Susa ama-Sprinkles namanye amafomu e-Valproate
U-Valproate uyisidakamizwa esibhekwa njengomuthi we-anticonvulsant ngakho-ke ngokuvamile uqondiswe ukulawula ukugwinya. Kanti futhi kunqunywe ngezikhathi ukuvimbela ikhanda lekhanda nokunciphisa iziqephu zomuntu nge-bipolar disorder. Abanye odokotela banquma futhi ukuba baphathe izimo eziyinselele ezifo zesifo se-Alzheimer kanye nezinye izinhlobo zokuwohloka komqondo .
Ukusebenzisa i-valproate ngale ndlela kubhekwa ngaphandle-ilebuli ngoba ayivunyelwe yi-US Food and Drug Administration (FDA) yalolu hlelo.
"Imikhiqizo ye-Valproate ihlanganisa i-valproate sodium (Depacon), i-divalproex sodium (i-Depakote, i-Depakote CP, ne-Depakote ER), i-valproic acid (i-Depakene ne-Stavzor), kanye ne-generic yabo," ngokusho kwe-FDA.
Amafomu ahlukene kaValproate
I-Valproate iza ngezindlela ezehlukene, kufaka phakathi amaphilisi, amaphilisi okukhululwa, ama-capsules ane-sprinkled valproate (lawa amakhisula angagwinya noma avuliwe futhi okuqukethwe okufafazwe ekudleni okulula kulabo abanenkinga yokugwinya) kanye nokujova / IVs kulabo abangakwazi thatha imithi yomlomo.
Kungani Valproate Yisetshenziselwe Ukubhekana Nezinkinga Ezicindezelayo E-Dementia?
Enye yezinkinga zesifo se-Alzheimer ukuthi ukuziphatha nokuziphatha kungashintsha ngenxa yesifo. Ezinye zezimo eziyinselele ekudemeni kwengqondo zingabandakanya ukuhlukumezeka , ukuphumula, ukuphikisana , ukuhlukumeza amazwi , ukumelana nokukhathalela, ukuzulazula nokucabanga okuphazamisayo .
Kungaba nzima ukwazi ukusabela kulezi zinhlobo zokuziphatha nemicabango.
Umphakathi wezokwelapha uzame izidakamizwa ezihlukahlukene ukuzama ukunciphisa lezi ziphathamandla, okufaka imishanguzo ye-antipsychotic (okungaba nemiphumela emibi emibi kakhulu futhi ilawulwa kakhulu embonini yezingane zokuhlengikaza), i-benzodiazepines (ebuyele nemiphumela emibi kanye nokusebenza okungaqiniseki) ama-antidepressant (okungekho ngaso sonke isikhathi esebenza kahle noma afanelekile).
Okubalulekile ukuthi ngokuvamile akuyona imithi ephumelelayo kakhulu ukuphatha ukuphazanyiswa kokuziphatha ekudemeni kwengqondo .
Ngakho-ke, i-valproate yavuka njengenkani emzamweni wokwelapha ukucindezeleka ekudemeni kwengqondo. Ngaphandle kwethemba lokuthi kube ukwelashwa okuphumelelayo, i-valproate yaba nenzuzo yokuba yimithi eyaqala ukuhamba kancane ngaphansi kwe-radar ngokwemithetho yezingane zokuhlengikaza-ezigxile ekunciphiseni nasekuqedeni imishanguzo ye-antipsychotic in ukuwohloka komqondo kodwa hhayi njengokugxila ku-valproate.
Ingabe i-Valproate kufanele isetshenziselwe ukubhekana nezinkinga ezithintekayo ku-Dementia?
Ngokwezifundo eziningi zocwaningo, impendulo ngokuvamile iwukuthi: Cha.
Kungani kungenjalo?
Kuvame ukungasebenzi. Yize kunezimo ezizimele zodwa zokuphumelela, ukubuyekezwa kwezifundo eziningi kwaphetha ngokuthi i-valproate ayisona usizo nakakhulu kune-placebo (iphilisi ekhohlisayo) ekunciphiseni ukuziphatha okunzima kokwehla komqondo.
