Ukusebenzisana Okuyinkimbinkimbi Phakathi Kwezakhi Zofuzo Nezemvelo Yakho
Njengesifo esizimele, i-plaque psoriasis isala into engumfihlakalo ekubangela ukuthi isifo. Nakuba izakhi zofuzo zidlala indima ebalulekile, ezinye izinto zikholelwa ukuthi zifaka isandla. Lokho esikwaziyo ukuthi izimo ezithile kanye nokuziphatha kungabangela izimpawu ze-psoriasis noma ukwandise imvamisa noma ubunzima bokugqashuka. Zihlukana nezifo ezibangelwa ukukhuluphala, imithi yokucindezeleka.
I-Genetics
Umlando womndeni yinkinga eyingozi kunazo zonke yokuthuthukisa i-psoriasis yama-plaque. Eqinisweni, cishe ingxenye eyodwa kwezintathu zabantu abathintekayo yi-psoriasis bazobika ukuba nelinye ilungu lomndeni lesifo. Ingozi ye-psoriasis ibonakala sengathi kungenzeka uma abazali bobabili benayo.
Ngesikhathi ososayensi bengakaboni ukuthi izakhi zofuzo zisebenza kanjani, zithole izindawo eziyisishiyagalolunye ezakhiweni ezihambisana nezimpawu ze-psoriasis, eziye zafaka i-PSORS1 nge-PSORS9. Kulezi, cishe amaphesenti angu-35 kuya kuma-50 abantu abaphethe i-psoriasis ye-plaque bazoba nokuguqulwa kwe-chromosomal ye-PSORS1.
Kuthemba ukuthi ngokuphula i-genetic code, ososayensi ngolunye usuku bangakwazi "ukuguqula" noma ukulungisa izinguquko ezihlobene nesifo.
Imibuzo evamile
Nakuba i-psoriasis ye-plaque ingathinta noma ubani, kunezinto eziningi ezibonakala zikhulisa amathuba okuba nezimpawu (ezaziwa nangokuthi ama-flares ).
Izifo
Zombili izifo ezinzima futhi ezingapheli zingabangela izimpawu ze-psoriasis. Sibona lokhu ikakhulukazi nge- HIV , isifo esingapheli esihambisana nokuvuvukala okuqhubekayo. Nakuba izinga le-psoriasis lilingana ncamashi nomphakathi jikelele, ubuhlungu besifo bubi nakakhulu uma i-HIV ihilelekile.
Ukususwa komzimba okubonakala sengathi kuyisici esiyinhloko, kungakhathaliseki ukuthi kubangelwa i-HIV noma ukutheleleka okunzima njenge-bronchitis, strep throat, noma umkhuhlane.
Ngokuphambene, ukwelashwa isifo ngokuvamile kunganciphisa izimpawu. Ucwaningo luye lwabonisa, isibonelo, ukuthi izidakamizwa ze-statin zinganciphisa ubukhulu be-psoriasis ejwayelekile kubantu abanesifo senhliziyo esingapheli. Okufanayo kubonakala kuyiqiniso lapho izidakamizwa ze-antiretroviral zisetshenziswa kubantu abane-HIV.
I-Skin Trauma
Ukuhlukunyezwa kwengqondo kungabangela nezimpawu ze-plaque psoriasis, ngokuvamile ebizwa ngokuthi yi- Koebner . Le mpendulo ibonakala nezinye izimo ezinjengama-warts, plan lichen , kanye ne- molluscum contagiosum .
Abaningi kubantu abane abane-psoriasis bakuthola lokhu, kubangelwe yizinto zonke ezivela ekushiseni kwelanga kanye nezinambuzane zokulonda ukuze zikhumbuze izifo ezibuhlungu kanye nezidakamizwa zesinaliti. Ngisho nokulimala kakhudlwana kakhudlwana, njengesilonda sokuhlinzwa noma tattoo, kungaba yindawo esemqoka ye-psoriasis flare.
Imithi
Imithi ethile iyaziwa ukuqala izimpawu ze-psoriasis. Ayithinti bonke abantu ngendlela efanayo futhi angeke ibangele izimpawu. Noma kunjalo, izidakamizwa ezivame ukukhonjiswa zihlanganisa:
- Lithium
- Beta-blockers
- Izidakamizwa ezingezona ukuvuvukala (non-steroidal anti-inflammatory (NSAIDs)
- Izidakamizwa zokulwa ne-malaria
- Abavimbela isiteshi se-Calcium
- Imithi yokunciphisa i-Lipid
Ngaphezu kwalokho, ukuqedwa ngokushesha kwe -corticosteroids yama-topic okusetshenziselwa ukwelapha i-psoriasis kungaba nomphumela "wokuvukela" futhi kuholele ekugqibeleni okukhulu. Ngenxa yalesi sizathu, i-corticosteroids kufanele ihlale igxiliwe kancane kancane, ngaphansi kokuqondiswa udokotela, uma ngabe isidakamizwa asisadingeki.
