Ubufakazi bokuthi nokulwa nokuvimbela ukuzama ukuhlasela
Izifundo zakuqala zaholela enjabulweni emkhakheni we-dementia mayelana nokuxhumaniseka okungenzeka phakathi kwezidakamizwa ezinciphisa i-cholesterol eyaziwa ngokuthi izitembu zokuvimbela ukukhubazeka komqondo . Kodwa izifundo zakamuva azizange zifinyelele iziphetho ezinjalo ezithembisayo.
I-Lancet Study Study ibonisa Ingozi Yokunciphisa Inhlekelele
Ngo-November 2000, isifundo eshicilelwe eLancet sathola ukuthi abantu abangaphezu kweminyaka engama-50 ababengumthetho wesimiso babe nomngcipheko owehla kakhulu wokuthuthukisa u-dementia .
Abacwaningi baqhathanisa nabantu abangu-284 abane-dementia ("amacala") anezintambo ezingu-1,080 ezingazange zenzeke. Lolu hlobo lokutadisha lwaziwa njengesifundo sokulawula icala. Labo bantu ababemiswe njenge-statins babenengozi encane uma kuqhathaniswa nalabo ababengazange bamiswe ama-statins, ngisho nangemva kokuba izinto ezifana nobudala, ubulili kanye nomlando wezifo zenhliziyo zicatshangelwe. Imiphumela yabaluleke kakhulu.
Izifundo Eziqhubekayo Ukuphikisana Kwezingqinamba ZamaSitatimende Nokuvimbela Ukunciphisa Umqondo
Nakuba isifundo sesibili esanyatheliswa ngo-2004 sathola ukuthi abasebenzisi be-statin babenengozi engaphansi kuka-39% yesifo se-Alzheimer uma kuqhathaniswa nabasebenzisi abangewona abakwa-statin, nalokhu kwakuyi-study control control. Ingabe lezi zifundo ezimbili zisho ukuthi ama-statins anciphisa ingozi yesifo se-Alzheimer? Ngeshwa akunjalo.
I- Cochrane Database Yokubuyekeza Okuhlelekile yaqokomisa izifundo ezimbili ezinkulu ezenziwa ekusetshenzisweni kwama-statins kubantu abasengozini ye-Alzheimer's and other dementias, ehilela inani labangu-26.340 abahlanganyeli.
Lezi zibili zombili izivivinyo ezilawulwa nge-placebo ezilawulwa ngokungahleliwe, uhlobo oluthile lokutadisha. Ngenxa yokuthi izifundo zokulawula icala zibukeka emuva ngesikhathi futhi zingenakulinganiswa, iziphetho ezingathathwa kuzo zilinganiselwe. Izifundo ezimbili eziyimpumputhe zibheke phambili ngesikhathi, zihleliwe ukuze abaphenyi abangezi ukuthi iziphi iziguli ezithola izidakamizwa nokuthi zithola i-placebo futhi zilungele kangcono ukubonisa ubudlelwane obangela kanye nomphumela.
Iziguli ezifundweni ezimbili zokuqala eziyimpumputhe zalandelwa iminyaka engama-3.2, kanti labo abasesifundweni sesibili iminyaka emihlanu. Umsebenzi wokuzicabangela wabantu esifundweni sokuqala wehla ngesilinganiso esifanayo. Futhi esifundweni sesibili, kwakungekho umehluko esihlalweni somqondo ophakathi kwezifundo ezaba nesimiso ngokumelene nalabo abene-placebo.
Njengoba kunikezwe amandla lalezi zifundo zakamuva, ubufakazi bokuphetha ngokuthi izitembu zivimbela i-Alzheimer noma enye i-dementias ngokungangabazi ngalesi sikhathi.
Imithombo:
I-Database Cochrane Yokubuyekeza Okuhlelekile. 2016 Jan 4; 1: Izitatimende Zokuvimbela Ukunciphisa Umqondo. http://www.ncbi.nlm.nih.gov/pubmed/26727124.
Jick H, MD, Zornberg GL, MD, Jick SS, DSc, Seshadri S, MD, Drachman DA, MD. "Izitatimende Nengozi Ye-Dementia." I-Lancet 2000 vol. 356, Issue 9242: 1627-31.
UMcGuinness B, Craig D, Inhlamvu Yombulunga R, Passmore P. "Izitatimende Zokuvimbela Ukudembula". Database Cochrane Yokuhlolwa Okuhlelekile 2009, Issue 2.
U-Zamrini E, uMcGwin G, uRoseman J. "Ukusebenzisana Phakathi KweStatin Ukusetshenziswa Nezifo Zama-Alzheimer". Neuroepidemiology 2004; 23: 94-98.
-Uhlelwe ngu-Esther Heerema, MSW