Ngokwesinye isifundo esashicilelwe ku- JAMA Psychiatry , i-valproate nayo yehluleka ukunciphisa ukuqhubeka kwengqondo kwengqondo, inzuzo enethemba elingazange ivele ngokusetshenziswa kwayo.
Okuqhamuka uma udla imishanguzo
Ucwaningo oluningi lwathola nokuthi abahlanganyeli abathola i-valproate babenengozi enkulu yemiphumela emibi evela emithini.
Lezo zinto ezimbi zahlanganisa i- thrombocytopenia (ukwehla amapulethi wegazi), ukukhushulwa okwanda, ukuphazamiseka okuphazamiseka, ukuthuthumela, ukuguquka nokulala, ukunxanxathela, ukuhlanza nokuhuda.
Ezinye izindlela zokuValproate
Kunokuba ufinyelele ibhodlela lemithi ukuze ushintshe izimo ezinzima ekudemeni kwengqondo, isu lokuqala kufanele ngaso sonke isikhathi sibe izindlela ezingezona izidakamizwa . Cabanga ngezinto ezingabangela lezo ziphathamandla ezifana nemvelo , ubuhlungu emzimbeni , ukunganaki noma ukuphumula futhi uzama ukulungisa futhi ulungise lezo zimbangela ezikhona.
Sebenzisa amaqhinga afana nokuvumela umuntu isikhathi esithile ukuzola phansi yedwa bese ebuya kamuva ukuqedela umsebenzi ozama ukuyifeza.
Okokugcina, qaphela ukuthi ukucindezeleka nokucindezeleka kungakwandisa ukuziphatha komuntu onesifo sengqondo sokugula. Ziqaphele ukuthi izibonakaliso zomnakekeli zidlula futhi zisebenzise umndeni, abangane kanye nezinsiza zomphakathi ukukusekela indima yakho yokunakekelwa.
Izwi kusuka
Kuyinto evamile futhi efanelekile ukufuna ukwelashwa okusiza ngezimo ezinzima ezivama ukukhula komqondo. Ngeshwa, asikafiki ukuthola imithi ephephile futhi ephumelelayo kule njongo.
Ngenxa yalokhu, qiniseka ukuthi ufuna ukwesekwa njengomnakekeli ngoba izimpawu zokuziphatha nokucindezeleka kwengqondo zingase zibe nzima ukubhekana nazo. Lokhu kusekelwa kungakusiza ukuba uzizwe ungasodwa futhi uvumele abahlinzeki ukuba bahlanganyele amasu ahlukene ayewasiza.
> Imithombo:
> ClinicalTrials.gov. I-Valproate ku-Dementia (VALID). Julayi 6, 2010.
> I-Cochrane Database Yokubuyekeza Okuhlelekile. 2009 Julayi 8; (3). Amalungiselelo e-Valproate wokugadluzwa ku-Dementia.
> Depakote. I-Depakote Formulations.
> I-JAMA Psychiatry. I-Chronic Divalproex Sodium Yokuvimbela Ukunciphisa Ukuguquka Nokunyuka Kwemithi Ye-Alzheimer's Illness.
> Umtholampilo wezeMpilo. 2012; 1 (11): 14. Ukuhlaselwa kukaValproate Kubantu Abakhulile Abanobudemayo: Ukuhlola Ukunqamuka Nokunciphisa I-Dose.
> Ukuphathwa Kwezokudla Nezidakamizwa zase-US. Ulwazi lwe-Valproate.
> Williams, L. Wonke Wasebenza Ngokubufakazi: Valproate for Agitation in Dementia.
> Yeh, Y. no-Ouyang, W. (2012). Ama-mood stabilizers ekwelapheni izimpawu zokuziphatha nokucindezeleka kwengqondo: Ukubuyekezwa kokubuyekezwa. I-Kaohsiung Journal of Medical Sciences , 28 (4), iphe.185-193.