I-Endometriosis yisimo lapho izicubu ezivame ukungena ngaphakathi kwesibeletho sakho (i-endometrium) ikhula kwezinye izindawo zomzimba - ikakhulukazi kuma-ovari, ama-tublopian tubes, nezinye izitho esifundeni sezintambo. Kungabangela ubuhlungu nokuphaphazeka okungavamile .
I-Endometriosis iyinkinga evamile, ethinta amantombazane angama-5.5 million aseMelika nabesifazane beminyaka yobudala bokuzala.
Izimpawu nazo zibonakala ziba zimbi kakhulu phakathi nesikhathi noma isikhathi sakho.
Ayikho ikhambi ye-endometriosis. Uma kungelashwa, kunganciphisa amathuba okuba ukhulelwe esikhathini esizayo. I-Endometriosis ingenye yezimbangela ezintathu eziphezulu zokungasebenzi. Umgomo wokwelashwa ukulawula ubuhlungu nokuvimbela i-endometriosis ukuba ingahambi nakakhulu. Ukwelashwa kungaba nemithi kanye / noma ukuhlinzwa. Uhlobo lwezokwelapha ongaluthola ngokuvamile luxhomeke ebuqilini bezimpawu zakho nokuthi ngabe ufuna ukukhulelwa noma cha.
I-Depo-subQ i-Provera 104 iyinjovo yokuvimbela ukukhulelwa equkethe i-progestin, i-medroxyprogesterone acetate. Ithole imvume ye-FDA ngo-Mashi 2005 yokwelashwa kobuhlungu obuhlobene ne-endometriosis. Lokhu kuvunywa kwe-FDA kwakungumuthi wokuqala wezokwelapha wokuphumula kwe-endometriosis ebuhlungu eminyakeni engu-15. Nakuba lokhu kuvunyelwa kwe-FDA kungasebenzi kudubula lokuqala lweDepo Provera, ama- injection kaDepo Provera angasiza futhi ukuphatha ubuhlungu obuhlobene ne-endometriosis.
I-Depo Provera Insiza Yiphatha I-Endometriosis Pain?
I-progestin eDepo Provera kucatshangwa ukuthi iyasiza ekunciphiseni ukukhula kwezicubu ze-endometrial futhi inganciphisa ukuvuvukala kwe-endometriosis.
Ngesikhathi sokujikeleza kwakho okuvamile, amahomoni akho enza ukuthi uhlaka lwamagciwane akho lungene ekulungiseleleni ukukhulelwa.
Uma ungakhulelwa, uhlaka lwesibindi sakho luyahamba, futhi ugeze (yilokho okubangela isikhathi sakho). Amahomoni alawula umjikelezo wakho wokuya esikhathini ngokwemvelo aphakama futhi awe phakathi nomjikelezo wakho. Lokhu kukhula nokuwa kungabangela izimpawu ze-endometriosis zibe zimbi nakakhulu. Futhi, uma une-endometriosis, uma unenkathi yakho, ukuphuma kwegazi akuveli nje emgqeni wesibeletho - izicubu ze-endometrial ezikhulile ngaphandle kwesibeletho sakho nazo ziphuma. Uma leli gciwane lithinta ezinye izitho, kungabangela ukulimala nokuvuvukala yilokho okubangela ubuhlungu.
Ukusetshenziswa kweDepo Provera kuvumela amazinga akho e-hormone ukuba ahlale eqinile kulo lonke umjikelezo wakho. Kuyasiza ukunciphisa uketshezi kwesibeletho - lokhu kungaholela ezinkathini zokukhanya noma akukho nhlobo. I-Depo Provera ingaphinde ivimbele ukuvunguza nokuncipha inani le-estrogen elijikelezayo emzimbeni wakho. Umqondo lapha wukuthi ukukhuthazwa kwe-estrogen engaphansi kwe-endometriosis izicubu ezitholakele, umsebenzi weselula omncane ukhona. Lokhu kunciphisa izinga lokukhula kwezicubu. Njengoba nje uhlaka lwesisu luphendula kula mazinga e-hormone, izicubu ze-endometriosis zenza kanjalo.
Yimiphi Imithi Eyayiphatha I-Endometriosis?
