Funda Eyisisekelo Sokwelashwa Kwe-Antioclonal Antibody
Ukwelashwa kwe-antioclonal antibody (TB) kuyindlela yokwelapha yomdlavuza . Ngezinye izikhathi kuthiwa yi-immunotherapy. Nakuba ukuhlinzwa , ukwelashwa kwemithi , kanye nokwelashwa kwemisebe kubalulekile ukukhetha ukwelashwa okubalulekile komdlavuza wekoloni, ukwelashwa kwe-monoclonal antibody (antioconal antibody) okutholakala kabanzi ukuze kusetshenziswe. Imithi yokwelashwa yama-monoclonal ejwayelekile kakhulu yokulawula umdlavuza we-colon yi-Bevacizumab (Avastin), Cetuximab (Erbitux), ne-Panitumumab (Vectibix).
Yini i-Antiocidal Monoclonal?
Ama-antibodies omzimba angama-protein asetshenziselwa i-laboratory. Lawa maprotheni aklanyelwe ukuba afakwe ezindaweni ezingaphezu kwamangqamuzana omdlavuza futhi aphazamise ukukhula nokusabalala kwawo. Ama-antibodies e-monoclonal afana namagciwane omzimba wakho okhiqiza ngokwemvelo uma ubhekene namagciwane noma amagciwane, njengomkhuhlane noma umkhuhlane (umkhuhlane).
I-Antiocidal Monoclonal Isebenza Kanjani?
Amaseli emzimbeni wethu, kufaka phakathi amangqamuzana omdlavuza, anezindawo eziphezulu ezibizwa ngokuthi i-receptors. Lezi zitholampilo zisiza ukulawula ukuthi amangqamuzana ethu akhula kanjani, ayeke ukukhula, noma enze noma yiziphi izinto amaseli avame ukwenza. Uma iprotheyini efanele ifika futhi ifaka (ibophezela) kumamukeli esitokisini, lokhu kubangela ukuba iseli liphendule.
Indlela enhle yokucabanga nge-receptors kanye namaprotheni abo ababophezelayo ukucabanga ngekhikhi nekhiye. Ilokhi ngeke livule ngaphandle kwesihluthulelo sokunene. Ngendlela efanayo, i-receptor ngeke ibangele iseli ukuthi likhule, lihlukanise, noma liphendule ngaphandle kokuthi "ukhiye" olufanele kulowo mamukeli ubambe kuqala.
Futhi ama-antibodies amakholomu "ayizihluthulelo" ezenzelwe ngokukhethekile ukunamathela kuma-receptors kumaseli omdlavuza.
Izibonelo ze-Monoclonal Antibody Therapies
I-Epidermal growth factor receptors (EGFRs) yinye isibonelo se-receptors ukuthi i-antibodies e-monoclonal ihlose. Ama-EGFR akhona kumaseli ajwayelekile namaseli omdlavuza, kodwa ngama-cancer amangqamuzana, lawa ma-receptors awavamile.
Kungase kube khona ama-EGFR amaningi kakhulu noma angalimala noma ashintshwe (ashintshwe) ngendlela evumela ukuba baphendule ngaphezu kwezibonakaliso zokukhula. Lokhu kwenza amangqamuzana omdlavuza akhule ngokushesha noma akhule ezindaweni akufanele bakhule.
Imithi yokwelapha yama-antioclonal i-Cetuximab (Erbitux) ne-Panitumumab (Vectibix) ixhuma ngokuqondile kuma-EGFR atholakalayo kumaseli omdlavuza. Uma zihlanganisa ne-EGFR, zivimbela izibonakaliso zokukhula ezivame ukukhiqiza umzimba wakho ekufinyeleleni amaseli omdlavuza. Lokhu kunciphisa noma kuvimbe ukukhula komdlavuza.
Ukucabanga ngokukhiya nokufanekisa okuyisisekelo, ungacabanga ukuthi i-Cetuximab ne-Panitumumab basebenza njengokungathi othile unamathele i-gum ekukhiyeni. Isihluthulelo asikwazi ukungena futhi umnyango awukwazi ukuvulwa ngoba i-receptor yesifo somdlavuza isivele "ihlanganiswe" yizifo eziphilayo ze-monoclonal. Lokhu kusho ukuthi amangqamuzana omdlavuza awasatholi izimpawu zokukhula abadinga ukuqhubeka zikhula futhi zisakazeka.
Ama-Antibodies ahlanganisiwe aMonoclonal
Ngaphandle nje kokuqeda imisebenzi yeselula ye-tumor, ama-antibodies angama-monoclonal angahlanganiswa nomuthi we-chemotherapy noma i-radioactive imithi (radioimmunotherapy) ngakho-ke bathatha isinyathelo sokwelashwa ngokuya komdlavuza hhayi kuma-cell evamile. Lokhu kusetshenziswa ngezinye izinhlobo ze-lymphoma kanye nomdlavuza webele kanye nezidakamizwa zingase zitholakale ukuphatha ezinye izinhlobo zomdlavuza.
