I-Endometriosis yisimo lapho izicubu ezivame ukungena ngaphakathi kwesibeletho (i-endometrium) ikhula kwezinye izindawo zomzimba. Kubangele ubuhlungu, ukuphuma kwegazi ngokungavamile, kanye nokungabikho komzimba. I-Endometriosis iyinkinga evamile futhi cishe iqala ngesikhathi sokuqala kokuya esikhathini. Umjovo we-Depo-subQ Provera 104 uye wavunyelwa yi- FDA ukusiza ukuphatha ubuhlungu obuhlobene ne-endometriosis.
Ezinye izisu zokubeletha kwe-hormonal zingasiza futhi.
Nakuba abesifazane abangaphezu kuka-80% base-US bazosebenzisa ukukhulelwa kwe-hormonal ( njengePilisi ) ngesikhathi esifanayo phakathi neminyaka yabo yokuzala, abaningi abaqapheli izinzuzo ezingalutholi zokusebenzisa lolu hlobo lokulawulwa kokuzalwa. Ukukhulelwa kwe-hormonal kuqukethe i- progestin , i-estrogen, noma kokubili.
Ukusebenzisa ukukhulelwa kweHormonal ukuphatha i-Endometriosis
Ezinye zalezi zinzalo zokubeletha zibonise ikhono elithile lokunciphisa ubuhlungu obuhlobene ne-endometriosis. Lokhu kusho ukuthi kubalulekile ukuthi uqaphele ukuthi isizathu esiyinhloko sokusebenzisa ukuvimbela ukuvimbela ukuvimbela ukuvimbela ukuvimbela ukubeletha (ukuvimbela ukukhulelwa okungahlosiwe ) - izinzuzo ezingenakunqunywa ezingacabangi zingacatshangwa uma unquma ukuthi iyiphi indlela yokulawula ukuzalwa kwe-hormonal engase ifaneleke kakhulu kuwe .
Okulandelayo luhlu lwezinqubo ezihlukahlukene zokulawulwa kokubeletha eziye zaboniswa ukuthi ziyasebenza ekunciphiseni ubuhlungu obuhlobene ne-endometriosis:
- UDepo Provera noDepo-subQ Provera 104 : Bobabili baye baboniswa ukunciphisa ubuhlungu obubangelwa yi-endometriosis. Umjovo we-Depo-subQ Provera 104 iyisiluleko sokuqala esisha eminyakeni engu-15 edlule ukuba i-FDA-evunyelwe ukwelashwa kobuhlungu obuhlobene ne-endometriosis. Ngokusho kocwaningo olunikezwa uPfizer, umkhiqizi weDepo Provera, uDepo-subQ Provera 104 uyaphatha ubuhlungu be-endometriosis ngendlela ephumelelayo njenge-leuprolide, kodwa ihlotshaniswa nezimpawu ezimbalwa ze-vasomotor (njengokushisa okushisayo noma ukujula) nokulahleka okukhulu kwethambo. Eqinisweni, u-Depo Provera wenza ukukhululeka kobuhlungu obulingana ne-leuprolide kuzo zonke izindawo ezihlobene ne-endometriosis - ubuhlungu be-pelvic, ubuhlungu be-pelvic, i-dysmenorrhea, ubulili obubuhlungu, nokuqina nokuqina kwezicubu.
- I-Implanon : Lokhu kuhlanganiswa kokukhulelwa kuye kwaboniswa ukunciphisa ubuhlungu obuvela ku-endometriosis. Nakuba kungaziwa kahle ukuthi i-progestin (etonogestrel) e-Implanon isisiza kanjani ukukhulula izimpawu ze-endometriosis, kucatshangwa ukuthi kusebenza ngokucindezela ukukhula kwezimpande ze-endometrial, ngaleyo ndlela kubangele ukuba kancane kancane kunciphise. I-progestin ingasiza ekunciphiseni ukuvuvukala kwesibeletho esibangelwa i-endometriosis (ngaleyo ndlela inikeze ukukhululeka ebuhlungu).
- I-Mirena : I-Mirena IUD iboniswe ukusiza ekwelapheni i- dysmenorrhea nobuhlungu obungapheli be-pelvic obuhlobene nokuphela kwe-endometriosis-nakuba kungakaze kuvunywe i-FDA ngalolu hlelo. Njengoba kunikezwe ukuthi i-Mirena ingashiywa endaweni iminyaka emihlanu, le-IUD inikeza amandla okuba ukwelashwa kwe-endometriosis yesikhathi eside kwabesifazane abafuna ukuhlehlisa ukukhulelwa. Izilingo ezincane ezincane zokwelashwa ziye zaphenya ukusebenza kwe-Mirena IUD ekwelapheni kwe-endometriosis; lolu cwaningo lubonise ukuthi i-Mirena ingase ibe usizo ekunciphiseni ubuhlungu bezinyanga eminyakeni emithathu, kanti iningi lentuthuko iba ezinyangeni ezingu-12-18 zokuqala. I-Mirena icatshangwa ukuthi ingasiza ukunciphisa izinga lokugeleza kwegazi ngesikhathi sowesifazane, okungasiza ekunciphiseni ubuhlungu obuhlobene ne-endometriosis. Eqinisweni, kwabesifazane abafisa ukuthola i-intrauterine yokukhulelwa, i-Mirena IUD manje ivunyelwe i-FDA ukuphatha izikhathi ezinzima.
- Amaphilisi Okulawula Ukuzalwa Kwama-Cycle Okunwetshwayo: Amaphilisi okulawula ukuzalwa okuqhubekayo ( njengoLybrel noma i- Seasonique ) anganikeza inzuzo eyengeziwe yokuqeda noma ukunciphisa izikhathi kanye nokuxilongwa kwe-dysmenorrhea ehlobene ne-endometriosis. Kodwa-ke, kukhona idatha elinganiselwe ukuphakamisa ukuthi ukuhlanganiswa kwamaphilisi okulawula ukubeletha kunganciphisa ubukhulu be-dysmenorrhea kwabesifazane abane-endometriosis.
> Imithombo:
> Jain, J. (2005). "Ukwelashwa: I-depot medroxyprogesterone i-acetate yokulawula ukuzalwa nokuhlungu kwe-endometriosis". I-OBG Management, Umq. 17, no-8 . Kufinyelelwe ngokubhalisa kwangasese.
> Lockhat FB, Emembolu JO, Konje JC. "I-effectiveness, side effects kanye namazinga okuqhubekela phambili kwabesifazane abane-endometriosis yesifo esithatha ukwelashwa nge-progestogen ephathwayo (levonorgestrel): Ukulandelwa kweminyaka engu-3." Hum Reprod 2005; 20: 789-93.
> Pfizer. (2005) "Depo-SubQ Provera 104."
> Pfizer. (2004) "UDepo Provera: Injection yokukhulelwa."
> Schweppe, KW. "Indawo yamanje ye-progestins ekwelapheni izikhalazo ezihlobene ne-endometriosis." I-Gynecol Endocrinol 2001; 15 (S6): 22-8.
> Sullivan, M. (2005). "Ukwelapha okusha kuvunyelwe ubuhlungu be-endometriosis". Izindaba ze-OB / GYN .
> Surrey, ES. "Indima ye-progestins ekwelapheni ubuhlungu be-endometriosis." I-G Min Gynecol Engenayo 2006; 13: 528-34.
> Vercellini, P., Fedele, L., Pietropaolo, G., Frontino G, Somigliana, E., Corsignani, PG. "I-progestogens ye-endometriosis: Phambili esikhathini esidlule." Ukuhlaziywa kwe-Hum Reprod 2003; 9: 387-96.