Ngaphambi kokusetshenziswa kwe-hormone therapy (njengoDepo Provera) yokwelashwa kwe-endometriosis, i-GnRH agonists (njenge- leuprolide ) ibe yimithi eyinhloko enqunyelwe ukuphumula kwe-endometriosis.
Lesi sidakamizwa siyinguqulo ye-hormone eyenzeka ngokwemvelo, eyaziwa ngokuthi i-hormonone ekhishwa yi-gonadotropin, esiza ukulawula umjikelezo wesimiso. Uma usebenzisa i-leuprolide, ngokuyisisekelo imisa yonke imisebenzi ye-hormone ne-ovarian. I-Leuprolide nayo ihlotshaniswa nemiphumela emibi kakhulu, ezinye zazo zihlanganisa:
- Izimpawu ze-Vasomotor (ukushisa okushisayo, ukuphosa, ukujuluka)
- Ukulahlekelwa kwethambo
- Izimpawu ze-hypoestrogenic (ukumelela kwesisu, ukushintsha kwemizwa, ukuphazamiseka kokulala)
- Izinsizwa
- Ukucindezeleka
- Kunciphise libido
Ucwaningo lukusho ngani ngoDepo Provera noLeuprolide?
Esinye sezifundo ezaziwa kakhulu kule ndawo kuqhathanisa uDepo-subQ Provera 104 kanye nokusetshenziswa kwe-leuprolide kumama-257 abesifazane ayebhekene ne- laparoscopically ane-endometriosis.
Kwakukhona abesifazane abangu-153 abasebenzisa uDepo-subQ Provera 104 no-146 abesifazane abasebenzisa i-leuprolide phakathi nezinyanga ezingu-6. Imiphumela yabonisa ukuthi:
- I-Depo-subQ Provera 104 ibuye isebenze ngokuphumelelayo ekwelapheni ubuhlungu obubangelwa i-endometriosis njenge-leuprolide.
- Kokubili i-Depo-subQ Provera 104 kanye nokusetshenziswa kwe-leuprolide kunciphisa ubuhlungu emiphakathini emihlanu eyinhloko ye-endometriosis: ubuhlungu be-pelvic, i- dysmenorrhea , ubuhlungu be-pelvic, i-dyspareunia (ubulili obubuhlungu), ne-induration (ukuqina nokuqina kwezicubu).
- Ngemuva kwezinyanga eziyisithupha zokusebenzisa, i-Depo-subQ Provera 104 yabangela ukulahlekelwa kwamathambo angaphansi kwe-leuprolide. Ezinyangeni ezingu-12 ngemuva kokwelashwa, amazinga okulahlekelwa ngamathambo abuyela kumazinga angaphambi kokwelapha abasebenzisi beDepo-subQ Provera 104, kodwa hhayi kulabo abasebenzisa i-leuprolide.
- Bobabili imithi ngokulinganayo ibangele ekuthuthukiseni okukhulu izinga lokuphila kanye nokukhiqiza okuphelele.
Abacwaningi baphetha ngokuthi iDepo-subQ Provera 104 iphatha ubuhlungu obubangelwa i-endometriosis ngokuphumelelayo njenge-leuprolide. Kodwa abesifazane abasebenzisa i-Depo-subQ Provera 104 babika ama-vasomotor angaphansi (njengamakhaza ashisa noma ama-sweats) izimpawu nezimpawu ze-hypoestrogenic (njengokuphazamiseka kokulala, ukuguquka kwesimo sengqondo, nokucasuka kwesisu) futhi abanolwazi oluncipha kakhulu emithini yamaminerali kunabesifazane abasebenzisa i-leuprolide. Ngakho-ke, hhayi kuphela ukuvimbela ukuvimbela kahle , i-Depo-subQ Provera 104 ifaneleka futhi isebenzise ukwelashwa ngendlela efanele njengoba i-leuprolide ekwelapheni ubuhlungu obuhlobene ne-endometriosis.