Yimiphi imiphumela emibi ye-Monoclonal Antibody Therapy?
Kubantu abaningi, imiphumela emibi ye-monoclonal antibody therapy inamandla kakhulu kunokhemotherapy futhi ifana ne-typeergic reaction response. Eminye imiphumela emibi ejwayelekile ye-monoclonal antibody therapy ihlanganisa:
- Ukuphuza isikhumba
- Ukubamba isikhumba noma ukusila
- Izimpawu ezifana ne-fever, chills, aces muscle, ukukhathala nokukhanda ikhanda
- Uhudo
- I-nausea nokuhlanza
- Umfutho wegazi ophansi
Abanye abantu banomthelela omkhulu ekwelapheni kwe-antioclonal antibody. Imiphumela emibi nakakhulu engabangela udokotela wakho ukuba ayeke ukwelashwa kwe-antioclonal antibody (TB) kuhlanganisa:
- Igazi eliphansi kakhulu libala
- Izinkinga zenhliziyo zihlanganisa ukushaya kwenhliziyo okungavamile, ukwehluleka kwenhliziyo, kanye nengozi eyengeziwe yokuhlaselwa yinhliziyo
- Amazinga aphansi we-magnesium, i-potassium, noma i-calcium egazini lakho, okungabangela izinkinga ezinkulu zezempilo
- Ukuhlukumeza okwengqondo okukhulu okuholela ekutheleleni
- Izinkinga zokuphuza
- Ukusabela okusheshayo ekukhusheni kufaka phakathi ukuphefumula, ukuvuthwa, ukuthuthumela, ukuphelelwa amandla, isizungu, umbono ongenalutho, ukuhlukunyezwa, noma ubuhlungu besifuba noma ukucindezelwa
Ngenhlanhla, lapho kusabela okukhulu, zivame ukwenzeka ngokushesha, uma uthola imithi emtholampilo wakho wokunakekelwa umdlavuza. Lokhu kusho ukuthi udokotela wakho nomhlengikazi uzokuqapha futhi bazokwazi ukumisa ukumnika uma kudingeka futhi bakunike ukunakekelwa ngokushesha kwezempilo.
Ngingayisebenzisa kanjani iMonoclonal Antibody Treatment Side Effects?
Izinto ezimbili ezibaluleke kakhulu ongayenza ukuphatha imiphumela emibi ye-monoclonal antibody therapy zilandelayo:
- Thatha yonke imithi yakho njengoba kunqunyiwe, ngoba kulula ukuvimbela imiphumela emibi kunokuwaphatha uma kwenzeka.
- Gcina imigqa yokuxhumana ivuliwe neqembu lakho lezokwelapha. Okusebenza ukuphatha imiphumela emibi yomuntu oyedwa kungase kungasebenzi kuwe. Khuluma nodokotela wakho noma umhlengikazi mayelana nezinketho ukukusiza ukuthi uphumelele ekwelapheni ngemiphumela emibi kakhulu.
Ungamukeli lo mzwelo kabi kungxenye yemvelo yokwelashwa komdlavuza. Kungase kube khona indlela ithimba lakho lezokwelapha likwazi ukuphatha kangcono imiphumela yakho yecala. Uma udinga usizo, cela. Futhi njalo, uma unemibuzo mayelana nemiphumela emibi, shayela ithimba lakho lezokwelapha ngokushesha.
Imithombo
Ama-antibodies e-Fakih M. Anti-EGFR e-mastradioal-colorectal umdlalo: isikhathi sokuba indlela yomuntu ngamunye? I-Expert Rev Anticancer Ther 2008 8: 1471-80.
I-Medline Plus. I-Bevacizumab Injection.
https://medlineplus.gov/druginfo/meds/a607001.html
I-Medline Plus. Ukungena kwe-Cetuximab.
https://medlineplus.gov/druginfo/meds/a607041.html
I-Medline Plus. I-Panitumumab Injection.
https://medlineplus.gov/druginfo/meds/a607066.html
I-Patel DK. Ukusetshenziswa kwemitholampilo ye-anti-epidermal growth factor receptor antioclonal antibodies emdlalweni we-metastatic colorectal. Pharmacotherapy 2008 28: 31S-41S.
URamos FJ, Macarulla T, Capdevila J, Elez E, Tabernero J. Ukuqonda indima yokubikezela ye-K-ras ye-epidermal ukukhula kwezinto ezithintekayo zokuthola imithi emdlalweni womdlavuza. I-Clin Colorectal Cancer 2008 7: S52-S57.
I-American Cancer Society. Ama-Antibodies aMonoclonal. Kufinyelelwe: Dec 4, 2015.
http://www.cancer.org/treatment/treatmentsandsideeffects/treatmenttypes/immunotherapy/immunotherapy-monoclonal-antibodies