Izindlela Zengozi Yokuphila
Ngaphandle kokuthi izingozi zokuphila zithinteka, kunezintathu ezingaxhunyaniswa ngokungafani ne-plaque psoriasis: ukucindezeleka, ukubhema nokukhuluphala.
Ukucindezeleka
Ukucindezeleka kunobungane obangela imbangela kanye nomphumela ku-psoriasis. Ngakolunye uhlangothi, ukucindezeleka kungabangela izimpawu, kanti, ezinye, izimpawu zingabangela ukucindezeleka.
Ngendlela efanayo lapho umzimba uthumela izibonakaliso zokuvuvukala ukuze uphulukise isilonda, ukucindezeleka kwengqondo kungabangela impendulo yokuvuvukala enomthelela omubi, ukuwohloka esikhundleni sokuthuthukisa isimo.
Lokhu kuyinkathazo ikakhulukazi kusukela i-psoriasis engapheli ihlotshaniswa namazinga aphezulu okucindezeleka nokukhathazeka. Kwezinye izimo, umjikelezo ononya ungaphulwa kuphela ngezokwelapha okufanelekile, kuhlanganise ne-psychotherapy kanye nokusetshenziswa okufanele kwezidakamizwa zokulwa nokucindezeleka noma ukulwa nokukhathazeka.
Ukubhema
Ucwaningo lwamuva luye lwabonisa ukuthi abantu ababhema ngaphezu kwepakethe kagwayi ngosuku banamathuba amabili okuba ne-psoriasis enzima kunalabo ababhema ugwayi 10 noma ngaphansi kwansuku zonke.
Ososayensi abaqiniseki ukuthi kungani lokhu kuyikho kodwa bakholelwa ukuthi ukubhema kungandisa inani le-autoantigens engxenyeni yangaphandle yesikhumba (eyaziwa ngokuthi i- epidermis ). Lawa amaprotheni ahlose amasosha omzimba omzimba wokuhlasela okuzenzakalelayo. Abanye baye basikisela ukuthi ukubhema kuvele kubangele noma kuphuthumayo impendulo yokuzimela.
Ukucwaninga okufanayo kuye kwaphetha nokuthi abesifazane ababhemayo basengozini enkulu ye-psoriasis enamandla kunamadoda. Isibalo seminyaka umuntu aphumayo futhi sinomthelela.
Ukukhuluphala
Ukukhuluphala ngokweqile kungavame ukudala ukwakhiwa kwamapulanka ngaphakathi kwesikhumba. Ngenkathi isizathu esiqondile salokhu singacacile, ucwaningo lubonisa ukuthi ukuqoqwa kwamafutha ngokweqile kwandisa ukukhiqizwa kwamaprotheni okuvuvukala okuthiwa yi- cytokines . Ama-Cytokines akhulisa nje ukuvuvukala okuvamile, okwenza izimpawu zibe zibi nakakhulu, kodwa zithuthukise ukwakheka kwamacwecwe ezindaweni lapho amafutha amaningi kakhulu (okungukuthi, amafolda esikhumba).
Le nhlangano ibonakala ngokwengeziwe ngobuhlobo phakathi kokukhuluphala, isifo sikashukela, ne-psoriasis. Nakuba ukukhuluphala kungaphazamisa ingozi yomuntu wesifo sikashukela sohlobo lwesibili , isifo sikashukela singandisa ingozi kanye nobukhulu be-plaque psoriasis ngamaphesenti angu-27.
> Imithombo:
> Arias-Santiago, S .; Espiñeira-Caromona, M .; and Aneiros-Fernández, J. "The Koebner Phenomenon: Psoriasis in Tattoos." I- CMAJ . 2013 Apr 16; 185 (7): 585. I-PMCID: PMC3626811.
> Armstrong, A .; I-Harskamp, i-C .; kanye ne-Armstrong, E. "Inhlangano Ephakathi Kwe-Psoriasis nokukhuluphala Ukubuyekezwa Okuhlelekile Nokuhlaziywa Kwezinhlelo Zokuhlola ." I- Nutrus Diabetes. 2012 Dec 3; 2: e54. I-DOI: 10.1038 / nutd.2012.26.
> Armstrong, A .; I-Harskamp, i-C .; Dhillon, J. et al. "I-Psoriasis nokubhema: Ukubuyekezwa okuhlelekile nokuhlaziywa kwe-Meta-Analysis." I- Br J Dermatol . 2014 Feb; 170 (2): 304-14. I-DOI: 10.1111 / bjd.12670.
> Jankovic, uS .; URaznatovic, uM .; UMarinkovic, J. et al. "Izingozi Ze-Psoriasis: Isifundo Sokulawula Amacala." J Dermatol. 2009 Jun; 36 (6): 328-34. I-DOI: 10.1111 / j.1346-8138.2009.00648.x.
> Mosiewicz, J .; I-Pietrzak, A .; Chodorowska, G et al. "Ukulinganisa ukusetshenziswa kwesimiso ngeziguli ze-psoriatic." I- Arch Dermatol Res . 2013 Aug; 305 (6): 467-72. I-DOI: 10.1007 / s00403-013-1374-1.