Ucwaningo olwengeziwe luqinisekisa le miphumela. Eqinisweni, abacwaningi baphenyisisa zonke izifundo ezaphenya ukusetshenziswa kweprogesin ekwelapheni kwe-endometriosis eyashicilelwa eminyakeni eyishumi edlule (1993-2003). Imiphumela ehlangene yazo zonke lezi zifundo yabonisa ukuthi i-medroxyprogesterone acetate, i-progestin e-Depo Provera isebenza kahle njenge-GnRH agonists (leuprolide) ekunciphiseni ubuhlungu obuhlobene ne-endometriosis nokuthuthukisa izinga elihlobene nempilo yezindaba zokuphila. Abalobi baphinde bachaze ukuthi ukusetshenziswa kukaDepo Provera kwabesifazane abane-endometriosis ephawulekayo kwaholela ekunciphiseni okukhulu kwezibonakaliso zobuhlungu futhi kuholele ekunciphiseni ukukhula kwe-endometriosis kwezicubu ezintsha.
I-Depo Provera njenge-Endometriosis Ukwelashwa: Izwi Lokugcina
I-Depo Provera isetshenziselwe ukuphatha ngempumelelo i-endometriosis. Isizathu esiyinhloko sokusebenza kwayo ukuthi uDepo Provera angasiza ekuvimbeleni ukuvuthwa . I-Depo Provera ithinta ngokuqondile izicubu ze-endometrial ngokuyenza ibe yincipha - lokhu kuholela emanzini aphansi ekukheni kwesikhashana - okuholela ekusizeni ubuhlungu.
Noma kunjalo, uDepo Provera ingaba ukwelashwa okwesikhashana kwe-endometriosis. Ngisho noma iphumelela esikhathini esifushane, ngemuva kokumisa uDepo Provera, kunethuba eliphezulu lokuthi ukukhula kwezicubu ze-endometrial kuzobuya. U-Depo Provera futhi akaphatheli ukungabi nalutho okuhlobene ne-endometriosis. Uma ufuna ukukhulelwa, ukuhlinzwa kungase kube ukhetho olungcono kakhulu lwezokwelapha lwe-endometriosis.
I-Depo Provera iphumelela njenge-leuprolide namanye ama-GnRH agonists ekwelapheni ubuhlungu obuhlobene ne-endometriosis. Kodwa, i-leuprolide iyabiza futhi ihlotshaniswa nemiphumela emibi engakhululekile. Lokhu kuthiwa, lapho uDepo Provera efika ngesixwayiso sokuphepha kwebhokisi elimnyama - uma lisetshenziselwa iminyaka engaphezu kwemibili, uDepo Provera angandisa ukwanda kwamathambo akho (okuholela engozini yokwanda kwe- osteoporosis ). Ukusetshenziswa kukaDepo Provera kungase kubambezele ukubuyiswa kokuzala kwakho (cishe ama-50% abesifazane bazokwazi ukukhulelwa zingakapheli izinyanga ezingu-10 ngemuva kokujola kweDepo Provera yokugcina, kodwa kungathatha izinyanga ezingu-18 ukuze kubuyele). Abanye besifazane babika ukuphuma okungavamile noma okuqhubekayo lapho usebenzisa i-Depo Provera kanye neminye imiphumela engadingeki . Ngeshwa, uma unikezwa ijoyi ye-Depo Provera, uma ungajabuli nemiphumela emibi, kufanele ulinde isikhathi sezinyanga ezintathu kuze kube yilapho zonke amahomoni avela kule mithi kancane kancane ushiya umzimba wakho. Ngakho-ke uma ucabanga ukusebenzisa i-Depo Provera njengendlela yokwelapha ye-endometriosis yakho, qinisekisa ukuthi ukhuluma nodokotela wakho , ngakho-ke unganquma ukuthi ngabe u-Depo Provera anganikeza yini lezi zinhlekelele ezingekho noma cha.
Imithombo:
I-Crosignani PG, uLuciano A, uRay A, noBergqvist A. "I-depro-medroxyprogesterone i-depotaneous acetate ne-leuprolide acetate ekwelapheni ubuhlungu be-endometriosis." U-Hum. Kuhlehlisiwe. 2006; 21 (1): 248-256.
I-Vercellini P, i-Fedele L, i-Pietropaolo G, i-Frontino G, iSomigliana E, no-Corsignani PG. "I-progestogens ye-endometriosis: Phambili esikhathini esidlule." Ukuvuselelwa kwe-Hum Reprod 2003; 9: 387-396.