitors.
Imiphumela emibi ye-Angiogenesis Inhibitors
Lapho ama-angiogenesis inhibitors eqala ukutholakala njengokwelashwa komdlavuza, kwakucatshangwa ukuthi babe nemiphumela emibi embalwa.
Lokho akulona iqiniso. Njengoba nje i-chemotherapy ibangela imiphumela emibi ngezenzo zayo kumaseli ajwayelekile (ngokwesibonelo, ngokuyeka ukuhlukaniswa kwamaseli ngezinwele zezinwele, umongo wesithambo, kanye nomgudu wamathumbu) i-angiogenesis inhibitors nayo ingabangela imiphumela emibi ehlobene nomsebenzi wayo emangqamuzaneni namathisini aphilile. Eminye yemiphumela emibi kakhulu ehlobene nalokhu:
- Ukuphulukiswa okulimazayo okulimazayo kusukela ku-angiogenesis inhibitors kungaphazamisi nje kuphela ikhono lamangqamuzana omdlavuza ukwenza imishaya yegazi elisha kodwa futhi liphazamise ikhono lamathishlo enempilo ukwenza imishaya yegazi entsha ibuyisele ukulimala.
- Ukumboza emithanjeni, okuzoholela ekuhlaselweni kwenhliziyo kanye nemivimbo.
- Umfutho wegazi ophezulu.
Izivivinyo Zesikhathi Esizayo / Zomtholampilo
Imithi eminingi kulezi zigaba ihlolwe ekuvivinyweni kwemitholampilo, futhi kukhona ithemba lokuthi ukuhlaselwa komdlavuza ngokombono wokuphazamiseka kwe-angiogenesis kuyoba yingxenye yemigomo eminingi yokwelashwa komdlavuza esikhathini esizayo.
Imithombo:
I-American Society of Clinical Oncology. I-Cancer.Net. I-Angiogenesis ne-Angiogenesis Inhibitors Yokuphatha I-Cancer. 07/2014. http://www.cancer.net/navigating-cancer-care/how-cancer-treated/personalized-and-targeted-therapies/angiogenesis-and-angiogenesis-inhibitors-treat-cancer
I-National Cancer Institute. Angiogenesis Inhibitors. Kubuyekezwe ngo-10/07/11. https://www.cancer.gov/about-cancer/treatment/types/immunotherapy/angiogenesis-inhibitors-fact-sheet